Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: The serpentine path to a novel mechanism-based inhibitor of acute inflammatory lung injury.

Authors: Fisher, Aron B

Published In J Appl Physiol (1985), (2014 Jun 15)

Abstract: The Comroe lecture on which this review is based described my research path during the past 45 years, beginning with studies of oxidant stress (hyperoxia) and eventuating in the discovery of a synthetic inhibitor of phospholipase A2 activity (called MJ33) that prevents acute lung injury in mice exposed to lipopolysaccharide. In between were studies of lung ischemia, lung surfactant metabolism, the protein peroxiredoxin 6 and its phospholipase A2 activity, and mechanisms for NADPH oxidase activation. These seemingly unrelated research activities provided the nexus for identification of a novel target and a potentially novel therapeutic agent for prevention or treatment of acute lung injury.

PubMed ID: 24744383 Exiting the NIEHS site

MeSH Terms: Acute Lung Injury/metabolism*; Acute Lung Injury/physiopathology; Animals; Humans; Inflammation/metabolism*; Inflammation/physiopathology; NADPH Oxidases/metabolism; Oxidative Stress/physiology; Peroxiredoxin VI/metabolism; Phospholipases A2/metabolism

Back
to Top