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Your Environment. Your Health.

Person Details

Superfund Research Program

Tom K. Hei

Columbia University Mailman School of Public Health
Department of Environmental Health Sciences
New York, NY 10032
Phone: 212-305-8462
Fax: 212-305-3229


Research Briefs



  • Huang, Sarah X L., Michael A. Partridge, Shanaz A. Ghandhi, Mercy M. Davidson, Sally A. Amundson, and Tom K. Hei. 2012. Mitochondria-derived reactive intermediate species mediate asbestos-induced genotoxicity and oxidative stress-responsive signaling pathways. Environmental Health Perspectives. 120:840-847. doi:10.1289/ehp.1104287
  • Li, Bingyan, Jing Sun, Hong Wei, Yu-Zhi Cheng, Lian Xue, Zhi-Hai Cheng, Jian-Mei Wan, Ai-Qing Wang, Tom K. Hei, and Jian Tong. 2012. Radon-induced reduced apoptosis in human bronchial epithelial cells with knockdown of mitochondira DNA. Journal of Toxicology and Environmental Health, Part A. 75:1111-1119. doi:10.1080/15287394.2012.699841
  • Li, Bingyan, Gengyun Wen, Yongliang Zhao, Jian Tong, and Tom K. Hei. 2012. The role of TGFBI in mesothelioma and breast cancer: Association with tumor suppression. BMC Cancer. 12:239. doi:10.1186/1471-2407-12-239


  • Huang, S.X., M.C. Jaurand, D.W. Kamp, J. Whysner, and Tom K. Hei. 2011. Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases. Journal of Toxicology & Environmental Health Part B: Critical Reviews. 14:179-245. doi:10.1080/10937404.2011.556051
  • Ivanov, Vladimir N. and Tom K. Hei. 2011. Regulation of apoptosis in human melanoma and neuroblastoma cells by statins, sodium arsenite and TRAIL: a role of combined treatment versus monotherapy. Apoptosis. 16(12):1268-1284. doi:10.1007/s10495-011-0649-2
  • Ivanov, Vladimir N., Michael A. Partridge, Sarah X L. Huang, and Tom K. Hei. 2011. Suppression of the Proinflammatory Response of Metastatic Melanoma Cells Increases TRAIL-Induced Apoptosis. Journal of Cellular Biochemistry. 112(2):463-475. doi:10.1002/jcb.22934
  • Wen, Gengyun, Mei Hong, Bingyan Li, Wupeng Liao, Simon K. Cheng, Burong Hu, Gloria M. Calaf, Ping Lu, Michael A. Partridge, Jian Tong, and Tom K. Hei. 2011. Transforming growth factor-B-induced protein (TGFBI) suppresses mesothelioma progression through the Akt/mTOR pathway. International Journal of Oncology. 39(4):1001-1009. doi:10.3892/ijo.2011.1097


  • Karasic, T., Tom K. Hei, and Vladimir N. Ivanov. 2010. Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma. Experimental Cell Research. 316(12):1994-2007. doi:10.1016/j.yexcr.2010.04.014
  • Roy, D., Tom K. Hei, B. Li, Gengyun Wen, Mei Hong, Gloria M. Calaf, and Michael A. Partridge. 2010. Phosphoproteomic profiling of arsenite-treated human small airway epithelial cells. Oncology Reports. 23(2):405-412. doi:10.3892/or_00000649



  • Ivanov, Vladimir N., Michael A. Partridge, Geoffrey E. Johnson, Sarah X L. Huang, Hongning Z. Zhou, and Tom K. Hei. 2008. Resveratrol sensitizes human melanomas to TRAIL through modulation of anti-apoptotic gene expression in conditions of partial suppression of mitochondrial function. Experimental Cell Research. 314(5):1163-1176. doi:10.1016/j.yexcr.2007.12.012
  • Wen, Gengyun, Gloria M. Calaf, Michael A. Partridge, Carlos Echiburu-Chau, Yongliang Zhao, Sarah X L. Huang, Yunfei Chai, Bingyan Li, Burong Hu, and Tom K. Hei. 2008. Neoplastic transformation of human small airway epithelial cells induced by arsenic. Molecular Medicine. 14(1-2):2-10. doi:10.2119/2007-00090.Wen


  • Partridge, Michael A., S.X. Huang, E. Hernandez-Rosa, Mercy M. Davidson, and Tom K. Hei. 2007. Arsenic induced mitochondrial DNA damage and alteredmitochondrial oxidative function: Implication for genotoxic mechanismsin mammalian cells. Cancer Research. 67(11):5239-5247.
  • Patridge, M., Mercy M. Davidson, and Tom K. Hei. 2007. The complete nucleotide sequence of Chinese hamster (Cricetulus griseus) mitochondrial DNA sequence. DNA Sequence. 18(5):341-346.
  • Vladimir, I., Hongning Z. Zhou, and Tom K. Hei. 2007. Gamma-irradiation or alpha-particle exposure sensitize human melanoma cells to TRAIL-mediated apoptosis through upregulation of TRAIL R2/DR5 expression and translocation to the cell surface. Cancer Research. 67:5397-5407.
  • Vladimir, I., Hongning Z. Zhou, and Tom K. Hei. 2007. Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. Cancer Research. 67(11):5397-5407.
  • Xu, An, S.X. Huang, Yu-Chin Lien, Lingzhi Bao, Zengliang Yu, and Tom K. Hei. 2007. Genotoxic mechanisms of asbestos fibers: role of extranuclear targets. Chemical Research in Toxicology. 20(5):724-33.
  • Xu, An, L.B. Smilenov, P. He, K. Masumura, T. Nohmi, Zengliang Yu, and Tom K. Hei. 2007. New insight into intrachromosomal deletions induced by chrysotile in the gpt delta transgenic mutation assay. Environmental Health Perspectives. 115(1):87-92.


  • Ivanov, Vladimir N. and Tom K. Hei. 2006. Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells. Experimental Cell Research. 312(8):1401-1417.
  • Ivanov, Vladimir N. and Tom K. Hei. 2006. Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. Experimental Cell Research. 312(20):4120-4138.
  • Ivanov, Vladimir N., Ze'ev Ronai, and Tom K. Hei. 2006. Opposite Roles of FAP-1 and Dynamin in the Regulation of Fas (CD95) Translocation to the Cell Surface and Susceptibility to Fas Ligand-mediated Apoptosis. Journal of Biological Chemistry. 281(3):1840-1852.
  • Zhou, Hongning Z., An Xu, Joseph A. Gillispie, Charles A. Waldren, and Tom K. Hei. 2006. Quantification of CD59-mutants in human-hamster hybrid (AL) cells by flow cytometry. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 594(1-2):113-119.


  • Liu, Su-Xian, Mercy M. Davidson, Xiuwei Tang, Winsom F. Walker, Mohammad Athar, Vladimir N. Ivanov, and Tom K. Hei. 2005. Mitochondrial Damage Mediates Genotoxicity of Arsenic in Mammalian Cells. Cancer Research. 65(8):3236-3242.



  • Hall, Eric J. and Tom K. Hei. 2003. Genomic instability and bystander effects induced by high-LET radiation. Oncogene. 22:7034-7042.
  • Zhou, Hongning Z., Gerhard Randes-Pehrson, Charles R. Geard, David J. Brenner, Eric J. Hall, Tom K. Hei, and Kazi M. Ahmed. 2003. Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiation Research. 160(5):512-516.


  • Kessel, Maris, Su-Xian Liu, An Xu, Regina M. Santella, and Tom K. Hei. 2002. Arsenic induces oxidative DNA damage in mammalian cells. Molecular and Cellular Biochemistry. 234-235:301-308.
  • Xu, An, Hongning Z. Zhou, Dennis Zengliang Yu, and Tom K. Hei. 2002. Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation patterns induced by reactive oxygen species. Environmental Health Perspectives. 110:1003-1008.



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