Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Prescription drug use and risk of acute myeloid leukemia by French-American-British subtype: results from a Los Angeles County case-control study.

Authors: Pogoda, Janice M; Katz, Jonathan; McKean-Cowdin, Roberta; Nichols, Peter W; Ross, Ronald K; Preston-Martin, Susan

Published In Int J Cancer, (2005 Apr 20)

Abstract: Chemotherapy is a well-established risk factor for acute myeloid leukemia (AML) but little is known about other prescription drugs and AML risk. We report data from a population-based Los Angeles County study in which 299 matched case-control pairs had complete data on prescription drug use and 88% of cases were subtyped according to the French-American-British (FAB) criteria. Cases were diagnosed between 1987 and 1994. Prescription nonsteroidal anti-inflammatory drug (NSAID) use for at least 4 weeks in the 2 to 10 years before diagnosis was associated with decreased risk (odds ratio = 0.5, 95% confidence interval=0.3, 1.0; p=0.04) with dose-response most evident for FAB subtype M2 (OR = 0.6, CI: 0.1, 2.9 for duration < or =6 months; OR = 0.2, CI: 0.0, 1.6 for >6 months). For subtype M4, ORs increased with increasing duration of benzodiazepine use in the 2 to 10 years before diagnosis (OR = 1.5, CI: 0.3, 9.0 for < or =6 months vs. OR = 5.0, CI: 0.6, 42.8 for >6 months). These results suggest that prescription drugs other than chemotherapy may have FAB subtype-specific effects on AML risk.

PubMed ID: 15609330 Exiting the NIEHS site

MeSH Terms: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Benzodiazepines/adverse effects; Case-Control Studies; Dose-Response Relationship, Drug; Drug Prescriptions*; Drug Therapy; Female; Humans; Leukemia, Myeloid, Acute/chemically induced*; Leukemia, Myeloid, Acute/classification*; Leukemia, Myeloid, Acute/etiology*; Los Angeles; Male; Middle Aged; Odds Ratio; Risk; Risk Factors; Time Factors

Back
to Top