Title: Darkening with UVRAG.
Authors: Li, Shun; Jang, Gyu-Beom; Quach, Christine; Liang, Chengyu
Published In Autophagy, (2019 02)
Abstract: Ultraviolet radiation (UVR)-induced skin pigmentation, afforded by the dark organelles termed melanosomes, accounts for the first-line protection against environmental UVR that increases the risk of developing skin cancers including melanoma. We have recently discovered that UVRAG, originally identified as a BECN1-binding macroautophagy/autophagy protein, appears to have a specialized function in melanosome biogenesis beyond autophagy through its interaction with the biogenesis of lysosome-related organelles complex 1 (BLOC-1). This melanogenic function of UVRAG is controlled by the melanocyte-specific transcription factor MITF as a downstream effector of the α-melanocyte-stimulating hormone (α-MSH)-cAMP signaling in the suntan response, which is compromised in BRAF mutant melanoma. Thus we propose a new mode of UVRAG activity and regulation in melanocyte biology that may affect melanoma predisposition.
PubMed ID: 30209981
MeSH Terms: Beclin-1; Humans; Melanins/metabolism; Melanocytes/metabolism; Melanocytes/radiation effects; Melanosomes/metabolism; Melanosomes/radiation effects; Skin Pigmentation*/radiation effects; Tumor Suppressor Proteins/metabolism*; Ultraviolet Rays