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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Clocks and cardiovascular function.

Authors: McLoughlin, Sarah C; Haines, Philip; FitzGerald, Garret A

Published In Methods Enzymol, (2015)

Abstract: Circadian clocks in central and peripheral tissues enable the temporal synchronization and organization of molecular and physiological processes of rhythmic animals, allowing optimum functioning of cells and organisms at the most appropriate time of day. Disruption of circadian rhythms, from external or internal forces, leads to widespread biological disruption and is postulated to underlie many human conditions, such as the incidence and timing of cardiovascular disease. Here, we describe in vivo and in vitro methodology relevant to studying the role of circadian rhythms in cardiovascular function and dysfunction.

PubMed ID: 25707279 Exiting the NIEHS site

MeSH Terms: Animals; Cardiovascular Physiological Phenomena*; Cells, Cultured; Circadian Rhythm*; Humans; Macrophages, Peritoneal/cytology; Mice; Myocytes, Cardiac/metabolism; Radio Waves; Telemetry/methods; Thrombosis/physiopathology

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