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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Let the sun shine in: mechanisms and potential for therapeutics in skin photodamage.

Authors: Wondrak, Georg T

Published In Curr Opin Investig Drugs, (2007 May)

Abstract: Photoaging and photocarcinogenesis are the two Janus faces of skin photodamage. Reactivity-based design of prototype agents that antagonize, modulate and reverse the chemistry of skin photodamage holds promise in delivering unprecedented therapeutic benefit. In contrast to structure-based approaches that use selective ligands to target macromolecules, reactivity-based drug discovery uses chemical reagents as therapeutics to target reactive chemical species as key mediators of skin photo-oxidative stress. The following classes of reactivity-based agents for skin photoprotection can be distinguished based on their mechanism of action: direct antagonists of photo-oxidative stress (sunscreens, quenchers of photo-excited states, antioxidants, redox modulators and glycation inhibitors) and skin photo-adaptation inducers (nuclear factor erythroid 2-related factor 2 [Nrf2] activators, heat-shock response inducers and metallothionein inducers).

PubMed ID: 17520868 Exiting the NIEHS site

MeSH Terms: Animals; Antioxidants/pharmacology; Antioxidants/therapeutic use*; Chelating Agents/pharmacology; Chelating Agents/therapeutic use*; Drug Design; Glycation End Products, Advanced/metabolism; Glycosylation/drug effects; Heat-Shock Response/drug effects; Humans; Metallothionein/metabolism; NF-E2-Related Factor 2/metabolism; Neoplasms, Radiation-Induced/metabolism; Neoplasms, Radiation-Induced/prevention & control*; Oxidation-Reduction; Oxidative Stress/drug effects; Photochemistry; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects; Skin Aging/drug effects; Skin Aging/radiation effects; Skin Neoplasms/metabolism; Skin Neoplasms/prevention & control*; Skin/drug effects*; Skin/metabolism; Skin/radiation effects; Sunburn/metabolism; Sunburn/prevention & control*; Sunscreening Agents/pharmacology; Sunscreening Agents/therapeutic use*; Ultraviolet Rays*; Up-Regulation

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