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Publication Detail

Title: The effect of atopy, childhood crowding, and other immune-related factors on non-Hodgkin lymphoma risk.

Authors: Cozen, W; Cerhan, J R; Martinez-Maza, O; Ward, M H; Linet, M; Colt, J S; Davis, S; Severson, R K; Hartge, P; Bernstein, L

Published In Cancer Causes Control, (2007 Oct)

Abstract: Since adult immune responsiveness is influenced by early childhood exposures, we examined the role of family size, history of atopic disease, and other childhood immune-related exposures in a multi-center case-control study of NHL.Interviews were completed with 1,321 cases ascertained from population-based cancer registries in Seattle, Detroit, Los Angeles and Iowa, and with 1,057 frequency-matched controls, selected by random-digit dialing and from the Medicare files database. Multivariable logistic regression was used to estimate risk.A history of any allergy (excluding drug allergies), decreased risk of all NHL (Odds Ratio [OR] = 0.7, 95% Confidence Interval [CI] = 0.6-1.0), diffuse large B-cell lymphoma [DLBCL] (OR = 0.6, 95% CI = 0.4-0.9), and follicular NHL (OR = 0.7, 95 CI = 0.5, 1.0). A similar effect was observed for hay fever. A history of eczema was associated with an increased risk of follicular lymphoma (OR = 1.9, 95% CI = 1.1-3.4), but not DLBCL (OR = 1.1, 95% CI = 0.6-2.0). Asthma did not affect risk. Youngest compared to oldest siblings had a 90% increased risk of DLBCL (95% CI = 1.2-3.1; p for trend with increasing birth order = 0.006), but not follicular lymphoma (OR = 1.1, 95% CI = 0.6-1.8).We infer that some childhood and immune-related factors may alter NHL risk.

PubMed ID: 17588155 Exiting the NIEHS site

MeSH Terms: Adult; Aged; Asthma/complications; Birth Order; Case-Control Studies; Crowding*; Eczema/complications; Family Characteristics; Female; Humans; Hypersensitivity, Immediate/complications*; Lymphoma, Non-Hodgkin/epidemiology*; Lymphoma, Non-Hodgkin/immunology; Male; Middle Aged; Rhinitis, Allergic, Seasonal/complications; Risk Assessment; Risk Factors; SEER Program

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