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Who We Fund: Publication Detail

Project Title: MANGANESE-RELATED NEUROTOXICITY IN ASYMPTOMATIC WELDERS
PI: Huang, Xuemei
Institution: Pennsylvania State Univ Hershey Med Ctr
Grant Number: R01ES019672

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Viewing 56 publications
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Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Effects of mixed metal exposures on MRI diffusion features in the medial temporal lobe.   Lee, Eun-Young; Kim, Juhee; Prado-Rico, Janina Manzieri; Du, Guangwei; Lewis, Mechelle M; Kong, ... R01ES019672 medRxiv (2024 Jan 30) 37503124 Exiting the NIEHS site 2024 
Higher hippocampal diffusivity values in welders are associated with greater R2* in the red nucleus ...   Lee, Eun-Young; Kim, Juhee; Prado-Rico, Janina Manzieri; Du, Guangwei; Lewis, Mechelle M; Kong, ... R01ES019672 Neurotoxicology (2023 May) 36966945 Exiting the NIEHS site 2023 
Parkinson's Disease Case Ascertainment in the Sister Study: A Cohort for Environmental Health Resear ...   Cao, Zichun; Song, Shengfang; Huang, Xuemei; Li, Chenxi; Luo, Zhehui; D'Aloisio, Aimee A; Suar ... R01ES019672, R01ES029227 J Parkinsons Dis (2023) 37334620 Exiting the NIEHS site 2023 
Predictors of Cognitive Change in Parkinson Disease: A 2-year Follow-up Study.   Gasca-Salas, Carmen; Duff-Canning, Sarah; McArthur, Eric; Armstrong, Melissa J; Fox, Susan; Mea ... R01ES019672 Alzheimer Dis Assoc Disord (2023 Oct-Dec 01) 37615480 Exiting the NIEHS site 2023 
Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Ni ...   Wang, Ernest W; Brown, Gregory L; Lewis, Mechelle M; Jellen, Leslie C; Pu, Cunfeng; Johnson, M ... F30ES030607, R01ES019672 Mov Disord (2023 Mar) 36598274 Exiting the NIEHS site 2023 
Covariate Information Number for Feature Screening in Ultrahigh-Dimensional Supervised Problems.   Nandy, Debmalya; Chiaromonte, Francesca; Li, Runze R01ES019672 J Am Stat Assoc (2022) 36172297 Exiting the NIEHS site 2022 
Higher R2* in the Red Nucleus Is Associated With Lead Exposure in an Asymptomatic Welder Cohort.   Prado-Rico, Janina Manzieri; Lee, Eun-Young; Wang, Ernest W; Yanosky, Jeff D; Kong, Lan; Chen, ... F30ES030607, R01ES019672 Toxicol Sci (2022 May 26) 35357496 Exiting the NIEHS site 2022 
Linear Hypothesis Testing in Linear Models With High-Dimensional Responses.   Li, Changcheng; Li, Runze R01ES019672 J Am Stat Assoc (2022) 36908313 Exiting the NIEHS site 2022 
Synergic control in asymptomatic welders during multi-finger force exertion and load releasing while ...   de Freitas, Paulo B; Freitas, Sandra M S F; Prado-Rico, Janina M; Lewis, Mechelle M; Du, Guangw ... R01ES019672 Neurotoxicology (2022 Dec) 36309163 Exiting the NIEHS site 2022 
HFE H63D Limits Nigral Vulnerability to Paraquat in Agricultural Workers.   Wang, Ernest W; Trojano, Max L; Lewis, Mechelle M; Du, Guangwei; Chen, Hairong; Brown, Gregory ... F30ES030607, R01ES019672 Toxicol Sci (2021 04 27) 33739421 Exiting the NIEHS site 2021 
Low plasma serotonin linked to higher nigral iron in Parkinson's disease.   Jellen, Leslie C; Lewis, Mechelle M; Du, Guangwei; Wang, Xi; Galvis, Martha L Escobar; Krzyzano ... R01ES019672 Sci Rep (2021 Dec 21) 34934078 Exiting the NIEHS site 2021 
Nigral MRI features of asymptomatic welders.   Lee, Eun-Young; Flynn, Michael R; Du, Guangwei; Lewis, Mechelle M; Goldenberg, Michael; Kong, ... R01ES019672 Parkinsonism Relat Disord (2021 04) 33691274 Exiting the NIEHS site 2021 
The neuroscience of social feelings: mechanisms of adaptive social functioning.   Eslinger, Paul J; Anders, Silke; Ballarini, Tommaso; Boutros, Sydney; Krach, Sören; Mayer, Ann ... R01ES019672 Neurosci Biobehav Rev (2021 Sep) 34089764 Exiting the NIEHS site 2021 
Variable selection for partially linear models via Bayesian subset modeling with diffusing prior.   Wang, Jia; Cai, Xizhen; Li, Runze R01ES019672 J Multivar Anal (2021 May) 33867594 Exiting the NIEHS site 2021 
Non-motor symptoms and striatal dopamine transporter binding in early Parkinson's disease.   Liu, Rui; Umbach, David M; Tröster, Alexander I; Huang, Xuemei; Chen, Honglei R01ES019672, R01ES029227 Parkinsonism Relat Disord (2020 03) 32092703 Exiting the NIEHS site 2020 
Parkinson's Disease-Related Motor and Nonmotor Symptoms in the Lancaster Amish.   Goldenberg, Michael D F; Huang, Xuemei; Chen, Honglei; Kong, Lan; Postolache, Teodor T; Stiller ... R01ES019672 Neuroepidemiology (2020) 32739915 Exiting the NIEHS site 2020 
Synergic control of action in levodopa-naïve Parkinson's disease patients: II. Multi-muscle synergie ...   Freitas, Sandra M S F; de Freitas, Paulo B; Falaki, Ali; Corson, Tyler; Lewis, Mechelle M; Huan ... R01ES019672 Exp Brain Res (2020 Dec) 33068173 Exiting the NIEHS site 2020 
The D1/D5 Dopamine Partial Agonist PF-06412562 in Advanced-Stage Parkinson's Disease: A Feasibility ...   Huang, Xuemei; Lewis, Mechelle M; Van Scoy, Lauren Jodi; De Jesus, Sol; Eslinger, Paul J; Arnol ... R01ES019672 J Parkinsons Dis (2020) 32986682 Exiting the NIEHS site 2020 
Brain cholesterol metabolism and Parkinson's disease.   Huang, Xuemei; Sterling, Nicholas W; Du, Guangwei; Sun, Dongxiao; Stetter, Christina; Kong, La ... R01ES019672 Mov Disord (2019 Mar) 30681742 Exiting the NIEHS site 2019 
Higher Hippocampal Mean Diffusivity Values in Asymptomatic Welders.   Lee, Eun-Young; Flynn, Michael R; Du, Guangwei; Lewis, Mechelle M; Kong, Lan; Yanosky, Jeff D; ... R01ES019672 Toxicol Sci (2019 04 01) 30629252 Exiting the NIEHS site 2019 
Individual preferences in motor coordination seen across the two hands: relations to movement stabil ...   de Freitas, Paulo B; Freitas, Sandra M S F; Lewis, Mechelle M; Huang, Xuemei; Latash, Mark L R01ES019672 Exp Brain Res (2019 Jan) 30298294 Exiting the NIEHS site 2019 
Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglia ...   Sarkar, Souvarish; Rokad, Dharmin; Malovic, Emir; Luo, Jie; Harischandra, Dilshan S; Jin, Huaj ... R01ES019672 Sci Signal (2019 01 08) 30622196 Exiting the NIEHS site 2019 
Multimodal MRI evaluation of parkinsonian limbic pathologies.   Wang, Ernest W; Du, Guangwei; Lewis, Mechelle M; Lee, Eun-Young; De Jesus, Sol; Kanekar, Sanga ... R01ES019672 Neurobiol Aging (2019 Apr) 30739076 Exiting the NIEHS site 2019 
Stability of steady hand force production explored across spaces and methods of analysis.   de Freitas, Paulo B; Freitas, Sandra M S F; Lewis, Mechelle M; Huang, Xuemei; Latash, Mark L R01ES019672 Exp Brain Res (2018 Jun) 29564506 Exiting the NIEHS site 2018 
Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes.   Lewis, Mechelle M; Du, Guangwei; Baccon, Jennifer; Snyder, Amanda M; Murie, Ben; Cooper, Felic ... R01ES019672 Mov Disord (2018 Sep) 29756231 Exiting the NIEHS site 2018 
Systemic effects of deep brain stimulation on synergic control in Parkinson's disease.   Falaki, Ali; Jo, Hang Jin; Lewis, Mechelle M; O'Connell, Barbara; De Jesus, Sol; McInerney, Ja ... R01ES019672 Clin Neurophysiol (2018 Jun) 29573980 Exiting the NIEHS site 2018 
Welding-related brain and functional changes in welders with chronic and low-level exposure.   Lee, Eun-Young; Flynn, Michael R; Lewis, Mechelle M; Mailman, Richard B; Huang, Xuemei R01ES019672 Neurotoxicology (2018 Jan) 28648949 Exiting the NIEHS site 2018 
Association of neurobehavioral performance with R2* in the caudate nucleus of asymptomatic welders.   Lee, Eun-Young; Eslinger, Paul J; Flynn, Michael R; Wagner, Daymond; Du, Guangwei; Lewis, Mech ... R01ES019672 Neurotoxicology (2017 Jan) 27871916 Exiting the NIEHS site 2017 
Combined Diffusion Tensor Imaging and Apparent Transverse Relaxation Rate Differentiate Parkinson Di ...   Du, G; Lewis, M M; Kanekar, S; Sterling, N W; He, L; Kong, L; Li, R; Huang, X R01ES019672 AJNR Am J Neuroradiol (2017 May) 28364007 Exiting the NIEHS site 2017 
Distinct neuroimaging features define Parkinson's disease and welding-related neurotoxicity.   Lee, Eun-Young; Lewis, Mechelle M; Mailman, Richard B; Huang, Xuemei R01ES019672 Neurologist (Hyderabad) (2017) 30151503 Exiting the NIEHS site 2017 
Dopaminergic modulation of multi-muscle synergies in postural tasks performed by patients with Parki ...   Falaki, Ali; Huang, Xuemei; Lewis, Mechelle M; Latash, Mark L R01ES019672 J Electromyogr Kinesiol (2017 Apr) 28110044 Exiting the NIEHS site 2017 
Lateralized Basal Ganglia Vulnerability to Pesticide Exposure in Asymptomatic Agricultural Workers.   Lewis, Mechelle M; Sterling, Nicholas W; Du, Guangwei; Lee, Eun-Young; Shyu, Grace; Goldenberg, ... R01ES019672 Toxicol Sci (2017 09 01) 28633499 Exiting the NIEHS site 2017 
Motor equivalence and structure of variance: multi-muscle postural synergies in Parkinson's disease.   Falaki, Ali; Huang, Xuemei; Lewis, Mechelle M; Latash, Mark L R01ES019672 Exp Brain Res (2017 Jul) 28455740 Exiting the NIEHS site 2017 
Editor's Highlight: Lower Fractional Anisotropy in the Globus Pallidus of Asymptomatic Welders, a Ma ...   Lee, Eun-Young; Flynn, Michael R; Du, Guangwei; Lewis, Mechelle M; Herring, Amy H; Van Buren, ... R01ES019672, T32ES007018 Toxicol Sci (2016 Sep) 27466214 Exiting the NIEHS site 2016 
Finger force changes in the absence of visual feedback in patients with Parkinson's disease.   Jo, Hang Jin; Ambike, Satyajit; Lewis, Mechelle M; Huang, Xuemei; Latash, Mark L R01ES019672 Clin Neurophysiol (2016 Jan) 26072437 Exiting the NIEHS site 2016 
Impaired synergic control of posture in Parkinson's patients without postural instability.   Falaki, Ali; Huang, Xuemei; Lewis, Mechelle M; Latash, Mark L R01ES019672 Gait Posture (2016 Feb) 27004660 Exiting the NIEHS site 2016 
Increased R2* in the Caudate Nucleus of Asymptomatic Welders.   Lee, Eun-Young; Flynn, Michael R; Du, Guangwei; Li, Yunqing; Lewis, Mechelle M; Herring, Amy H ... R01ES019672, T32ES007018 Toxicol Sci (2016 Apr) 26769335 Exiting the NIEHS site 2016 
Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders.   Lewis, Mechelle M; Flynn, Michael R; Lee, Eun-Young; Van Buren, Scott; Van Buren, Eric; Du, Gu ... R01ES019672, T32ES007018 Neurotoxicology (2016 12) 27567731 Exiting the NIEHS site 2016 
Serum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk.   Shrestha, Srishti; Lutsey, Pamela L; Alonso, Alvaro; Huang, Xuemei; Mosley Jr, Thomas H; Chen, ... R01ES019672 Mov Disord (2016 07) 27090608 Exiting the NIEHS site 2016 
Synergy as a new and sensitive marker of basal ganglia dysfunction: A study of asymptomatic welders.   Lewis, Mechelle M; Lee, Eun-Young; Jo, Hang Jin; Du, Guangwei; Park, Jaebum; Flynn, Michael R; ... R01ES019672 Neurotoxicology (2016 Sep) 27373673 Exiting the NIEHS site 2016 
The NINDS Parkinson's disease biomarkers program.   Rosenthal, Liana S; Drake, Daniel; Alcalay, Roy N; Babcock, Debra; Bowman, F DuBois; Chen-Plotk ... R01ES019672 Mov Disord (2016 06) 26442452 Exiting the NIEHS site 2016 
Heart rate variability and the risk of Parkinson disease: The Atherosclerosis Risk in Communities st ...   Alonso, Alvaro; Huang, Xuemei; Mosley, Thomas H; Heiss, Gerardo; Chen, Honglei R01ES019672 Ann Neurol (2015 May) 25707861 Exiting the NIEHS site 2015 
Neural control of movement stability: Lessons from studies of neurological patients.   Latash, M L; Huang, X R01ES019672 Neuroscience (2015 Aug 20) 26047732 Exiting the NIEHS site 2015 
Potential sex differences in nonmotor symptoms in early drug-naive Parkinson disease.   Liu, Rui; Umbach, David M; Peddada, Shyamal D; Xu, Zongli; Tröster, Alexander I; Huang, Xuemei ... R01ES019672 Neurology (2015 May 26) 25925983 Exiting the NIEHS site 2015 
Prehension synergies and hand function in early-stage Parkinson's disease.   Jo, Hang Jin; Park, Jaebum; Lewis, Mechelle M; Huang, Xuemei; Latash, Mark L R01ES019672 Exp Brain Res (2015 Feb) 25370346 Exiting the NIEHS site 2015 
Previous Injury and Chronic Pain are Associated with Side of Onset in Parkinson's Disease.   Tekin, Izel; Vgontzas, Angeliki; Lewis, Mechelle M; Kothari, Saira; Kong, Lan; Lu, Yue; Vrana, ... R01ES019672 J Neurol Neurobiol (2015 Jul) 26937489 Exiting the NIEHS site 2015 
Statins, plasma cholesterol, and risk of Parkinson's disease: a prospective study.   Huang, Xuemei; Alonso, Alvaro; Guo, Xuguang; Umbach, David M; Lichtenstein, Maya L; Ballantyne, ... R01ES019672 Mov Disord (2015 Apr) 25639598 Exiting the NIEHS site 2015 
T1 Relaxation Rate (R1) Indicates Nonlinear Mn Accumulation in Brain Tissue of Welders With Low-Leve ...   Lee, Eun-Young; Flynn, Michael R; Du, Guangwei; Lewis, Mechelle M; Fry, Rebecca; Herring, Amy ... R01ES019672, T32ES007018 Toxicol Sci (2015 Aug) 25953701 Exiting the NIEHS site 2015 
Dopaminergic modulation of motor coordinaton in Parkinson's disease.   Park, Jaebum; Lewis, Mechelle M; Huang, Xuemei; Latash, Mark L R01ES019672 Parkinsonism Relat Disord (2014 Jan) 24090949 Exiting the NIEHS site 2014 
History of smoking and olfaction in Parkinson's disease.   Lucassen, Elisabeth B; Sterling, Nicholas W; Lee, Eun-Young; Chen, Honglei; Lewis, Mechelle M; ... R01ES019672 Mov Disord (2014 Jul) 24833119 Exiting the NIEHS site 2014 
Microstructural changes in the substantia nigra of asymptomatic agricultural workers.   Du, Guangwei; Lewis, Mechelle M; Sterling, Nicholas W; Kong, Lan; Chen, Honglei; Mailman, Rich ... R01ES019672 Neurotoxicol Teratol (2014 Jan-Feb) 24334261 Exiting the NIEHS site 2014 
Short-term outcomes of sport- and recreation-related concussion in patients admitted to a pediatric ...   Bramley, Harry; Mcfarland, Carol; Lewis, Mechelle M; Shaffer, Michele L; Cilley, Robert; Engbre ... R01ES019672 Clin Pediatr (Phila) (2014 Jul) 24790025 Exiting the NIEHS site 2014 
The perplexing paradox of paraquat: the case for host-based susceptibility and postulated neurodegen ...   Jones, Byron C; Huang, Xuemei; Mailman, Richard B; Lu, Lu; Williams, Robert W R01ES019672 J Biochem Mol Toxicol (2014 May) 24599642 Exiting the NIEHS site 2014 
Higher iron in the red nucleus marks Parkinson's dyskinesia.   Lewis, Mechelle M; Du, Guangwei; Kidacki, Michal; Patel, Nisargkumar; Shaffer, Michele L; Mailm ... R01ES019672 Neurobiol Aging (2013 May) 23177595 Exiting the NIEHS site 2013 
The meaning of a "hippo" response on the Montreal Cognitive Assessment in Parkinson's disease.   Armstrong, Melissa J; Duff-Canning, Sarah; Tang-Wai, David F; Fox, Susan; Zadikoff, Cindy; Kenn ... R01ES019672 Parkinsonism Relat Disord (2013 Apr) 23036511 Exiting the NIEHS site 2013 
Roles of Education and IQ in Cognitive Reserve in Parkinson's Disease-Mild Cognitive Impairment.   Armstrong, M J; Naglie, G; Duff-Canning, S; Meaney, C; Gill, D; Eslinger, P J; Zadikoff, C; M ... R01ES019672 Dement Geriatr Cogn Dis Extra (2012 Jan) 22962558 Exiting the NIEHS site 2012 
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