| Project Title: | ROLES OF LIG3 AND XRCC1 GENES IN GENOME STABILITY |
|---|---|
| PI: | Tomkinson, Alan E |
| Institution: | University Of New Mexico Health Scis Ctr |
| Grant Number: | R01ES012512 |
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Viewing 44 publications
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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in ... | Kodavati, Manohar; Wang, Haibo; Guo, Wenting; Mitra, Joy; Hegde, Pavana M; Provasek, Vincent; ... | R01ES012512 | Nat Commun (2024 Mar 09) |
38461154
|
2024 |
| Mammalian DNA ligases; roles in maintaining genome integrity. | Sallmyr, Annahita; Bhandari, Seema Khattri; Naila, Tasmin; Tomkinson, Alan E | R01ES012512 | J Mol Biol (2024 Jan 01) |
37714297
|
2024 |
| FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in ... | Kodavati, Manohar; Wang, Haibo; Guo, Wenting; Mitra, Joy; Hegde, Pavana M; Provasek, Vincent; ... | R01ES012512 | Res Sq (2023 Jul 12) |
37502965
|
2023 |
| Purification and Characterization of Human DNA Ligase IIIα Complexes After Expression in Insect Cell ... | Rashid, Ishtiaque; Tsai, Miaw-Sheue; Sverzhinsky, Aleksandr; Hlaing, Aye Su; Shih, Brian; Thwin ... | R01ES012512 | Methods Mol Biol (2022) |
35290642
|
2022 |
| An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα wit ... | Hammel, Michal; Rashid, Ishtiaque; Sverzhinsky, Aleksandr; Pourfarjam, Yasin; Tsai, Miaw-Sheue; ... | R01ES012512 | Nucleic Acids Res (2021 01 11) |
33330937
|
2021 |
| Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III cata ... | Rashid, Ishtiaque; Hammel, Michal; Sverzhinsky, Aleksandr; Tsai, Miaw-Sheue; Pascal, John M; Ta ... | R01ES012512 | J Biol Chem (2021 08) |
34181949
|
2021 |
| Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 def ... | Ali, Reem; Alabdullah, Muslim; Algethami, Mashael; Alblihy, Adel; Miligy, Islam; Shoqafi, Ahme ... | R01ES012512 | Theranostics (2021) |
34373746
|
2021 |
| Human DNA ligases in replication and repair. | Sallmyr, Annahita; Rashid, Ishtiaque; Bhandari, Seema Khattri; Naila, Tasmin; Tomkinson, Alan E | R01ES012512 | DNA Repair (Amst) (2020 09) |
33087274
|
2020 |
| 1HN, 13C, and 15N backbone resonance assignments of the human DNA ligase 3 DNA-binding domain (resid ... | Roth, Braden M; Varney, Kristen M; Yang, Hui; Weber, David J; Tomkinson, Alan E | R01ES012512 | Biomol NMR Assign (2019 10) |
31093909
|
2019 |
| 1HN, 13C, and 15N resonance assignments of human calmodulin bound to a peptide derived from the STRA ... | Varney, Kristen M; Wilder, Paul T; Godoy-Ruiz, Raquel; Mancia, Filippo; Weber, David J | R01ES012512 | Biomol NMR Assign (2019 10) |
30875027
|
2019 |
| SUMOning the base excision repair machinery for differentiation. | Wiest, Nathaniel E; Tomkinson, Alan E | R01ES012512 | EMBO J (2019 01 03) |
30545824
|
2019 |
| Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Scl ... | Wang, Haibo; Guo, Wenting; Mitra, Joy; Hegde, Pavana M; Vandoorne, Tijs; Eckelmann, Bradley J; ... | R01ES012512 | Nat Commun (2018 Sep 11) |
30206235
|
2018 |
| Repair of DNA double-strand breaks by mammalian alternative end-joining pathways. | Sallmyr, Annahita; Tomkinson, Alan E | R01ES012512 | J Biol Chem (2018 07 06) |
29530982
|
2018 |
| Optimization of Native and Formaldehyde iPOND Techniques for Use in Suspension Cells. | Wiest, Nathaniel E; Tomkinson, Alan E | R01ES012512 | Methods Enzymol (2017) |
28645366
|
2017 |
| Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncomp ... | Howes, Timothy R L; Sallmyr, Annahita; Brooks, Rhys; Greco, George E; Jones, Darin E; Matsumoto ... | R01ES012512 | DNA Repair (Amst) (2017 Dec) |
29078112
|
2017 |
| The Human Ligase IIIα-XRCC1 Protein Complex Performs DNA Nick Repair after Transient Unwrapping of N ... | Cannan, Wendy J; Rashid, Ishtiaque; Tomkinson, Alan E; Wallace, Susan S; Pederson, David S | R01ES012512 | J Biol Chem (2017 Mar 31) |
28184006
|
2017 |
| Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1-Dependent Apoptosis in Cancer Cells. | Sallmyr, Annahita; Matsumoto, Yoshihiro; Roginskaya, Vera; Van Houten, Bennett; Tomkinson, Alan ... | R01ES012512 | Cancer Res (2016 Sep 15) |
27503931
|
2016 |
| SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV. | Greco, George E; Matsumoto, Yoshihiro; Brooks, Rhys C; Lu, Zhengfei; Lieber, Michael R; Tomkins ... | R01ES012512 | DNA Repair (Amst) (2016 07) |
27235626
|
2016 |
| Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining. | Kukshal, Vandna; Kim, In-Kwon; Hura, Gregory L; Tomkinson, Alan E; Tainer, John A; Ellenberger, ... | R01ES012512 | Nucleic Acids Res (2015 Aug 18) |
26130724
|
2015 |
| Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining. | Ghezraoui, Hind; Piganeau, Marion; Renouf, Benjamin; Renaud, Jean-Baptiste; Sallmyr, Annahita; ... | R01ES012512 | Mol Cell (2014 Sep 18) |
25201414
|
2014 |
| DNA ligases as therapeutic targets. | Tomkinson, Alan E; Howes, Timothy R L; Wiest, Nathaniel E | R01ES012512 | Transl Cancer Res (2013 Jun) |
24224145
|
2013 |
| Structure and function of the DNA ligases encoded by the mammalian LIG3 gene. | Tomkinson, Alan E; Sallmyr, Annahita | R01ES012512 | Gene (2013 Dec 01) |
24013086
|
2013 |
| Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic mye ... | Tobin, L A; Robert, C; Rapoport, A P; Gojo, I; Baer, M R; Tomkinson, A E; Rassool, F V | R01ES012512 | Oncogene (2013 Apr 04) |
22641215
|
2013 |
| Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the hum ... | Dey, Sanjib; Maiti, Amit K; Hegde, Muralidhar L; Hegde, Pavana M; Boldogh, Istvan; Sarkar, Par ... | R01ES012512 | DNA Repair (Amst) (2012 Jun 01) |
22497777
|
2012 |
| Targeting abnormal DNA repair in therapy-resistant breast cancers. | Tobin, Lisa A; Robert, Carine; Nagaria, Pratik; Chumsri, Saranya; Twaddell, William; Ioffe, Ol ... | R01ES012512 | Mol Cancer Res (2012 Jan) |
22112941
|
2012 |
| The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critic ... | Della-Maria, Julie; Hegde, Muralidhar L; McNeill, Daniel R; Matsumoto, Yoshihiro; Tsai, Miaw-Sh ... | R01ES012512 | J Biol Chem (2012 Nov 09) |
22992732
|
2012 |
| The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision ... | Goula, Agathi-Vasiliki; Pearson, Christopher E; Della Maria, Julie; Trottier, Yvon; Tomkinson, ... | R01ES012512 | Biochemistry (2012 May 8) |
22497302
|
2012 |
| Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alte ... | Della-Maria, Julie; Zhou, Yi; Tsai, Miaw-Sheue; Kuhnlein, Jeff; Carney, James P; Paull, Tanya ... | R01ES012512 | J Biol Chem (2011 Sep 30) |
21816818
|
2011 |
| Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair. | Odell, Ian D; Barbour, Joy-El; Murphy, Drew L; Della-Maria, Julie A; Sweasy, Joann B; Tomkinson ... | R01ES012512 | Mol Cell Biol (2011 Nov) |
21930793
|
2011 |
| Replication protein A safeguards genome integrity by controlling NER incision events. | Overmeer, René M; Moser, Jill; Volker, Marcel; Kool, Hanneke; Tomkinson, Alan E; van Zeeland, ... | R01ES012512 | J Cell Biol (2011 Feb 07) |
21282463
|
2011 |
| Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ova ... | Berquist, Brian R; Singh, Dharmendra Kumar; Fan, Jinshui; Kim, Daemyung; Gillenwater, Elizabeth ... | R01ES012512 | Nucleic Acids Res (2010 Aug) |
20385586
|
2010 |
| Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states. | Cotner-Gohara, Elizabeth; Kim, In-Kwon; Hammel, Michal; Tainer, John A; Tomkinson, Alan E; Elle ... | R01ES012512 | Biochemistry (2010 Jul 27) |
20518483
|
2010 |
| Targeting abnormal DNA double strand break repair in cancer. | Rassool, Feyruz V; Tomkinson, Alan E | R01ES012512 | Cell Mol Life Sci (2010 Nov) |
20697770
|
2010 |
| Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing abilit ... | Chen, Xi; Ballin, Jeff D; Della-Maria, Julie; Tsai, Miaw-Sheue; White, Elizabeth J; Tomkinson, ... | R01ES012512 | DNA Repair (Amst) (2009 Aug 6) |
19589734
|
2009 |
| Eukaryotic DNA ligases: structural and functional insights. | Ellenberger, Tom; Tomkinson, Alan E | R01ES012512 | Annu Rev Biochem (2008) |
18518823
|
2008 |
| Identification and validation of human DNA ligase inhibitors using computer-aided drug design. | Zhong, Shijun; Chen, Xi; Zhu, Xiao; Dziegielewska, Barbara; Bachman, Kurtis E; Ellenberger, To ... | R01ES012512 | J Med Chem (2008 Aug 14) |
18630893
|
2008 |
| Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. | Chen, Xi; Zhong, Shijun; Zhu, Xiao; Dziegielewska, Barbara; Ellenberger, Tom; Wilson, Gerald M ... | R01ES012512 | Cancer Res (2008 May 1) |
18451142
|
2008 |
| Two DNA-binding and nick recognition modules in human DNA ligase III. | Cotner-Gohara, Elizabeth; Kim, In-Kwon; Tomkinson, Alan E; Ellenberger, Tom | R01ES012512 | J Biol Chem (2008 Apr 18) |
18238776
|
2008 |
| Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repai ... | Sallmyr, Annahita; Tomkinson, Alan E; Rassool, Feyruz V | R01ES012512 | Blood (2008 Aug 15) |
18524993
|
2008 |
| ATM mediates oxidative stress-induced dephosphorylation of DNA ligase IIIalpha. | Dong, Zhiwan; Tomkinson, Alan E | R01ES012512 | Nucleic Acids Res (2006) |
17040896
|
2006 |
| DNA ligases: structure, reaction mechanism, and function. | Tomkinson, Alan E; Vijayakumar, Sangeetha; Pascal, John M; Ellenberger, Tom | R01ES012512 | Chem Rev (2006 Feb) |
16464020
|
2006 |
| Human DNA ligases I, III, and IV-purification and new specific assays for these enzymes. | Chen, Xi; Pascal, John; Vijayakumar, Sangeetha; Wilson, Gerald M; Ellenberger, Tom; Tomkinson, ... | R01ES012512 | Methods Enzymol (2006) |
16793394
|
2006 |
| NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in h ... | Das, Aditi; Wiederhold, Lee; Leppard, John B; Kedar, Padmini; Prasad, Rajendra; Wang, Huxian; ... | R01ES012512 | DNA Repair (Amst) (2006 Dec 09) |
16982218
|
2006 |
| Translocation of XRCC1 and DNA ligase IIIalpha from centrosomes to chromosomes in response to DNA da ... | Okano, Satoshi; Lan, Li; Tomkinson, Alan E; Yasui, Akira | R01ES012512 | Nucleic Acids Res (2005) |
15653642
|
2005 |