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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Air pollution and inflammation in type 2 diabetes: a mechanism for susceptibility.

Authors: O'Neill, M S; Veves, A; Sarnat, J A; Zanobetti, A; Gold, D R; Economides, P A; Horton, E S; Schwartz, J

Published In Occup Environ Med, (2007 Jun)

Abstract: Particulate air pollution has been associated with several adverse cardiovascular health outcomes, and people with diabetes may be especially vulnerable. One potential pathway is inflammation and endothelial dysfunction-processes in which cell adhesion molecules and inflammatory markers play important roles.To examine whether plasma levels of soluble intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and von Willebrand factor (vWF) were associated with particle exposure in 92 Boston area residents with type 2 diabetes.Daily average ambient levels of air pollution (fine particles (PM2.5), black carbon (BC) and sulphates) were measured approximately 500 m from the patient examination site and evaluated for associations with ICAM-1, VCAM-1 and vWF. Linear regressions were fit to plasma levels of ICAM-1, VCAM-1 and vWF, with the particulate pollutant index, apparent temperature, season, age, race, sex, glycosylated haemoglobin, cholesterol, smoking history and body mass index as predictors.Air pollutant exposure measures showed consistently positive point estimates of association with the inflammatory markers. Among participants not taking statins and those with a history of smoking, associations between PM(2.5), BC and VCAM-1 were particularly strong.These results corroborate evidence suggesting that inflammatory mechanisms may explain the increased risk of air pollution-associated cardiovascular events among those with diabetes.

PubMed ID: 17182639 Exiting the NIEHS site

MeSH Terms: Adult; Boston/epidemiology; Cross-Sectional Studies; Diabetes Mellitus, Type 2/blood*; Diabetes Mellitus, Type 2/epidemiology; Diabetic Angiopathies/blood*; Diabetic Angiopathies/chemically induced; Diabetic Angiopathies/epidemiology; Disease Susceptibility/blood; Disease Susceptibility/chemically induced; Environmental Exposure/adverse effects; Environmental Exposure/analysis; Female; Humans; Intercellular Adhesion Molecule-1/metabolism; Male; Particulate Matter/toxicity*; Vascular Cell Adhesion Molecule-1/metabolism; Vasculitis/blood; Vasculitis/chemically induced*; Vasculitis/epidemiology; von Willebrand Factor/metabolism

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