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National Institute of Environmental Health Sciences

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Publication Detail

Title: Prospective assessment of serum periostin as a biomarker for diagnosis and monitoring of eosinophilic oesophagitis.

Authors: Dellon, E S; Higgins, L L; Beitia, R; Rusin, S; Woosley, J T; Veerappan, R; Selitsky, S R; Parker, J S; Genta, R M; Lash, R H; Aranda, R; Peach, R J; Grimm, M

Published In Aliment Pharmacol Ther, (2016 Jul)

Abstract: Periostin is highly expressed in eosinophilic oesophagitis (EoE), but has not been extensively studied as a non-invasive biomarker.To assess whether serum periostin distinguished EoE from controls at baseline, had utility for monitoring treatment response, or was associated with IL-13 levels.This was a sub-analysis of a prospective cohort study of adults undergoing out-patient upper endoscopy. Incident cases of EoE were diagnosed per consensus guidelines. Controls were subjects with either GERD or dysphagia without EoE. EoE patients were treated with swallowed/topical steroids and had repeat endoscopy/biopsy. Serum periostin levels for cases and controls were compared at baseline, and pre/post-treatment levels were compared for cases. Serum IL-13 and tissue expression of periostin were also assessed.A total of 61 incident EoE cases and 87 controls were analysed. Despite a marked increase in tissue periostin expression in cases, the median baseline serum periostin level was only slightly higher in cases than controls (22.1 ng/mL vs. 20.7; P = 0.04); there was no change in post-treatment levels. There was also no difference in serum periostin for cases by histologic response or atopic status. There was a strong trend towards higher serum IL-13 levels in cases in the highest periostin quartile (57.1 pg/mL vs. 2.6; P = 0.07).Serum periostin levels were similar in cases and controls, and there were no changes post-treatment. Given elevated IL-13 levels in the EoE patients with the highest periostin levels, future studies could explore periostin as a biomarker in EoE, perhaps in the setting of anti-IL-13 therapy.

PubMed ID: 27193351 Exiting the NIEHS site

MeSH Terms: Adult; Biomarkers/blood; Biopsy; Cell Adhesion Molecules/blood*; Deglutition Disorders/diagnosis; Endoscopy/methods; Eosinophilic Esophagitis/diagnosis*; Female; Humans; Interleukin-13/blood*; Male; Middle Aged; Outpatients; Prospective Studies

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