Title: Microbial monotherapy with Prevotella histicola for patients with multiple sclerosis.

Authors: Mangalam, Ashutosh K; Murray, Joseph

Published In Expert Rev Neurother, (2019 01)

Abstract: Introduction: The gut microbiome helps to maintain a person's healthy state while perturbations in its function often leading to the development of inflammatory diseases including multiple sclerosis (MS). Consequently, gut-commensals which restore homeostasis have the potential to become novel therapeutic options for treating MS. MS patients have presented gut dysbiosis with a reduction in bacteria belonging to the Prevotella genus. Notably, increased levels of Prevotella are observed when disease-modifying therapies are used. Additionally, Prevotella histicola, an anaerobic bacterium derived from the human, can suppress disease in mice with experimental autoimmune encephalomyelitis, a preclinical MS model. Areas covered: This review compares MS microbiome studies from different geographical regions to identify common gut bacteria. Literature on the potential use of P. histicola as a therapy for MS and the next steps for developing microbial monotherapies in MS is also discussed. Expert commentary: Recent findings presenting an inverse correlation between Prevotella and MS disease severity and ability of P. histicola to suppress disease in preclinical models suggest that P. histicola might provide an additional treatment option for MS patients. However, rigorous testing in well-designed control trials should be performed to determine the safety and efficacy P. histicola in MS patients.

PubMed ID: 30513004

MeSH Terms: Animals; Dysbiosis/diet therapy*; Dysbiosis/microbiology; Gastrointestinal Microbiome*; Humans; Multiple Sclerosis/diet therapy*; Multiple Sclerosis/microbiology; Prevotella*; Probiotics/therapeutic use*