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National Institute of Environmental Health Sciences

 

Person Details

Superfund Research Program

Tom K. Hei

Columbia University Mailman School of Public Health
Department of Environmental Health Sciences
New York, NY 10032
Phone: 212-305-8462
Fax: 212-305-3229
Email:

Projects

Research Briefs

Publications

2012
  • Huang, Sarah X L., Michael A. Partridge, Shanaz A. Ghandhi, Mercy M. Davidson, Sally A. Amundson, and Tom K. Hei. 2012. Mitochondria-derived reactive intermediate species mediate asbestos-induced genotoxicity and oxidative stress-responsive signaling pathways. Environmental Health Perspectives. 120:840-847. doi:10.1289/ehp.1104287  
  • Li, Bingyan, Jing Sun, Hong Wei, Yu-Zhi Cheng, Lian Xue, Zhi-Hai Cheng, Jian-Mei Wan, Ai-Qing Wang, Tom K. Hei, and Jian Tong. 2012. Radon-induced reduced apoptosis in human bronchial epithelial cells with knockdown of mitochondira DNA. Journal of Toxicology and Environmental Health, Part A.   75:1111-1119. doi:10.1080/15287394.2012.699841  
  • Li, Bingyan, Gengyun Wen, Yongliang Zhao, Jian Tong, and Tom K. Hei. 2012. The role of TGFBI in mesothelioma and breast cancer: Association with tumor suppression. BMC Cancer. 12:239. doi:10.1186/1471-2407-12-239  
2011
  • Ivanov, Vladimir N. and Tom K. Hei. 2011. Regulation of apoptosis in human melanoma and neuroblastoma cells by statins, sodium arsenite and TRAIL: a role of combined treatment versus monotherapy. Apoptosis. 16(12):1268-1284. doi:10.1007/s10495-011-0649-2  
  • Ivanov, Vladimir N., Michael A. Partridge, Sarah X L. Huang, and Tom K. Hei. 2011. Suppression of the Proinflammatory Response of Metastatic Melanoma Cells Increases TRAIL-Induced Apoptosis. Journal of Cellular Biochemistry.   112(2):463-475. doi:10.1002/jcb.22934  
  • Wen, Gengyun, Mei Hong, Bingyan Li, Wupeng Liao, Simon K. Cheng, Burong Hu, Gloria M. Calaf, Ping Lu, Michael A. Partridge, Jian Tong, and Tom K. Hei. 2011. Transforming growth factor-B-induced protein (TGFBI) suppresses mesothelioma progression through the Akt/mTOR pathway. International Journal of Oncology.   39(4):1001-1009. doi:10.3892/ijo.2011.1097  
2010
  • Karasic, T., Tom K. Hei, and Vladimir N. Ivanov. 2010. Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma. Experimental Cell Research. 316(12):1994-2007. doi:10.1016/j.yexcr.2010.04.014  
  • Roy, D., Tom K. Hei, B. Li, Gengyun Wen, Mei Hong, Gloria M. Calaf, and Michael A. Partridge. 2010. Phosphoproteomic profiling of arsenite-treated human small airway epithelial cells. Oncology Reports.   23(2):405-412. doi:10.3892/or_00000649  
2009
2008
  • Ivanov, Vladimir N., Michael A. Partridge, Geoffrey E. Johnson, Sarah X L. Huang, Hongning Z. Zhou, and Tom K. Hei. 2008. Resveratrol sensitizes human melanomas to TRAIL through modulation of anti-apoptotic gene expression in conditions of partial suppression of mitochondrial function. Experimental Cell Research. 314(5):1163-1176. doi:10.1016/j.yexcr.2007.12.012  
  • Wen, Gengyun, Gloria M. Calaf, Michael A. Partridge, Carlos Echiburu-Chau, Yongliang Zhao, Sarah X L. Huang, Yunfei Chai, Bingyan Li, Burong Hu, and Tom K. Hei. 2008. Neoplastic transformation of human small airway epithelial cells induced by arsenic. Molecular Medicine.   14(1-2):2-10. doi:10.2119/2007-00090.Wen  
2007
  • Partridge, M., S.X. Huang, E. Hernandez-Rosa, Mercy M. Davidson, and Tom K. Hei. 2007. Arsenic induced mitochondrial DNA damage and alteredmitochondrial oxidative function: Implication for genotoxic mechanismsin mammalian cells. Cancer Research.   67(11):5239-5247.
  • Patridge, M., Mercy M. Davidson, and Tom K. Hei. 2007. The complete nucleotide sequence of Chinese hamster (Cricetulus griseus) mitochondrial DNA sequence. DNA Sequence.   18(5):341-346.
  • Vladimir, I., Hongning Z. Zhou, and Tom K. Hei. 2007. Gamma-irradiation or alpha-particle exposure sensitize human melanoma cells to TRAIL-mediated apoptosis through upregulation of TRAIL R2/DR5 expression and translocation to the cell surface. Cancer Research.   67:5397-5407.
  • Vladimir, I., Hongning Z. Zhou, and Tom K. Hei. 2007. Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. Cancer Research.   67(11):5397-5407.
  • Xu, An, S.X. Huang, Yu-Chin Lien, Lingzhi Bao, Zengliang Yu, and Tom K. Hei. 2007. Genotoxic mechanisms of asbestos fibers: role of extranuclear targets. Chemical Research in Toxicology.   20(5):724-33.
  • Xu, An, L.B. Smilenov, P. He, K. Masumura, T. Nohmi, Z. Yu, and Tom K. Hei. 2007. New insight into intrachromosomal deletions induced by chrysotile in the gpt delta transgenic mutation assay. Environmental Health Perspectives. 115(1):87-92.
2006
  • Ivanov, Vladimir N. and Tom K. Hei. 2006. Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells. Experimental Cell Research. 312(8):1401-1417.
  • Ivanov, Vladimir N. and Tom K. Hei. 2006. Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. Experimental Cell Research. 312(20):4120-4138.
  • Ivanov, Vladimir N., Ze'ev Ronai, and Tom K. Hei. 2006. Opposite Roles of FAP-1 and Dynamin in the Regulation of Fas (CD95) Translocation to the Cell Surface and Susceptibility to Fas Ligand-mediated Apoptosis. Journal of Biological Chemistry.   281(3):1840-1852.
  • Zhou, Hongning Z., An Xu, Joseph A. Gillispie, Charles A. Waldren, and Tom K. Hei. 2006. Quantification of CD59-mutants in human-hamster hybrid (AL) cells by flow cytometry. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis.   594(1-2):113-119.
2005
  • Liu, Su-Xian, Mercy M. Davidson, Xiuwei Tang, Winsom F. Walker, Mohammad Athar, Vladimir N. Ivanov, and Tom K. Hei. 2005. Mitochondrial Damage Mediates Genotoxicity of Arsenic in Mammalian Cells. Cancer Research.   65(8):3236-3242.
2004
2003
  • Hall, Eric J. and Tom K. Hei. 2003. Genomic instability and bystander effects induced by high-LET radiation. Oncogene.   22:7034-7042.
  • Zhou, Hongning Z., Gerhard Randes-Pehrson, Charles R. Geard, David J. Brenner, Eric J. Hall, Tom K. Hei, and Kazi M. Ahmed. 2003. Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiation Research.   160(5):512-516.
2002
  • Kessel, Maris, Su-Xian Liu, An Xu, Regina M. Santella, and Tom K. Hei. 2002. Arsenic induces oxidative DNA damage in mammalian cells. Molecular and Cellular Biochemistry.   234-235:301-308.
  • Xu, An, Hongning Z. Zhou, Dennis Zengliang Yu, and Tom K. Hei. 2002. Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation patterns induced by reactive oxygen species. Environmental Health Perspectives. 110:1003-1008.
2001
1998