Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: On comparing 2 correlated C indices with censored survival data.

Authors: Han, Xiaoxia; Zhang, Yilong; Shao, Yongzhao

Published In Stat Med, (2017 Nov 10)

Abstract: As new biomarkers and risk prediction procedures are in rapid development, it is of great interest to develop valid methods for comparing predictive power of 2 biomarkers or risk score systems. Harrell C statistic has been routinely used as a global adequacy assessment of a risk score system, and the difference of 2 Harrell C statistics as a test statistic has been suggested in recent literature for comparison of predictive power of 2 biomarkers for censored outcome. In this study, we showed that such a test can have severely inflated type I errors as the difference between the 2 Harrell C statistics does not converge to zero under the null hypothesis of equal predictive power measured by concordance probabilities, as illustrated by 2 counterexamples and corresponding numerical simulations. We further investigate a necessary and sufficient condition under which the difference of 2 Harrell C statistics converges to zero under the null hypothesis.

PubMed ID: 28758216 Exiting the NIEHS site

MeSH Terms: Bayes Theorem; Bias*; Biomarkers; Biometry/methods; Data Interpretation, Statistical*; Humans; Probability; Risk Assessment/methods; Statistics, Nonparametric; Survival Analysis*

Back
to Top