Title: Maternal Lifetime Stress and Prenatal Psychological Functioning and Decreased Placental Mitochondrial DNA Copy Number in the PRISM Study.
Authors: Brunst, Kelly J; Sanchez Guerra, Marco; Gennings, Chris; Hacker, Michele; Jara, Calvin; Bosquet Enlow, Michelle; Wright, Robert O; Baccarelli, Andrea; Wright, Rosalind J
Published In Am J Epidemiol, (2017 Dec 01)
Abstract: Psychosocial stress contributes to placental oxidative stress. Mitochondria are vulnerable to oxidative stress, which can lead to changes in mitochondrial DNA copy number (mtDNAcn). We examined associations of maternal lifetime stress, current negative life events, and depressive and posttraumatic-stress-disorder symptom scores with placental mtDNAcn in a racially/ethnically diverse sample (n = 147) from the Programming of Intergenerational Stress Mechanisms (PRISM) study (Massachusetts, March 2011 to August 2012). In linear regression analyses adjusted for maternal age, race/ethnicity, education, prenatal fine particulate matter exposure, prenatal smoking exposure, and the sex of the child, all measures of stress were associated with decreased placental mtDNAcn (all P values < 0.05). Weighted-quantile-sum (WQS) regression showed that higher lifetime stress and depressive symptoms accounted for most of the effect on mtDNAcn (WQS weights: 0.25 and 0.39, respectively). However, among white individuals, increased lifetime stress and posttraumatic stress disorder symptoms explained the majority of the effect (WQS weights: 0.20 and 0.62, respectively) while among nonwhite individuals, lifetime stress and depressive symptoms accounted for most of the effect (WQS weights: 0.27 and 0.55, respectively). These analyses are first to link increased maternal psychosocial stress with reduced placental mtDNAcn and add to literature documenting racial/ethnic differences in the psychological sequelae of chronic stress that may contribute to maternal-fetal health.
PubMed ID: 28595325
MeSH Terms: African Americans/psychology; African Americans/statistics & numerical data; Biomarkers/blood; DNA Copy Number Variations*; DNA, Mitochondrial/blood*; DNA, Mitochondrial/genetics; Depression/genetics; Depression/physiopathology*; Educational Status; European Continental Ancestry Group/psychology; European Continental Ancestry Group/statistics & numerical data; Female; Hispanic Americans/psychology; Hispanic Americans/statistics & numerical data; Humans; Infant, Newborn; Linear Models; Male; Massachusetts/epidemiology; Oxidative Stress/genetics; Oxidative Stress/physiology*; Placenta*; Pregnancy; Pregnancy Complications/ethnology; Pregnancy Complications/etiology; Pregnancy Complications/genetics; Pregnancy Complications/psychology*; Prospective Studies; Stress Disorders, Post-Traumatic/genetics; Stress Disorders, Post-Traumatic/physiopathology*; Stress, Psychological/genetics; Stress, Psychological/physiopathology*