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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Untargeted metabolomics reveals multiple metabolites influencing smoking-related DNA methylation.

Authors: Huang, Yunfeng; Hui, Qin; Walker, Douglas I; Uppal, Karan; Goldberg, Jack; Jones, Dean P; Vaccarino, Viola; Sun, Yan V

Published In Epigenomics, (2018 Apr 01)

Abstract: We conducted a joint metabolomic-epigenomic study to identify patterns of epigenetic associations with smoking-related metabolites.We performed an untargeted metabolome-wide association study of smoking and epigenome-wide association studies of smoking-related metabolites among 180 male twins. We examined the patterns of epigenetic association linked to smoking-related metabolites using hierarchical clustering.Among 12 annotated smoking-related metabolites identified from a metabolome-wide association study, we observed significant hypomethylation associated with increased level of N-acetylpyrrolidine, cotinine, 5-hydroxycotinine and nicotine and hypermethylation associated with increased level of 8-oxoguanine. Hierarchical clustering revealed common and unique epigenetic-metabolic associations related to smoking.Our study suggested that a joint metabolome-epigenome approach can reveal additional details in molecular responses to the environmental exposure to understand disease risk.

PubMed ID: 29528243 Exiting the NIEHS site

MeSH Terms: CpG Islands; DNA Methylation*; Epigenesis, Genetic; Genetic Association Studies; Humans; Male; Metabolomics; Middle Aged; Smoking/genetics*

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