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Publication Detail

Title: Hexavalent chromium is cytotoxic and genotoxic to American alligator cells.

Authors: Wise, Sandra S; Wise, Catherine; Xie, Hong; Guillette Jr, Louis J; Zhu, Cairong; Wise Jr, John Pierce; Wise Sr, John Pierce

Published In Aquat Toxicol, (2016 Feb)

Abstract: Metals are a common pollutant in the aquatic ecosystem. With global climate change, these levels are anticipated to rise as lower pH levels allow sediment bound metals to be released. The American alligator (Alligator mississippiensis) is an apex predator in the aquatic ecosystem and is considered a keystone species; as such it serves as a suitable monitor for localized pollution. One metal of increasing concern is hexavalent chromium (Cr(VI)). It is present in the aquatic environment and is a known human carcinogen and reproductive toxicant. We measured the cytotoxicity and genotoxicity of Cr(VI) in American alligator cells derived from scute tissue. We found that particulate and soluble Cr(VI) are both cytotoxic and genotoxic to alligator cells in a concentration-dependent manner. These data suggest that alligators may be used as a model for assessing the effects of environmental Cr(VI) contamination as well as for other metals of concern.

PubMed ID: 26730726 Exiting the NIEHS site

MeSH Terms: Alligators and Crocodiles/genetics; Alligators and Crocodiles/physiology*; Animals; Cell Line; Cell Survival/drug effects; Cells, Cultured; Chromium/toxicity*; Chromosome Aberrations/chemically induced; Climate Change; DNA Damage/drug effects*; Skin/drug effects; United States; Water Pollutants, Chemical/toxicity*

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