Title: Clinical importance of the cytochromes P450.
Authors: Nebert, Daniel W; Russell, David W
Published In Lancet, (2002 Oct 12)
Abstract: The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid and eicosanoids; cholesterol metabolism and bile-acid biosynthesis; steroid synthesis and metabolism; vitamin D(3) synthesis and metabolism; retinoic acid hydroxylation; and those of still unknown function. Cytochrome P450 was once believed to be mainly a hepatic drug detoxication system, but is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes cause inborn errors of metabolism and contribute to many clinically relevant diseases.
PubMed ID: 12387968
MeSH Terms: Alleles; Animals; Cytochrome P-450 Enzyme System/genetics*; Cytochrome P-450 Enzyme System/physiology; Genetic Variation; Humans; Inactivation, Metabolic/genetics*; Inactivation, Metabolic/physiology; Metabolism, Inborn Errors/enzymology; Metabolism, Inborn Errors/genetics*; Mutation/genetics