Superfund Research Program

Aquatic Biomarkers in Site Characterization and Remediation

Project Leader: David E. Hinton (Duke University)
Grant Number: P42ES004699
Funding Period: 1995 - 2005

Project-Specific Links

Publications

2004

• Hinton DE, Wakamatsu Y, Ozato K, Kashiwada S. 2004. Imaging liver development/remodeling in the see-through medaka fish. Comp Hepatol 3Suppl1:S30. doi:10.1186/1476-5926-2-S1-S30 PMID:14960182 PMCID:PMC2410249

2003

• Kullman SW, Matsumura F, Hinton DE. 2003. Estrogen signaling in trout liver: estrogen receptor and mitogenic mediated cellular responses. Environ Sci (Ruse) 10(4):223-237.
• Liu Z, Kullman SW, Bencic DC, Torten M, Hinton DE. 2003. ras oncogene mutations in diethylnitrosamine-induced hepatic tumors in medaka (Oryzias latipes), a teleost fish. Mutat Res 539(1-2):43-53. PMID:12948813

2002

• Davis CR, Okihiro MS, Hinton DE. 2002. Effects of husbandry practices, gender, and normal physiological variation on growth and reproduction of Japanese medaka, Oryzias latipes. Aquat Toxicol 60(3-4):185-201. PMID:12200085

2001

• Arukwe A, Kullman SW, Hinton DE. 2001. Differential biomarker gene and protein expressions in nonylphenol and estradiol-17b treated juvenile rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol C Toxicol Pharmacol 129(1):1-10.
• Hamm JT, Wilson BW, Hinton DE. 2001. Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes). Toxicol Sci 61(2):304-313. PMID:11353139

2000

• Hamm JT, Hinton DE. 2000. The role of development and duration of exposure to the embryotoxicity of diazinon. Aquat Toxicol 48:403-418. PMID:10794827
• Okihiro MS, Hinton DE. 2000. Partial hepatechtomy and bile duct ligation in rainbow trout (Oncorhynchus mykiss): histologic, immunohistochemical, and enzyme histochemical characterization of hepatic regeneration and biliary hyperplasis. Toxicol Pathol 28(2):342-356. PMID:10805153
• Villalobos SA, Hamm JT, Teh SJ, Hinton DE. 2000. Thiobencarb-induced embryotoxicity in medaka (Oryzias latipes): stage specific toxicity and the protective role of chorion. Aquat Toxicol 48(2-3):309-326. PMID:10686335

1999

• Okihiro MS, Hinton DE. 1999. Progression of hepatic neoplasia in medaka (Oryzias latipes) exposed to diethylnitrosamine. Carcinogenesis 20(6):933-940. PMID:10357770
• Teh SJ, Clark SL, Brown CL, Luoma SN, Hinton DE. 1999. Enzymatic and histopathologic biomarkers as indicators of contaminant exposure and effect in Asian clam (Potamocorbula amurensis). Biomarkers 4(6):497-509. PMID:23902395
• Werner I, Hinton DE. 1999. Field validation of hsp 70 stress proteins as biomarker in Asian clam (Potamocorbula amurensis). Biomarkers 4(6):473-484. PMID:23902392

1998

• Hamm JT, Wilson BW, Hinton DE. 1998. Organophosphate-induced acetylcholinesterase inhibition and embryonic retinal cell necrosis in vivo in the teleost (Oryzias latipes). Neurotoxicology 19(6):853-870. PMID:9863774
• Hinton DE. 1998. Multiple stressors in the Sacramento River watershed. Chapter 86 in: EXS (Basel); Fish Ecotoxicology. Birkhauser Publishers, Basel, Switzerland. pp.303-317.
• Hinton DE, Crouch JA. 1998. Architectural pattern, tissue and cellular morphology in livers of fishes: Relationship to experimentally-induced neoplastic responses. Chapter 86 in: EXS (Basel); Fish Ecotoxicology. Birkhauser Publishers, Basel, Switzerland. pp.141-164.
• Teh SJ, Hinton DE. 1998. Gender-specific growth and hepatic neoplasia in medaka (Oryzias latipes). Aquat Toxicol 41(1-2):141-159.

1997

• Boorman GA, Botts S, Bunton TE, Fournie JW, Harshbarger JC, Hawkins WE, Hinton DE, Jokinen MP, Okihiro MS, Wolfe MJ. 1997. Diagnostic criteria for degenerative, inflammatory, proliferative nonneoplastic and neoplastic liver lesions in medaka (Oryzias latipes): Consensus of a national toxicology program pathology working group. Toxicol Pathol 25(2):202-210. PMID:9125779
• Hinton DE. 1997. Histologic responses signifying exposure or effect and their application to aquatic ecotoxicology. In: Ecotoxicology: Responses, Biomarkers, & Risk Assessment, an OECD Workshop. SOS Publications, Fair Haven, NJ. pp.293-309.
• Teh SJ, Adams SM, Hinton DE. 1997. Histopathologic biomarkers in feral freshwater fish populations exposed to different types of contaminant stress. Aquat Toxicol 37(1):51-70.
• Washburn BS, Rein KS, Baden DG, Walsh PJ, Hinton DE, Tullis K, Denison MS. 1997. Brevetoxin-6 (PbTx-6), a nonaromatic marine neurotoxin, is a ligand of the aryl hydrocarbon receptor. Arch Biochem Biophys 343(2):149-156. PMID:9224724

1996

• Anderson MJ, Miller MR, Hinton DE. 1996. In vitro modulation of 17-²-estradiol-induced vitellogenin synthesis: Effects of cytochrome P4501A1 inducing compounds on rainbow trout (Oncorhynchus mykiss) liver cells. Aquat Toxicol 34(4):327-350. doi:10.1016/0166-445X(95)00047-8
• Anderson MJ, Olsen H, Matsumura F, Hinton DE. 1996. In vivo modulation of 17²-estradiol-induced vitellogenin synthesis and estrogen receptor in rainbow trout (Oncorhynchus mykiss) liver cells by ²-naphthoflavone. Toxicol Appl Pharmacol 137(2):210-218. doi:10.1006/taap.1996.0074 PMID:8661346
• Hinton DE. 1996. Eighth international symposium "Pollutant responses in marine organisms" (PRIMO 8). Mar Environ Res 42(1-4):

1995

• Wolfe MJ, Hinton DE, Seiber JN. 1995. Aqueous sample preparation for bioassay using supercritical fluid extraction. Environ Toxicol Chem 14(6):1001-1009.