Title: Post-translational modifications in MeHg-induced neurotoxicity.
Authors: Ke, Tao; Gonçalves, Filipe Marques; Gonçalves, Cinara Ludvig; Dos Santos, Alessandra Antunes; Rocha, João B T; Farina, Marcelo; Skalny, Anatoly; Tsatsakis, Aristidis; Bowman, Aaron B; Aschner, Michael
Published In Biochim Biophys Acta Mol Basis Dis, (2019 08 01)
Abstract: Mercury (Hg) exposure remains a major public health concern due to its widespread distribution in the environment. Organic mercurials, such as MeHg, have been extensively investigated especially because of their congenital effects. In this context, studies on the molecular mechanism of MeHg-induced neurotoxicity are pivotal to the understanding of its toxic effects and the development of preventive measures. Post-translational modifications (PTMs) of proteins, such as phosphorylation, ubiquitination, and acetylation are essential for the proper function of proteins and play important roles in the regulation of cellular homeostasis. The rapid and transient nature of many PTMs allows efficient signal transduction in response to stress. This review summarizes the current knowledge of PTMs in MeHg-induced neurotoxicity, including the most commonly PTMs, as well as PTMs induced by oxidative stress and PTMs of antioxidant proteins. Though PTMs represent an important molecular mechanism for maintaining cellular homeostasis and are involved in the neurotoxic effects of MeHg, we are far from understanding the complete picture on their role, and further research is warranted to increase our knowledge of PTMs in MeHg-induced neurotoxicity.
PubMed ID: 30385410
MeSH Terms: Animals; Humans; Methylmercury Compounds/adverse effects*; Mitochondria/drug effects; Mitochondria/metabolism; Neurotoxicity Syndromes/etiology; Neurotoxicity Syndromes/metabolism*; Oxidative Stress/drug effects; Phosphorylation/drug effects; Protein Processing, Post-Translational/drug effects*; Proteins/metabolism; Reactive Oxygen Species/metabolism