Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling.

Authors: Lehmler, H J; Robertson, L W

Published In Chemosphere, (2001 Dec)

Abstract: An improved synthesis of hydroxylated polychlorinated biphenyls (PCBs) which are structurally related to the major hydroxy PCB congeners identified in human plasma is described. The coupling of (chlorinated) aryl boronic acids with bromochloro anisoles using the standard conditions of the Suzuki coupling gave the desired hydroxylated PCB metabolites in good to excellent yields. The approach offers the advantage of high selectivity and good yields compared to conventional methods such as the Cadogan reaction and allows the use of less toxic starting materials.

PubMed ID: 11695625 Exiting the NIEHS site

MeSH Terms: Anisoles/chemistry; Boronic Acids/chemistry; Environmental Pollutants/analysis*; Hydroxylation; Polychlorinated Biphenyls/chemical synthesis*; Polychlorinated Biphenyls/chemistry

Back
to Top