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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Distribution of serotonin 5-HT1C receptor mRNA in adult rat brain.

Authors: Hoffman, B J; Mezey, E

Published In FEBS Lett, (1989 Apr 24)

Abstract: Based on in situ hybridization histochemistry (ISHH), we describe the anatomical distribution of the serotonin 5-HT1C receptor mRNA. In addition to the very high levels in epithelial cells of the choroid plexus, 5-HT1C receptor mRNA is found throughout the limbic system, in catecholaminergic cells and in serotonergic neurons. Receptor transcripts are also present in the hypothalamus, numerous motor nuclei and the subthalamus. Our results correlate well with serotonin (5-HT) innervation and receptor binding. Receptor mRNA is present in many brain structures in addition to regions previously shown to have 5-HT1C receptor binding. The distribution of this receptor mRNA suggests that the 5-HT1C receptor may mediate a number of the central effects of 5-HT.

PubMed ID: 2714444 Exiting the NIEHS site

MeSH Terms: Animals; Brain Chemistry*; Cerebellum/analysis; Diencephalon/analysis; Male; Medulla Oblongata/analysis; Mesencephalon/analysis; Neurons/analysis; Nucleic Acid Hybridization; Oligonucleotide Probes; Pons/analysis; RNA, Messenger/analysis*; Rats; Rats, Inbred Strains; Receptors, Serotonin/genetics*; Telencephalon/analysis; Tissue Distribution

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