Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort.

Authors: Graff, M; North, K E; Richardson, A S; Young, K L; Mazul, A L; Highland, H M; Mohlke, K L; Lange, L A; Lange, E M; Mullan Harris, K; Gordon-Larsen, P

Published In Int J Obes (Lond), (2017 05)

Abstract: OBJECTIVE: The association of obesity susceptibility variants with change in body mass index (BMI) across the life course is not well understood. SUBJECTS: In ancestry-stratified models of 5962 European American (EA), 2080 African American (AA) and 1582 Hispanic American (HA) individuals from the National Longitudinal Study of Adolescent to Adult Health (Add Health), we examined associations between 34 obesity single-nucleotide polymorphisms (SNPs) with per year change in BMI, measured by the slope from a growth-curve analysis of two or more BMI measurements between adolescence and young adulthood. For SNPs nominally associated with BMI change (P<0.05), we interrogated age differences within data collection Wave and time differences between age categories that overlapped between Waves. RESULTS: We found SNPs in/near FTO, MC4R, MTCH2, TFAP2B, SEC16B and TMEM18 were significantly associated (P<0.0015≈0.05/34) with BMI change in EA and the ancestry-combined meta-analysis. rs9939609 in FTO met genome-wide significance at P<5e-08 in the EA and ancestry-combined analysis, respectively [Beta(se)=0.025(0.004);Beta(se)=0.021(0.003)]. No SNPs were significant after Bonferroni correction in AA or HA, although five SNPs in AA and four SNPs in HA were nominally significant (P<0.05). In EA and the ancestry-combined meta-analysis, rs3817334 near MTCH2 showed larger effects in younger respondents, whereas rs987237 near TFAP2B, showed larger effects in older respondents across all Waves. Differences in effect estimates across time for MTCH2 and TFAP2B are suggestive of either era or cohort effects. CONCLUSION: The observed association between variants in/near FTO, MC4R, MTCH2, TFAP2B, SEC16B and TMEM18 with change in BMI from adolescence to young adulthood suggest that the genetic effect of BMI loci varies over time in a complex manner, highlighting the importance of investigating loci influencing obesity risk across the life course.

PubMed ID: 28025578 Exiting the NIEHS site

MeSH Terms: Adolescent; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics; Body Mass Index*; Cohort Studies; DNA-Binding Proteins/genetics; Ethnicity/genetics*; Female; Genetic Loci/genetics*; Genetic Predisposition to Disease/genetics*; Genetic Variation; Genome-Wide Association Study; Humans; Male; Membrane Proteins/genetics; Mitochondrial Membrane Transport Proteins/genetics; National Longitudinal Study of Adolescent Health; Obesity/epidemiology; Obesity/genetics*; Polymorphism, Single Nucleotide; Receptor, Melanocortin, Type 4/genetics; Transcription Factor AP-2/genetics; United States/epidemiology; Weight Gain/genetics; Weight Gain/physiology; Young Adult

Back
to Top