Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons.

Authors: Woodward, Nicholas C; Pakbin, Payam; Saffari, Arian; Shirmohammadi, Farimah; Haghani, Amin; Sioutas, Constantinos; Cacciottolo, Mafalda; Morgan, Todd E; Finch, Caleb E

Published In Neurobiol Aging, (2017 05)

Abstract: Traffic-related air pollution (TRAP) is associated with lower cognition and reduced white matter volume in older adults, specifically for particulate matter <2.5-μm diameter (PM2.5). Rodents exposed to TRAP have shown microglial activation and neuronal atrophy. We further investigated age differences of TRAP exposure, with focus on hippocampus for neuritic atrophy, white matter degeneration, and microglial activation. Young- and middle-aged mice (3 and 18 months female C57BL/6J) were exposed to nanoscale-PM (nPM, <0.2 μm diameter). Young mice showed selective changes in the hippocampal CA1 region, with neurite atrophy (-25%), decreased MBP (-50%), and increased Iba1 (+50%), with dentate gyrus relatively unaffected. Exposure to nPM of young mice decreased GluA1 protein (-40%) and increased TNFa mRNA (10×). Older controls had age changes approximating nPM effects on young, with no response to nPM, suggesting an age-ceiling effect. The CA1 selective vulnerability in young mice parallels CA1 vulnerability in Alzheimer's disease. We propose that TRAP-associated human cognitive and white matter changes involve hippocampal responses to nPM that begin at younger ages.

PubMed ID: 28212893 Exiting the NIEHS site

MeSH Terms: Aging/drug effects*; Aging/pathology*; Aging/psychology; Air Pollution/adverse effects*; Animals; Atrophy; CA1 Region, Hippocampal/cytology*; CA1 Region, Hippocampal/drug effects; CA1 Region, Hippocampal/pathology; Cognition; Female; Mice, Inbred C57BL; Microglia/drug effects; Microglia/pathology; Myelin Sheath/drug effects*; Myelin Sheath/pathology*; Neurites/drug effects*; Neurites/pathology*; Neurons/drug effects*; Neurons/pathology*; Particle Size; Particulate Matter/adverse effects*; Vehicle Emissions/toxicity*; White Matter/drug effects; White Matter/pathology

Back
to Top