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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Urinary triclosan concentrations and diminished ovarian reserve among women undergoing treatment in a fertility clinic.

Authors: Mínguez-Alarcón, Lidia; Christou, Georgios; Messerlian, Carmen; Williams, Paige L; Carignan, Courtney C; Souter, Irene; Ford, Jennifer B; Calafat, Antonia M; Hauser, Russ; EARTH Study Team

Published In Fertil Steril, (2017 Aug)

Abstract: To investigate the association between urinary triclosan concentrations and antral follicle count (AFC), a well-accepted marker of ovarian reserve, among women from a fertility center.Prospective cohort study.Hospital fertility center.A total of 109 women.Urinary triclosan concentrations quantified by online solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry.AFC through transvaginal ultrasonography on the third day of an unstimulated menstrual cycle or on the third day of a progesterone withdrawal bleed.The geometric mean of the specific gravity-adjusted urinary triclosan concentrations for the 225 samples provided by the 109 women was 13.0 μg/L (95% confidence interval [CI], 8.9, 19.1). Women had median (with interquartile range) AFC of 13 (8, 18). The specific gravity-adjusted urinary triclosan concentrations were inversely associated with AFC (-4%; 95% CI, -7%, -1%). Women with triclosan concentrations above the median had lower AFC compared with those whose triclosan concentrations were equal to or below the median, with an adjusted difference of -3.2 (95% CI, -3.9, -1.6) among those with a body mass index <25 kg/m2 and -1.8 (95% CI, -3.2, -0.3) among those who were <35 years old.Specific gravity-adjusted urinary triclosan concentrations were inversely associated with AFC in women seeking care at a fertility center. This association was modified by age and body mass index, with the younger and leaner women showing larger decreases in AFC.

PubMed ID: 28583664 Exiting the NIEHS site

MeSH Terms: Adult; Age Distribution; Aging/metabolism; Biomarkers/urine; Boston/epidemiology; Endocrine Disruptors/urine*; Environmental Exposure/statistics & numerical data*; Female; Humans; Infertility, Female/diagnosis; Infertility, Female/epidemiology*; Infertility, Female/urine*; Ovarian Reserve*; Pregnancy; Triclosan/urine*

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