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National Institute of Environmental Health Sciences

 

Person Details

Superfund Research Program

Alan R. Buckpitt

University of California-Davis
Department of Molecular Biosciences
220 Everson Hall: Vet Med
Davis, CA 95616
Phone: 530-752-7674
Fax: 530-752-4698
Email:

Projects

Research Briefs

Publications

2010
2009
  • Lin, Ching Yu, Asa M. Wheelock, Dexter Morin, R. Michael Baldwin, Myong Gyong Lee, A. Taff, Charles G. Plopper, Alan R. Buckpitt, and Arlean Rohde. 2009. Toxicity and metabolism of methylnaphthalenes: Comparison with naphthalene and 1-nitronaphthalene. Toxicology.   260(1-3):16-27. doi:10.1016/j.tox.2009.03.002  
2008
  • Morisseau, Christophe, John W. Newman, Craig E. Wheelock, Thomas Hill, Dexter Morin, Alan R. Buckpitt, and Bruce D. Hammock. 2008. Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. Chemical Research in Toxicology.   21(4):951-7. doi:10.1021/tx700446u  
2006
  • Lin, Ching Yu, Bridget C. Boland, Young Jin Lee, Michelle R. Salemi, Dexter Morin, Lisa A. Miller, Charles G. Plopper, and Alan R. Buckpitt. 2006. Identification of proteins adducted by reactive metabolites of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques. Proteomics. 6(3):972-982.
  • Wheelock, Asa M., Dexter Morin, Matthew J. Bartosiewicz, and Alan R. Buckpitt. 2006. Use of a fluorescent internal protein standard to achieve quantitative two-dimensional gel electrophoresis. Proteomics. 6(5):1385-1398.
2005
  • Baldwin, R.Michael, Michael A. Shultz, and Alan R. Buckpitt. 2005. Bioactivation of the Pulmonary Toxicants Naphthalene and 1-Nitronaphthalene by Rat CYP2F4. Journal of Pharmacology and Experimental Therapeutics.   312(2):857-865.
  • Isbell, Margaret A., Dexter Morin, Bridget C. Boland, Alan R. Buckpitt, Michelle R. Salemi, and Jack M. Presley. 2005. Identification of proteins adducted by reactive naphthalene metabolites in vitro. Proteomics. 5(16):4197-4204.
  • Lee, Myong Gyong, Andrew J. Phimister, Dexter Morin, Alan R. Buckpitt, and Charles G. Plopper. 2005. In situ naphthalene bioactivation and nasal airflow cause region-specific injury patterns in the nasal mucosa of rats exposed to naphthalene by inhalation. Journal of Pharmacology and Experimental Therapeutics.   314(1):103-110.
  • Lin, Ching Yu, Margaret A. Isbell, Dexter Morin, Bridget C. Boland, Michelle R. Salemi, William T. Jewell, Alison J. Weir, Michelle V. Fanucchi, Gregory L. Baker, Charles G. Plopper, and Alan R. Buckpitt. 2005. Characterization of a structurally intact in situ lung model and comparison of naphthalene protein adducts generated in this model vs. lung rway incubation in situ vs. lung microsomes. Chemical Research in Toxicology.   18(5):802-813.
  • Phimister, Andrew J., Herbert T. Nagasawa, Alan R. Buckpitt, and Charles G. Plopper. 2005. Prevention of naphthalene-induced pulmonary toxicity by glutathione prodrugs: roles for glutathione depletion in adduct formation and cell injury. Journal of Biochemical and Molecular Toxicology.   19(1):42-51.
  • Wheelock, Asa M., Bridget C. Boland, Margaret A. Isbell, Dexter Morin, Teresa C. Wegesser, Charles G. Plopper, and Alan R. Buckpitt. 2005. In Vivo effects of ozone exposure on protein adduct formation by 1-nitronaphthalene rat lung. American Journal of Respiratory and Critical Care Medicine.   33(2):130-137.
  • Wheelock, Asa M. and Alan R. Buckpitt. 2005. Software-induced variance in two-dimensional gel electrophoresis image analysis. Electrophoresis.   26:4508-4520.
2004
  • Boland, Bridget C., Ching Yu Lin, Dexter Morin, Lisa A. Miller, Charles G. Plopper, and Alan R. Buckpitt. 2004. Site specific metabolism of naphthalene and 1-nitronaphthalene in dissected airways of Rhesus macaques. Journal of Pharmacology and Experimental Therapeutics.   310(2):546-554.
  • Phimister, Andrew J., Myong Gyong Lee, Dexter Morin, Alan R. Buckpitt, and Charles G. Plopper. 2004. Glutathione depletion is a major determinant of inhaled naphthalene respiratory toxicity and naphthalene metabolism in mice. Toxicological Sciences.   82(1):268-278.
  • Shultz, Michael A., Lu Zhang, Yi-Zhong Gu, Gregory L. Baker, Michelle V. Fanucchi, Allan M. Padua, Wlliam A. Gurske, Dexter Morin, Sharron G. Penn, Steven B. Jovanovich, Charles G. Plopper, and Alan R. Buckpitt. 2004. Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development. American Journal of Respiratory Cell and Molecular Biology.   30(3):296-310.
  • Wheelock, Asa M., Lu Zhang, Mai-Uyen Tran, Dexter Morin, Sharron G. Penn, Alan R. Buckpitt, and Charles G. Plopper. 2004. Isolation of rodent airway epithelial cell proteins facilitates in vivo proteomics studies of lung toxicity. American Journal of Physiology - Lung Cellular and Molecular Physiology.   286(2):L399-L410.
2002
  • Buckpitt, Alan R., Bridget C. Boland, Margaret A. Isbell, Dexter Morin, Michael A. Shultz, R. Michael Baldwin, K. Chan, A. Karlsson, C. Lin, A. Taff, Jay AA West, Michelle V. Fanucchi, Laura S. Van Winkle, and Charles G. Plopper. 2002. Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity. Drug Metabolism Reviews.   34(4):791-820.
  • Pakehham, Gwyn, Jozsef Lango, Michael Buonarati, Dexter Morin, and Alan R. Buckpitt. 2002. Urinary naphthalene mercapturates as biomarkers of exposure and stereoselectivity of naphthalene epoxidation. Drug Metabolism and Disposition.   30(3):247-253.
  • West, Jay AA, Kurt J. Williams, Elina Toskala, Susan J. Nishio, Chad A. Fleschner, Henry Jay Forman, Alan R. Buckpitt, and Charles G. Plopper. 2002. Induction of tolerance to naphthalene in Clara cells is dependent on a stable phenotypic adaptation favoring maintenance of the glutathione pool. American Journal of Pathology.   160(3):1115-1127.
2001
  • Bartosiewicz, Matthew J., David Jenkins, Sharron G. Penn, Jennifer Emery, and Alan R. Buckpitt. 2001. Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants. Journal of Pharmacology and Experimental Therapeutics.   297(3):895-905.
  • Bartosiewicz, Matthew J., Sharron G. Penn, and Alan R. Buckpitt. 2001. Applications of gene arrays in environmental toxicology: Fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene. Environmental Health Perspectives. 109(1):71-74.
  • Plopper, Charles G., Laura S. Van Winkle, Michelle V. Fanucchi, Sonia RC Malburg, Susan J. Nishio, Ai-Min Chang, and Alan R. Buckpitt. 2001. Early events in naphthalene-induced acute Clara cell toxicity - II. Comparison of glutathione depletion and histopathology by airway location. American Journal of Respiratory Cell and Molecular Biology.   24(3):272-281.
  • Shultz, Michael A., Dexter Morin, Ai-Min Chang, and Alan R. Buckpitt. 2001. Metabolic capabilities of CYP2F2 with various pulmonary toxicants and its relative abundance in mouse lung subcompartments. Journal of Pharmacology and Experimental Therapeutics.   296(2):510-519.
  • West, Jay AA, Gwyn Pakehham, Dexter Morin, Chad A. Fleschner, Charles G. Plopper, and Alan R. Buckpitt. 2001. Inhaled naphthalene causes dose dependent Clara cell toxicity in mice but not in rats. Toxicology and Applied Pharmacology.   173(2):114-119.
2000
  • Bartosiewicz, Matthew J., Mary Trounstine, David Barker, Richard Johnston, and Alan R. Buckpitt. 2000. Development of a toxicological gene array and quantitative assessment of this technology. Archives of Biochemistry and Biophysics.   376(1):66-73.
  • Fanucchi, Michelle V., Alan R. Buckpitt, M. Murphy, David H. Storms, Bruce D. Hammock, and Charles G. Plopper. 2000. Development of phase II xenobiotic metabolizing enzymes in differentiating murine Clara cells. Toxicology and Applied Pharmacology.   168(3):253-267.
  • Lakritz, Jeffery, Bruce S. Winder, Jaffar Noorouz-Zadeh, Tien L. Huang, Alan R. Buckpitt, Bruce D. Hammock, and Charles G. Plopper. 2000. Hepatic and pulmonary enzyme activities in horses. American Journal of Veterinary Research.   61(2):152-157.
  • Watt, Katherine C. and Alan R. Buckpitt. 2000. Species differences in the regio- and stereo-selectivity of 1-nitronaphthalene metabolism. Drug Metabolism and Disposition.   28(4):376-378.
  • West, Jay AA, Alan R. Buckpitt, and Charles G. Plopper. 2000. Elevated airway GSH resynthesis confers protection to Clara cells from naphthalene injury in mice made tolerant by repeated exposures. Journal of Pharmacology and Experimental Therapeutics.   294(2):516-523.
  • West, Jay AA, Christine Chichester, Alan R. Buckpitt, Nancy K. Tyler, Patricia Brennan, Cimity Helton, and Charles G. Plopper. 2000. Heterogeneity of Clara cell glutathione - A possible basis for differences in cellular responses to pulmonary cytotoxicants. American Journal of Respiratory Cell and Molecular Biology.   23(1):27-36.
1999
  • Shultz, Michael A., Prabahakara Choudary, and Alan R. Buckpitt. 1999. Role of murine CYP2F2 in the metabolic activation of naphthalene and in the metabolism of other xenobiotics. Journal of Pharmacology and Experimental Therapeutics.   290(1):281-288.
  • Watt, Katherine C., Dexter Morin, Mark Kurth, Roger S. Mercer, Charles G. Plopper, and Alan R. Buckpitt. 1999. Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: Identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy. Chemical Research in Toxicology.   12(9):831-839.
1997
  • Lakritz, Jeffery, Charles G. Plopper, and Alan R. Buckpitt. 1997. Validated high-performance liquid chromatography-electrochemical method for determination of glutathione and glutathione disulfide in small tissue samples. Analytical Biochemistry.   247(1):63-68.
1996
  • Lakritz, Jeffery, Ai-Min Chang, Alison J. Weir, Susan J. Nishio, Dallas Hyde, Richard M. Philpot, Alan R. Buckpitt, and Charles G. Plopper. 1996. Cellular and metabolic basis of clara cell tolerance to multiple doses of cytochrome P450-activated cytotoxicants. I: Bronchiolar epithelial reorganization and expression of cytochrome P450 monooxygenases in mice exposed to multiple doses of naphthalene. Journal of Pharmacology and Experimental Therapeutics.   278(3):1408-1418.
  • Van Winkle, Laura S., Alan R. Buckpitt, and Charles G. Plopper. 1996. Maintenance of differentiated murine clara cells in microdissected airway cultures. American Journal of Respiratory Cell and Molecular Biology.   14(6):586-598.
1995
  • Buckpitt, Alan R., Ai-Min Chang, Alison J. Weir, Laura S. Van Winkle, Xiuzhen Duan, Richard M. Philpot, and Charles G. Plopper. 1995. Relationship of cytochrome P450 activity to Clara cell cytotoxicity. IV. Metabolism of naphthalene and naphthalene oxide in microdissected airways from mice, rats, and hamsters. Molecular Pharmacology.   47(1):74-81.
  • Cho, Myung-Haeng, Christine Chichester, Charles G. Plopper, and Alan R. Buckpitt. 1995. Biochemical factors important in Clara cell selective toxicity in the lung. Drug Metabolism Reviews.   27(1-2):369-386.
  • Van Winkle, Laura S., Alan R. Buckpitt, Susan J. Nishio, Jonathan M. Isaac, and Charles G. Plopper. 1995. Cellular response in naphthalene-induced Clara cell injury and bronchiolar epithelial repair in mice. American Journal of Physiology - Lung Cellular and Molecular Physiology.   269(6):L800-L818.

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