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National Institute of Environmental Health Sciences

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Publication Detail

Title: Synthesis and Characterization of Thermoresponsive Hydrogels Based on N-Isopropylacrylamide Crosslinked with 4,4'-Dihydroxybiphenyl Diacrylate.

Authors: Tang, Shuo; Floy, Martha; Bhandari, Rohit; Sunkara, Manjula; Morris, Andrew J; Dziubla, Thomas D; Hilt, J Zach

Published In ACS Omega, (2017 Dec 31)

Abstract: A novel crosslinker [4,4'-dihydroxybiphenyl diacrylate (44BDA)] was developed, and a series of temperature-responsive hydrogels were synthesized through free radical polymerization of N-isopropylacrylamide (NIPAAm) with 44BDA. The temperature-responsive behavior of the resulting gels was characterized by swelling studies, and the lower critical solution temperature (LCST) of the hydrogels was characterized through differential scanning calorimetry. Increased content of 44BDA led to a decreased swelling ratio and shifted the LCST to lower temperatures. These novel hydrogels also displayed resiliency through multiple swelling-deswelling cycles, and their temperature responsiveness was reversible. The successful synthesis of NIPAAm-based hydrogels crosslinked with 44BDA has led to a new class of temperature-responsive hydrogel systems with a variety of potential applications.

PubMed ID: 29302630 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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