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Who We Fund: Publication Detail

Project Title: MOLECULAR AND CELLULAR BASIS OF PCB DEVELOPMENTAL NEUROTOXICITY
PI: Lein, Pamela J
Institution: University Of California At Davis
Grant Number: R01ES014901

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Viewing 127 publications
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Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Assessing CaMPARI as new approach methodology for evaluating neurotoxicity.   Biechele-Speziale, Dana; Camarillo, Manuel; Martin, Nathan R; Biechele-Speziale, John; Lein, Pa ... P30ES023513, R01ES014901, R01ES030109 Neurotoxicology (2023 Jul) 37244562 Exiting the NIEHS site 2023 
Detection of Transgene Location in the CYP2A13/2B6/2F1-transgenic Mouse Model using Optical Genome M ...   Ding, Xinxin; Han, John; Van Winkle, Laura S; Zhang, Qing-Yu P30ES006694, P42ES004940, R01ES014901, R01ES020867 Drug Metab Dispos (2023 Jan) 36273825 Exiting the NIEHS site 2023 
Developmental Neurotoxicity Screen of Psychedelics and Other Drugs of Abuse in Larval Zebrafish (Dan ...   Tombari, Robert J; Mundy, Paige C; Morales, Kelly M; Dunlap, Lee E; Olson, David E; Lein, Pame ... P30ES023513, R01ES014901 ACS Chem Neurosci (2023 Mar 01) 36753397 Exiting the NIEHS site 2023 
Disposition and metabolomic effects of 2,2',5,5'-tetrachlorobiphenyl in female rats following intrap ...   Bullert, Amanda; Li, Xueshu; Chunyun, Zhang; Lee, Kendra; Pulliam, Casey F; Cagle, Brianna S; ... P30ES005605, P42ES013661, R01ES014901, R01ES031098 Environ Toxicol Pharmacol (2023 Sep) 37572994 Exiting the NIEHS site 2023 
Disposition and Metabolomic Effects of 2,2',5,5'-Tetrachlorobiphenyl in Female Rats Following Intrap ...   Bullert, Amanda; Li, Xueshu; Zhang, Chunyun; Lee, Kendra; Pulliam, Casey F; Cagle, Brianna S; ... P30ES005605, P42ES013661, R01ES014901, R01ES031098 bioRxiv (2023 Aug 09) 37609242 Exiting the NIEHS site 2023 
Enantiomeric Fractions Reveal Differences in the Atropselective Disposition of 2,2',3,5',6-Pentachlo ...   Li, Xueshu; Bullert, Amanda J; Han, Weiguo; Yang, Weizhu; Zhang, Qing-Yu; Ding, Xinxin; Lehmle ... P30ES005605, P30ES006694, P42ES013661, R01ES014901, R01ES020867, R01ES031098 Chem Res Toxicol (2023 Aug 21) 37467352 Exiting the NIEHS site 2023 
Gene×environment interactions in autism spectrum disorders.   Keil-Stietz, Kimberly; Lein, Pamela J P30ES023513, R00ES029537, R01ES014901 Curr Top Dev Biol (2023) 36707213 Exiting the NIEHS site 2023 
Rebuttal to Correspondence on "Machine Learning-Assisted Identification and Quantification of Hydrox ...   Zhang, Chun-Yun; Li, Xueshu; Keil Stietz, Kimberly P; Sethi, Sunjay; Yang, Weizhu; Marek, Rach ... P30ES005605, P30ES006694, P30ES023513, P42ES013661, R01ES014901, R01ES031098 Environ Sci Technol (2023 Apr 18) 37017328 Exiting the NIEHS site 2023 
Assessing cytochrome P450 function using genetically engineered mouse models.   Hannon, Sarrah L; Ding, Xinxin F31ES034268, P30ES006694, P42ES004940, R01ES014901, R01ES020867, R01ES031529, T32ES007091 Adv Pharmacol (2022) 35953157 Exiting the NIEHS site 2022 
Machine Learning-Assisted Identification and Quantification of Hydroxylated Metabolites of Polychlor ...   Zhang, Chun-Yun; Li, Xueshu; Keil Stietz, Kimberly P; Sethi, Sunjay; Yang, Weizhu; Marek, Rach ... P30ES005605, P30ES023513, P42ES013661, R01ES014901, R01ES031098 Environ Sci Technol (2022 Sep 20) 36047920 Exiting the NIEHS site 2022 
Metabolism of 3-Chlorobiphenyl (PCB 2) in a Human-Relevant Cell Line: Evidence of Dechlorinated Meta ...   Zhang, Chun-Yun; Li, Xueshu; Flor, Susanne; Ruiz, Patricia; Kruve, Anneli; Ludewig, Gabriele; ... P30ES005605, P42ES013661, R01ES014901, R01ES031098 Environ Sci Technol (2022 Sep 06) 35994059 Exiting the NIEHS site 2022 
Probing the Role of CYP2 Enzymes in the Atropselective Metabolism of Polychlorinated Biphenyls Using ...   Lehmler, Hans-Joachim; Uwimana, Eric; Dean, Laura E; Kovalchuk, Nataliia; Zhang, Qing-Yu; Ding, ... P30ES005605, P42ES013661, R01ES014901, R01ES020867 Chem Res Toxicol (2022 Dec 19) 36473170 Exiting the NIEHS site 2022 
The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice.   Li, Xueshu; Lim, Joe Jongpyo; Wang, Kai; Prasad, Bhagwat; Bhatt, Deepak K; Cui, Julia Yue; Leh ... P30ES005605, P30ES007033, P42ES013661, R01ES014901, R01ES031098, T32ES007032 Environ Toxicol Pharmacol (2022 May) 35331926 Exiting the NIEHS site 2022 
Triiodothyronine or Antioxidants Block the Inhibitory Effects of BDE-47 and BDE-49 on Axonal Growth ...   Chen, Hao; Carty, Rhianna K; Bautista, Adrienne C; Hayakawa, Keri A; Lein, Pamela J P30ES023513, P42ES004699, R01ES014901, T32ES007059 Toxics (2022 Feb 18) 35202279 Exiting the NIEHS site 2022 
Characterization of the Metabolic Pathways of 4-Chlorobiphenyl (PCB3) in HepG2 Cells Using the Metab ...   Zhang, Chun-Yun; Flor, Susanne; Ruiz, Patricia; Ludewig, Gabriele; Lehmler, Hans-Joachim P30ES005605, P42ES013661, R01ES014901, R01ES031098 Environ Sci Technol (2021 07 06) 34125531 Exiting the NIEHS site 2021 
Developmental Exposure to a Human-Relevant Polychlorinated Biphenyl Mixture Causes Behavioral Phenot ...   Sethi, Sunjay; Keil Stietz, Kimberly P; Valenzuela, Anthony E; Klocke, Carolyn R; Silverman, Ji ... P30ES023513, P42ES013661, R00ES029537, R01ES014901, T32ES007059 Front Neurosci (2021) 34938155 Exiting the NIEHS site 2021 
Disposition of PCB 11 in Mice Following Acute Oral Exposure.   Zhang, Chun-Yun; Klocke, Carolyn R; Lein, Pamela J; Lehmler, Hans-Joachim P30ES005605, P42ES013661, R01ES014901, R01ES031098 Chem Res Toxicol (2021 04 19) 33734669 Exiting the NIEHS site 2021 
In utero and lactational PCB exposure drives anatomic changes in the juvenile mouse bladder.   Keil Stietz, Kimberly P; Kennedy, Conner L; Sethi, Sunjay; Valenzuela, Anthony; Nunez, Alexandr ... P30ES005605, P30ES023513, P42ES013661, R00ES029537, R01ES014901, T32ES007015, T32ES007059 Curr Res Toxicol (2021) 34337439 Exiting the NIEHS site 2021 
Nontarget analysis reveals gut microbiome-dependent differences in the fecal PCB metabolite profiles ...   Li, Xueshu; Liu, Yanna; Martin, Jonathan W; Cui, Julia Yue; Lehmler, Hans-Joachim P30ES005605, P30ES007033, P42ES013661, R01ES014901, R01ES030197, R01ES031098 Environ Pollut (2021 Jan 01) 33032095 Exiting the NIEHS site 2021 
Sex and Genotype Modulate the Dendritic Effects of Developmental Exposure to a Human-Relevant Polych ...   Keil Stietz, Kimberly P; Sethi, Sunjay; Klocke, Carolyn R; de Ruyter, Tryssa E; Wilson, Machell ... P30ES023513, P42ES013661, R00ES029537, R01ES014901, T32ES007059 Front Neurosci (2021) 34924936 Exiting the NIEHS site 2021 
The Bladder Is a Novel Target of Developmental Polychlorinated Biphenyl Exposure Linked to Increased ...   Kennedy, Conner L; Spiegelhoff, Audrey; Wang, Kathy; Lavery, Thomas; Nunez, Alexandra; Manuel, ... P30ES005605, P42ES013661, R00ES029537, R01ES014901, T32ES007015 Toxics (2021 Sep 08) 34564365 Exiting the NIEHS site 2021 
The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Compreh ...   Bullert, Amanda J; Doorn, Jonathan A; Stevens, Hanna E; Lehmler, Hans-Joachim P30ES005605, P42ES013661, R01ES014901 Chem Res Toxicol (2021 Sep 20) 34491731 Exiting the NIEHS site 2021 
3,3'-Dichlorobiphenyl Is Metabolized to a Complex Mixture of Oxidative Metabolites, Including Novel ...   Zhang, Chun-Yun; Flor, Susanne; Ruiz, Patricia; Dhakal, Ram; Hu, Xin; Teesch, Lynn M; Ludewig, ... P30ES005605, P30ES019776, P42ES013661, R01ES014901 Environ Sci Technol (2020 Oct 06) 32910851 Exiting the NIEHS site 2020 
Automated high content image analysis of dendritic arborization in primary mouse hippocampal and rat ...   Schmuck, Martin R; Keil, Kimberly P; Sethi, Sunjay; Morgan, Rhianna K; Lein, Pamela J P30ES005605, P30ES023513, R00ES029537, R01ES014901, T32ES007059 J Neurosci Methods (2020 Jul 15) 32461071 Exiting the NIEHS site 2020 
Evidence Implicating Non-Dioxin-Like Congeners as the Key Mediators of Polychlorinated Biphenyl (PCB ...   Klocke, Carolyn; Lein, Pamela J P30ES023513, R01ES014901 Int J Mol Sci (2020 Feb 04) 32033061 Exiting the NIEHS site 2020 
Fatty liver and impaired hepatic metabolism alter the congener-specific distribution of polychlorina ...   Li, Xueshu; Zhang, Chunyun; Wang, Kai; Lehmler, Hans-Joachim P30ES005605, P42ES013661, R01ES014901, R01ES031098 Environ Pollut (2020 Nov) 32712482 Exiting the NIEHS site 2020 
Human Cerebral Cortex Proteome of Fragile X-Associated Tremor/Ataxia Syndrome.   Holm, Katharine Nichole; Herren, Anthony W; Taylor, Sandra L; Randol, Jamie L; Kim, Kyoungmi; E ... R01ES014901 Front Mol Biosci (2020) 33585555 Exiting the NIEHS site 2020 
Polychlorinated Biphenyls (PCBs): Risk Factors for Autism Spectrum Disorder?   Panesar, Harmanpreet Kaur; Kennedy, Conner L; Keil Stietz, Kimberly P; Lein, Pamela J P30ES005605, P30ES023513, R00ES029537, R01ES014901, T32ES007015, T32ES007059 Toxics (2020 Sep 17) 32957475 Exiting the NIEHS site 2020 
Ryanodine Receptor Type 2: A Molecular Target for Dichlorodiphenyltrichloroethane- and Dichlorodiphe ...   Truong, Kim M; Feng, Wei; Pessah, Isaac N P30ES005605, P42ES004699, R01ES014901 Toxicol Sci (2020 Nov 01) 32894766 Exiting the NIEHS site 2020 
The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similar ...   Klocke, Carolyn; Sethi, Sunjay; Lein, Pamela J P30ES005605, P30ES023513, R01ES014901, T32ES007059 Environ Sci Pollut Res Int (2020 Mar) 31713823 Exiting the NIEHS site 2020 
The influence of sex, genotype, and dose on serum and hippocampal cytokine levels in juvenile mice d ...   Matelski, Lauren; Keil Stietz, Kimberly P; Sethi, Sunjay; Taylor, Sandra L; Van de Water, Judy; ... P30ES005605, P30ES023513, P42ES013661, R00ES029537, R01ES014901, T32ES007059 Curr Res Toxicol (2020 Jun 10) 34296199 Exiting the NIEHS site 2020 
Translational Toxicology in Zebrafish.   Tal, Tamara; Yaghoobi, Bianca; Lein, Pamela J P30ES005605, P30ES023513, R01ES014901 Curr Opin Toxicol (2020) 32656393 Exiting the NIEHS site 2020 
Commentary: Fc Gamma Receptors are Expressed in the Developing Rat Brain and Activate Downstream Sig ...   Stamou, Marianna; Lein, Pamela J P30ES005605, P30ES023513, R01ES014901 J Neurol Neuromedicine (2019) 31131371 Exiting the NIEHS site 2019 
Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Acti ...   Sethi, Sunjay; Morgan, Rhianna K; Feng, Wei; Lin, Yanping; Li, Xueshu; Luna, Corey; Koch, Mad ... P30ES005605, P30ES023513, P42ES013661, R01ES014901, T32ES007059 Environ Sci Technol (2019 04 02) 30821444 Exiting the NIEHS site 2019 
Developmental exposure to environmentally relevant concentrations of bifenthrin alters transcription ...   Frank, Daniel F; Brander, Susanne M; Hasenbein, Simone; Harvey, Danielle J; Lein, Pamela J; Gei ... P30ES005605, P30ES023513, R01ES014901 Aquat Toxicol (2019 Jan) 30414561 Exiting the NIEHS site 2019 
Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe ...   Rude, Kavi M; Pusceddu, Matteo M; Keogh, Ciara E; Sladek, Jessica A; Rabasa, Gonzalo; Miller, ... P30ES005605, P30ES023513, R00ES029537, R01ES014901, T32ES007059 Environ Pollut (2019 Oct) 31336350 Exiting the NIEHS site 2019 
Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile mice.   Keil, Kimberly P; Sethi, Sunjay; Wilson, Machelle D; Silverman, Jill L; Pessah, Isaac N; Lein, ... P30ES005605, P30ES023513, R01ES014901, T32ES007059 Genes Brain Behav (2019 Jan) 30311737 Exiting the NIEHS site 2019 
Influence of Nanomolar Deltamethrin on the Hallmarks of Primary Cultured Cortical Neuronal Network a ...   Zheng, Jing; Yu, Yiyi; Feng, Wei; Li, Jing; Liu, Ju; Zhang, Chunlei; Dong, Yao; Pessah, Isaa ... P42ES004699, R01ES014901 Environ Health Perspect (2019 06) 31166131 Exiting the NIEHS site 2019 
Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) Wit ...   Truong, Kim M; Cherednichenko, Gennady; Pessah, Isaac N P42ES004699, R01ES014901 Toxicol Sci (2019 08 01) 31127943 Exiting the NIEHS site 2019 
MicroRNAs are Necessary for BMP-7-induced Dendritic Growth in Cultured Rat Sympathetic Neurons.   Pravoverov, Kristina; Whiting, Katherine; Thapa, Slesha; Bushong, Trevor; Trang, Karen; Lein, ... P30ES005605, R01ES014901 Cell Mol Neurobiol (2019 Oct) 31104181 Exiting the NIEHS site 2019 
Neurotoxicity of polychlorinated biphenyls and related organohalogens.   Pessah, Isaac N; Lein, Pamela J; Seegal, Richard F; Sagiv, Sharon K P30ES005605, P42ES004699, R01ES014901 Acta Neuropathol (2019 Sep) 30976975 Exiting the NIEHS site 2019 
Polychlorinated biphenyls influence on autism spectrum disorder risk in the MARBLES cohort.   Granillo, Lauren; Sethi, Sunjay; Keil, Kimberly P; Lin, Yanping; Ozonoff, Sally; Iosif, Ana-Ma ... P30ES005605, P30ES023513, R01ES014901, T32ES007059 Environ Res (2019 Apr) 30665119 Exiting the NIEHS site 2019 
Saikosaponin d causes apoptotic death of cultured neocortical neurons by increasing membrane permeab ...   Zheng, Jing; Chen, Juan; Zou, Xiaohan; Zhao, Fang; Guo, Mengqi; Wang, Hongbo; Zhang, Tian; Zh ... P30ES005605, P42ES004699, R01ES014901 Neurotoxicology (2019 Jan) 30458186 Exiting the NIEHS site 2019 
Sex-Dependent Effects of 2,2',3,5',6-Pentachlorobiphenyl on Dendritic Arborization of Primary Mouse ...   Keil, Kimberly P; Sethi, Sunjay; Lein, Pamela J P30ES005605, P30ES023513, R01ES014901, T32ES007059 Toxicol Sci (2019 Mar 01) 30395321 Exiting the NIEHS site 2019 
3,3'-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a ...   Sethi, Sunjay; Keil, Kimberly P; Lein, Pamela J P30ES005605, P30ES023513, P42ES013661, R01ES014901, T32ES007059 Arch Toxicol (2018 Nov) 30225637 Exiting the NIEHS site 2018 
A Prospective Study of Environmental Exposures and Early Biomarkers in Autism Spectrum Disorder: Des ...   Hertz-Picciotto, Irva; Schmidt, Rebecca J; Walker, Cheryl K; Bennett, Deborah H; Oliver, McKenz ... P30ES005605, P30ES023513, R01ES014901 Environ Health Perspect (2018 Nov) 30465702 Exiting the NIEHS site 2018 
Authentication of synthetic environmental contaminants and their (bio)transformation products in tox ...   Li, Xueshu; Holland, Erika B; Feng, Wei; Zheng, Jing; Dong, Yao; Pessah, Isaac N; Duffel, Mic ... P30ES005605, P42ES004699, P42ES013661, R01ES014901 Environ Sci Pollut Res Int (2018 Jun) 29322390 Exiting the NIEHS site 2018 
Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and ...   Frank, Daniel F; Miller, Galen W; Harvey, Danielle J; Brander, Susanne M; Geist, Juergen; Conno ... P30ES005605, R01ES014901 Aquat Toxicol (2018 Jul) 29727771 Exiting the NIEHS site 2018 
Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint o ...   Miller, Galen W; Chandrasekaran, Vidya; Yaghoobi, Bianca; Lein, Pamela J P30ES005605, P30ES023513, R01ES014901 Neurotoxicology (2018 Jul) 29704525 Exiting the NIEHS site 2018 
Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproduc ...   Zheng, Jing; McKinnie, Shaun M K; El Gamal, Abrahim; Feng, Wei; Dong, Yao; Agarwal, Vinayak; F ... P30ES005605, P42ES004699, R01ES014901 Environ Sci Technol (2018 May 01) 29617551 Exiting the NIEHS site 2018 
PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms.   Keil, Kimberly P; Miller, Galen W; Chen, Hao; Sethi, Sunjay; Schmuck, Martin R; Dhakal, Kiran; ... P30ES005605, P30ES023513, R01ES014901, T32ES007059 Arch Toxicol (2018 Oct) 30132043 Exiting the NIEHS site 2018 
Prenatal exposure to organophosphate pesticides and risk of autism spectrum disorders and other non- ...   Philippat, Claire; Barkoski, Jacqueline; Tancredi, Daniel J; Elms, Bill; Barr, Dana Boyd; Ozono ... P30ES019776, P30ES023513, P42ES004699, R01ES014901 Int J Hyg Environ Health (2018 Apr) 29478806 Exiting the NIEHS site 2018 
Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as ...   Chen, Xiaopeng; Walter, Kyla M; Miller, Galen W; Lein, Pamela J; Puschner, Birgit P30ES005605, R01ES014901, T32ES007059 Biomed Chromatogr (2018 Jun) 29314156 Exiting the NIEHS site 2018 
An Extended Structure-Activity Relationship of Nondioxin-Like PCBs Evaluates and Supports Modeling P ...   Holland, Erika B; Feng, Wei; Zheng, Jing; Dong, Yao; Li, Xueshu; Lehmler, Hans-Joachim; Pessah ... P30ES005605, P42ES004699, P42ES013661, R01ES014901 Toxicol Sci (2017 Jan) 27655348 Exiting the NIEHS site 2017 
Association of Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs) with Hype ...   Walter, Kyla M; Lin, Yan-Ping; Kass, Philip H; Puschner, Birgit R01ES014901, T32ES007059 BMC Vet Res (2017 May 03) 28468659 Exiting the NIEHS site 2017 
Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ ...   Robin, Gaëlle; López, José R; Espinal, Glenda M; Hulsizer, Susan; Hagerman, Paul J; Pessah, Is ... R01ES014901 Hum Mol Genet (2017 Jul 15) 28444183 Exiting the NIEHS site 2017 
Comparison of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in the ser ...   Lau, Grace; Walter, Kyla; Kass, Philip; Puschner, Birgit R01ES014901, T32ES007059 PeerJ (2017) 28924500 Exiting the NIEHS site 2017 
Detection of 3,3'-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic ...   Sethi, Sunjay; Keil, Kimberly P; Chen, Hao; Hayakawa, Keri; Li, Xueshu; Lin, Yanping; Lehmler, ... P30ES005605, P30ES023513, P42ES013661, R01ES014901, T32ES007059 Toxicol Sci (2017 Aug 01) 28510766 Exiting the NIEHS site 2017 
Developing and applying the adverse outcome pathway concept for understanding and predicting neuroto ...   Bal-Price, Anna; Lein, Pamela J; Keil, Kimberly P; Sethi, Sunjay; Shafer, Timothy; Barenys, Ma ... R01ES014901, T32ES007059 Neurotoxicology (2017 Mar) 27212452 Exiting the NIEHS site 2017 
Divergent Mechanisms Leading to Signaling Dysfunction in Embryonic Muscle by Bisphenol A and Tetrabr ...   Zhang, Rui; Pessah, Isaac N R01ES014901, T32ES007059 Mol Pharmacol (2017 04) 28143888 Exiting the NIEHS site 2017 
Editor's Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating M ...   Kania-Korwel, Izabela; Lukasiewicz, Tracy; Barnhart, Christopher D; Stamou, Marianna; Chung, Ha ... P30ES005605, P42ES013661, R01ES014901, T32ES007059 Toxicol Sci (2017 Jul 01) 28431184 Exiting the NIEHS site 2017 
Enantioselectivity of 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Atropisomers toward Ryanodine Recepto ...   Feng, Wei; Zheng, Jing; Robin, Gaëlle; Dong, Yao; Ichikawa, Makoto; Inoue, Yoshihisa; Mori, T ... P42ES004699, R01ES014901 Environ Sci Technol (2017 Dec 19) 29131945 Exiting the NIEHS site 2017 
From the Cover: BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cu ...   Chen, Hao; Streifel, Karin M; Singh, Vikrant; Yang, Dongren; Mangini, Linley; Wulff, Heike; Le ... P30ES023513, R01ES014901, T32ES007059 Toxicol Sci (2017 Apr 01) 28003438 Exiting the NIEHS site 2017 
Identification of lipidomic markers of chronic 3,3',4,4',5-pentachlorobiphenyl (PCB 126) exposure in ...   Kania-Korwel, Izabela; Wu, Xianai; Wang, Kai; Lehmler, Hans-Joachim P30ES005605, P42ES013661, R01ES014901 Toxicology (2017 Sep 01) 28890136 Exiting the NIEHS site 2017 
In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal an ...   Keil, Kimberly P; Sethi, Sunjay; Wilson, Machelle D; Chen, Hao; Lein, Pamela J R01ES014901, T32ES007059 Sci Rep (2017 Aug 16) 28814778 Exiting the NIEHS site 2017 
Polychlorinated biphenyl and polybrominated diphenyl ether profiles in serum from cattle, sheep, and ...   Sethi, S; Chen, X; Kass, P H; Puschner, B P42ES004699, R01ES014901, T32ES007059 Chemosphere (2017 Aug) 28426942 Exiting the NIEHS site 2017 
Quantification of Polychlorinated Biphenyls and Polybrominated Diphenyl Ethers in Commercial Cows' M ...   Chen, Xiaopeng; Lin, Yanping; Dang, Katherine; Puschner, Birgit P30ES023513, P42ES004699, R01ES014901 PLoS One (2017) 28085917 Exiting the NIEHS site 2017 
Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) poten ...   Aschner, Michael; Ceccatelli, Sandra; Daneshian, Mardas; Fritsche, Ellen; Hasiwa, Nina; Hartung ... R01ES007331, R01ES010563, R01ES014901 ALTEX (2017) 27452664 Exiting the NIEHS site 2017 
Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A ...   Holland, Erika B; Goldstone, Jared V; Pessah, Isaac N; Whitehead, Andrew; Reid, Noah M; Karchne ... P42ES004699, R01ES014901 Aquat Toxicol (2017 Nov) 28942070 Exiting the NIEHS site 2017 
Species and Sex Differences in the Morphogenic Response of Primary Rodent Neurons to 3,3'-Dichlorobi ...   Sethi, Sunjay; Keil, Kimberly P; Lein, Pamela J P30ES023513, P42ES013661, R01ES014901, T32ES007059 Toxics (2017 Dec 23) 29295518 Exiting the NIEHS site 2017 
Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish ...   Frank, Daniel F; Miller, Galen W; Connon, Richard E; Geist, Juergen; Lein, Pamela J R01ES014901 PeerJ (2017) 29201571 Exiting the NIEHS site 2017 
Valid statistical approaches for analyzing sholl data: Mixed effects versus simple linear models.   Wilson, Machelle D; Sethi, Sunjay; Lein, Pamela J; Keil, Kimberly P P30ES023513, R01ES014901, T32ES007059 J Neurosci Methods (2017 Mar 01) 28104486 Exiting the NIEHS site 2017 
BMP7-induced dendritic growth in sympathetic neurons requires p75(NTR) signaling.   Courter, Lauren A; Shaffo, Frances C; Ghogha, Atefeh; Parrish, Diana J; Lorentz, Christina U; H ... R01ES014901 Dev Neurobiol (2016 09) 26663679 Exiting the NIEHS site 2016 
Chiral polychlorinated biphenyls: absorption, metabolism and excretion--a review.   Kania-Korwel, Izabela; Lehmler, Hans-Joachim P30ES005605, P42ES007380, P42ES013661, R01ES014901 Environ Sci Pollut Res Int (2016 Feb) 25651810 Exiting the NIEHS site 2016 
Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, ...   Dunaway, Keith W; Islam, M Saharul; Coulson, Rochelle L; Lopez, S Jesse; Vogel Ciernia, Annie; ... R01ES014901, T32ES007059 Cell Rep (2016 Dec 13) 27974215 Exiting the NIEHS site 2016 
DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum dis ...   Keil, Kimberly P; Lein, Pamela J R01ES014901 Environ Epigenet (2016 Mar) 27158529 Exiting the NIEHS site 2016 
Effects of thiol antioxidants on the atropselective oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl ( ...   Wu, Xianai; Lehmler, Hans-Joachim P30ES005605, P30ES006694, P42ES013661, R01ES014901 Environ Sci Pollut Res Int (2016 Feb) 26155892 Exiting the NIEHS site 2016 
Phenobarbital use and neurological problems in FMR1 premutation carriers.   Saldarriaga, Wilmar; Lein, Pamela; González Teshima, Laura Yuriko; Isaza, Carolina; Rosa, Lina; ... R01ES014901 Neurotoxicology (2016 Mar) 26802682 Exiting the NIEHS site 2016 
Toxicokinetics of chiral polychlorinated biphenyls across different species--a review.   Kania-Korwel, Izabela; Lehmler, Hans-Joachim P30ES005605, P42ES013661, R01ES014901 Environ Sci Pollut Res Int (2016 Feb) 25824003 Exiting the NIEHS site 2016 
Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and ...   Kania-Korwel, Izabela; Barnhart, Christopher D; Lein, Pamela J; Lehmler, Hans-Joachim P30ES005605, P42ES004699, P42ES013661, R01ES014901, T32ES007059 Chem Res Toxicol (2015 Sep 21) 26271003 Exiting the NIEHS site 2015 
Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (F ...   Fritsch, Erika B; Stegeman, John J; Goldstone, Jared V; Nacci, Diane E; Champlin, Denise; Jayar ... P42ES004699, R01ES014901 Aquat Toxicol (2015 Feb) 25546006 Exiting the NIEHS site 2015 
Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB ...   Wu, Xianai; Barnhart, Christopher; Lein, Pamela J; Lehmler, Hans-Joachim P30ES005605, P30ES006694, P42ES004699, P42ES013661, R01ES014901, T32ES007059 Environ Sci Technol (2015 Jan 06) 25420130 Exiting the NIEHS site 2015 
Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultur ...   Harrill, Joshua A; Chen, Hao; Streifel, Karin M; Yang, Dongren; Mundy, William R; Lein, Pamela ... R01ES014901, T32ES007059 Mol Brain (2015 Feb 15) 25757474 Exiting the NIEHS site 2015 
Putative adverse outcome pathways relevant to neurotoxicity.   Bal-Price, Anna; Crofton, Kevin M; Sachana, Magdalini; Shafer, Timothy J; Behl, Mamta; Forsby, ... R01ES014901 Crit Rev Toxicol (2015 Jan) 25605028 Exiting the NIEHS site 2015 
Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neu ...   Chandrasekaran, Vidya; Lea, Charlotte; Sosa, Jose Carlo; Higgins, Dennis; Lein, Pamela J R01ES014901 Mol Cell Neurosci (2015 Jul) 26079955 Exiting the NIEHS site 2015 
Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alte ...   Stamou, Marianna; Uwimana, Eric; Flannery, Brenna M; Kania-Korwel, Izabela; Lehmler, Hans-Joach ... P30ES005605, P42ES004699, R01ES014901 Toxicology (2015 Dec 02) 26463278 Exiting the NIEHS site 2015 
Using the Morris water maze to assess spatial learning and memory in weanling mice.   Barnhart, Christopher D; Yang, Dongren; Lein, Pamela J P42ES004699, R01ES014901, T32ES007059 PLoS One (2015) 25886563 Exiting the NIEHS site 2015 
Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent difference ...   Stamou, Marianna; Wu, Xianai; Kania-Korwel, Izabela; Lehmler, Hans-Joachim; Lein, Pamela J P30ES005605, P42ES004699, R01ES014901 Drug Metab Dispos (2014 Feb) 24255117 Exiting the NIEHS site 2014 
Microsomal oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) results in species-dependent chi ...   Wu, Xianai; Kammerer, Austin; Lehmler, Hans-Joachim P30ES005605, P30ES006694, P42ES013661, R01ES014901 Environ Sci Technol (2014 Feb 18) 24467194 Exiting the NIEHS site 2014 
Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independen ...   Cao, Zhengyu; Cui, Yanjun; Nguyen, Hai M; Jenkins, David Paul; Wulff, Heike; Pessah, Isaac N P42ES004699, R01ES014901 Mol Pharmacol (2014 Apr) 24482397 Exiting the NIEHS site 2014 
PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in c ...   Yang, Dongren; Kania-Korwel, Izabela; Ghogha, Atefeh; Chen, Hao; Stamou, Marianna; Bose, Dipti ... P30ES005605, P42ES004699, P42ES013661, R01ES014901, T32ES007059 Toxicol Sci (2014 Apr) 24385416 Exiting the NIEHS site 2014 
The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR1 ...   Lesiak, Adam; Zhu, Mingyan; Chen, Hao; Appleyard, Suzanne M; Impey, Soren; Lein, Pamela J; Way ... P42ES004699, R01ES014901, T32ES007059 J Neurosci (2014 Jan 15) 24431430 Exiting the NIEHS site 2014 
Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenoba ...   Wu, Xianai; Kania-Korwel, Izabela; Chen, Hao; Stamou, Marianna; Dammanahalli, Karigowda J; Duff ... P30ES005605, P30ES006694, P42ES004699, P42ES013661, R01ES014901, T32ES007059 Xenobiotica (2013 Nov) 23581876 Exiting the NIEHS site 2013 
Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for ...   Stamou, Marianna; Streifel, Karin M; Goines, Paula E; Lein, Pamela J P42ES004699, R01ES014901 Neurotoxicol Teratol (2013) 23269408 Exiting the NIEHS site 2013 
Simultaneous determination of polybrominated diphenyl ethers and polychlorinated biphenyls by gas ch ...   Lin, Yan-ping; Pessah, Isaac N; Puschner, Birgit P42ES004699, R01ES014901 Talanta (2013 Sep 15) 23708622 Exiting the NIEHS site 2013 
Structure-activity relationship of non-coplanar polychlorinated biphenyls toward skeletal muscle rya ...   Fritsch, Erika B; Pessah, Isaac N P42ES004699, R01ES014901 Aquat Toxicol (2013 Sep 15) 23827775 Exiting the NIEHS site 2013 
Structure-activity relationship of selected meta- and para-hydroxylated non-dioxin like polychlorina ...   Niknam, Yassaman; Feng, Wei; Cherednichenko, Gennady; Dong, Yao; Joshi, Sudhir N; Vyas, Sandhy ... P30ES005605, P42ES004699, P42ES013661, R01ES014901 Toxicol Sci (2013 Dec) 24014653 Exiting the NIEHS site 2013 
Triclosan impairs swimming behavior and alters expression of excitation-contraction coupling protein ...   Fritsch, Erika B; Connon, Richard E; Werner, Inge; Davies, Rebecca E; Beggel, Sebastian; Feng, ... P42ES004699, R01ES014901 Environ Sci Technol (2013 Feb 19) 23305567 Exiting the NIEHS site 2013 
2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enric ...   Kania-Korwel, Izabela; Barnhart, Christopher D; Stamou, Marianna; Truong, Kim M; El-Komy, Moham ... P30ES005605, P42ES004699, P42ES013661, R01ES014901, T32ES007059 Environ Sci Technol (2012 Oct 16) 22974126 Exiting the NIEHS site 2012 
Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826 ...   Barrientos, Genaro C; Feng, Wei; Truong, Kim; Matthaei, Klaus I; Yang, Tianzhong; Allen, Paul ... R01ES014901 J Biol Chem (2012 Jan 20) 22139840 Exiting the NIEHS site 2012 
Inducing dendritic growth in cultured sympathetic neurons.   Ghogha, Atefeh; Bruun, Donald A; Lein, Pamela J R01ES014901 J Vis Exp (2012) 22473299 Exiting the NIEHS site 2012 
Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental invo ...   Mitchell, Michelle M; Woods, Rima; Chi, Lai-Har; Schmidt, Rebecca J; Pessah, Isaac N; Kostyniak ... R01ES014901 Environ Mol Mutagen (2012 Oct) 22930557 Exiting the NIEHS site 2012 
Maternal transfer of BDE-47 to offspring and neurobehavioral development in C57BL/6J mice.   Koenig, Claire M; Lango, Jozsef; Pessah, Isaac N; Berman, Robert F P42ES004699, R01ES014901, T32ES007059 Neurotoxicol Teratol (2012 Nov-Dec) 23022914 Exiting the NIEHS site 2012 
Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to mal ...   Yuen, Benjamin; Boncompagni, Simona; Feng, Wei; Yang, Tianzhong; Lopez, Jose R; Matthaei, Klau ... R01ES014901 FASEB J (2012 Mar) 22131268 Exiting the NIEHS site 2012 
PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendriti ...   Wayman, Gary A; Bose, Diptiman D; Yang, Dongren; Lesiak, Adam; Bruun, Donald; Impey, Soren; Le ... P42ES004699, R01ES014901, T32ES007060 Environ Health Perspect (2012 Jul) 22534176 Exiting the NIEHS site 2012 
PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms.   Wayman, Gary A; Yang, Dongren; Bose, Diptiman D; Lesiak, Adam; Ledoux, Veronica; Bruun, Donald ... P42ES004699, R01ES014901, T32ES007060 Environ Health Perspect (2012 Jul) 22534141 Exiting the NIEHS site 2012 
Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and ...   van Thriel, Christoph; Westerink, Remco H S; Beste, Christian; Bale, Ambuja S; Lein, Pamela J; ... R01ES014901 Neurotoxicology (2012 Aug) 22008243 Exiting the NIEHS site 2012 
2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is enantioselectively oxidized to hydroxylated metabolit ...   Wu, Xianai; Pramanik, Ananya; Duffel, Michael W; Hrycay, Eugene G; Bandiera, Stelvio M; Lehmler ... P30ES005605, P30ES006694, P42ES013661, R01ES014901 Chem Res Toxicol (2011 Dec 19) 22026639 Exiting the NIEHS site 2011 
Acute hippocampal slice preparation and hippocampal slice cultures.   Lein, Pamela J; Barnhart, Christopher D; Pessah, Isaac N R01ES014901, T32ES007059 Methods Mol Biol (2011) 21815062 Exiting the NIEHS site 2011 
Bioaccumulation and behavioral effects of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in perinatally ...   Ta, Tram Anh; Koenig, Claire M; Golub, Mari S; Pessah, Isaac N; Qi, Lihong; Aronov, Pavel A; B ... P42ES004699, R01ES014901, T32ES007059 Neurotoxicol Teratol (2011 May-Jun) 21334437 Exiting the NIEHS site 2011 
Channelopathies: summary of the hot topic keynotes session.   Magby, Jason P; Neal, April P; Atchison, William D; Pessah, Isaac P; Shafer, Timothy J P30ES005022, P42ES004699, R01ES014901 Neurotoxicology (2011 Oct) 21756936 Exiting the NIEHS site 2011 
Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultur ...   Abdu, Emun; Bruun, Donald A; Yang, Dongren; Yang, Jun; Inceoglu, Bora; Hammock, Bruce D; Alkay ... P42ES004699, R01ES014901 J Neurochem (2011 May) 21155804 Exiting the NIEHS site 2011 
Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C ...   Feng, Wei; Barrientos, Genaro C; Cherednichenko, Gennady; Yang, Tianzhong; Padilla, Isela T; Tr ... P42ES004699, R01ES014901 Mol Pharmacol (2011 Mar) 21156754 Exiting the NIEHS site 2011 
Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ...   Kim, Kyung Ho; Bose, Diptiman D; Ghogha, Atefeh; Riehl, Joyce; Zhang, Rui; Barnhart, Christoph ... P42ES004699, R01ES014901, T32ES007059 Environ Health Perspect (2011 Apr) 21106467 Exiting the NIEHS site 2011 
Perinatal exposure to environmental polychlorinated biphenyls sensitizes hippocampus to excitotoxici ...   Kim, Kyung Ho; Pessah, Isaac N P42ES004699, R01ES014901 Neurotoxicology (2011 Dec) 21571002 Exiting the NIEHS site 2011 
Transcriptional responses of cultured rat sympathetic neurons during BMP-7-induced dendritic growth.   Garred, Michelle M; Wang, Michael M; Guo, Xin; Harrington, Christina A; Lein, Pamela J R01ES014901 PLoS One (2011) 21765909 Exiting the NIEHS site 2011 
Method for Shipping Live Cultures of Dissociated Rat Hippocampal Neurons.   Yang, Dongren; Bruun, Donald; Andres, Douglas A; Lein, Pamela J R01ES014901 Curr Neurobiol (2010 Oct) 24052689 Exiting the NIEHS site 2010 
Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity.   Pessah, Isaac N; Cherednichenko, Gennady; Lein, Pamela J P42ES004699, R01ES014901 Pharmacol Ther (2010 Feb) 19931307 Exiting the NIEHS site 2010 
Polychlorinated biphenyls increase apoptosis in the developing rat brain.   Yang, Dongren; Lein, Pamela J R01ES014901 Curr Neurobiol (2010 Mar) 24052688 Exiting the NIEHS site 2010 
Animal models of autism spectrum disorders: information for neurotoxicologists.   Halladay, Alycia K; Amaral, David; Aschner, Michael; Bolivar, Valerie J; Bowman, Aaron; DiCicco ... P42ES004699, R01ES014901 Neurotoxicology (2009 Sep) 19596370 Exiting the NIEHS site 2009 
Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating.   Samsó, Montserrat; Feng, Wei; Pessah, Isaac N; Allen, P D R01ES014901 PLoS Biol (2009 Apr 14) 19402748 Exiting the NIEHS site 2009 
Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic p ...   Yang, Dongren; Kim, Kyung Ho; Phimister, Andrew; Bachstetter, Adam D; Ward, Thomas R; Stackman, ... R01ES014901 Environ Health Perspect (2009 Mar) 19337518 Exiting the NIEHS site 2009 
Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 ...   Pessah, Isaac N; Lehmler, Hans-Joachim; Robertson, Larry W; Perez, Claudio F; Cabrales, Elaine; ... P42ES004699, P42ES013661, R01ES014901 Chem Res Toxicol (2009 Jan) 18954145 Exiting the NIEHS site 2009 
Excitatory and inhibitory synaptic transmission is differentially influenced by two ortho-substitute ...   Kim, Kyung Ho; Inan, Salim Yalcin; Berman, Robert F; Pessah, Isaac N P42ES004699, R01ES014901 Toxicol Appl Pharmacol (2009 Jun 01) 19289137 Exiting the NIEHS site 2009 
Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key en ...   Morisseau, Christophe; Merzlikin, Oleg; Lin, Amy; He, Guochun; Feng, Wei; Padilla, Isela; Deni ... P42ES004699, R01ES014901 Environ Health Perspect (2009 Dec) 20049205 Exiting the NIEHS site 2009 
Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats.   Dziennis, Suzan; Yang, Dongren; Cheng, Jian; Anderson, Kim A; Alkayed, Nabil J; Hurn, Patricia ... R01ES014901 Environ Health Perspect (2008 Apr) 18414629 Exiting the NIEHS site 2008 
Immunologic and neurodevelopmental susceptibilities of autism.   Pessah, Isaac N; Seegal, Richard F; Lein, Pamela J; LaSalle, Janine; Yee, Benjamin K; Van De Wa ... R01ES014901 Neurotoxicology (2008 May) 18394707 Exiting the NIEHS site 2008 
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