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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells.

Authors: Wongrakpanich, Amaraporn; Mudunkotuwa, Imali A; Geary, Sean M; Morris, Angie S; Mapuskar, Kranti A; Spitz, Douglas R; Grassian, Vicki H; Salem, Aliasger K

Published In Environ Sci Nano, (2016 Apr 01)

Abstract: The increasing use of copper oxide (CuO) nanoparticles (NPs) in medicine and industry demands an understanding of their potential toxicities. In this study, we compared the in vitro cytotoxicity of CuO NPs of two distinct sizes (4 and 24 nm) using the A549 human lung cell line. Despite possessing similar surface and core oxide compositions, 24 nm CuO NPs were significantly more cytotoxic than 4 nm CuO NPs. The difference in size may have affected the rate of entry of NPs into the cell, potentially influencing the amount of intracellular dissolution of Cu2+ and causing a differential impact on cytotoxicity.

PubMed ID: 27347420 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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