Title: Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia.
Authors: Luperchio, S A; Schauer, D B
Published In Microbes Infect, (2001 Apr)
Abstract: Here we review the history, clinical significance, pathology and molecular pathogenesis of Citrobacter rodentium, the causative agent of transmissible murine colonic hyperplasia. C. rodentium serves as an important model pathogen for investigating the mechanisms controlling attaching and effacing pathology, epithelial hyperproliferation, and tumor promotion in the distal colon of the mouse.
PubMed ID: 11334751
MeSH Terms: Animals; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Citrobacter freundii/genetics; Citrobacter freundii/pathogenicity*; Cocarcinogenesis; Colon/microbiology; Colon/pathology*; Colonic Diseases/microbiology; Colonic Diseases/pathology*; Colonic Neoplasms/etiology; Disease Models, Animal; Enterobacteriaceae Infections/microbiology; Enterobacteriaceae Infections/pathology*; Humans; Hyperplasia; Mice; Virulence/genetics