Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: From Prevention to Disease Perturbations: A Multi-Omic Assessment of Exercise and Myocardial Infarctions.

Authors: Odenkirk, Melanie T; Stratton, Kelly G; Bramer, Lisa M; Webb-Robertson, Bobbie-Jo M; Bloodsworth, Kent J; Monroe, Matthew E; Burnum-Johnson, Kristin E; Baker, Erin S

Published In Biomolecules, (2020 Dec 30)

Abstract: While a molecular assessment of the perturbations and injury arising from diseases is essential in their diagnosis and treatment, understanding changes due to preventative strategies is also imperative. Currently, complex diseases such as cardiovascular disease (CVD), the leading cause of death worldwide, suffer from a limited understanding of how the molecular mechanisms taking place following preventive measures (e.g., exercise) differ from changes occurring due to the injuries caused from the disease (e.g., myocardial infarction (MI)). Therefore, this manuscript assesses lipidomic changes before and one hour after exercise treadmill testing (ETT) and before and one hour after a planned myocardial infarction (PMI) in two separate patient cohorts. Strikingly, unique lipidomic perturbations were observed for these events, as could be expected from their vastly different stresses on the body. The lipidomic results were then combined with previously published metabolomic characterizations of the same patients. This integration provides complementary insights into the exercise and PMI events, thereby giving a more holistic understanding of the molecular changes associated with each.

PubMed ID: 33396843 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

to Top