Superfund Research Program

The Long-term Impacts of Early Life Exposure to Superfund Chemicals in Humans and Wildlife

Center Director: David H. Sherr
Grant Number: P42ES007381
Funding Period: 1995-2021

Program Links

Publications

2024

• Miller JT, Clark BW, Reid NM, Karchner SI, Roach J, Hahn ME, Nacci DE, Whitehead A. 2024. Independently evolved pollution resistance in four killifish populations is largely explained by few variants of large effect. Evol Appl 17(1):doi:10.1111/eva.13648 PMID:38293268 PMCID:10824703

2023

• Aschengrau A, Winter MR, Shea M. 2023. Association between resilience promotion factors during childhood and risk of drug use disorder during adulthood. Addict Subst Abus 2(1):1-10. doi:10.46439/addiction.2.007 PMID:37427318 PMCID:PMC10326717
• Nielsen G, Heiger-Bernays WJ, Levy JI, White RF, Axelrad DA, Lam J, Chartres N, Abrahamsson DP, Rayasam SD, Shaffer RM, Zeise L, Woodruff TJ, Ginsberg GL. 2023. Application of probabilistic methods to address variability and uncertainty in estimating risks for non-cancer health effects. Environmental Health 21(Suppl1):129. doi:10.1186/s12940-022-00918-z PMID:36635712 PMCID:PMC9835218
• Woodruff TJ, Rayasam SD, Axelrad DA, Koman PD, Chartres N, Bennett DH, Birnbaum LS, Brown P, Carignan C, Cooper C, Cranor CF, Diamond ML, Franjevic S, Gartner EC, Hattis D, Hauser R, Heiger-Bernays WJ, Joglekar R, Lam J, Levy JI, MacRoy PM, Maffini MV, Marquez EC, Morello-Frosch R, Nachman KE, Nielsen G, Oksas C, Abrahamsson DP, Patisaul HB, Patton S, Robinson JF, Rodgers KM, Rossi MS, Rudel RA, Sass JB, Sathyanarayana S, Schettler T, Shaffer RM, Shamasunder B, Shepard PM, Shrader-Frechette K, Solomon G, Subra W, Vandenberg LN, Varshavsky J, White RF, Zarker K, Zeise L. 2023. A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement. Environmental Health 21(Suppl1):132. doi:10.1186/s12940-022-00930-3 PMID:36635734 PMCID:PMC9835243

2022

• Bozinovic G, Feng Z, Shea D, Oleksiak MF. 2022. Cardiac physiology and metabolic gene expression during late organogenesis among F. heteroclitus embryo families from crosses between pollution-sensitive and -resistant parents. BMC Ecol Evol 22(3):doi:10.1186/s12862-022-01959-1 PMID:34996355 PMCID:PMC8739662
• Sen P, Qadri S, Luukkonen PK, Ragnarsdottir O, McGlinchey A, Jantti S, Juuti A, Arola J, Schlezinger JJ, Webster TF, Oresic M, Yki-Jarvinen H, Hyotylainen T. 2022. Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease. J Hepatol 76(2):doi:10.1016/j.jhep.2021.09.039 PMID:34627976
• Zhang W, Xie HQ, Li Y, Zhou M, Zhou Z, Wang R, Hahn ME, Zhao B. 2022. The aryl hydrocarbon receptor: A predominant mediator for the toxicity of emerging dioxin-like compounds. J Hazard Mater 426:doi:10.1016/j.jhazmat.2021.128084 PMID:34952507

2021

• Bozinovic G, Shea D, Feng Z, Hinton DE, Sit TL, Oleksiak MF. 2021. PAH-pollution effects on sensitive and resistant embryos: Integrating structure and function with gene expression. PLoS One 16(4):e0249432. doi:10.1371/journal.pone.0249432 PMID:33822796 PMCID:PMC8023486
• Brun NR, Panlilio JM, Zhang K, Zhao Y, Ivashkin E, Stegeman JJ, Goldstone JV. 2021. Developmental exposure to non-dioxin-like polychlorinated biphenyls promotes sensory deficits and disrupts dopaminergic and GABAergic signaling in zebrafish. Commun Biol 4:doi:10.1038/s42003-021-02626-9 PMID:34561524 PMCID:PMC8463681
• Brun NR, Salanga MC, Mora-Zamorano FX, Lamb DC, Goldstone JV, Stegeman JJ. 2021. Orphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish. Sci Rep 11:doi:10.1038/s41598-021-03068-3 PMID:34903767 PMCID:PMC8669017
• Celander MC, Goldstone JV, Brun NR, Clark BW, Jayaraman S, Nacci DE, Stegeman JJ. 2021. Resistance to Cyp3a induction by polychlorinated biphenyls, including non-dioxin-like PCB153, in gills of killifish (Fundulus heteroclitus) from New Bedford Harbor. Environ Toxicol Pharmacol 83:103580. doi:10.1016/j.etap.2020.103580 PMID:33429071
• Cleary BM, Romano M, Chen CY, Heiger-Bernays WJ, Crawford KA. 2021. Comparison of recreational fish consumption advisories across the USA. Curr Environ Health Rep 8(2):doi:10.1007/s40572-021-00312-w PMID:33934293 (ahead of print)
• Crespi E, Burnap R, Chen J, Das M, Gassman N, Rosa E, Simmons R, Wada H, Wang ZQ, Xiao J, Yang B, Yin J, Goldstone JV. 2021. Resolving the rules of robustness and resilience in biology across scales. Integr Comp Biol 61(6):doi:10.1093/icb/icab183 PMID:34427654 PMCID:PMC8825770
• De Silva AO, Armitage JM, Bruton TA, Dassuncao C, Heiger-Bernays WJ, Hu XC, Karrman A, Kelly B, Ng CA, Robuck AR, Sun M, Webster TF, Sunderland EM. 2021. PFAS exposure pathways for humans and wildlife: A synthesis of current knowledge and key gaps in understanding. Environ Toxicol Chem 40(3):631-657. doi:10.1002/etc.4935 PMID:33201517 PMCID:PMC7906948
• Eide M, Zhang X, Karlsen OA, Goldstone JV, Stegeman JJ, Jonassen I, Goksoyr A. 2021. The chemical defensome of five model teleost fish. Sci Rep doi:10.1038/s41598-021-89948-0 PMID:34006915 PMCID:PMC8131381
• Hoover AG, Heiger-Bernays WJ, Ojha S, Pennell KG. 2021. Balancing incomplete COVID-19 evidence and local priorities: Risk communication and stakeholder engagement strategies for school re-opening. Rev Environ Health 36:27-37. doi:10.1515/reveh-2020-0092 PMID:33001857 PMCID:PMC7933073
• Kenison JE, Wang Z, Yang K, Snyder M, Quintana FJ, Sherr DH. 2021. The aryl hydrocarbon receptor suppresses immunity to oral squamous cell carcinoma through immune checkpoint regulation. Proc Natl Acad Sci U S A 118:doi:10.1073/pnas.2012692118 PMID:33941684 PMCID:PMC8126867
• Kim S, Reed E, Monti S, Schlezinger JJ. 2021. A data-driven transcriptional taxonomy of adipogenic chemicals to identify white and brite adipogens. Environ Health Perspect 129(7):77006. doi:10.1289/EHP6886 PMID:34323617 PMCID:PMC8320370
• Reed E, Monti S. 2021. Multi-resolution characterization of molecular taxonomies in bulk and single-cell transcriptomics data. Nucleic Acids Res 49(17):doi:10.1093/nar/gkab552 PMID:34226941 (ahead of print)
• Schlezinger JJ, Hyotylainen T, Sinjoja T, Moore Boston C, Puckett H, Oliver J, Heiger-Bernays WJ, Webster TF. 2021. Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPAR(alpha) mice fed an American diet. Toxicol Appl Pharmacol 426:115644. doi:10.1016/j.taap.2021.115644 PMID:34252412 PMCID:PMC8338894
• Vieira VM, Levy JI, Fabian MP, Korrick SA. 2021. Assessing the relation of chemical and non-chemical stressors with risk-taking related behavior and adaptive individual attributes among adolescents living near the New Bedford Harbor Superfund site. Environ Int 146:106199. doi:10.1016/j.envint.2020.106199 PMID:33126063 PMCID:PMC7775916

2020

• Andrews FV, Kim S, Edwards L, Schlezinger JJ. 2020. Identifying adipogenic chemicals: Disparate effects in 3T3-L1, OP9 and primary mesenchymal multipotent cell models. Toxicol In Vitro 67:12. doi:10.1016/j.tiv.2020.104904 PMID:32473317
• Aranguren-Abadia L, Lille-Langoy R, Madsen AK, Karchner SI, Franks DG, Yadetie F, Hahn ME, Goksoyr A, Karlsen OA. 2020. Molecular and Functional Properties of the Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a. Environ Sci Technol 54,2:1033-1044. doi:10.1021/acs.est.9b05312 PMID:31852180 PMCID:PMC7003535
• Aschengrau A, Grippo A, Winter MR, Shea M, White RF, Saitz R. 2020. Drug use disorder following early life exposure to tetrachloroethylene (PCE)-contaminated drinking water: a retrospective cohort study. Environmental Health 19:99. doi:10.1186/s12940-020-00638-2 PMID:32943075 PMCID:PMC7495895
• Aschengrau A, Winter MR, Gallagher L, Vieira VM, Butler L, Fabian MP, Carwile JL, Wesselink AK, Mahalingaiah S, Janulewicz PA, Weinberg JM, Webster TF, Ozonoff DM. 2020. Reproductive and developmental health effects of prenatal exposure to tetrachloroethylene-contaminated drinking water. Environ Sci Process Impacts 22:555-566. doi:10.1039/c9em00590k PMID:32051987
• Avilla MN, Malecki K, Hahn ME, Wilson RH, Bradfield CA. 2020. The ah receptor: adaptive metabolism, ligand diversity, and the xenokine model. Chem Res Toxicol 33:860-879. doi:10.1021/acs.chemrestox.9b00476 PMID:32259433 PMCID:PMC7175458
• Crawford KA, Clark BW, Heiger-Bernays WJ, Karchner SI, Hahn ME, Nacci DE, Schlezinger JJ. 2020. Tributyltin disrupts fin development in Fundulus heteroclitus from both PCB-sensitive and resistant populations: Investigations of potential interactions between AHR and PPARy. Aquat Toxicol 218:105334. doi:10.1016/j.aquatox.2019.105334 PMID:31743820 PMCID:PMC6935467
• Hahn ME, Sadler K. 2020. Casting a Wide Net: Use of Diverse Model Organisms to Advance Toxicology. Dis Model Mech 13:4. doi:10.1242/dmm.043844 PMID:32094287 PMCID:PMC7132827
• Kazzaz SA, Tagliabue SG, Franks DG, Denison MS, Hahn ME, Bonati L, Powell WH. 2020. An aryl hydrocarbon receptor from the caecilian Gymnopis multiplicata suggests low dioxin affinity in the ancestor of all three amphibian orders. Gen Comp Endocrinol 299(10):doi:10.1016/j.ygcen.2020.113592 PMID:32858041 PMCID:PMC7771225
• Kim S, Rabhi N, Blum BC, Hekman R, Wynne K, Emili A, Farmer S, Schlezinger JJ. 2020. Triphenyl phosphate is a selective PPARy modulator that does not induce brite adipogenesis in vitro and in vivo. Arch Toxicol 17:3087-3103. doi:10.1007/s00204-020-02815-1 PMID:32683515
• Schlezinger JJ, Puckett H, Nielsen OG, Heiger-Bernays WJ, Webster TF. 2020. Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPAR alpha mice fed an American diet. Toxicol Appl Pharmacol 405:115204. doi:10.1016/j.taap.2020.115204 PMID:32822737 PMCID:PMC7503133
• Shankar P, Dasgupta S, Hahn ME, Tanguay RL. 2020. A review of the functional roles of the zebrafish aryl hydrocarbon receptors. Toxicol Sci 178:215-238. doi:10.1093/toxsci/kfaa143 PMID:32976604 PMCID:PMC7706399
• Walker JA, Richards S, Belghasem ME, Arinze N, Yoo SB, Tashjian JY, Whelan SA, Lee N, Kolachalama VB, Francis J, Ravid K, Sherr DH, Chitalia VC. 2020. Temporal and tissue-specific activation of aryl hydrocarbon receptor in discrete mouse models of kidney disease. Kidney International 97:538-550. doi:10.1016/j.kint.2019.09.029 PMID:31932072

2019

• Ash P, Dhawan U, Boudeau S, Lei S, Carlomagno Y, Knobel M, Al Mohanna L, Boomhower S, Newland MC, Sherr DH, Wolozin B. 2019. Heavy metal neurotoxicants induce ALS-linked TDP-43 pathology. Toxicol Sci 167(1):105-115. doi:10.1093/toxsci/kfy267 PMID:30371865 PMCID:PMC6317426
• Bai L, Gillen DL, Bartell SM, Vieira VM. 2019. Mapping smoothed spatial effect estimates from individual-level data: MapGAM. R J (in press)
• Butler L, Gallagher L, Winter MR, Fabian MP, Wesselink AK, Aschengrau A. 2019. Residential proximity to roadways and placental-associated stillbirth: a case-control study. Int J Environ Health Res 31:465-474. doi:10.1080/09603123.2019.1673882 PMID:31587563 PMCID:PMC7131873
• Chen L, Ouyang J, Wienand K, Bojarczuk K, Hao Y, Chapuy B, Neuberg D, Juszczynski P, Lawton LN, Rodig S, Monti S, Shipp M. 2019. CXCR4 upregulation is an indicator of sensitivity to B-cell receptor/PI3K blockade and a potential resistance mechanism in B-cell receptor-dependent diffuse large B-cell lymphomas. Haematologica doi:10.3324/haematol.2019.216218 PMID:31471373 (in press)
• Crawford KA, Clark BW, Heiger-Bernays WJ, Karchner SI, Claus Henn B, Griffith KN, Howes BL, Schlezinger DR, Hahn ME, Nacci DE, Schlezinger JJ. 2019. Altered lipid homeostasis in a PCB-resistant Atlantic killifish (Fundulus heteroclitus) population from New Bedford Harbor, MA, U.S.A. Aquat Toxicol 210:30-43. doi:10.1016/j.aquatox.2019.02.011 PMID:30822701 PMCID:PMC6544361
• Crawford KA, Schlezinger DR, Craffey P, Heiger-Bernays WJ. 2019. Spatiotemporal trends in polychlorinated biphenyl concentrations in seafood based on long-term monitoring and remediation in New Bedford Harbor, Massachusetts. bioRxivorg doi:10.1101/675355
• Edwards L, Watt J, Webster TF, Schlezinger JJ. 2019. Assessment of total, ligand-induced peroxisome proliferator activated receptor gamma ligand activity in serum. Environ Health 18(45):doi:10.1186/s12940-019-0486-2 PMID:31072366 PMCID:PMC6506953
• Federico A, Karagiannis T, Karri K, Kishore D, Koga Y, Campbell J, Monti S. 2019. Pipeliner: a nextflow-based framework for the definition of sequencing data processing pipelines. Front Genet 10:614. doi:10.3389/fgene.2019.00614 PMID:31316552 PMCID:PMC6609566
• Federico A, Monti S. 2019. hypeR: An R Package for Geneset Enrichment Workflows. Bioinformatics PMID:31498385 (in press)
• Kartha V, Sebastiani P, Kern J, Zang L, Varelas X, Monti S. 2019. CaDrA: A computational framework for performing candidate driver analyses using genomic features. Front Genet 10:121. doi:10.3389/fgene.2019.00121 PMID:30838036 PMCID:PMC6390206
• Khalili R, Bartell SM, Levy JI, Fabian MP, Korrick SA, Vieira VM. 2019. Using birth cohort data to estimate prenatal chemical exposures for all births around the New Bedford Harbor Superfund Site in Massachusetts. Environ Health Perspect 127:doi:10.1289/EHP4849 PMID:31449464 PMCID:PMC6792387
• Li A, Chapuy B, Varelas X, Sebastiani P, Monti S. 2019. Identification of candidate cancer drivers by integrative epi-DNA and gene expression (iEDGE) data analysis. Sci Rep 9:16904. doi:10.1038/s41598-019-52886-z PMID:31729402 PMCID:PMC6858347
• Li A, Lu X, Natoli T, Bittker J, Sipes N, Subramanian A, Auerbach SS, Sherr DH, Monti S. 2019. The Carcinogenome Project: in vitro gene expression profiling of chemical perturbations to predict long-term carcinogenicity. Environ Health Perspect 127:47002. doi:10.1289/EHP3986 PMID:30964323 PMCID:PMC6785232
• McDonough CA, Franks DG, Hahn ME, Lohmann R. 2019. Aryl hydrocarbon receptor-mediated activity of gas-phase ambient air derived from passive sampling and an in vitro bioassay. Environ Toxicol Chem 38(4):748-759. doi:10.1002/etc.4361 PMID:30648756 PMCID:PMC6467651
• Mohamed HT, Gadalla R, El-Husseiny N, Hassan H, Wang Z, Ibrahim SA, El-Shinawi M, Sherr DH, Mohamed M. 2019. Inflammatory breast cancer: Activation of the aryl hydrocarbon receptor and its target CYP1B1 correlates closely with Wnt5a/b-beta-catenin signalling, the stem cell phenotype and disease progression. J. Adv. Res 16:75-86. doi:10.1016/j.jare.2018.11.006 PMID:30899591 PMCID:PMC6413307
• Moore Boston C, Banacos N, Heiger-Bernays WJ. 2019. Per- and Polyfluoroalkyl Substances: A National Priority for Safe Drinking Water. Public Health Rep 134(2):112-117. doi:10.1177/0033354919826567 PMID:30763146 PMCID:PMC6410471
• Padilla CM, Painblanc F, Soler-Michael P, Vieira VM. 2019. Mapping variation in breast cancer screening: Where to intervene?. Int J Environ Res Public Health 16(13):2274. doi:10.3390/ijerph16132274 PMID:31252599 PMCID:PMC6651541
• Peters J, Fabian MP, Levy JI. 2019. Epidemiologically-informed cumulative risk hypertension models simulating the impact of changes in metal, organochlorine, and non-chemical exposures in an environmental justice community. Environ Res doi:10.1016/j.envres.2019.108544 PMID:31271923 PMCID:PMC6716580
• Reed E, Moses E, Xiao X, Liu G, Campbell J, Perdomo C, Monti S. 2019. Assessment of a highly multiplexed RNA sequencing platform and comparison to existing high-throughput gene expression profiling techniques. Front Genet 10:150. doi:10.3389/fgene.2019.00150 PMID:30891063 PMCID:PMC6411637
• Ribeiro AI, Santos AC, Vieira VM, Barros H. 2019. Hotspots of childhood obesity in a large metropolitan area: does neighbourhood social and built environment play a part?. Int J Epidemiol doi:10.1093/ije/dyz205 PMID:31603208 PMCID:PMC7394944
• Salanga MC, Brun NR, Francolini RD, Stegeman JJ, Goldstone JV. 2019. CRISPR-Cas9 mutated pregnane x receptor (pxr) retains pregnenolone-induced expression of cyp3a65 in zebrafish. Toxicol Sci 174:51-62. doi:10.1093/toxsci/kfz246 PMID:31868891 PMCID:PMC7043230
• Sebastiani P, Monti S, Morris M, Gurinovich A, Toshiko T, Andersen SL, Sweigart B, Ferrucci L, Jennings LL, Glass DJ, Perls TT. 2019. A Serum Protein Signature of APOE Genotypes in Centenarian. Aging-US doi:10.1111/acel.13023 PMID:31385390 PMCID:PMC6826130 (in press)
• Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao C, Gutierrez-Vazquez C, Kenison JE, Tjon EC, Barroso A, Vandeventer T, Alves de Lima K, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr DH, Farez M, Pratt A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ. 2019. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci 22:729-740. doi:10.1038/s41593-019-0370-y PMID:30962630
• Zhang W, Xie HQ, Li Y, Jin T, Li J, Xu L, Zhou Z, Zhang S, Ma D, Hahn ME, Zhao B. 2019. Transcriptomic analysis of Anabas testudineus and its defensive mechanisms in response to persistent organic pollutants exposure. Sci Total Environ 669:621-630. doi:10.1016/j.scitotenv.2019.02.440 PMID:30893621 PMCID:PMC6581032
• Zhang W, Xie HQ, Li Y, Zou X, Xu L, Ma D, Li J, Ma Y, Jin T, Hahn ME, Zhao B. 2019. Characterization of the aryl hydrocarbon receptor (AhR) pathway in anabas testudineus and mechanistic exploration of the reduced sensitivity of AhR2a. Environ Sci Technol 53:12803-12811. doi:10.1021/acs.est.9b04181 PMID:31566365 PMCID:PMC6832778

2018

• Aschengrau A, Gallagher L, Winter MR, Butler L, Patricia FM, Vieira VM. 2018. Modeled exposure to tetrachloroethylene-contaminated drinking water and the risk of placenta-related stillbirths. Environ Health 17:58. doi:10.1186/s12940-018-0402-1 PMID:29970097 PMCID:PMC6029409
• Aschengrau A, Gallagher LG, Winter MR, Butler L, Fabian MP, Vieira VM. 2018. Modeled exposure to tetrachloroethylene-contaminated drinking water and the occurrence of birth defects: a case-control study from Massachusetts and Rhode Island. Environ Health 17(1):75. doi:10.1186/s12940-018-0419-5 PMID:30400949 PMCID:PMC6219161
• Basra K, Fabian MP, Scammell MK. 2018. Consumption of contaminated seafood in an environmental justice community: A qualitative and spatial analysis of fishing controls. Environ Justice 11(1):doi:10.1089/env.2017.0010 PMID:30828408 PMCID:PMC5830855 (ahead of print)
• Basra K, Scammell MK, Benson EB, Heiger-Bernays WJ. 2018. Ambient air exposure to PCBs: Regulation and monitoring at five contaminated sites in EPA Regions 1, 2, 4, and 5. New Solut 28(2):262-282. doi:10.1177/1048291118763620 PMID:29558851
• Eide M, Rydbeck H, Torresen OK, Lille-Langoy R, Puntervoll P, Goldstone JV, Jakobsen KS, Stegeman JJ, Goksoyr A, Karlsen OA. 2018. Independent losses of a xenobiotic receptor across teleost evolution. Sci Rep 8(1):10404. doi:10.1038/s41598-018-28498-4 PMID:29991818 PMCID:PMC6039460
• Esser C, Lawrence BP, Sherr DH, Perdew GH, Puga A, Barouki R, Coumoul X. 2018. Old receptor, new tricks the ever-expanding universe of aryl hydrocarbon receptor functions. Report from the 4th AHR Meeting, 29 31 August 2018 in Paris, France. Int J Mol Sci 19(11):3603. doi:10.3390/ijms19113603 PMID:30445691
• Glazer L, Kido Soule MC, Longnecker K, Kujawinski EB, Aluru N. 2018. Hepatic metabolite profiling of polychlorinated biphenyl (PCB)-resistant and sensitive populations of Atlantic killifish (Fundulus heteroclitus). Aquat Toxicol 205:114-122. doi:10.1016/j.aquatox.2018.10.007 PMID:30368057 PMCID:PMC6246827
• Hahn ME. 2018. Evolutionary concepts can benefit both fundamental research and applied research in toxicology (A comment on Brady et al. 2017). Evol Appl 12:350-352. doi:10.1111/eva.12695 PMID:30697345 PMCID:PMC6346646
• Heiger-Bernays WJ, Wegner S, Dix DJ. 2018. High-throughput in vitro data to inform prioritization of ambient water monitoring and testing for endocrine active chemicals. Environ Sci Technol 52(2):783-793. doi:10.1021/acs.est.7b00014 PMID:29214797
• Kim S, Li A, Monti S, Schlezinger JJ. 2018. Tributyltin induces a transcriptional response without a brite adipocyte signature in adipocyte models. Arch Toxicol 1-16. doi:10.1007/s00204-018-2268-y PMID:30027469
• Lemaire B, Karchner SI, Goldstone JV, Lamb DC, Drazen JC, Rees F, Hahn ME, Stegeman JJ. 2018. Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus. Biochim Biophys Acta 1866:155-165. doi:10.1016/j.bbapap.2017.06.026 PMID:28694077 PMCID:PMC5693637
• Lille-Langoy R, Karlsen OA, Myklebust LM, Goldstone JV, Mork-Jansson A, Male R, Blumberg B, Stegeman JJ, Goksoyr A. 2018. Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function. Toxicol Sci 168:28-39. doi:10.1093/toxsci/kfy269 PMID:30371853 PMCID:PMC6390661
• Narasimhan S, Zulick ES, Novikov O, Parks A, Schlezinger JJ, Wang Z, Laroche F, Feng H, Mulas F, Monti S, Sherr DH. 2018. Towards resolving the pro- and anti-tumor effects of the aryl hydrocarbon receptor. Int J Mol Sci 19:24. doi:10.3390/ijms19051388 PMID:29735912 PMCID:PMC5983651
• Rothhammer V, Borucki DM, Kenison JE, Hewson P, Wang Z, Bakshi R, Sherr DH, Quintana FJ. 2018. Detection of aryl hydrocarbon receptor agonists in human samples. Sci Rep 8:doi:10.1038/s41598-018-23323-4 PMID:29563571 PMCID:PMC5862868
• Tomsho KS, Basra K, Rubin SM, Miller CB, Juang R, Broude S, Martinez A, Hornbuckle KC, Heiger-Bernays WJ, Scammell MK. 2018. Community reporting of ambient air polychlorinated biphenyl concentrations near a Superfund site. Environ Sci Pollut Res Int 25(17):16389-16400. doi:10.1007/s11356-017-0286-6 PMID:29079973 PMCID:PMC6015112
• Ulin A, Henderson J, Pham MT, Meyo J, Chen Y, Karchner SI, Goldstone JV, Hahn ME, Williams LM. 2018. Developmental regulation of nuclear factor erythroid-2 related factors (nrfs) by AHR1b in zebrafish (Danio rerio). Toxicol Sci 167(2):536-545. doi:10.1093/toxsci/kfy257 PMID:30321412 PMCID:PMC6358246
• Vieira VM, Hansen J, Gredal O, Weisskopf MG. 2018. Spatial analyses of ALS incidence in Denmark over three decades. Amyotroph Lateral Scler Frontotemporal Degener 19:275-284. doi:10.1080/21678421.2018.1432658 PMID:29383960
• Watt J, Baker AH, Meeks B, Pajevic PD, Morgan EF, Gerstenfeld LC, Schlezinger JJ. 2018. Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice. Journal of Cellular Physiology 233:7007-7021. doi:10.1002/jcp.26495 PMID:29380368
• Weisskopf MG, Seals RM, Webster TF. 2018. Bias amplification in epidemiologic analysis of exposure to mixtures. Environ Health Perspect 126:8. doi:10.1289/ehp2450 PMID:29624292
• Wesselink AK, Hatch EE, Wise L, Rothman KJ, Vieira VM, Aschengrau A. 2018. Exposure to tetrachloroethylene-contaminated drinking water and time to pregnancy. Environ Res 167:136-143. doi:10.1016/j.envres.2018.07.012 PMID:30014895

2017

• Basra K, Fabian MP, Holberger RR, French R, Levy JI. 2017. Community-engaged modeling of geographic and demographic patterns of multiple public health risk factors. Int J Environ Res Public Health 14:730. doi:10.3390/ijerph14070730 PMID:28684710 PMCID:PMC5551168
• Butler L, Janulewicz PA, Carwile JL, White RF, Winter MR, Aschengrau A. 2017. Childhood and adolescent fish consumption and adult neuropsychological performance: An analysis from the Cape Cod Health Study. Neurotoxicol Teratol 61:47-57. doi:10.1016/j.ntt.2017.03.001 PMID:28263856
• Gallagher LG, Webster TF, Aschengrau A. 2017. Exploring associations between prenatal solvent exposures and teenage drug and alcohol use: a retrospective cohort study. Environ Health 16(1):26. doi:10.1186/s12940-017-0232-6 PMID:28283038 PMCID:PMC5346200
• Hahn ME, Karchner SI, Merson RR. 2017. Diversity as opportunity: insights from 600 Million years of AHR evolution. Curr Opin Toxicol 2:58-71. doi:10.1016/j.cotox.2017.02.003 PMID:28286876 PMCID:PMC5343764
• Hoffman K, Weisskopf MG, Roberts AL, Raz R, Hart JE, Lyall K, Hoffman E, Laden F, Vieira VM. 2017. Geographic patterns of autism spectrum disorder among children of Nurses’ Health Study II women. Am J Epidemiol 186:834–842. doi:10.1093/aje/kwx158 PMID:28525627
• Holland EB, Goldstone JV, Pessah IN, Whitehead A, Reid NM, Karchner SI, Hahn ME, Nacci DE, Clark BW, Stegeman JJ. 2017. Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): a phylogenetic and population-based comparison. Aquat Toxicol 192:105-115. doi:10.1016/j.aquatox.2017.09.002 PMID:28942070 PMCID:PMC5662517
• Kassotis CD, Masse L, Kim S, Schlezinger JJ, Webster TF, Stapleton HM. 2017. Characterization of adipogenic chemicals in three different cell culture systems: Implications for reproducibility based on cell source and handling. Sci Rep 7(42104):doi:10.1038/srep42104 PMID:28176856 PMCID:PMC5296734
• Leung MC, Procter AC, Goldstone JV, Foox J, DeSalle R, Mattingly CJ, Siddall ME, Timme-Laragy AR. 2017. Applying evolutionary genetics to developmental toxicology and risk assessment. Reprod Toxicol 69:174-186. doi:10.1016/j.reprotox.2017.03.003 PMID:28267574
• Levy JI, Scammell MK, Heiger-Bernays WJ. 2017. Measuring the health of the climate by how sick we aren't. (non-peer reviewed)
• Martinez A, Hadnott BN, Awad AM, Herkert N, Tomsho KS, Basra K, Scammell MK, Heiger-Bernays WJ, Hornbuckle KC. 2017. Release of airborne polychlorinated biphenyls from New Bedford Harbor results in elevated concentrations in the surrounding air. Environ Sci Technol Lett 4(4):127-131. doi:10.1021/acs.estlett.7b00047 PMID:28413805 PMCID:PMC5390305
• Mulas F, Li A, Sherr DH, Monti S. 2017. Network-based analysis of transcriptional profiles from chemical perturbation experiments. BMC Biochem 18:130. doi:10.1186/s12859-017-1536-9 PMID:28361664 PMCID:PMC5374700 (in press)
• Reid NM, Jackson CE, Gilbert D, Minx P, Montague MJ, Hampton TH, Helfrich LW, King BL, Nacci DE, Aluru N, Karchner SI, Colbourne JK, Hahn ME, Shaw JR, Oleksiak MF, Crawford DL, Warren WC, Whitehead A. 2017. The landscape of extreme genomic variation in the highly adaptable Atlantic killifish. Genome Biol Evol 9:659-676. doi:10.1093/gbe/evx023 PMID:28201664 PMCID:PMC5381573
• Sant KE, Hansen JM, Williams LM, Tran NL, Goldstone JV, Stegeman JJ, Hahn ME, Timme-Laragy AR. 2017. The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo. Redox Biol 13:207-218. doi:10.1016/j.redox.2017.05.023 PMID:28582729 PMCID:PMC5458767
• Timme-Laragy AR, Hahn ME, Hansen JM, Rastogi A, Roy MA. 2017. Redox stress and signaling during vertebrate embryonic development: regulation and responses. Semin Cell Dev Biol 80:17-28. doi:10.1016/j.semcdb.2017.09.019 PMID:28927759 PMCID:PMC5650060
• Vieira VM, Fabian MP, Webster TF, Levy JI, Korrick SA. 2017. Spatial variability in ADHD-related behaviors among children born to mothers residing near the New Bedford Harbor superfund site. Am J Epidemiol 185(10):1-9. doi:10.1093/aje/kww208 PMID:28444119 PMCID:PMC5430935 (ahead of print)
• Vieira VM, Villanueva C, Chang J, Ziogas A, Bristow RE. 2017. Impact of community disadvantage and air pollution burden on geographic disparities of ovarian cancer survival in California. Environ Res 156:388-393. doi:10.1016/j.envres.2017.03.057 PMID:28395243 PMCID:PMC546773
• Wang Z, Monti S, Sherr DH. 2017. The diverse and important contributions of the AHR to cancer and cancer immunity. Curr Opin Toxicol 2:93-102. doi:10.1016/j.cotox.2017.01.008 (in press)
• Wesselink AK, Carwile JL, Fabian MP, Winter MR, Butler L, Mahalingaiah S, Aschengrau A. 2017. Residential proximity to roadways and ischemic placental disease in the Cape Cod Family Health Study. Int J Environ Res Public Health 14:682. doi:10.3390/ijerph14070682 PMID:28672786 PMCID:PMC5551120
• Whitehead A, Clark BW, Reid NM, Hahn ME, Nacci DE. 2017. When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations. Evol Appl 10:762-783. doi:10.1111/eva.12470 PMID:29151869 PMCID:PMC5680427

2016

• Aschengrau A, Gallagher LG, Winter MR, Vieira VM, Webster TF, Janulewicz PA, Ozonoff DM. 2016. No association between unintentional head injuries and early-life exposure to tetrachloroethylene (PCE)-contaminated drinking water. J Occup Environ Med 58(10):1040-1045. doi:10.1097/JOM.0000000000000850 PMID:27513173 PMCID:PMC5704661
• Aschengrau A, Janulewicz PA, White RF, Vieira VM, Gallagher LG, Getz KD, Webster TF, Ozonoff DM. 2016. Long-term neurotoxic effects of early-life exposure to tetrachloroethylene-contaminated drinking water. Ann Glob Health 82(1):169-179. doi:10.1016/j.aogh.2016.01.013 PMID:27325074 PMCID:PMC4916338
• Auerbach SS, Filer D, Reif DM, Walker V, Blumberg B, Clegg D, Holloway A, Schlezinger JJ, Srinivasan S, White M, Svoboda D, Judson RR, Bucher JR, Thayer KA. 2016. Identifying environmental chemicals to test for obesity and diabetes outcomes: clues from ToxCast high throughput screening data. Environ Health Perspect 128:1141-1154.
• Bolt AM, Grant MP, Flores Molina M, Plourde D, Kelly AD, Negro Silva LF, Lemaire M, Schlezinger JJ, Mwale F, Mann K. 2016. Tungsten promotes sex-specific adipogenesis in the bone by altering differentiation of bone marrow-resident mesenchymal stromal cells. Toxicol Sci 150(2):333-346. doi:10.1093/toxsci/kfw008 PMID:26865663 PMCID:PMC4900133
• Braun JM, Gennings C, Hauser R, Webster TF. 2016. What can epidemiological studies tell us about the impact of chemical mixtures on human health?. Environ Health Perspect 124(1):A6-A9. doi:10.1289/ehp.1510569 PMID:26720830 PMCID:PMC4710611
• Butler L, Scammell MK, Benson EB. 2016. The Flint, Michigan water crisis: a case study in regulatory failure and environmental injustice. Environ Justice 9:93-97. doi:10.1089/env.2016.0014
• Carignan C, Fang M, Stapleton HM, Heiger-Bernays WJ, McClean MD, Webster TF. 2016. Urinary biomarkers of flame retardant exposure among collegiate US gymnasts. Environ Int 94:362-368. doi:10.1016/j.envint.2016.06.030 PMID:27395335 PMCID:PMC4980234
• Carwile JL, Butler L, Janulewicz PA, Winter MR, Aschengrau A. 2016. Childhood fish consumption and learning and behavioral disorders. Int J Environ Res Public Health 13(11):doi:10.3390/ijerph13111069 PMID:27827868 PMCID:PMC5129279
• Chapuy B, Cheng H, Watahiki A, Ducar M, Tan Y, Chen L, Roemer M, Ouyang J, Christie A, Zhang L, Gusenleitner D, Abo R, Farinha P, von Bonin F, Thorner A, Sun H, Gascoyne R, Pinkus G, van Hummelen P, Wulf G, Aster J, Weinstock D, Monti S, Rodig S, Wang Y, Shipp M. 2016. Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease. Blood 127(18):2203-2213. doi:10.1182/blood-2015-09-672352 PMID:26773040 PMCID:PMC4859195
• Cotter KA, Nacci DE, Champlin D, Yeo AT, Gilmore TD, Callard GV. 2016. Adaptive significance of ERα splice variants in killifish (Fundulus heteroclitus) resident in an estrogenic environment. Endocrinology 157(6):2294-2308. doi:10.1210/en.2016-1052 PMID:27070100
• Girguis M, Strickland M, Hu X, Liu Y, Bartell SM, Vieira VM. 2016. Maternal exposure to traffic-related air pollution and birth defects in Massachusetts. Environ Res 146:1-9. doi:10.1016/j.envres.2015.12.010 PMID:26705853 PMCID:PMC4761511
• Goldstone JV, Sundaramoorthy M, Zhao B, Waterman MR, Stegeman JJ, Lamb DC. 2016. Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution. Mol Phylogenet Evol 94(PtB):676-687. doi:10.1016/j.ympev.2015.09.012 PMID:26432395 PMCID:PMC4801120
• Hewlett MM, Chow E, Aschengrau A, Mahalingaiah S. 2016. Prenatal exposure to endocrine disruptors: a developmental etiology for polycystic ovary syndrome. Reprod Sci 24(1):19-27. doi:10.1177/1933719116654992 PMID:27342273
• Lemaire B, Kubota A, O'Meara CM, Lamb DC, Tanguay RL, Goldstone JV, Stegeman JJ. 2016. Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicol Appl Pharmacol 296:73-84. doi:10.1016/j.taap.2016.02.001 PMID:26853319 PMCID:PMC4807407
• Mahalingaiah S, Hart JE, Laden F, Farland LV, Hewlett MM, Chavarro J, Aschengrau A, Missmer SA. 2016. Adult air pollution exposure and risk of infertility in the Nurses' Health Study II. Hum Reprod 31(3):638-647. doi:10.1093/humrep/dev330 PMID:26724803 PMCID:PMC4755443
• Mahalingaiah S, Winter MR, Aschengrau A. 2016. Association of prenatal and early life exposure to tetrachloroethylene (PCE) with polycystic ovary syndrome and other reproductive disorders in the cape cod health study: A retrospective cohort study. Reprod Toxicol 65:87-94. doi:10.1016/j.reprotox.2016.07.005 PMID:27412368 PMCID:PMC5091798
• Maldonado A, Lavodo R, Knuston S, Slattery M, Ankisetty S, Goldstone JV, Watanabe K, Hoh E, Gadepalli RS, Rimoldi JM, Ostrander GK, Schlenk D. 2016. Biochemical mechanisms for geographical adaptations to novel toxin exposures in butterflyfish. PLoS One 11(5):e0154208. doi:10.1371/journal.pone.0154208 PMID:27136924 PMCID:PMC4854401
• Nacci DE, Hahn ME, Karchner SI, Jayaraman S, Mostello C, Miller KM, Blackwell CG, Nisbet IC. 2016. Integrating monitoring and genetic methods to infer historical risks of PCBs and DDE to common and roseate terns nesting near the New Bedford Harbor Superfund site (Massachusetts, USA). Environ Sci Technol 50(18):10226-10235. doi:10.1021/acs.est.6b02108 PMID:27564328 PMCID:PMC5110212
• Osterberg D, Scammell MK. 2016. PCBs in schools--where communities and science come together. Environ Sci Pollut Res Int 23(3):1998-2002. doi:10.1007/s11356-015-5009-2 PMID:26194237 PMCID:PMC4770789
• Padilla CM, Kihal-Talantikite W, Vieira VM, Deguen S. 2016. City-specific spatiotemporal infant and neonatal mortality clusters: links with socioeconomic and air pollution spatial patterns in France. Int J Environ Res Public Health 13(6):doi:10.3390/ijerph13060624 PMID:27338439 PMCID:PMC4924081
• Parente T, Moreira DA, Magalhaes M, Andrade PC, Furtado C, Haas B, Stegeman JJ, Hahn ME. 2016. The liver transcriptome of suckermouth armoured catfish (Pterygoplichthys anisitsi, Loricariidae): Identification of expansions in defensome gene families. Mar Pollut Bull 115:352-361. PMID:28062095 PMCID:PMC5310677
• Pennell KG, Scammell MK, McClean MD, Suuberg EM, Moradi A, Moradi A, Roghani M, Ames J, Friguglietti L, Indeglia PA, Shen R, Yao Y, Heiger-Bernays WJ. 2016. Field data and numerical modeling: a multiple lines of evidence approach for assessing vapor intrusion exposure risks. Sci Total Environ 556:291-301. doi:10.1016/j.scitotenv.2016.02.185 PMID:26977535 PMCID:PMC4844003
• Reid N, Proestou DA, Clark BW, Warren WC, Colbourne JK, Shaw JR, Karchner SI, Hahn ME, Nacci DE, Oleksiak MF, Crawford DL, Whitehead A. 2016. The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. Science 354(6317):1305-1308. doi:10.1126/science.aah4993 PMID:27940876 PMCID:PMC5206662
• Schaider LA, Ackerman JM, Rudel RA. 2016. Septic systems as sources of organic wastewater compounds in domestic drinking water wells in a shallow sand and gravel aquifer. Sci Total Environ 547:470-481. doi:10.1016/j.scitotenv.2015.12.081 PMID:26822473
• Shivanna S, Kolandaivelu K, Shashar M, Belghasim M, Al-Rabadi L, Balcells M, Zhang A, Weinberg JM, Francis J, Pollastri MP, Edelman ER, Sherr DH, Chitalia VC. 2016. The aryl hydrocarbon receptor is a critical regulator of tissue factor stability and an antithrombotic target in uremia. J Am Soc Nephrol 27(1):189-201. doi:10.1681/ASN.2014121241 PMID:26019318 PMCID:PMC4696580
• Smith BW, Stanford EA, Sherr DH, Murphy GJ. 2016. Genome editing of the CYP1A1 locus in iPSCs as a platform to map AHR expression throughout human development. Stem Cells Int 2016:2574152. doi:10.1155/2016/2574152 PMID:27148368 PMCID:PMC4842384
• Stacy SL, Eliot M, Calafat AM, Chen A, Lanphear BP, Hauser R, Papandonatos GD, Sathyanarayana S, Ye X, Yolton K, Braun JM. 2016. Patterns, variability, and predictors of urinary bisphenol A concentrations during childhood. Environ Res 50(11):5981-5990. doi:10.1021/acs.est.6b00794 PMID:27152530
• Stanford EA, Ramirez-Cardenas A, Wang Z, Novikov O, Alamoud K, Koutrakis P, Mizgerd JP, Genco CA, Kukuruzinska M, Monti S, Bais MV, Sherr DH. 2016. Role for the aryl hydrocarbon receptor and diverse ligands in oral squamous cell carcinoma migration and tumorigenesis. Mol Cancer Res 14(8):696-706. doi:10.1158/1541-7786.MCR-16-0069 PMID:27130942 PMCID:PMC4987205
• Stanford EA, Wang Z, Mulas F, Landesman-Bollag E, Monti S, Smith BW, Seldin DC, Murphy GJ, Sherr DH. 2016. The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells. BMC Biol 14:20. doi:10.1186/s12915-016-0240-y PMID:26984638 PMCID:PMC4794823
• Stanford EA, Wang Z, Novikov O, Ramirez-Cardenas A, Mulas F, Landesman-Bollag E, Monti S, Smith BW, Bais MV, Kukuruzinska M, Murphy GJ, Sherr DH. 2016. A role for the aryl hydrocarbon receptor (Ahr) in the production and function of breast and oral cancer stem-like cells and the potential therapeutic value of Ahr modulators. Toxicol Lett 259:S20. doi:10.1016/j.toxlet.2016.07.090
• Stawski L, Kartha V, Han R, Haines P, Gallagher G, Noonan V, Kukuruzinska M, Monti S, Trojanowska M. 2016. PDGFRβ is a novel marker of stromal activation in oral squamous cell carcinomas. PLoS One 11(4):e0154645. doi:10.1371/journal.pone.0154645 PMID:27128408 PMCID:PMC4851360
• Taylor KW, Joubert BR, Braun JM, Dilworth C, Gennings C, Hauser R, Heindel JJ, Rider CV, Webster TF, Carlin DJ. 2016. Statistical approaches for assessing health effects of environmental chemical mixtures in epidemiology: lessons from an innovative workshop. Environ Health Perspect 124(12):A227-A229. doi:10.1289/EHP547 PMID:27905274 PMCID:PMC5132642
• Tokunaga S, Woodin BR, Stegeman JJ. 2016. Plant lignan secoisolariciresinol suppresses pericardial edema caused by dioxin-like compounds in developing zebrafish: Implications for suppression of morphological abnormalities. Food Chem Toxicol 96:160-166. doi:10.1016/j.fct.2016.07.012 PMID:27427306
• Townley IK, Karchner SI, Skripnikova E, Wiese T, Hahn ME, Rees BB. 2016. Sequence and functional characterization of hypoxia inducible factors, HIF1α, HIF2αa, and HIF3α, from the estuarine fish, Fundulus heteroclitus. Am J Physiol Regul Integr Comp Physiol 312(3):R412-R425. doi:10.1152/ajpregu.00402.2016 PMID:28039194 PMCID:PMC5402000
• Voena C, Varesio L, Zhang L, Menotti M, Poggio T, Panizza E, Wang Q, Minero V, Fagoonee S, Compagno M, Altruda F, Monti S, Chiarle R. 2016. Oncogenic ALK regulates EMT in non-small cell lung carcinoma through repression of the epithelial splicing regulatory protein 1. Oncotarget 7(22):33316-33330. doi:10.18632/oncotarget.8955 PMID:27119231 PMCID:PMC5078097
• Watt J, Webster TF, Schlezinger JJ. 2016. Generalized concentration addition modeling predicts mixture effects of environmental PPARγ agonists. Toxicol Sci 153(1):18-27. doi:10.1093/toxsci/kfw100 PMID:27255385 PMCID:PMC5013877
• Wincent E, Kubota A, Timme-Laragy A, Jonsson ME, Hahn ME, Stegeman JJ. 2016. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacol 110-111:117-129. doi:10.1016/j.bcp.2016.04.012 PMID:27112072 PMCID:PMC4887394

2015

• Aluru N, Karchner SI, Franks DG, Champlin D, Hahn ME. 2015. Targeted mutagenesis of aryl hydrocarbon receptor 2a and 2b genes in Atlantic killifish (Fundulus heteroclitus). Aquat Toxicol 158:192-201. doi:10.1016/j.aquatox.2014.11.016 PMID:25481785 PMCID:PMC4272816
• Aschengrau A, Winter MR, Vieira VM, Webster TF, Janulewicz PA, Gallagher LG, Weinberg JM, Ozonoff DM. 2015. Long-term health effects of early life exposure to tetrachloroethylene (PCE)-contaminated drinking water: a retrospective cohort study. Environ Health 14:36. doi:10.1186/s12940-015-0021-z PMID:25889838 PMCID:PMC4397674
• Baker AH, Watt J, Huang CK, Gerstenfeld LC, Schlezinger JJ. 2015. Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. Chem Res Toxicol 28(6):1156-1166. doi:10.1021/tx500433r PMID:25932594 PMCID:PMC4737589
• Bragdon B, Burns R, Baker AH, Belkina AC, Morgan EF, Denis GV, Gerstenfeld LC, Schlezinger JJ. 2015. Intrinsic sex-linked variations in osteogenic and adipogenic differentiation potential of bone marrow multipotent stromal cells. Journal of Cellular Physiology 230(2):296-307. doi:10.1002/jcp.24705 PMID:24962433 PMCID:PMC4317374
• Bristow RE, Chang J, Ziogas A, Gillen DL, Bai L, Vieira VM. 2015. Spatial analysis of advanced-stage ovarian cancer mortality in California. Am J Obstet Gynecol 213(1):43.e1-43.e8. doi:10.1016/j.ajog.2015.01.045 PMID:25644440 PMCID:PMC4485540
• Cotter KA, Nacci DE, Champlin D, Chuprin J, Callard GV. 2015. Cloning of multiple ERα mRNA variants in killifish (Fundulus heteroclitus), and differential expression by tissue type, stage of reproduction, and estrogen exposure in fish from polluted and unpolluted environments. Aquat Toxicol 159:184-197. doi:10.1016/j.aquatox.2014.12.012 PMID:25550165 PMCID:PMC4300264
• DeGroot DE, Franks DG, Higa T, Tanaka J, Hahn ME, Denison MS. 2015. Naturally occurring marine brominated indoles are aryl hydrocarbon receptor ligands/agonists. Chem Res Toxicol 28(6):1176-1185. doi:10.1021/acs.chemrestox.5b00003 PMID:26001051 PMCID:PMC4469569
• Di Salvo F, Meneghini E, Vieira VM, Baili P, Mariottini M, Baldini M, Micheli A, Sant M. 2015. Spatial variation in mortality risk for hematological malignancies near a petrochemical refinery: a population-based case-control study. Environ Res 140:641-648. doi:10.1016/j.envres.2015.05.022 PMID:26073202 PMCID:PMC4492869
• Fang M, Webster T, Stapleton HM. 2015. Effect-directed analysis of human peroxisome proliferator-activated nuclear receptors (PPARγ1) ligands in indoor dust. Environ Sci Technol 49(16):10065-10073. doi:10.1021/acs.est.5b01524 PMID:26172369 PMCID:PMC4786017
• Fang M, Webster TF, Ferguson PL, Stapleton HM. 2015. Characterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust. Environ Health Perspect 123(2):166-172. doi:10.1289/ehp.1408522 PMID:25314719 PMCID:PMC4314249
• Fang M, Webster TF, Stapleton HM. 2015. Activation of human peroxisome proliferator-activated nuclear receptors (PPARγ1) by semi-volatile compounds (SVOCs) and chemical mixtures in indoor dust. Environ Sci Technol 49(16):10057-10064. doi:10.1021/acs.est.5b01523 PMID:26172262 PMCID:PMC4786016
• Fritsch EB, Stegeman JJ, Goldstone JV, Nacci DE, Champlin D, Jayaraman S, Connon RE, Pessah IN. 2015. Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA. Aquat Toxicol 159:156-166. doi:10.1016/j.aquatox.2014.12.017 PMID:25546006 PMCID:PMC4300256
• Grans J, Wassmur B, Fernandez-Santoscoy M, Zanette J, Woodin BR, Karchner SI, Nacci DE, Champlin D, Jayaraman S, Hahn ME, Stegeman JJ, Celander MC. 2015. Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor. Aquat Toxicol 159:198-207. doi:10.1016/j.aquatox.2014.12.010 PMID:25553538 PMCID:PMC4311260
• Hahn ME, Timme-Laragy AR, Karchner SI, Stegeman JJ. 2015. Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio). Free Radic Biol Med 88(PtB):275-289. doi:10.1016/j.freeradbiomed.2015.06.022 PMID:26130508 PMCID:PMC4698826
• Hall D, Kozakov D, Whitty A, Vajda S. 2015. Lessons from hot spot analysis for fragment-based drug discovery. Trends Pharmacol Sci 36(11):724-736. doi:10.1016/j.tips.2015.08.003 PMID:26538314 PMCID:PMC4640985
• Hoffman K, Aschengrau A, Webster TF, Bartell SM, Vieira VM. 2015. Associations between residence at birth and mental health disorders: a spatial analysis of retrospective cohort data. BMC Public Health 15:688. doi:10.1186/s12889-015-2011-z PMID:26195105 PMCID:PMC4508761
• Kozakov D, Grove LE, Hall D, Bohnuud T, Mottarella SE, Luo L, Xia B, Beglov D, Vajda S. 2015. The FTMap family of web servers for determining and characterizing ligand-binding hot spots of proteins. Nat Protoc 10(5):733-755. doi:10.1038/nprot.2015.043 PMID:25855957 PMCID:PMC4762777
• Kubota A, Goldstone JV, Lemaire B, Takata M, Woodin BR, Stegeman JJ. 2015. Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish. Toxicol Sci 143(2):398-407. doi:10.1093/toxsci/kfu240 PMID:25424564 PMCID:PMC4306721
• Lille-Langoy R, Goldstone JV, Rusten M, Milnes MR, Male R, Stegeman JJ, Blumberg B, Goksoyr A. 2015. Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently. Toxicol Appl Pharmacol 284(1):54-64. doi:10.1016/j.taap.2015.02.001 PMID:25680588 PMCID:PMC4387200
• Stegeman JJ, Behrendt L, Woodin BR, Kubota A, Lemaire B, Pompon D, Goldstone JV, Urban P. 2015. Functional characterization of zebrafish cytochrome P450 1 family proteins expressed in yeast. Biochim Biophys Acta 1850(11):2340-2352. doi:10.1016/j.bbagen.2015.07.010 PMID:26231923 PMCID:PMC4587093
• Watt J, Schlezinger JJ. 2015. Structurally-diverse, PPARγ-activating environmental toxicants induce adipogenesis and suppress osteogenesis in bone marrow mesenchymal stromal cells. Toxicology 331:66-77. doi:10.1016/j.tox.2015.03.006 PMID:25777084 PMCID:PMC4406869
• Wincent E, Stegeman JJ, Jonsson ME. 2015. Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: implications for physiological and toxicological AHR functions. Toxicol Appl Pharmacol 284(2):163-179. doi:10.1016/j.taap.2015.02.014 PMID:25711857 PMCID:PMC4747639
• Yazdy MM, Werler MM, Anderka M, Langlois PH, Vieira VM. 2015. Spatial analysis of gastroschisis in Massachusetts and Texas. Ann Epidemiol 25(1):7-14. doi:10.1016/j.annepidem.2014.10.001 PMID:25454289 PMCID:PMC4255145
• Yazdy MM, Werler MM, Feldkamp M, Shaw GM, Mosley B, Vieira VM. 2015. Spatial analysis of gastroschisis in the National Birth Defects Prevention Study. Birth Defects Res A Clin Mol Teratol 103(6):544-553. PMID:25850424
• Zachek C, Rubin SM, Scammell MK. 2015. Whatever works: Legal tactics and scientific evidence in environmental justice cases. Environ Justice 8:20-25. doi:10.1089/env.2014.0024

2014

• Bristow RE, Chang J, Ziogas A, Anton-Culver H, Vieira VM. 2014. Spatial analysis of adherence to treatment guidelines for advanced-stage ovarian cancer and the impact of race and socioeconomic status. Gynecol Oncol 134(1):60-67. doi:10.1016/j.ygyno.2014.03.561 PMID:24680770 PMCID:PMC4095874
• Gusenleitner D, Auerbach SS, Melia T, Gomez HF, Sherr DH, Monti S. 2014. Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action. PLoS One 9(7):e102579. doi:10.1371/journal.pone.0102579 PMID:25058030 PMCID:PMC4109923
• Hahn ME, McArthur AG, Karchner SI, Franks DG, Jenny MJ, Timme-Laragy AR, Stegeman JJ, Woodin BR, Cipriano MJ, Linney EA. 2014. The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin. PLoS One 9(11):e113158. doi:10.1371/journal.pone.0113158 PMID:25402455 PMCID:PMC4234671
• Hoffman K, Vieira VM, Daniels J. 2014. Diminishing geographic variability in autism spectrum disorders over time?. J Autism Dev Disord 44:712-718. doi:10.1007/s10803-013-1907-7 PMID:23959585 PMCID:PMC3997746
• Kleensang A, Maertens A, Rosenberg M, Fitzpatrick S, Lamb J, Auerbach SS, Brennan R, Crofton K, Gordon B, Fornace AJ, Gaido KW, Gerhold D, Haw R, Henney A, Ma'ayan A, McBride M, Monti S, Ochs MF, Pandey A, Sharan R, Stierum R, Tugendreich S, Willett C, Wittwehr C, Xia J, Patton GW, Arvidson K, Bouhifd M, Hogberg HT, Luechtefeld T, Smirnova L, Zhao L, Adeleye Y, Kanehisa M, Carmichael PL, Andersen ME, Hartung T. 2014. t4 workshop report: Pathways of toxicity. ALTEX 31(1):53-61. doi:10.14573/altex.1309261 PMID:24127042 PMCID:PMC4041485
• Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger JJ, Sherr DH, Silverstone AE, Hahn ME, McCune JM. 2014. Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One 9(2):15. doi:10.1371/journal.pone.0087877 PMID:24498387 PMCID:PMC3912126
• Mahalingaiah S, Hart JE, Aschengrau A, Laden F, Missmer SA. 2014. Air pollution exposures during adulthood and risk of endometriosis in the Nurses' Health Study II. Environ Health Perspect 122(1):58-64. doi:10.1289/ehp.1306627 PMID:24225723 PMCID:PMC3888567
• Mahalingaiah S, Hart JE, Laden F, Aschengrau A, Missmer SA, Terry KL, Boynton-Jarrett R. 2014. Air pollution and risk of uterine leiomyomata. Epidemiology 25(5):682-688. doi:10.1097/EDE.0000000000000126 PMID:24815304 PMCID:PMC4209294
• Morrison AM, Goldstone JV, Lamb DC, Kubota A, Lemaire B, Stegeman JJ. 2014. Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase. Biochim Biophys Acta 1840(6):1825-1836. doi:10.1016/j.bbagen.2013.12.009 PMID:24361620 PMCID:PMC4118742
• Padilla CM, Kihal-Talantikite W, Vieira VM, Rossello P, Le Nir G, Zmirou-Navier D, Deguen S. 2014. Air quality and social deprivation in four French metropolitan areas--a localized spatio-temporal environmental inequality analysis. Environ Res 134:315-324. doi:10.1016/j.envres.2014.07.017 PMID:25199972 PMCID:PMC4294705
• Parks A, Pollastri MP, Hahn ME, Stanford EA, Novikov O, Franks DG, Haigh SE, Narasimhan S, Ashton TD, Hopper TG, Kozakov D, Beglov D, Vajda S, Schlezinger JJ, Sherr DH. 2014. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol 86(5):593-608. doi:10.1124/mol.114.093369 PMID:25159092 PMCID:PMC4201140
• Pillai HK, Fang M, Beglov D, Kozakov D, Vajda S, Stapleton HM, Webster TF, Schlezinger JJ. 2014. Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. Environ Health Perspect 122(11):1225-1232. doi:10.1289/ehp.1408111 PMID:25062436 PMCID:PMC4216168
• Reitzel AM, Karchner SI, Franks DG, Evans BR, Nacci DE, Champlin D, Vieira VM, Hahn ME. 2014. Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats. BMC Evol Biol 14:6. doi:10.1186/1471-2148-14-6 PMID:24422594 PMCID:PMC3899389
• Simmons AL, Schlezinger JJ, Corkey BE. 2014. What are we putting in our food that is making us fat? Food additives, contaminants, and other putative contributors to obesity. Curr Obes Rep 3(2):273-285. doi:10.1007/s13679-014-0094-y PMID:25045594 PMCID:PMC4101898
• Teraoka H, Okuno Y, Nijoukubo D, Yamakoshi A, Peterson RE, Stegeman JJ, Kitazawa T, Hiraga T, Kubota A. 2014. Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish. Aquat Toxicol 154:19-26. doi:10.1016/j.aquatox.2014.04.025 PMID:24858302 PMCID:PMC4326229
• Tokunaga S, Stegeman JJ. 2014. Elimination of nonspecific bands in non-radioactive electrophoretic mobility shift assays using the digoxigenin system. Anal Biochem 465:70-72. doi:10.1016/j.ab.2014.06.020 PMID:25004462 PMCID:PMC4318779
• Winter MR, Mahalingaiah S, Aschengrau A, Carwile JL. 2014. Prenatal drinking-water exposure to tetrachloroethylene and ischemic placental disease: a retrospective cohort study. Environ Health 13:72. doi:10.1186/1476-069X-13-72 PMID:25270247 PMCID:PMC4183765

2013

• Amemiya CT, Alfoldi J. 2013. The African coelacanth genome provides insights into tetrapod evolution. Nature 496:311–316. doi:10.1038/nature12027 PMID:23598338 PMCID:PMC3633110
• Bainy AC, Kubota A, Goldstone JV, Lille-Langoy R, Karchner SI, Celander MC, Hahn ME, Goksoyr A, Stegeman JJ. 2013. Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio). Aquat Toxicol 142-143:447-457. doi:10.1016/j.aquatox.2013.09.014 PMID:24121122 PMCID:PMC3873750
• Bozinovic G, Sit TL, Di Giulio RT, Wills LF, Oleksiak MF. 2013. Genomic and physiological responses to strong selective pressure during late organogenesis: Few gene expression changes found despite striking morphological differences. BMC Genomics 14:779. doi:10.1186/1471-2164-14-779 PMID:24215130 PMCID:PMC3835409
• Fraccalvieri D, Soshilov AA, Karchner SI, Franks DG, Pandini A, Bonati L, Hahn ME, Denison MS. 2013. Comparative analysis of homology models of the AH receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. Biochemistry 52:714-725. doi:10.1021/bi301457f PMID:23286227 PMCID:PMC3568667
• Harbeitner RC, Hahn ME, Timme-Laragy AR. 2013. Differential sensitivity to pro-oxidant exposure in two populations of killifish (Fundulus heteroclitus). Ecotoxicology 22:387-401. doi:10.1007/s10646-012-1033-x PMID:23329125 PMCID:PMC3573531
• Janulewicz PA, Killiany RJ, White RF, Martin BR, Winter MR, Weinberg JM, Aschengrau A. 2013. Structural Magnetic Resonance Imaging in an adult cohort following prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water. Neurotoxicol Teratol 38:13-20. doi:10.1016/j.ntt.2013.03.060 PMID:23571160 PMCID:PMC3893699
• Kubota A, Bainy AC, Woodin BR, Goldstone JV, Stegeman JJ. 2013. The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Toxicol Appl Pharmacol 272(1):172–179. doi:10.1016/j.taap.2013.05.017 PMID:23726801 PMCID:PMC3846545
• Leung A, Nah SK, Reid W, Ebata A, Koch CM, Monti S, Genereux JC, Wiseman RL, Wolozin B, Connors LH, Berk JL, Seldin DC, Mostoslavsky G, Kotton DN, Murphy GJ. 2013. Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis. Stem Cell Reports 1(5):451–463. doi:10.1016/j.stemcr.2013.10.003 PMID:24286032 PMCID:PMC3841264
• Nelson DR, Goldstone JV, Stegeman JJ. 2013. The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s. Philos Trans R Soc Lond B Biol Sci 368:20120474. doi:10.1098/rstb.2012.0474 PMID:23297357 PMCID:PMC3538424
• Pennell KG, Scammell MK, McClean MD, Ames J, Weldon B, Friguglietti L, Suuberg EM, Shen R, Indeglia PA, Heiger-Bernays WJ. 2013. Sewer gas: An indoor air source of PCE to consider during vapor intrusion investigations. Ground Water Monit Remediat 33(3):119-126. PMID:23950637 PMCID:PMC3740581
• Quintana FJ, Sherr DH. 2013. Aryl hydrocarbon receptor control of adaptive immunity. Pharmacol Rev 65(4):1148-1161. doi:10.1124/pr.113.007823 PMID:23908379 PMCID:PMC3799235
• Sherr DH, Monti S. 2013. The role of the aryl hydrocarbon receptor in normal and malignant B cell development. Semin Immunopathol 35(6):705-716. doi:10.1007/s00281-013-0390-8 PMID:23942720 PMCID:PMC3824572
• Smith BW, Rozelle SS, Leung A, Ubellacker J, Parks A, Nah SK, French D, Gadue P, Monti S, Chui DK, Steinberg MH, Frelinger AL, Michelson AD, Theberge R, McComb ME, Costello CE, Kotton DN, Mostoslavsky G, Sherr DH, Murphy GJ. 2013. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood 122:376-385. doi:10.1182/blood-2012-11-466722 PMID:23723449 PMCID:PMC3716202
• Timme-Laragy AR, Goldstone JV, Imhoff BR, Stegeman JJ, Hahn ME, Hansen JM. 2013. Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free Radic Biol Med 65:89-101. doi:10.1016/j.freeradbiomed.2013.06.011 PMID:23770340 PMCID:PMC3823629
• Vieira VM, Holmqvist M, Hart JE, Costenbader K, Bengtsson C, Klareskog L, Karlson E, Alfredsson L. 2013. Regional differences regarding risk of developing rheumatoid arthritis in Stockholm County, Sweden: results from the Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study. Scand J Rheumatol 42(5):337-343. doi:10.3109/03009742.2013.769062 PMID:23611369 PMCID:PMC3815679
• Webster TF. 2013. Mixtures of endocrine disruptors: how similar must mechanisms be for concentration addition to apply?. Toxicology 313(2-3):129-133. doi:10.1016/j.tox.2013.01.009 PMID:23357612
• Williams LM, Timme-Laragy AR, Goldstone JV, McArthur AG, Stegeman JJ, Smolowitz RM, Hahn ME. 2013. Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. PLoS One doi:10.1371/journal.pone.0079574 PMID:24298298 PMCID:PMC3840143
• Wolenski FS, Bradham CA, Finnerty JR, Gilmore TD. 2013. NF-kappa B is required for cnidocyte development in the sea anemone Nematostella vectensis. Dev Biol 373(1):205-215. doi:10.1016/j.ydbio.2012.10.004 PMID:23063796
• Zanette J, Jenny MJ, Goldstone JV, Parente T, Woodin BR, Bainy AC, Stegeman JJ. 2013. Identification and expression of multiple CYP1-like and CYP3-like genes in the bivalve mollusk Mytilus edulis. Aquat Toxicol 128-129:101-112. doi:10.1016/j.aquatox.2012.11.017 PMID:23277104 PMCID:PMC3846546
• Zanette J, Stegeman JJ. 2013. The members of cytochrome P450 family 1 and new perspectives in aquatic pollution. In: Exploring Themes on Aquatic Toxicology. pp.89-101.

2012

• Bliss RL, Weinberg JM, Webster TF, Vieira VM. 2012. Determining the probability distribution and evaluating sensitivity and false positive rate of a confounder detection method applied to logistic regression. J Biom Biostat 3(4):142. doi:10.4172/2155-6180.1000142 PMID:23420565 PMCID:PMC3571096
• Dorrington T, Zanette J, Zacchi FL, Stegeman JJ, Bainy AC. 2012. Basal and 3-methylcholanthrene-induced expression of cytochrome P450 1A, 1B and 1C genes in the Brazilian guppy, Poecilia vivipara. Aquat Toxicol 124-125:106-113. doi:10.1016/j.aquatox.2012.08.006 PMID:22940225 PMCID:PMC4349553
• Getz KD, Janulewicz PA, Rowe S, Weinberg JM, Winter MR, Martin BR, Vieira VM, White RF, Aschengrau A. 2012. Prenatal and early childhood exposure to tetrachloroethylene and adult vision. Environ Health Perspect doi:10.1289/ehp.1103996 PMID:22784657 PMCID:PMC3440105
• Gilmore TD, Wolenski FS. 2012. NF-kappa B: where did it come from and why?. Immunol Rev Rev.246:14-35. doi:10.1111/j.1600-065X.2012.01096.x PMID:22435545
• Goldstone JV, Stegeman JJ. 2012. Methodological approaches to cytochrome P450 profiling in embryos. Methods Mol Biol 889:265-275. doi:10.1007/978-1-61779-867-2_16 PMID:22669670 PMCID:PMC3949507
• Handley-Goldstone HM, Tokunaga S, Schlezinger JJ, Goldstone JV, Stegeman JJ. 2012. EZR1: A novel family of highly expressed retroelements induced by TCDD and regulated by a NF-kapa B-like factor in embroyos of zebrafish (Danio rerio). Zebrafish 9:15-25. doi:10.1089/zeb.2011.0722 PMID:22356696 PMCID:PMC3308714
• Janulewicz PA, White RF, Martin BR, Winter MR, Weinberg JM, Vieira VM, Aschengrau A. 2012. Adult neuropsychological performance following prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water. Neurotoxicol Teratol 34(3):350–359. doi:10.1016/j.ntt.2012.04.001 PMID:22522125 PMCID:PMC3553661
• Jonsson ME, Kubota A, Timme-Laragy AR, Woodin BR, Stegeman JJ. 2012. Ahr2-dependence of PCB126 effects on the swim bladder in relation to expression of CYPI and cox-2 genes in developing zebrafish. Toxicol Appl Pharmacol 265:166-174. doi:10.1016/j.taap.2012.09.023 PMID:23036320 PMCID:PMC3529150
• Weinberg JM, Vieira VM, Webster TF, Bliss RL. 2012. Adjusted significance cutoffs for hypothesis tests applied with generalized additive models with bivariate smoothers. Spat Spatiotemporal Epidemiol 2(4):291-300. doi:10.1016/j.sste.2011.09.001 PMID:22748227 PMCID:PMC3389351

2011

• Andersen ME, Clewell H, Carmichael PL, Boekelheide K. 2011. Can case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?". ALTEX 28(3):175-182. PMID:21993955 PMCID:PMC3943477 (Completed with ARRA Funds)
• Bagchi G, Stanley KA, Zhang Y, Waxman DJ. 2011. Complex modulation of androgen responsive gene expression by methoxyacetic acid. Reprod Biol Endocrinol 9:doi:10.1186/1477-7827-9-42 PMID:21453523 PMCID:PMC3083340
• Bhattacharya S, Zhang Q, Carmichael PL, Boekelheide K, Andersen ME. 2011. Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways. PLoS One 6(6):doi:10.1371/journal.pone.0020887 PMID:21701582 PMCID:PMC3118802 (Completed with ARRA Funds)
• Bozinovic G, Sit TL, Hinton DE, Oleksiak MF. 2011. Gene expression throughout a vertebrate's embryogenesis. BMC Genomics 12:132. doi:10.1186/1471-2164-12-132 PMID:21356103 PMCID:PMC3062618
• Callard GV, Tarrant AM, Novillo-Villajos A, Yacci P, Ciaccia L, Vajda S, Chuang G, Kozakov D, Greytak SR, Sawyer SJ, Hoover CA, Cotter KA. 2011. Evolutionary origins of the estrogen signaling system: Insights from amphioxus. Psychiatr Pol 127:176-188. doi:10.1016/j.jsbmb.2011.03.022 PMID:21514383 PMCID:PMC3179578
• Fu J, Suuberg EM. 2011. Solid vapor pressure for five heavy PAHs via the Knudsen effusion method. J Chem Thermodyn 43:1660–1665. doi:10.1016/j.jct.2011.05.030 PMID:22021935 PMCID:PMC3196620 (Completed with ARRA Funds)
• Fu J, Suuberg EM. 2011. Vapor pressure of solid polybrominated diphenyl ethers determined via Knudsen effusion method. Wiley Interdisciplinary Reviews: Systems Biology and Medicine 30:2216-2219. doi:10.1002/etc.621 PMID:21766320 PMCID:PMC3634866 (Completed with ARRA Funds)
• Gao K, Brandt I, Goldstone JV, Jonsson ME. 2011. Cytochrome P450 1A, 1B, and 1C mRNA induction patterns in three-spined stickleback exposed to a transient and a persistent inducer. Comp Biochem Physiol 154:42-55. doi:10.1016/j.cbpc.2011.02.005 PMID:21354474 PMCID:PMC3560405
• Godard-Codding CJ, Clark R, Fossi MC, Marsili L, Maltese S, West AG, Valenzuela L, Rowntree V, Polyak I, Cannon JC, Pinkerton K, Rubio-Cisneros N, Mesnick SL, Cox SB, Kerr I, Payne R, Stegeman JJ. 2011. Pacific ocean-wide profile of CYP1A1 expression, stable carbon and nitrogen isotope ratios, and organic contaminant burden in Sperm Whale skin biopsies. Environ Health Perspect 119:337-343. doi:10.1289/ehp.0901809 PMID:21134820 PMCID:PMC3059996
• Grimshaw P, Calo JM, Hradil G. 2011. Co-electrodeposition/removal of copper and nickel in a spouted electrochemical reactor. Ind Eng Chem Res 50(16):9532–9538. doi:10.1021/ie200670g PMID:21874093 PMCID:PMC3160638 (Completed with ARRA Funds)
• Grimshaw P, Calo JM, Hradil G. 2011. Cyclic electrowinning/precipitation (CEP) system for the removal of heavy metal mixtures from aqueous solutions. Chem Eng J 175:103-109. doi:10.1016/j.cej.2011.09.062 PMID:22102792 PMCID:PMC3217272 (Completed with ARRA Funds)
• Grimshaw P, Calo JM, Shirvanian PA, Hradil G. 2011. Electrodeposition/removal of nickel in a spouted electrochemical reactor. Ind Eng Chem Res 50(16):9525–9531. doi:10.1021/ie200669b PMID:22039317 PMCID:PMC3203021 (Completed with ARRA Funds)
• Hahn ME. 2011. Mechanistic research in aquatic toxicology: perspectives and future directions. Aquat Toxicol 105:67-71. doi:10.1016/j.aquatox.2011.06.001 PMID:22099346 PMCID:PMC3220193
• Jonsson ME, Berg C, Goldstone JV, Stegeman JJ. 2011. New CYP1 genes in the frog Xenopus (Silurana) tropicalis: induction patterns and effects of AHR agonists during development. Toxicol Appl Pharmacol 250:170-183. doi:10.1016/j.taap.2010.10.010 PMID:20965207 PMCID:PMC3014448
• Jonsson ME, Woodin BR, Stegeman JJ, Brunstrom B. 2011. Cytochrome P450 1 genes in birds: evolutionary relationships and transcription profiles in chicken and Japanese quail embryos. PLoS One 6(12):e28257. doi:10.1371/journal.pone.0028257 PMID:22164255 PMCID:PMC3229566
• Kubota A, Stegeman JJ, Goldstone JV, Nelson DR, Kim EY, Tanabe S, Iwata H. 2011. Cytochrome P450 CYP2 genes in the common cormorant: Evolutionary relationships with 130 diapsid CYP2 clan sequences and chemical effects on their expression. Comp Biochem Physiol C Toxicol Pharmacol 153:280-289. doi:10.1016/j.cbpc.2010.11.006 PMID:21130899 PMCID:PMC3560406
• Liu J, Pennell KG, Hurt RH. 2011. Kinetics and mechanisms of nanosilver oxysulfidation. Environ Sci Technol 45(17):7345–7353. doi:10.1021/es201539s PMID:21770469 PMCID:PMC3164758 (Completed with ARRA Funds)
• Maccani MA, Padbury JF, Marsit CJ. 2011. miR-16 and miR-21 expression in the placenta is associated with fetal growth. PLoS One 6:doi:10.1371/journal.pone.0021210 PMID:21698265 PMCID:PMC3115987 (Completed with ARRA Funds)
• Marquez EC, Traylor-Knowles N, Novillo-Villajos A, Callard IP. 2011. Cloning of estrogen receptor alpha and aromatase cDNAs and gene expression in turtles (Chrysemys picta and Pseudemys scripta) exposed to different environments. Comp Biochem Physiol C Toxicol Pharmacol 154(3):213-225. doi:10.1016/j.cbpc.2011.05.008 PMID:21664488
• Marquez EC, Traylor-Knowles N, Novillo-Villajos A, Callard IP. 2011. Novel cDNA sequences of aryl hydrocarbon receptors and gene expression in turtles (Chrysemys picta and Pseudemys scripta) exposed to different environments. Comp Biochem Physiol C Toxicol Pharmacol 154:305-317. doi:10.1016/j.cbpc.2011.06.017 PMID:21763458 PMCID:PMC3176672
• Oleksiak MF, Karchner SI, Jenny MJ, Franks DG, Mark Welch DB, Hahn ME. 2011. Transcriptomic assessment of resistance to effects of an aryl hydrocarbon receptor (AHR) agonist in embryos of Atlantic killifish (Fundulus heteroclitus) from a marine Superfund site. BMC Genomics 12:263. doi:10.1186/1471-2164-12-263 PMID:21609454 PMCID:PMC3213123
• Pacheco SE, Christensen BC, Marsit CJ, Kelsey KT, Sigman M, Boekelheide K. 2011. Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm. PLoS One 6:doi:10.1371/journal.pone.0020280 PMID:21674046 PMCID:PMC3107223 (Completed with ARRA Funds)
• Parente T, Rebelo MF, da-Silva ML, Woodin BR, Goldstone JV, Bisch PM, Paumgartten FJ, Stegeman JJ. 2011. Structural features of cytochrome P450 1A associated with the absence of EROD activity in liver of the loricariid catfish Pterygoplichthys sp. Gene 489:111-118. doi:10.1016/j.gene.2011.07.023 PMID:21840383 PMCID:PMC3200446
• Rice JW, Suuberg EM. 2011. Thermodynamics of Multicomponent PAH Mixtures and Development of Tar-Like Behavior. Ind Eng Chem Res 50(6):3613-3620. doi:10.1021/ie102325d PMID:21442010 PMCID:PMC3062962 (Completed with ARRA Funds)
• Robins J, Marsit CJ, Padbury J, Sharma S. 2011. Endocrine disruptors, environmental oxygen, epigenetics and pregnancy. Front Biosci (Landmark Ed) 3:690-700. PMID:21196344 PMCID:PMC3050574 (Completed with ARRA Funds)
• Whitehead A, Galvez F, Zhang S, Williams LM, Oleksiak MF. 2011. Functional genomics of physiological plasticity and local adaptation in Killifish. J Hered 102:499-511. doi:10.1093/jhered/esq077 PMID:20581107 PMCID:PMC3156563
• Wirgin II, Roy NK, Loftus M, Chambers RC, Franks DG, Hahn ME. 2011. Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River. Science 331(6022):1322-1325. doi:10.1126/science.1197296 PMID:21330491 PMCID:PMC3246799
• Yao Y, Shen R, Pennell KG, Suuberg EM. 2011. Comparison of the Johnson-Ettinger vapor intrusion screening model predictions with full three-dimensional model results. Environ Sci Technol 46(6):2227–2235. doi:10.1021/es102602s PMID:21344848 PMCID:PMC3664551 (Completed with ARRA Funds)
• Zhitkovich A. 2011. Chromium in drinking water: sources, metabolism, and cancer risks. Chem Res Toxicol 24(10):1617–1629. doi:10.1021/tx200251t PMID:21766833 PMCID:PMC3196244 (Completed with ARRA Funds)

2010

• Allan LL, Sherr DH. 2010. Disruption of human plasma cell differentiation by an environmental polycyclic aromatic hydrocarbon: a mechanistic immunotoxicological study. Environ Health 9:15. doi:10.1186/1476-069X-9-15 PMID:20334656 PMCID:PMC2851679
• Aluru N, Karchner SI, Hahn ME. 2010. Role of DNA methylation of AHR1 and AHR2 promoters in differential sensitivity to PCBs in Atlantic Killifish, Fundulus heteroclitus. Aquat Toxicol 101:288-94. doi:10.1016/j.aquatox.2010.10.010 PMID:21111492 PMCID:PMC3019765
• Arany I, Baliga R, Tian N, Waxman DJ. 2010. Cytochrome-P450 2B1 gene silencing attenuates puromycin aminonucleoside-induced cytotoxicity in glomerular epithelial cells. Kidney International 78:182-190. doi:10.1038/ki.2010.100 PMID:20407477 PMCID:PMC3053138
• Bagchi G, Zhang Y, Waxman DJ. 2010. Impact of methoxyacetic acid on mouse Leydig cell gene expression. Reprod Biol Endocrinol 8:65. doi:10.1186/1477-7827-8-65 PMID:20565877 PMCID:PMC2909983
• Behrendt L, Jonsson ME, Goldstone JV, Stegeman JJ. 2010. Induction of cytochrome P450 1 genes and stress response genes in developing zebrafish exposed to ultraviolet radiation. Aquat Toxicol 98(1):74-82. doi:10.1016/j.aquatox.2010.01.008 PMID:20189255 PMCID:PMC2864789
• Bissonnette SL, Haas A, Mann KK, Schlezinger JJ. 2010. The role of CaMKII in calcium-activated death pathways in bone marrow B cells. Toxicol Sci 118(1):108-118. doi:10.1093/toxsci/kfq256 PMID:20810541 PMCID:PMC2955217
• Bliss RL, Weinberg JM, Vieira VM, Ozonoff A, Webster TF. 2010. Power of permutation tests using generalized additive models with bivariate smoothers. J Biom Biostat 1:doi:10.4172/2155-6180.1000104 PMID:21701694 PMCID:PMC3119353
• Fu J, Rice JW, Suuberg EM. 2010. Phase behavior and vapor pressures of the pyrene + 9,10-dibromoanthracene system. Fluid Phase Equilib 298(2):219-224. doi:10.1016/j.fluid.2010.07.023 PMID:21076624 PMCID:PMC2976556 (Completed with ARRA Funds)
• Gallagher LG, Webster TF, Aschengrau A, Vieira VM. 2010. Using residential history and groundwater modeling to examine drinking water exposure and breast cancer. Environ Health Perspect 118(6):749-755. doi:10.1289/ehp.0901547 PMID:20164002 PMCID:PMC2898849
• Goldstone JV, McArthur AG, Kubota A, Zanette J, Parente T, Jonsson ME, Nelson DR, Stegeman JJ. 2010. Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish. BMC Genomics 11:643. doi:10.1186/1471-2164-11-643 PMID:21087487 PMCID:PMC3012610
• Greytak SR, Tarrant AM, Nacci DE, Hahn ME, Callard GV. 2010. Estrogen responses in killifish (Fundulus heteroclitus) from polluted and unpolluted environments are site- and gene-specific. Aquat Toxicol 99(2):291-299. doi:10.1016/j.aquatox.2010.05.009 PMID:20570371 PMCID:PMC2907899
• Hoffman K, Webster TF, Weisskopf MG, Weinberg JM, Vieira VM. 2010. Exposure to polyfluoroalkyl chemicals and attention deficit/hyperactivity disorder in U.S. children 12-15 years of age. Environ Health Perspect 118:1762-1767. doi:10.1289/ehp.1001898 PMID:20551004 PMCID:PMC3002197
• Howard G, Schlezinger JJ, Hahn ME, Webster TF. 2010. Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists. Environ Health Perspect 118(5):666-672. doi:10.1289/ehp.0901312 PMID:20435555 PMCID:PMC2866683
• Leung MC, Goldstone JV, Boyd W, Freedman JH, Meyer JN. 2010. Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B-1 but not benzo a pyrene in vivo. Toxicol Sci 118:444-453. doi:10.1093/toxsci/kfq295 PMID:20864627 PMCID:PMC2984530
• Ling G, Sugathan A, Mazor T, Fraenkel E, Waxman DJ. 2010. Unbiased, genome-wide in vivo mapping of transcriptional regulatory elements reveals sex differences in chromatin structure associated with sex-specific liver gene expression. Mol Cell Biol 30(23):5531-5544. doi:10.1128/MCB.00601-10 PMID:20876297 PMCID:PMC2976433
• Liu H, Tian N, Arany I, Bigler S, Waxman DJ, Shah S, Baliga R. 2010. Cytochrome P450 2B1 mediates complement-dependent sublytic injury in a model of membranous nephropathy. J Biol Chem 285:40901-10. doi:10.1074/jbc.M110.165498 PMID:20947506 PMCID:PMC3003390
• Liu J, Sonshine D, Shervani S, Hurt RH. 2010. Controlled release of biologically active silver from nanosilver surfaces. ACS Nano 4(11):6903-6913. doi:10.1021/nn102272n PMID:20968290 PMCID:PMC3004478 (Completed with ARRA Funds)
• McCurley A, Callard GV. 2010. Time course analysis of gene expression patterns in zebrafish eye during optic nerve regeneration. J Neurosci 17:13. PMID:20740047 PMCID:PMC2926816
• Pietruska JR, Johnston T, Zhitkovich A, Kane AB. 2010. XRCC1 deficiency sensitizes human lung epithelial cells to genotoxicity by crocidolite asbestos and Libby amphibole. Environ Health Perspect 118(12):1707-1713. doi:10.1289/ehp.1002312 PMID:20705543 PMCID:PMC3205592 (Completed with ARRA Funds)
• Rice JW, Suuberg EM. 2010. Thermodynamic study of (anthracene + benzo[a]pyrene) solid mixtures. J Chem Thermodyn 42(11):1356-1360. doi:10.1016/j.jct.2010.05.019 PMID:20814451 PMCID:PMC2929985 (Completed with ARRA Funds)
• Scammell MK. 2010. Qualitative environmental health research: an analysis of the literature, 1991-2008. Environ Health Perspect 118:1146-1154. doi:10.1289/ehp.0901762 PMID:20421191 PMCID:PMC2920087
• Teague J, Ryu H, Kirber M, Sherr DH, Schlezinger JJ. 2010. Proximal events in 7,12-dimethylbenz a anthracene-induced, stromal cell-dependent bone marrow B cell apoptosis: stromal cell-B cell communication and apoptosis signaling. J Immunol 185:3369-3378. doi:10.4049/jimmunol.0902541 PMID:20720205 PMCID:PMC2933279
• Vieira VM, Hart JE, Webster TF, Weinberg JM, Laden F, Costenbader K, Karlson E, Puett R. 2010. Association between residences in US northern latitudes and rheumatoid arthritis: a spatial analysis of the Nurses' Health Study. Environ Health Perspect 118(7):957-961. doi:10.1289/ehp.0901861 PMID:20338859 PMCID:PMC2920915
• Wauthier V, Sugathan A, Meyer RD, Dombkowski AA, Waxman DJ. 2010. Intrinsic Sex Differences in the Early Growth Hormone Responsiveness of Sex-Specific Genes in Mouse Liver. Mol Endocrinol 24(3):667-668. doi:10.1210/me.2009-0454 PMID:20150183 PMCID:PMC2840812
• Young RL, Weinberg JM, Vieira VM, Aschengrau A, Webster TF. 2010. A multilevel non-hierarchical study of birth weight and socioeconomic status. Int J Health Geogr 9:36. doi:10.1186/1476-072X-9-36 PMID:20618954 PMCID:PMC2909180

2009

• Bagchi G, Hurst CH, Waxman DJ. 2009. Interactions of methoxyacetic acid with androgen receptor. Toxicol Appl Pharmacol 238(2):101-110. doi:10.1016/j.taap.2008.03.015 PMID:18486176 PMCID:PMC2742301
• Beglov D, Brenke R, Chuang G, Hall D, Landon MR, Ngan CM, Shen Y, Thiel S, Zerbe B, Kozakov D, Vajda S. 2009. Identification of druggable hot spots on proteins and in protein-protein interfaces. In: Computational Protein-Protein Interactions.
• Brenke R, Kozakov D, Chuang G, Beglov D, Hall D, Landon MR, Mattos C, Vajda S. 2009. Fragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques. Bioinformatics 25(5):621-627. doi:10.1093/bioinformatics/btp036 PMID:19176554 PMCID:PMC2647826
• Hahn ME, Allan LL, Sherr DH. 2009. Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor. Biochem Pharmacol 77(4):485-497. doi:10.1016/j.bcp.2008.09.016 PMID:18848529 PMCID:PMC2701375
• Karchner SI, Jenny MJ, Tarrant AM, Evans BR, Kang HJ, Bae I, Sherr DH, Hahn ME. 2009. The active form of human aryl hydrocarbon receptor (AHR) repressor lacks exon 8, and its Pro 185 and Ala 185 variants repress both AHR and hypoxia-inducible factor. Mol Cell Biol 29(13):3465-3477. doi:10.1128/MCB.00206-09 PMID:19380484 PMCID:PMC2698758
• Scammell MK, Senier L, Darrah-Okike J, Brown P, Santos A. 2009. Tangible evidence, trust and power: public perceptions of community environmental health studies. Soc Sci Med 68(1):143-153. doi:10.1016/j.socscimed.2008.10.002 PMID:18995942 PMCID:PMC2657232

2008

• Aschengrau A, Gallagher LG, Webster TF, Heeren T, Ozonoff DM, Spence LA. 2008. Evaluation of the Webler-Brown model for estimating tetrachloroethylene exposure from vinyl-lined asbestos-cement pipes. Environ Health 7:24. doi:10.1186/1476-069X-7-24 PMID:18518975 PMCID:PMC2432054
• Aschengrau A, Weinberg JM, Rogers S, Gallagher LG, Winter MR, Vieira VM, Webster TF, Ozonoff DM. 2008. Prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of adverse birth outcomes. Environ Health Perspect 116(6):814-820. doi:10.1289/ehp.10414 PMID:18560539 PMCID:PMC2430239
• Bagchi G, Waxman DJ. 2008. Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression. Int J Androl 31(2):269-274. doi:10.1111/j.1365-2605.2007.00846.x PMID:18179559 PMCID:PMC3286123
• Bissonnette SL, Emberley JK, Sherr DH. 2008. An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways. J Immunol 181:1728-1736. PMID:18641309
• Celenligil-Cetin R, Paraskevopoulou P, Dinda R, Lalioti N, Sanakis Y, Rawashdeh A, Staples RJ, Sinn E, Stavropoulos P. 2008. Oxidative ligand rearrangement due to incipient aminyl radicals in the oxidation of iron(ll) species with dioxygen. European Journal of Inorganic Chemistry 5:673-677. doi:10.1002/ejic.200701297
• Celenligil-Cetin R, Paraskevopoulou P, Dinda R, Sanakis Y, Staples RJ, Sinn E, Rath NP, Stavropoulos P. 2008. Synthesis, characterization, and reactivity of iron trisamidoamine complexes that undergo both metal- and ligand-centered oxidative transformations. Inorg Chem 47(3):1165-1172. doi:10.1021/ic702154z PMID:18179206
• Evans BR, Karchner SI, Allan LL, Pollenz RS, Tanguay RL, Jenny MJ, Sherr DH, Hahn ME. 2008. Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator. Mol Pharmacol 73(2):387-98. PMID:18000031
• Hansson MC, Hahn ME. 2008. Functional properties of the four Atlantic salmon (Salmo salar) aryl hydrocarbon receptor type 2 (AHR2) isoforms. Aquat Toxicol 86(2):121-30. PMID:18063141
• Holloway MG, Miles GD, Dombkowski AA, Waxman DJ. 2008. Liver-Specific Hepatocyte Nuclear Factor-4α Deficiency: Greater Impact on Gene Expression in Male than in Female Mouse Liver. Mol Endocrinol 22(5):1274-1286. doi:10.1210/me.2007-0564 PMID:18276827 PMCID:PMC2366185
• Janulewicz PA, White RF, Winter MR, Weinberg JM, Gallagher LG, Vieira VM, Webster TF, Aschengrau A. 2008. Risk of learning and behavioral disorders following prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water. Neurotoxicol Teratol 30(3):175-185. doi:10.1016/j.ntt.2008.01.007 PMID:18353612 PMCID:PMC2494864
• Johnston TP, Waxman DJ. 2008. Circulating free fatty acids are increased independently of PPARgamma activity after administration of poloxamer 407 to mice. Can J Physiol Pharmacol 86(9):643-649. doi:10.1139/y08-070 PMID:18758514 PMCID:PMC2615679
• Johnston TP, Waxman DJ. 2008. Peroxisome proiiferator-actlvated receptor (PPAR) agonists: using a mouse model of atherogenic dyslipidemia to better understand the PPAR-LXR-ABCA1 signaling pathway for accelerating cholesterol elimination. In: 22nd Ann Mtg Amer Assoc Pharm Sci.
• Johnston TP, Waxman DJ. 2008. The induction of atherogenic dyslipidaemia in poloxamer 407-treated mice is not mediated through PPARalpha. J Pharm Pharmacol 60(6):753-759. doi:10.1211/jpp.60.6.0011 PMID:18498712 PMCID:PMC2496925
• Kitana N, Callard IP. 2008. Effect of cadmium on gonadal development in freshwater turtle (Trachemys scripta, Chrysemys picta) embryos. J Environ Sci Health A Tox Hazard Subst Environ Eng 43(3):262-271. doi:10.1080/10934520701792753 PMID:18205057
• Lutton BV, Callard IP. 2008. Influence of reproductive activity, sex steroids, and seasonality on epigonal organ cellular proliferation in the skate (Leucoraja erinacea). Gen Comp Endocrinol 155(1):116-25. PMID:17499739
• McCuriey AT, Callard GV. 2008. Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment. BMC Mol Biol 9:102. doi:10.1186/1471-2199-9-102 PMID:19014500 PMCID:PMC2588455
• Nelson J, Scammell MK, Webster TF, Ozonoff DM, Altman RG. 2008. A new spin on research translation: The Boston Consensus Conference on Human Biomonitoring. Environ Health Perspect 117:495-499. doi:10.1289/ehp.0800037 PMID:19440485 PMCID:PMC2679590
• Oleksiak MF. 2008. Changes in gene expression due to chronic exposure to environmental pollutants. Aquat Toxicol 90(3):161-171. doi:10.1016/j.aquatox.2008.08.010 PMID:18929415 PMCID:PMC2584160
• Oleksiak MF. 2008. Toxicogenomics. Chapter 2 in: Molecular and Biochemical Toxicology, 4th Edition. Wiley, pp.25-39.
• Ozonoff DM, Pogel A. 2008. Contingency Structures and Concept Analysis. In: Formal Concept Analysis. Springer,
• Qelenligil-Qetin R, Paraskevopoulou P, Lalioti N, Sanakis Y, Staples RJ, Rath NP, Stavropoulos P. 2008. Metalloradical complexes of manganese and chromium featuring an oxidatively rearranged ligand. Inorg Chem 47(23):10998-11009. doi:10.1021/ic801219u PMID:18937446 PMCID:PMC2648835
• Vieira VM, Webster TF, Weinberg JM, Aschengrau A. 2008. Spatial-temporal analysis of breast cancer in upper Cape Cod, Massachusetts. Int J Health Geogr 7:46. doi:10.1186/1476-072X-7-46 PMID:18700963 PMCID:PMC2538515
• Waxman DJ, Chang TK. 2008. Nuclear receptor regulation of hepatic cytochrome P450 enzymes. In: Encyclopedia of Molecular Pharmacology (2nd ed.). Springer, pp.889-893.
• Webster TF, Hoffman K, Weinberg JM, Vieira VM, Aschengrau A. 2008. Community- and individual-level socioeconomic status and breast cancer risk: multilevel modeling on Cape Cod, Massachusetts. Environ Health Perspect 116(8):1125-1129. doi:10.1289/ehp.10818 PMID:18709175 PMCID:PMC2516595
• Whalen KE, Morin D, Lin C, Tjeerdema RS, Goldstone JV, Hahn ME. 2008. Proteomic identification, cDNA cloning and enzymatic activity of glutathione S-transferases from the generalist marine gastropod, Cyphoma gibbosum. Arch Biochem Biophys 478(1):7-17. doi:10.1016/j.abb.2008.07.007 PMID:18671936

2007

• Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, Gomez-Chiarri M, Hahn ME, Hoover CA, Karchner SI, Katoh F, MacLatchy DL, Marshall WS, Meyer JN, Nacci DE, Rees BB, Singer TD, Stegeman JJ, Towle DW, van Veld PA, Vogelbein WK, Whitehead A, Winn RN, Crawford DL, Oleksiak MF. 2007. Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics. Comp Biochem Physiol Part D Genomics Proteomics 2(4):257-286. doi:10.1016/j.cbd.2007.09.001 PMID:18071578 PMCID:PMC2128618
• Carvan MJ, Gallagher EP, Goksoyr A, Hahn ME, Joakim DG. 2007. Fish models in toxicology. Zebrafish 4(1):9-20. doi:10.1089/zeb.2006.9998 PMID:18041939
• Clodfelter KH, Miles GD, Wauthier V, Holloway MG, Zhang X, Hodor P, Ray WJ, Waxman DJ. 2007. Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis. Physiol Genomics 31:63-74. PMID:17536022
• Engel KB, Callard GV. 2007. Endocrinology of Leydig cells in nonmammalian vertebrates. Chapter 15 in: The Leydig Cell in Health and Disease. Humana Press, pp.207-224.
• Goldstone JV, Handley-Goldstone HM, Morrison AM, Tarrant AM, Kern SE, Woodin BR, Stegeman JJ. 2007. Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family. Mol Biol Evol 24(12):2619-31. doi:10.1093/molbev/msm200 PMID:17916789
• Goldstone JV, Stegeman JJ. 2007. Gene structure of the novel cytochrome P4501D1 genes in stickleback (Gasterosteus aculeatus) and medaka (Oryzias latipes). Mar Environ Res 66(1):19--20. PMID:18400289
• Greytak SR, Callard GV. 2007. Cloning of three estrogen receptors (ER) from killifish (Fundulus heteroclitus): differences in populations from polluted and reference environments. Gen Comp Endocrinol 150(1):174-88. PMID:16962596
• Hahn ME, Hestermann EV. 2007. Receptor-mediated mechanisms of toxicity. Chapter 5 in: The Toxicology of Fishes. Taylor & Francis, Boca Raton, FL. pp.235-272.
• Howard G, Schlezinger JJ, Webster TF. 2007. Interactions of TCDD with AhR partial agonists and a competitive antagonist: implications for TEFs. Organohalogen Compounds 69:1065-1068.
• Jonsson ME, Jenny MJ, Woodin BR, Hahn ME, Stegeman JJ. 2007. Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 100(1):180-93. PMID:17686920
• Jonsson ME, Orrego R, Woodin BR, Goldstone JV, Stegeman JJ. 2007. Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish. Toxicol Appl Pharmacol 221(1):29-41. PMID:17445853
• Kitana N, Won S, Callard IP. 2007. Reproductive deficits in male freshwater turtle Chrysemys picta from Cape Cod, Massachusetts. Biol Reprod 76(3):346-52. PMID:17123946
• Lutton BV, Callard IP. 2007. Effects of reproductive activity and sex hormones on apoptosis in the epigonal organ of the skate (Leucoraja erinacea). Gen Comp Endocrinol 154(1-3):75-84. doi:10.1016/j.ygcen.2007.06.014 PMID:17714713
• Ma X, Idle JR, Malfatti MA, Krausz KW, Nebert DW, Chen C, Felton JS, Waxman DJ, Gonzalez FJ. 2007. Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis 28(3):732-737. doi:10.1093/carcin/bgl184 PMID:17052995 PMCID:PMC1829392
• Pinnapareddy D. 2007. Synthesis and characterization of metal reagents mediating C-X Activation (X = Cl, H) of hydrocarbon. .
• Prasad JC, Goldstone JV, Camacho CJ, Vajda S, Stegeman JJ. 2007. Ensemble modeling of substrate binding to cytochromes P450: Analysis of catalytic differences between CYP1A orthologues. Biochemistry 46(10):2640-2654. PMID:17300179
• Reddy CM, Stegeman JJ, Hahn ME. 2007. Organic Pollutants: Presence and Effects in Humans and Marine Animals. Chapter 7 in: Oceans and Human Health: Risks and Remedies from the Seas. pp.121-144.
• Schlezinger JJ, Emberley JK, Sherr DH, Bissonnette SL. 2007. An L-tyrosine derivative and PPARγ agonist, GW7845, activates a multi-faceted capase cascade in bone marrow B cells. Toxicol Sci 98(1):125-36. PMID:17400580
• Silberstein M, Damborsky J, Vajda S. 2007. Exploring the binding sites of the haloalkane dehalogenase DhlA from Xanthobacter autotrophicus GJ10. Biochemistry 46(32):9239-9249. doi:10.1021/bi700336y PMID:17645312
• Sun L, Chen C, Waxman DJ, Liu H, Halpert JR, Kumar S. 2007. Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide. Arch Biochem Biophys 458(2):167-174. doi:10.1016/j.abb.2006.12.021 PMID:17254539 PMCID:PMC1805465
• Vajda S. 2007. Mapping of Proteins for the Binding of Functional Groups from Xenobiotics. (non-peer reviewed)
• Wilson JY, Wells R, Aguilar AA, Borrell A, Tornero V, Reijnders P, Moore M, Stegeman JJ. 2007. Correlates of cytochrome P450 1A1 expression in bottlenose dolphin (Tursiops truncatus) integument biopsies. Toxicol Sci 97(1):111-9. PMID:17324949
• . 2007. GBPSR helps develop two exciting new environmental health resources at the Boston University Superfund Basic Research Program.2. (non-peer reviewed)

2006

• Allan LL, Schlezinger JJ, Shansab M, Sherr DH. 2006. CYP1A1 in polycyclic aromatic hydrocarbon-induced B lymphocyte growth suppression. Biochem Biophys Res Commun 342(1):227-235. PMID:16472762
• Aschengrau A. 2006. Drinking water detective story: connecting water contamination and disease. 77(5):9. (non-peer reviewed)
• Bradbury BD, Wilk JB, Aschengrau A, Lash TL. 2006. Departure from multiplicative interaction for catechol-O-methyltransferase genotype and active/passive exposure to tobacco smoke among women with breast cancer. J Carcinog 5:3. doi:10.1186/1477-3163-5-3 PMID:16417624 PMCID:PMC1373621
• Brody JG, Aschengrau A, Swartz CH, McKelvey W, Rudel RA. 2006. Breast cancer risk and drinking water contaminated by wastewater: a case control study. Environ Health 5:28. doi:10.1186/1476-069X-5-28 PMID:17026759 PMCID:PMC1622744
• Chang TK, Crespi CL, Waxman DJ. 2006. Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.127-131.
• Chang TK, Crespi CL, Waxman DJ. 2006. Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation. Methods Mol Biol 320:127-131. doi:10.1385/1-59259-998-2:127 PMID:14577224
• Chang TK, Waxman DJ. 2006. Catalytic assays for human cytochrome P450. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.73-83.
• Chang TK, Waxman DJ. 2006. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2 and CYP1B1 with 7-ethoxyresorufin as substrate. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.85-90.
• Chang TK, Waxman DJ. 2006. Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). J Mol Biol 38(1-2):51-73. PMID:16684648
• Clodfelter KH, Holloway MG, Hodor P, Park S, Ray WJ, Waxman DJ. 2006. Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis. Mol Endocrinol 20(6):1333-1351. doi:10.1210/me.2005-0489 PMID:16469768
• Clodfelter KH, Waxman DJ, Vajda S. 2006. Computational solvent mapping reveals the importance of local conformational changes for broad substrate specificity in mammalian cytochromes P450. Biochemistry 45(31):9393-407. PMID:16878974
• Crespi CL, Chang TK, Waxman DJ. 2006. CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high performance liquid chromatography with fluorescence detection. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.121-125.
• Dong W, Muramoto W, Nagai Y, Takehana K, Stegeman JJ, Teraoka H, Hiraga T. 2006. Retinal neuronal cell is a toxicological target of tributyltin in developing zebrafish. J Vet Med Sci 68(6):573-9. PMID:16820714
• Dong W, Muramoto W, Takehana K, Stegeman JJ, Teraoka H, Hiraga T. 2006. Oxidative stress and apoptosis induced by tributyltin in retinal neuronal cells of developing zebrafish. Nihon Juigaku Zasshi
• Garrick RA, Woodin BR, Wilson JY, Middlebrooks BL, Stegeman JJ. 2006. Cytochrome P4501A is induced in endothelial cell lines from the kidney and lung of the bottlenose dolphin, Tursiops truncatus. Aquat Toxicol 76(3-4):295-305. PMID:16290286
• Goldstone JV, Hamdoun A, Cole BJ, Howard-Ashby M, Nebert DW, Scally M, Dean M, Epel D, Hahn ME, Stegeman JJ. 2006. The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Dev Biol 300(1):366-384. doi:10.1016/j.ydbio.2006.08.066 PMID:17097629 PMCID:PMC3166225
• Hahn ME, Karchner SI, Evans BR, Franks DG, Merson RR, Lapseritis JM. 2006. Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomic. J Exp Zool 305(9):693-706. PMID:16902966
• Handley-Goldstone HM, Stegeman JJ. 2006. A revised evolutionary history of the CYP1A subfamily: gene duplication, gene conversion, and positive selection. J Mol Evol 62(6):708-717. PMID:16752211
• Handley-Goldstone HM, Stegeman JJ. 2006. Molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin cardiovascular embryotoxicity. J Mol Biol 38(1-2):261-289. PMID:16684661
• Kaya T, Mohr SC, Waxman DJ, Vajda S. 2006. Computational screening of phthalate monoesters for binding to PPARgamma. Chem Res Toxicol 19(8):999-1009. doi:10.1021/tx050301s PMID:16918238
• Kitana N, Khonsue W, Won S, Lance VA, Callard IP. 2006. Gonadotropin and estrogen responses in freshwater turtle (Chrysemys picta) from Cape Cod, Massachusetts. Gen Comp Endocrinol 149(1):49-57. PMID:16774753
• Kubota A, Iwata H, Handley-Goldstone HM, Kim EY, Stegeman JJ, Tanabe S. 2006. Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds. Toxicol Sci 92(2):394-408. doi:10.1093/toxsci/kfl001 PMID:16679348
• Landon MR, Lancia DR, Clodfelter KH, Vajda S. 2006. Clustering of domains of functionally related enzymes in the interaction database PRECISE by the generation of primary sequence patterns. Journal of Molecular Graphics and Modelling 24(6):426-433. PMID:16221553
• Malins DC, Anderson KM, Stegeman JJ, Jaruga P, Green VM, Gilman NK, Dizdaroglu M. 2006. Biomarkers signal contaminant effects on the organs of English sole (Parophrys vetulus) from Puget Sound. Environ Health Perspect 114(6):823-829. PMID:16759979
• Matsuo AY, Woodin BR, Reddy CM, Val AL, Stegeman JJ. 2006. Humic substances and crude oil induce cytochrome P450 1A expression in the Amazonian fish species Colossoma macropomum (Tambaqui). Environ Sci Technol 40(8):2851-8. PMID:16683634
• Merson RR, Franks DG, Karchner SI, Hahn ME. 2006. Development and characterization of polyclonal antibodies against the aryl hydrocarbon receptor protein family (AHR1, AHR2, and AHR repressor) of Atlantic killifish Fundulus heteroclitus. Comp Biochem Physiol C Toxicol Pharmacol 142(1-2):85-94. doi:10.1016/j.cbpc.2005.10.013 PMID:16364694
• Novillo A, Kitana N, Won S, Callard IP. 2006. Comparative environmental endocrinology, genomics and endocrine disruption. In: Proceedings of the 5th Intercongress Symposium of the Asia and Oceania Society for Comparative Endocrinology. Bangkok, Thailand. pp.77-82.
• Ozonoff DM, Pogel A, Hannan T. 2006. Generalized contingency tables and concept lattices. In: Discrete Methods in Epidemiology, DIMACS: Series in Discrete Mathematics and Theoretical Computer Science. American Mathematical Society, Providence, RI. pp.93.
• Puinean AM, Labadie P, Hill EM, Osada M, Kishida M, Novillo A, Callard IP, Rotchell JM. 2006. Laboratory exposure to 17beta-estradiol fails to induce vitellogenin and estrogen receptor gene expression in the marine invertebrate Mytilus edulis. Aquat Toxicol 79(4):376-383. doi:10.1016/j.aquatox.2006.07.006 PMID:16930737
• Sawyer SJ, Gerstner KA, Callard GV. 2006. Development of a real time PCR assay for the differential detection and quantification of cytochrome P450 aromatase isoforms in zebrafish: tissue distribution, sex differences, developmental programming, and estrogen regulation. Gen Comp Endocrinol 147(2):108-117.
• Sawyer SJ, Gerstner KA, Callard GV. 2006. Real-time PCR analysis of cytochrome P450 aromatase expression in zebrafish: gene specific tissue distribution, sex differences, developmental programming, and estrogen regulation. Gen Comp Endocrinol 147(2):108-17. PMID:16458310
• Schlezinger JJ, Emberley JK, Sherr DH. 2006. Activation of multiple mitogen-activated protein kinases in pro/pre-B cells by GW7845, a peroxisome proliferator-activated receptor gamma agonist, and their contribution to GW7845-induced apoptosis. Toxicol Sci 92(2):433-44. PMID:16672323
• Schlezinger JJ, Struntz WD, Goldstone JV, Stegeman JJ. 2006. Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners. Aquat Toxicol 77(4):422-432. PMID:16500718
• Sea Urchin Genome Sequencing Consortium, Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, et al. 2006. The genome of the sea urchin Strongylocentrotus purpuratus. Science 314(5801):941-952. doi:10.1126/science.1133609 PMID:17095691 PMCID:PMC3159423
• Shipley JM, Waxman DJ. 2006. Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methycholanthrene. Toxicol Appl Pharmacol 213(2):87-97. PMID:16257430
• Stavropoulous P, Celenligil-Cetin R, Kiani S, Tapper AE, Pinnapareddy D, Paraskevopoulou P. 2006. lron,bis(pyridine)bis(2-pyridinecarboxylato-N1,O2. In: Encyclopedia of Reagents for Organic Synthesis. John Wiley & Sons, Inc.,
• Stavropoulous P, Qelenligil-Qetin R, Kiani S, Tapper AE, Pinnapareddy D, Paraskevopoulou P. 2006. lron,bis(pyridine)bis(2-pyridinecarboxylato-N1,02). In: Encyclopedia of Reagents for Organic Synthesis. John Wiley & Sons, Inc., pp.414-15.
• Stuchal L, Kleinow KM, Stegeman JJ, James MO. 2006. Demethylation of the pesticide methoxychlor in liver and intestine from untreated, methoxychlor-treated, and 3-methylcholanthrene-treated channel catfish (Ictalurus punctatus): evidence for roles of CYP1 and CYP3A family isozymes. Drug Metab Dispos 34(6):932-8. PMID:16510540
• Tarrant AM, Greytak SR, Callard GV, Hahn ME. 2006. Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness. J Mol Endocrinol 37(1):105-20. PMID:16901928
• Teraoka H, Urakawa S, Nanba S, Nagai Y, Dong W, Imagawa T, Tanguay RL, Svoboda K, Handley-Goldstone HM, Stegeman JJ, Hiraga T. 2006. Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions. Toxicol Appl Pharmacol 212(1):24-34. PMID:16051294
• Verslycke T, Goldstone JV, Stegeman JJ. 2006. Isolation and phylogeny of novel cytochrome P450 genes from tunicates (Ciona spp): a CYP3 line in early deuterostomes?. Mol Phylogenet Evol 40(3):760-771. doi:10.1016/j.ympev.2006.04.017 PMID:16777437
• Vieira VM, Webster TF, Weinberg JM, Aschengrau A. 2006. Temporal-Spatial analysis of breast cancer on upper Cape Cod, Massachusetts. In: Proceedings of the Spatial Epidemiology Conference, 2006. London, United Kingdom. pp.115-119.
• Vieira VM, Webster TF, Weinberg JM, Aschengrau A. 2006. Temporal-spatial analysis of breast cancer risk on upper Cape Cod, Massachusetts, USA. Epidemiology 19:S484.
• Waxman DJ, Chang TK. 2006. Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2 and CYP3 families. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.153-156.
• Waxman DJ, Chang TK. 2006. Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families. Methods Mol Biol 320:153-156. doi:10.1385/1-59259-998-2:153 PMID:14577228
• Webster TF. 2006. Cross-level bias in partially ecologic studies. In: Proceedings of the Spatial Epidemiology Conference, 2006. London, United Kingdom. pp.127-132.
• Webster TF, Vieira VM, Weinberg JM, Aschengrau A. 2006. Method for mapping population-based case-control studies: an application using generalized additive models. Int J Health Geogr 5:26. doi:10.1186/1476-072X-5-26 PMID:16764727 PMCID:PMC1526437
• Webster TF, Weinberg JM, Vieira VM, Hoffman K, Aschengrau A. 2006. The impact of community and individual-level socioeconomic status on the risk of breast cancer: multi-level modeling in Massachusetts. Epidemiology 17(6):S210.
• Abello J, Cormode G, eds. 2006. Discrete Methods in Epidemiology, DIMACS: Series in Discrete Mathematics and Theoretical Computer Science American Mathematical Society, Providence, RI.

2005

• Callard IP, George JS, Koob TJ. 2005. Endocrine Control of the Female Reproductive Tract. Chapter 9 in: The Reproductive Biology and Phylogeny of Chondrichthyes: sharks, batoids and chimaeras. Science Publishers, Enfield, NH. pp.283-300.
• Chang TK, Waxman DJ. 2005. Pregnane X receptor-mediated transcription. Methods Enzymol 400:588-598. doi:10.1016/S0076-6879(05)00033-9 PMID:16399372
• Custodia-Lora N, Novillo A, Callard IP. 2005. Synergistic role for pituitary growth hormone in the regulation of hepatic estrogen and progesterone receptors and vitellogenesis in female freshwater turtles, Chrysemys picta. Gen Comp Endocrinol 140:25-32. PMID:15596068
• Evans BR, Karchner SI, Franks DG, Hahn ME. 2005. Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: structure, function, evolution, and AHR-dependent regulation in vivo. Arch Biochem Biophys 441(2):151-167. doi:10.1016/j.abb.2005.07.008 PMID:16122694
• Garrick RA, Woodin BR, Stegeman JJ. 2005. Cytochrome p4501a induced differentially in endothelial cells cultured from different organs of Anguilla rostrata. In Vitro Cell Dev Biol Anim 41(1-2):57-63. doi:10.1290/0409063.1 PMID:15926861
• Godard-Codding CJ, Goldstone JV, Said MR, Dickerson RL, Woodin BR, Stegeman JJ. 2005. The new vertebrate CYP1C family: cloning of new subfamily members and phylogenetic analysis. Biochem Biophys Res Commun 331(4):1016-1024. PMID:15882979
• Greytak SR, Champlin D, Callard GV. 2005. Isolation and characterization of two cytochrome P450 aromatase forms in killifish (Fundulus heteroclitus): differential expression in fish from polluted and unpolluted environments. Aquat Toxicol 71(4):371-389. doi:10.1016/j.aquatox.2004.12.007 PMID:15710484
• Handley-Goldstone HM, Grow MW, Stegeman JJ. 2005. Cardiovascular gene expression profiles of dioxin exposure in zebrafish embryos. Toxicol Sci 85(1):683-693. PMID:15716485
• Hurst CH, Waxman DJ. 2005. Interactions of endocrine-active environmental chemicals with the nuclear receptor PXR. Toxicol Sci 87:299-311.
• Kumar S, Chen C, Waxman DJ, Halpert JR. 2005. Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide. J Biol Chem 280(20):19569-19575. doi:10.1074/jbc.M500158200 PMID:15774478
• Lash TL, Bradbury BD, Wilk JB, Aschengrau A. 2005. A case-only analysis of the interaction between N-acetyltransferase 2 haplotypes and tobacco smoke in breast cancer etiology. Breast Cancer Research 7(3):R385-R393. PMID:15987434
• Lutton BV, George JS, Murrin CR, Fileti LA, Callard IP. 2005. The Elasmobranch Ovary. Chapter 8 in: The Reproductive Biology and Phylogeny of Chondrichthyes: sharks, batoids and chimaeras. Science Publishers, Enfield, NH. pp.237-82.
• Malins DC, Stegeman JJ, Green VM, Gilman NK, Anderson KM. 2005. Spectral Models for Assessing Exposure of Fish to Contaminants. In: Techniques in Aquatic Toxicology. CRC Press, Inc., Boca Raton, FL. pp.537-545.
• Novillo A, Kitana N, Marquez E, Callard IP. 2005. Genotoxicity in repiles. In: New Perspectives: Toxicology and the Environment. Taylor and Francis, London, England. pp.241-166.
• Novillo A, Won S, Li C, Callard IP. 2005. Changes in nuclear receptor and vitellogenin gene expression in response to steroids and heavy metal in Caenorhabditis elegans. Integr Comp Biol 45:61-71. PMID:21676746
• Ozonoff A, Webster TF, Vieira VM, Weinberg JM, Ozonoff DM, Aschengrau A. 2005. Cluster detection methods applied to the Upper Cape Cod cancer data. Environ Health 4:19. doi:10.1186/1476-069X-4-19 PMID:16164750 PMCID:PMC1242352
• Ozonoff DM. 2005. On being careful what we wish for: some difficulties with operationalizing the precautionary principle (Reprinted from the European Journal of Oncology Library, vol 2, 2003). Human and Ecological Risk Assessment: An International Journal 11(1):53-62.
• Rie MT, Kitana N, Lendas KA, Won S, Callard IP. 2005. Reproductive endocrine disruption in a sentinel species (Chrysemys picta) on Cape Cod, Massachusetts. Arch Environ Contam Toxicol 48(2):217-224. PMID:15719200
• Ryu H, Emberley JK, Schlezinger JJ, Allan LL, Na S, Sherr DH. 2005. Environmental chemical-induced bone marrow B cell apoptosis: death receptor-independent activation of a caspase-3 to caspase-8 pathway. Mol Pharmacol 68(4):1087-1096. PMID:16014577
• Scammell MK. 2005. Roots of community research: primer on the legacy of participatory research partnerships. Race, Poverty & The Environment XINo.2:
• Sheu S, Kaya T, Waxman DJ, Vajda S. 2005. Exploring the binding site structure of the PPAR gamma ligand-binding domain by computational solvent mapping. Biochemistry 44(4):1193-1209. doi:10.1021/bi048032c PMID:15667213
• Sheu S, Lancia DR, Clodfelter KH, Landon MR, Vajda S. 2005. PRECISE: a database of predicted and consensus interaction sites in enzymes. Nucleic Acids Res 33(Databaseissue):D206-D211. doi:10.1093/nar/gki091 PMID:15608178 PMCID:PMC540045
• Stavropoulous P, Celenligil-Cetin R, Kiani S, Tapper AE, Pinnapareddy D, Paraskevopoulou P. 2005. Gif Reactions. Chapter 2.1.1 in: Handbook of C-H Transformations: Applications in Organic Synthesis, Two Volumes. Wiley-VCH, Weinheim, Germany. pp.497-507.
• Timme-Laragy AR, Meyer JN, Waterland RA, Di Giulio RT. 2005. Analysis of CpG methylation in the killifish CYP1A promoter. Comp Biochem Physiol C Toxicol Pharmacol 141(4):406-411. PMID:16257583
• Vieira VM, Aschengrau A, Ozonoff DM. 2005. Impact of tetrachloroethylene-contaminated drinking water on the risk of breast cancer: using a dose model to assess exposure in a case-control study. Environ Health 4(1):3. doi:10.1186/1476-069X-4-3 PMID:15733317 PMCID:PMC554766
• Vieira VM, Webster TF, Weinberg JM, Aschengrau A. 2005. Spatial analysis of low birth weight on Cape Cod, MA using generalized additive modeling. Epidemiology 16(5):S104.
• Vieira VM, Webster TF, Weinberg JM, Aschengrau A, Ozonoff DM. 2005. Spatial analysis of lung, colorectal, and breast cancer on Cape Cod: an application of generalized additive models to case-control data. Environ Health 4:11. doi:10.1186/1476-069X-4-11 PMID:15955253 PMCID:PMC1183231
• Webster TF, Vieira VM. 2005. Negative confounding in spatial epidemiology: an example from breast cancer. Epidemiology 16(5):S105-S106.
• Won S, Novillo A, Custodia N, Rie MT, Fitzgerald K, Osada M, Callard IP. 2005. The fresh water mussel (Elliptic complanata) as a sentinel species: vitellogenin and steroid receptors. Integr Comp Biol 45:72-80.
• Yang X, Liu D, Murray TJ, Mitchell GC, Hesterman EV, Karchner SI, Merson RR, Hahn ME, Sherr DH. 2005. The aryl hydrocarbon receptor constitutively represses c-myc transcription in human mammary tumor cells. Oncogene 24(53):7869-7881. doi:10.1038/sj.onc.1208938 PMID:16091746

2004

• Ahluwalia A, Clodfelter KH, Waxman DJ. 2004. Sexual dimorphism of rat liver gene expression: Regulatory role of growth hormone revealed by deoxyribonucleic acid microarray analysis. Mol Endocrinol 18(3):747-760. PMID:14684848
• Brody JG, Aschengrau A, McKelvey W, Rudel RA, Swartz CH, Kennedy T. 2004. Breast cancer risk and historical exposure to pesticides from wide-area applications assessed with GIS. Environ Health Perspect 112(8):889-897. PMID:15175178
• Clodfelter KH, Waxman DJ. 2004. Computational solvent mapping reveals major differences in substrate binding between bacterial and mammalian cytochrome. In: Proceedings of the New England Member Enzyme Conference.
• Comeau SR, Gatchell DW, Vajda S, Camacho CJ. 2004. ClusPro: A fully automated algorithm for protein-protein docking. Nucleic Acids Res 32:W96-W99. PMID:15215358
• Comeau SR, Gatchell DW, Vajda S, Camacho CJ. 2004. ClusPro: An automated docking and discrimination method for the prediction of protein complexes. Bioinformatics 20(1):45-50. PMID:14693807
• Custodia-Lora N, Novillo A, Callard IP. 2004. Effect of gonadal steroids on progesterone receptor, estrogen receptor, and vitellogenin expression in male turtles (Chrysemys picta). J Exp Zool 301A(1):15-25. PMID:14695685
• Custodia-Lora N, Novillo A, Callard IP. 2004. Regulation of hepatic progesterone and estrogen receptors in the female turtle, Chrysemys picta: relationship to vitellogenesis. Gen Comp Endocrinol 136(2):232-240. PMID:15028527
• Dong W, Teraoka H, Tsujimoto Y, Stegeman JJ, Hiraga T. 2004. Role of aryl hydrocarbon receptor in mesencephalic circulation failure and apoptosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 77(1):109-116. PMID:14657521
• Hahn ME, Karchner SI, Franks DG, Merson RR. 2004. Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus). Pharmacogenet Genomics 14(2):131-143. PMID:15077014
• Hurst CH, Waxman DJ. 2004. Environmental phthalate monoesters activate pregnane X receptor-mediated transcription. Toxicol Appl Pharmacol 199(3):266-274. PMID:15364542
• Malins DC, Stegeman JJ, Anderson JW, Johnson PM, Gold J, Anderson KM. 2004. Structural changes in gill DNA reveal the effects of contaminants on Puget Sound fish. Environ Health Perspect 112(5):511-515. PMID:15064153
• Powell WH, Morrison HG, Weil EJ, Karchner SI, Sogin ML, Stegeman JJ, Hahn ME. 2004. Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus). Mar Environ Res 58(2-5):119-124. PMID:15178023
• Prasad JC, Vajda S, Camacho CJ. 2004. Consensus alignment server for reliable comparative modeling with distant templates. Nucleic Acids Res 32:W50-W54. PMID:15215349
• Schlezinger JJ, Howard G, Hurst CH, Emberley JK, Waxman DJ, Webster TF, Sherr DH. 2004. Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: Interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-Deoxy-Delta(12,14)-prostaglandin J(2). J Immunol 173(5):3165-3177. PMID:15322177
• Shipley JM, Waxman DJ. 2004. Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b. Toxicol Appl Pharmacol 199(3):275-284. PMID:15364543
• Su T, Waxman DJ. 2004. Impact of dimethyl sulfoxide on expression of nuclear receptors and drug-inducible cytochromes P450 in primary rat hepatocytes. Arch Biochem Biophys 424(2):226-234. doi:10.1016/j.abb.2004.02.008 PMID:15047195
• Zodrow JM, Stegeman JJ, Tanguay RL. 2004. Histological analysis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in zebrafish. Aquat Toxicol 66(1):25-38. PMID:14687977

2003

• Allan LL, Mann KK, Matulka RA, Ryu H, Schlezinger JJ, Sherr DH. 2003. Bone marrow stromal-B cell interactions in polycyclic aromatic hydrocarbon-induced pro/pre-B cell apoptosis. Toxicol Sci 76(2):357-365. PMID:14514961
• Aschengrau A, Rogers S, Ozonoff DM. 2003. Perchloroethylene-contaminated drinking water and the risk of breast cancer: additional results from Cape Cod, Massachusetts, USA. Environ Health Perspect 111(2):167-173. PMID:12573900
• Carnell AN, Goodman JI, Abriola LM. 2003. The long (LINEs) and the short (SINEs) of it: altered methylation as a precursor to toxicity. Toxicol Sci 65:229-235. PMID:12773759
• Chen Y, Su HJ, Guo YL, Hsueh Y, Ryan LM, Lee M, Christiani DC. 2003. Arsenic methylation and bladder cancer risk in Taiwan. Cancer Causes Control 14(4):303-310. PMID:12846360
• Collier JM, Selmin O, Johnson PD, Runyan RB. 2003. Trichloroethylene effects on gene expression during cardiac development. Birth Defects Res A Clin Mol Teratol 67(7):488-495. doi:10.1002/bdra.10073 PMID:14565619
• Custodia-Lora N, Callard IP. 2003. Effects of gonadal steroids on progesterone receptor mRNA and progesterone receptor, estrogen receptor mRNA and vitellogenin mRNA and vitellogenin. Gen Comp Endocrinol
• Goldstone JV, Stegeman JJ. 2003. Quantification of ROS Production and Enzyme Inactivation of CYP 1A by Polychlorinated Biphenyls and by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
• Henderson PT, Delaney JC, Muller JG, Neeley WL, Tannenbaum SR, Burrows CJ, Essigmann JM. 2003. The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo. Biochemistry 42(31):9257-9262. doi:10.1021/bi0347252 PMID:12899611
• Hurst CH, Waxman DJ. 2003. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci 74(2):297-308. doi:10.1093/toxsci/kfg145 PMID:12805656
• Jahnavi C, Prasad JC. 2003. Differences in Substrate Binding Between Mammalian and Fish Cytochrome P450 1As Predicted by Comparative Modeling and Flexible Docking. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
• Kortvelyesi T, Dennis S, Silberstein S, Brown L, Vajda S. 2003. Algorithms for computational solvent mapping of proteins. Proteins: Structure, Function, and Genetics 51(3):340-351. PMID:12696046
• Kortvelyesi T, Silberstein M, Dennis S, Vajda S. 2003. Improved mapping of protein binding sites. J Comput Aided Mol Des 17(2-4):173-186. PMID:13677484
• McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC. 2003. Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family. J Mol Evol 57(2):200-211. doi:10.1007/s00239-003-2466-x PMID:14562963
• Meyer JN, Wassenberg DM, Karchner SI, Hahn ME, Di Giulio RT. 2003. Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environ Toxicol Chem 22(10):2337-2343. PMID:14551997
• Monk SA, Denison MS, Rice RH. 2003. Reversible stepwise negative regulation of CYP1A1 in cultured rat epidermal cells. Arch Biochem Biophys 419(12):158-169. PMID:14592459
• Morrison A, Stegeman JJ. 2003. In Vitro Assessment of CYP51 Azole Sensitivity in Fish: Dos Upregulation of CYP1A Protect the CYP51?. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
• Oleksiak MF, Wu S, Parker C, Qu W, Cox RL, Zeldin DC, Stegeman JJ. 2003. Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. Arch Biochem Biophys 411(2):223-234. PMID:12623071
• Ozonoff DM. 2003. Superfund Basic Research Program: a model for contemporary research programs. Environ Health Perspect 111(3):A140-A141. PMID:12611669
• Prasad JC, Comeau SR, Vajda S, Camacho CJ. 2003. Consensus alignment for reliable framework prediction in homology modeling. Bioinformatics 19(13):1682-1691. PMID:12967965
• Prasad JC, Silberstein M, Camacho CJ, Vajda S. 2003. Homology modeling of proteins using multiple models and consensus sequence alignment. Lecture Notes in Bioinformatics 2812:389-401.
• Prasad JC, Vajda S, Goldstone JV, Camacho CJ, Stegeman JJ. 2003. Differences in Substrate Binding Between Mammalian and Fish Cytochrome P450 1As Predicted by Comparative Modeling and Flexible Docking. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
• Prasch AL, Teraoka H, Carney SA, Dong W, Hiraga T, Stegeman JJ, Heideman W, Peterson RE. 2003. Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish. Toxicol Sci 76(1):138-150. PMID:12883077
• Ryu H, Mann KK, Schlezinger JJ, Jensen B, Sherr DH. 2003. Environmental chemical-induced pro/pre-B cell apoptosis: analysis of c-Myc, p27(Kipl), and p21(WAF1) reveals a death pathway distinct from clonal deletion. J Immunol 170(10):4897-4907. PMID:12734332
• Shipley JM, Waxman DJ. 2003. Down-regulation of STAT5b transcriptional activity by ligand-activated peroxisome proliferator-activated receptor (PPAR) alpha and PPAR gamma. Mol Pharmacol 64(2):355-364. PMID:12869640
• Silberstein M, Dennis S, Brown L, Kortvelyesi T, Clodfelter KH, Vajda S. 2003. Identification of substrate binding sites in enzymes by computational solvent mapping. J Mol Biol 332(5):1095-1113. doi:10.1016/j.jmb.2003.08.019 PMID:14499612
• Su T, Waxman DJ. 2003. Impact of dimethyl sulphoxide on expression of nuclear receptors and drug-inducible cytochromes P450 (CYPs) in primary rat hepatocytes. FASEB J 17(4):A240-A240Part1Suppl..
• Takai Y, Canning J, Perez GI, Pru JK, Schlezinger JJ, Sherr DH, Kolesnick RN, Yuan J, Flavell RA, Korsmeyer SJ, Tilly JL. 2003. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. Endocrinology 144(1):69-74. PMID:12488331
• Teraoka H, Dong W, Tsujimoto Y, Iwasa H, Endoh D, Ueno N, Stegeman JJ, Peterson RE, Hiraga T. 2003. Induction of cytochrome P450 1A is required for circulation failure and edema by 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish. Biochem Biophys Res Commun 304(2):223-228. PMID:12711302
• Waxman DJ. 2003. Nuclear receptor regulation of drug-metzbolizing P450 enzymes. In: Encyclopedia Reference of Molecular Pharmacology. Springer-Verlag Press,
• Webster TF, Sherr DH. 2003. Types of AhREs and their Implications. Organohalogen Compounds 65:106-109.
• Webster TF, Vieira VM, Weinberg JM, Aschengrau A. 2003. Spatial Analysis of Lung, Breast and Colorectal Cancer Using Generalized Additive Models. In: Proceedings of the EUROHEIS-SAHSU (European Health and Environment Information System-Small Area Health Statistics Unit) Conference 2003. Small Area Health Statistics Unit. Imperial College, London, England.
• Zhang Q, Salnikow K, Kluz T, Chen L, Su W, Costa M. 2003. Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. Toxicol Appl Pharmacol 192(3):201-211. PMID:14575637
• Zhou HZ, Randes-Pehrson G, Geard CR, Brenner DJ, Hall EJ, Hei TK, Ahmed KM. 2003. Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiation Research 160(5):512-516. PMID:14565832 PMCID:PMC4041543

2002

• Ahluwalia A, Waxman DJ. 2002. Global gene expression profiling in rat liver using oligonucleotide microarrays: evaluation of the regulatory role of hormones and xenobiotics. In: New England Drug Metabolism Discussion Group Summer Symposium. Worcester, MA.
• Andreasen EA, Spitsbergen JM, Tanguay RL, Stegeman JJ, Heideman W, Peterson RE. 2002. Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Toxicol Sci 68(2):403-419. PMID:12151636
• Baader M, Gnerre C, Stegeman JJ, Meyer UA. 2002. Transcriptional activation of cytochrome P-450 CYP2C45 by drugs is mediated by the chicken xenobiotic receptor CXR interacting with a phenobarbital-response enhancer unit. J Biol Chem 277(18):15647-15653. PMID:11867618
• Bard SM, Bello SM, Hahn ME, Stegeman JJ. 2002. Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics. Aquat Toxicol 59(3-4):237-251. PMID:12127740
• Bard SM, Woodin BR, Stegeman JJ. 2002. Expression of P-glycoprotein and cytochrome p450 1A in intertidal fish (Anoplarchus purpurescens) exposed to environmental contaminants. Aquat Toxicol 60(1-2):17-32. PMID:12204584
• Custodia-Lora N, Callard IP. 2002. Progesterone and progesterone receptors in reptiles. Gen Comp Endocrinol 127:1-7. PMID:12161195
• Custodia-Lora N, Callard IP. 2002. Seasonal changes in hepatic progesterone receptor mRNA, estrogen receptor mRNA, and vitellogenin mRNA in the painted turtle, Chrysemys picta. Gen Comp Endocrinol 128:193-204. PMID:12392693
• Dennis S, Kortvelyesi T, Vajda S. 2002. Computational mapping identifies the binding sites of organic solvents on proteins. Proc Natl Acad Sci U S A 99(7):4290-4295. PMID:11904374
• Dennis S, Kortvelyesi T, Vajda S. 2002. Computational solvent mapping for the analysis of enzyme active sites. Abstr Pap Am Chem Soc 224:221-COMPPart1.
• Duggan AE, Marie RS, Callard IP. 2002. Expression of SR-BI (Scavenger Receptor Class B Type I) in turtle (Chrysemys picta) tissues and other nonmammalian vertebrates. J Exp Zool 292(5):430-434. PMID:11857477
• Goss KA, Clodfelter KH, Waxman DJ. 2002. Understanding P450 structure-function relationships using DNA shuffling mutagenesis. In: Boston University-Humboldt University Bioinformatics Workshop, Boston, MA.
• Hoyer AP, Gerdes AM, Jorgensen T, Rank F, Hartvig HB. 2002. Organochlorines, p53 mutations in relation to breast cancer risk and survival. A Danish cohort-nested case-controls study. Breast Cancer Res Treat 71(1):59-65. PMID:11859874
• Iwata H, Yoshinari K, Negishi M, Stegeman JJ. 2002. Species-specific responses of constitutively active receptor (CAR)-CYP2B coupling: lack of CYP2B inducer-responsive nuclear translocation of CAR in marine teleost, scup (Stenotomus chrysops). Comp Biochem Physiol C Toxicol Pharmacol 131(4):501-510. PMID:11976065
• Karchner SI, Franks DG, Powell WH, Hahn ME. 2002. Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2. J Biol Chem 277(9):6949-6959. doi:10.1074/jbc.M110779200 PMID:11742002
• Lash TL, Aschengrau A. 2002. A null association between active or passive cigarette smoking and breast cancer risk. Breast Cancer Res Treat 75(2):181-184. PMID:12243511
• Nicholls J, Lasley BL, Nakajima ST, Setchell KD, Schneeman BO. 2002. Effect of soy consumption on gonadotropin secretion and acute pituitary response to GnRH in women. J Nutr 132:708-714. PMID:11925465
• Paulu C, Aschengrau A, Ozonoff DM. 2002. Exploring associations between residential location and breast cancer incidence in a case-control study. Environ Health Perspect 110(5):471-478. PMID:12003750
• Powell WH, Hahn ME. 2002. Identification and functional characterization of hypoxia-inducible factor 2alpha from the estuarine teleost, Fundulus heteroclitus: interaction of HIF-2alpha with two ARNT2 splice variants. J Exp Zool 294(1):17-29. PMID:11932946
• Schlezinger JJ, Jensen B, Mann KK, Ryu H, Sherr DH. 2002. Peroxisome proliferator-activated receptor gamma-mediated NF-kappa B activation and apoptosis in pre-B cells. J Immunol 169(12):6831-6841. PMID:12471115
• Vieira VM, Webster TF, Aschengrau A, Ozonoff DM. 2002. A method for spatial analysis of risk in a population-based case-control study. Int J Hyg Environ Health 205(1-2):115-120. PMID:12018004
• Webster TF. 2002. Commentary: Does the specter of ecologic bias haunt epidemiology?. Int J Epidemiol 31:161-162. PMID:11914313
• Yamazaki K, Teraoka H, Dong W, Stegeman JJ, Hiraga T. 2002. cDNA cloning and expressions of cytochrome P450 1A in zebrafish embryos. J Vet Med Sci 64(9):829-833. PMID:12399609
• Zhou Y, Davey HW, McLachlan MJ, Xie T, Waxman DJ. 2002. Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of transcription signaling pathways. Toxicol Appl Pharmacol 182(1):1-10. PMID:12127257

2001

• Bello SM, Franks DG, Stegeman JJ, Hahn ME. 2001. Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: in vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes. Toxicol Sci 60(1):77-91. PMID:11222875
• Callard GV, Tchoudakova AV, Kishida M, Wood E. 2001. Differential tissue distribution, developmental programming, estrogen regulation and promoter characteristics of cyp19 genes in teleost fish. Psychiatr Pol 79(1-5):305-314. PMID:11850237
• Custodia N, Won S, Novillo A, Wieland M, Li C, Callard IP. 2001. Caenorhabditis elegans as an environmental monitor using DNA microarray analysis. Ann N Y Acad Sci 948:32-42. PMID:11795393
• Duggan AE, Paolucci M, Tercyak A, Gigliotti M, Small D, Callard IP. 2001. Seasonal variation in plasma lipids, lipoproteins, apolipoprotein A-I and vitellogenin in the freshwater turtle, Chrysemys picta. Comp Biochem Physiol 130(2):253-269. PMID:11544071
• Hahn ME. 2001. Dioxin toxicology and the aryl hydrocarbon receptor: insights from fish and other non-traditional models. Mar Biotechnol (NY) 3:S224-S238. PMID:14961319
• Handley H, Grow MW, Fishman MC, Stegeman JJ. 2001. Broad-scale characterization of gene expression patterns associated with embryonic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 60(1):1604S.
• Huang Y, Stegeman JJ, Woodin BR, Karasov WH. 2001. Immunohistochemical localization of cytochrome P450 1A induced by 3,3',4,4',5-pentachlorobiphenyl (PCB126) in multiple organs of the northern leopard frog Rana pipiens. Environ Toxicol Chem 20(1):191-197.
• Kishida M, Callard GV. 2001. Distinct cytochrome P450 aromatase isoforms in zebrafish (Danio rerio) brain and ovary are differentially programmed and estrogen regulated during early development. Endocrinology 142(2):740-750. doi:10.1210/endo.142.2.7928 PMID:11159846
• Kishida M, McLellan M, Miranda JA, Callard GV. 2001. Estrogen and xenoestrogens upregulate the brain aromatase isoform (P450aromB) and perturb markers of early development in zebrafish (Danio rerio). Comp Biochem Physiol 129(2-3):261-268. PMID:11399458
• Mann KK, Doerre S, Schlezinger JJ, Sherr DH, Quadri SA. 2001. The role of NF-kB as a survival factor in environmental chemical-induced preB cell apoptosis. Mol Pharmacol 59(2):302-309. PMID:11160867
• Matikainen T, Perez GI, Jurisicova A, Pru JK, Schlezinger JJ, Ryu H, Laine J, Sakai T, Korsmeyer SJ, Casper RF, Sherr DH, Tilly JL. 2001. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nat Genet 28(4):355-360. PMID:11455387
• Morabia A, Lash TL, Aschengrau A. 2001. Passive cigarette smoking and breast cancer. In: Environmental tobacco smoke: toxicity, treatment and prevention. CRC Press, Boca Raton, FL.
• Rie MT, Lendas KA, Callard IP. 2001. Cadmium: Tissue distribution and binding protein induction in the painted turtle, Chrysemys picta. Comp Biochem Physiol 130(1):41-51. PMID:11544142
• Shideler SE, Gee NA, Laughlin LS, Lasley BL. 2001. Estrogen and progesterone metabolites and follicle-stimulating hormone in the aged macaque female. Biol Reprod 65(6a0:1718-1725. PMID:11717133
• Stavropoulos P, Celenligil-Cetin R, Tapper AE. 2001. The gif paradox. Accounts of Chemical Research 34(9):745-752. PMID:11560474
• Tchoudakova AV, Kishida M, Wood E, Callard GV. 2001. Promoter characteristics of two cyp19 genes differentially expressed in the brain and ovary of teleost fish. Psychiatr Pol 78(5):427-439. PMID:11738553
• Toomey BH, Bello SM, Hahn ME, Cantrell S, Wright P, Tillitt DE, Di Giulio RT. 2001. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquat Toxicol 53(2):127-138. PMID:11311389
• Verbrugge LA, Giesy JP, Verbrugge DA, Woodin BR, Stegeman JJ. 2001. Catalytic and immunochemical properties of hepatic cytochrome P450 1A in three avian species treated with beta-naphthoflavone or isosafrole. Comp Biochem Physiol C Toxicol Pharmacol 130(1):67-83. doi:10.1016/S1532-0456(01)00221-6 PMID:11544144
• Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM. 2001. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci U S A 98(6):3375-3380. PMID:11248086
• Zhao J, Mak P, Tchoudakova AV, Callard GV, Chen S. 2001. Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatatase isozymes. Gen Comp Endocrinol 123(2):180-191. PMID:11482939

2000

• Betka M, Welenc A, Franks DG, Hahn ME, Callard GV. 2000. Characterization of two aryl hydrocarbon receptor (AHR) mRNA forms in Squalus acanthias and stage-dependent expression during spermatogenesis. Bull Mt Desert Isl Biol Lab Salisb Cove Maine 39:65-67.
• Callard GV, Wang C. 2000. PCR-Differential display identifies a subset of stage-dependent and cadmium-regulated mitochondrial genes during spermatogenesis. In: Proceedings of the International Symposium on Hormones & Endocrine Disruptors in Food and Water: Possible Effects on Human Health. Copenhagen, Denmark.
• Callard IP. 2000. C.elegans as a model for environmental change. In: Proceedings of "e. hormone 2000". New Orleans, LA.
• Callard IP. 2000. Field and laboratory studies of endocrine disruption by heavy metals in wildlife species. In: Proceedings of the Gordon Research Conference on "Environmental Endocrine Disrupters".
• Callard IP, Li C, Won S. 2000. Caenorhabditis elegans as a potential bioindicator species for xenobiotics. In: Proceedings of the Workshop on "Endocrine Disrupters in Food and Water: Possible impact on human health". Copenhagen, Denmark. pp.30.
• Callard IP, Rie MT. 2000. Assessment of the effects of groundwater pollution on a sentinel species, Chrysemys picta, on Cape Cod: tissue contaminant levels and hepatic and reproductive bioindicators. In: Proceedings of the Workshop on "Endocrine Disrupters in Food and Water: Possible impact on human health". Copenhagen, Denmark. pp.29.
• Celenligil-Cetin R, Staples RJ, Stavropoulos P. 2000. Synthesis, characterization, and reactivity of ferrous and ferric oxo/peroxo pivalate complexes in relation to Gif-type oxygenation of substrates. Inorg Chem 39(25):5838-5846. PMID:11151387
• Custodia N, Callard IP. 2000. The turtle hepatic progesterone receptor: expression and potential role in the regulation of vitellogenin gene expression. In: Proceedings of the 11^th International Congress of Endocrinology, 2000.
• Custodia N, Won S, Novillo A, Li C, Callard IP. 2000. Potential use of cultured C. elegans as a test system for xenobiotics. In: Proceedings of the Superfund Basic Research Program Conference: "Oxidative Processes: Stress to Remediation". Chapel Hill, NC. pp.18.
• Godard-Codding CJ, Leaver MJ, Said MR, Dickerson RL, George S, Stegeman JJ. 2000. Identification of cytochrome P450 1B-like sequences in two teleost fish species (scup, Stenotomus chrysops and plaice, Pleuronectes platessa) and in a cetacean (striped dolphin, Stenella coeruleoalba). Mar Environ Res 50(1-5):7-10. PMID:11460754
• Hoyer AP, Grandjean P, Jorgensen T, Brock JW, Hartvig HB. 2000. Organochlorine exposure and breast cancer (in Danish). Ugeskr Laeger 162:922-926.
• Hoyer AP, Jorgensen T, Brock JW, Grandjean P. 2000. Organochlorine exposure and breast cancer survival. J Clin Epidemiol 53(3):323-330. PMID:10760644
• Iwata H, Stegeman JJ. 2000. In situ RT-PCR detection of CYP1A mRNA in pharyngeal epithelium and chondroid cells from chemically untreated fish: involvement in vertebrate craniofacial skeletal development?. Biochem Biophys Res Commun 271(1):130-137. doi:10.1006/bbrc.2000.2543 PMID:10777692
• Karchner SI, Kennedy SW, Trudeau S, Hahn ME. 2000. Towards molecular understanding of species differences in dioxin sensitivity: initial characterization of Ah receptor cDNAs in birds and an amphibian. Mar Environ Res 50(1-5):51-56. PMID:11460741
• Kiani S, Tapper AE, Staples RJ, Stavropoulos P. 2000. Functional aspects of Gif-type oxidation of hydrocarbons mediated by iron picolinate H2O2-dependent systems: Evidence for the generation of carbon- and oxygen-centered radicals. J Am Chem Soc 122(31):7503-7517.
• Kim DW, Gazourian L, Quadri SA, Romieu-Mourez R, Sherr DH, Sonenshein GE. 2000. The RelA NF-kappaB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells. Oncogene 19(48):5498. PMID:11114727
• Lash TL, Aschengrau A. 2000. Alcohol drinking and risk of breast cancer. Breast J 6(6):396-399. PMID:11348398
• Novak CM, Nunez AA. 2000. A sparse projection from the suprachiasmatic nucleus to the sleep active ventrolateral preoptic area in the rat. Neuroreport 11(1):93-96. PMID:10683837
• Novak CM, Smale L, Nunez AA. 2000. Rhythms in Fos expression in brain areas related to the sleep-wake cycle in the diurnal Arvicanthis niloticus. Am J Physiol Regul Integr Comp Physiol 278(5):R1267-R1274. PMID:10801296
• Oleksiak MF, Wu S, Parker C, Zeldin DC. 2000. Identification, functional characterization, and regulation of a new cytochrome P450 subfamily, the CYP2Ns. J Biol Chem 275(4):2312-2321. PMID:10644680
• Powell WH, Bright R, Bello SM, Hahn ME. 2000. Developmental and tissue-specific expression of AHR1, AHR2, and ARNT2 in dioxin-sensitive and -resistant populations of the marine fish, Fundulus heteroclitus. Toxicol Sci 57(2):229-239. PMID:11006353
• Powell WH, Hahn ME. 2000. The evolution of aryl hydrocarbon signaling proteins: diversity of ARNT isoforms among fish species. Mar Environ Res 50(1-5):39-44. PMID:11460724
• Quadri SA, Qadri AN, Hahn ME, Mann KK, Sherr DH. 2000. The bioflavonoid galangin blocks aryl hydrocarbon receptor (AhR) activation and polycyclic aromatic hydrocarbon-induced Pre-B cell apoptosis. Mol Pharmacol 58:515-525. PMID:10953044
• Rie MT, Lendas KA, Woodin BR, Stegeman JJ, Callard IP. 2000. Hepatic biotransformation enzymes in a sentinel species, the painted turtle (Chrysemys picta), from Cape Cod, Massachusetts: seasonal-, sex- and location related differences. Biomarkers 5(5):382-394. doi:10.1080/135475000424384 PMID:23886024
• Rie MT, Lendas KA, Woodin BR, Stegeman JJ, Callard IP. 2000. Multiple bioindicators of environmental pollution in a sentinel species, Chrysemys picta, on Cape Cod,MA. Mar Environ Res 50(1):436-437.
• Robles R, Morita Y, Mann KK, Perez GI, Yang S, Matikainen T, Sherr DH, Tilly JL. 2000. The aryl hydrocarbon receptor, a basic helix-loop-helix transcription factor of the PAS gene family, is required for normal ovarian germ cell dynamics in the mouse. Endocrinology 141(1):450-453. PMID:10614669
• Schlezinger JJ, Blickarz CE, Mann KK, Doerre S, Stegeman JJ. 2000. Identification of NF-kB in the marine fish Stenotomus chrysops and examination of its activation by aryl hydrocarbon receptor agonists. Chem Biol Interact 126(2):137-157. PMID:10862814
• Schlezinger JJ, Keller J, Verbrugge LA, Stegeman JJ. 2000. 3,3',4,4'-Tetrachlorobiphenyl oxidation in fish, bird and reptile species: relationship to cytochrome P450 1A inactivation and reactive oxygen production. Comp Biochem Physiol C Toxicol Pharmacol 125(3):273-286. PMID:11790349
• Schlezinger JJ, Stegeman JJ. 2000. Dose and inducer-dependent induction of cytochrome P450 1A in endothelia of the eel, including in the swimbladder rete mirabile, a model microvascular structure. Drug Metab Dispos 28(6):701-708. PMID:10820144
• Schlezinger JJ, Stegeman JJ. 2000. Induction of cytochrome P450 1A in the American Eel by model halogenated and non-halogenated aryl hydrocarbon receptor agonists. Aquat Toxicol 50(4):375-386. PMID:10967399
• Tapper AE, Long JR, Staples RJ, Stavropoulos P. 2000. Oxygenation of hydrocarbons mediated by mixed-valent basic iron trifluoroacetate and valence-separated component species under Gif-type conditions involves carbon- and oxygen-centered radicals. Angew Chem Int Ed Engl 39(13):2343-2346. PMID:10941085
• Toomey BH, Bello SM, Hahn ME, Cantrell S, Wright P, Tillitt DE, Di Giulio RT. 2000. TCDD induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquat Toxicol
• Trombino AF, Near RI, Matulka RA, Yang S, Hafer LF, Toselli P, Kim DW, Rogers AE, Sonenshein GE, Sherr DH. 2000. Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcription in a rat model of mammary tumorigenesis. Breast Cancer Res Treat 63(2):117-131. PMID:11097088
• Waxman DJ. 2000. Receptor-mediated signaling events in cytochrome P450 gene regulation. In: Proceedings of the Early Toxicity Screening in Drug Discovery Conference.
• Webster TF. 2000. Bias in ecologic and semi-individual studies. D.Sc. Thesis. Boston University.
• Webster TF. 2000. Bias magnification in ecologic studies. In: Proceedings of the International Society for Environmental Epidemiology. Buffalo, NY.
• Webster TF. 2000. Can semi-individual studies have ecologic bias?. In: Proceedings of the International Society for Environmental Epidemiology. Buffalo, NY.

1999

• Bello SM. 1999. Characterization of resistance to halogenated aromatic hydrocarbons in a population of Fundulus heteroclitus from a marine Superfund site. Ph.D. Thesis, Woods Hole Oceanographic Institution / Massachusetts Institute of Technology.
• Betka M, Callard GV. 1999. Stage-dependent accumulation of cadmium and induction of metallothionein-like binding activity in the testis of the dogfish shark Squalus acanthias. Biol Reprod 60(1):14-22. PMID:9858481
• Betka M, Welenc A, Hahn ME, Callard GV. 1999. Stage-related distribution of two arylhydrocarbon receptor (AhR) mRNA variants and differential effects of Ah ligands on cell proliferation and death during spermatogenesis in the spiny dogfish shark (Squalus acanthias). In: Proceedings of the 1999 SETAC (Society of Environmental Toxcology and Chemistry) Annual Meeting.
• Black VH, Shaw PM, Karchner SI, Powell WH, Hahn ME. 1999. Differential expression of CYP1A1 and CYP1A2, but not AHR or ARNT, in guinea pig adrenal and liver. Endocr Res 24:631-632.
• Callard GV, Callard IP. 1999. Spermatogenesis in subavian vertebrates. In: Encyclopedia of Reproduction, Vol 4. Academic Press, pp.563-570.
• Callard GV, McClusky LM, Betka M. 1999. Stage-specific effects of hormones and spermatotoxicants on germ cell proliferation and death: the shark testis model. In: Proceedings of the Symposium on Endocrine Disruptors. 5th International Congress Physiology Biochemistry Calgary. Calgary, Canada.
• Callard GV, Wang C, Sikora R, Betka M. 1999. In vivo effects of cadmium on the estrogen signaling pathway during spermatogenesis. In: Proceedings of the Symposium on Estrogens in the Environment. New Orleans, LA.
• Custodia N, Won S, Callard IP. 1999. A cDNA from the freshwater mussel (Elliptio complanata) with homology to vertebrate steroid receptors. In: Proceedings of the Symposium on Environmental Hormones. Tulane University, New Orleans, LA.
• Elskus AA, Monosson E, McElroy AE, Stegeman JJ, Woltering DS. 1999. Altered CYP1A expression in Fundulus heteroclitus adults and larvae: a sign of pollutant resistance?. Aquat Toxicol 45(2-3):99-113.
• Gensemer RW, Dixon DG, Greenberg BM. 1999. Using chlorophyll fluorescence induction to detect the onset of anthracene photoinduced toxicity in Lemna gibba, and the mitigating effects of humic acid. Limnology and Oceanography 44(3,Part2):878-888.
• Karchner SI, Powell WH, Hahn ME. 1999. Structural and functional characterization of two highly divergent aryl hydrocarbon receptors (AHR1 and AHR2) in the teleost Fundulus heteroclitus. Evidence for a novel class of ligand-binding basic helix-loop-helix Per-ARNT-Sim (bHLH-PAS) factors. J Biol Chem 274:33814-33824.
• Kleinow KM, Doi AM, Smith AA. 1999. Distribution of C219 detectable P-glycoprotein transporter in the catfish. In: Proceedings of the PRIMO Meeting.
• Ma W, Kamdem P, Loconto PR, Pan Y, Gage DM, Dawson-Andoh BE. 1999. Characterization and bioremediation of birch condensate. Wood and Fiber Science 31(4):370-375.
• Maloney EK, Waxman DJ. 1999. trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. Toxicol Appl Pharmacol 161(2):209-218. PMID:10581215
• Mann KK, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The role of DMBA metabolites in preB cell apoptosis. Toxicol Sci 48(1-S):
• Mann KK, Matulka RA, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenzanthracene-induced pre-B cell apoptosis. Toxicol Appl Pharmacol 161:10-22.
• Mann KK, Matulka RA, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The role of cytochrome P-450 enzymes in 7,12-dimethylbenz[a]anthracene-induced apoptosis. Toxicol Appl Pharmacol 161:10. PMID:10558919
• Nunez AA, Bult A, McElhinny TL, Smale L. 1999. Daily rhythms of Fos expression in hypothalamic targets of the suprachiasmatic nucleus in diurnal and nocturnal rodents. J Biol Rhythms 14(4):300-306. PMID:10447310
• Paulu C, Aschengrau A, Ozonoff DM. 1999. Tetrachloroethylene-contaminated drinking water in Massachusetts and the risk of colon-rectum, lung, and other cancers. Environ Health Perspect 107(4):265-271. PMID:10090704
• Powell WH, Karchner SI, Bright R, Hahn ME. 1999. Functional diversity of vertebrate ARNT proteins: identification of ARNT2 as the predominant form of ARNT in the marine teleost, Fundulus heteroclitus. Arch Biochem Biophys 361(1):156-163. doi:10.1006/abbi.1998.0992 PMID:9882441
• Rie MT, Callard IP. 1999. Changes in bioindicators of environmental pollution in sentinel species, Chrysemys picta and Elliptio complanata, on Cape Cod, MA. In: Proceedings of the Keystone Symposium. Keystone, CO. pp.225.
• Rie MT, Lendas KA, Callard IP. 1999. Reproductive changes in the turtle, Chrysemys picta, on Cape Cod, MA: indices of endocrine disruption?. Biol Reprod 60:194.
• Rie MT, Lendas KA, Woodin BR, Stegeman JJ, Callard IP. 1999. Multiple bioindicators of environmental pollution, Chrysemys picta, on Cape Cod, MA. In: Proceedings of the PRIMO Meeting. pp.58.
• Schlezinger JJ, White RD, Stegeman JJ. 1999. Oxidative inactivation of cytochrome P450 1A stimulated by 3,3',4,4'-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As. Mol Pharmacol 56(3):588-597. PMID:10462547
• Waxman DJ. 1999. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR and PPAR. Arch Biochem Biophys 369(1):11-23. PMID:10462436
• Won S, Flynn A, Ammerman M, Callard IP. 1999. Putative vitellogenins in the freshwater mussel, Elliptio complanata. Soc Study of Reproduction Abs 60(Suppl1):293.
• Zhou Y, Waxman DJ. 1999. Inhibitory cross-talk between JAK2/STAT5b and PPARa. In: Proceedings of the 81st Annual Endocrine Society Meeting. pp.108.
• Zhou Y, Waxman DJ. 1999. STAT5b down-regulates peroxisome proliferator-activated receptor alpha transcription by inhibition of ligand-independent activation function region-1 trans-activation domain. J Biol Chem 274(42):29874-29882. PMID:10514468

1998

• Aschengrau A, Paulu C, Ozonoff DM. 1998. Tetrachloroethylene-contaminated drinking water and the risk of breast cancer. Environ Health Perspect 106:947-953. PMID:9703477
• Bello SM, Franks DG, Stegeman JJ, Hahn ME. 1998. Dioxin Resistance in Killifish (Fundulus heteroclitus) from the New Bedford Harbor Superfund Site: In Vivo and In Vitro studies of CYP1A1 Inducibility. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC) 19^th Annual Meeting. Charlotte, NC. pp.168.
• Besselink HT, Denison MS, Hahn ME, Karchner SI, Vethaak AD, Koeman JH, Brouwer A. 1998. Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): characterization of the Ah receptor and the role of CYP1A inhibition. Toxicol Sci 43(2):161-171. doi:10.1006/toxs.1998.2455 PMID:9710958
• Betka M, Callard GV. 1998. Cloning of an androgen receptor cDNA from Squalus acanthias testis. Bull Mt Desert Isl Biol Lab Salisb Cove Maine 37:111.
• Betka M, Callard GV. 1998. Negative feedback control of the spermatogenic progression by testicular estrogen synthesis: insights from the shark testis model. APMIS 106(1-6):252-258. doi:10.1111/j.1699-0463.1998.tb01344.x PMID:9524587
• Callard GV, McClusky LM, Betka M. 1998. Apoptosis as a normal mechanism of growth control and target of toxicant actions during spermatogenesis: insights using the shark testis model. In: New Developments in Marine Biotechnology. Kluwer Academic Publishers, pp.125-128.
• Chang TK, Waxman DJ. 1998. Catalytic assays for human cytochrome P450. Methods Mol Biol 107:95-102. PMID:14577216
• Chang TK, Waxman DJ. 1998. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods Mol Biol 107:103-109. PMID:14577217
• Crespi CL, Chang TK, Waxman DJ. 1998. CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high-performance liquid chromatography with fluorescence detection. Methods Mol Biol 107:141-145. PMID:14577223
• Hahn ME. 1998. Mechanisms of innate and acquired resistance to dioxin-like compounds. Reviews in Toxicology 2:395-443.
• Hahn ME. 1998. The aryl hydrocarbon receptor: a comparative perspective. Comp Biochem Physiol 121(1-3):23-53. PMID:9972449
• Hahn ME, Karchner SI, Shapiro MA, Perera SA. 1998. The aryl hydrocarbon receptor in early vertebrates. Mar Environ Res 46(1-5):41-44.
• Hoyer AP, Grandjean P, Jorgensen T, Brock JW, Hartvig HB. 1998. Organochlorine exposure and risk of breast cancer. Lancet 352(9143):1816-1820. PMID:9851382
• Mann KK, Quadri SA, Qadri AN, Shneider AM, Sherr DH. 1998. Involvement of NF-CB and c-myc in DMBA-induced preB lymphocyte apoptosis. Environ Health Perspect 42:89.
• Marsh DE, Prystupa J, Gensemer RW. 1998. Development of photosynthetic assays for the toxicity of organics and metals using submerged rooted macrophytes. In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA.
• Matulka RA, Mann KK, Sherr DH. 1998. DMBA (7,12-dimethlbenzanthracene) induces preB cell death via a soluble stromal cell factor. Environ Health Perspect 42:190.
• McClusky LM. 1998. In vitro analysis of cadmium actions during spermatogenesis. In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA.
• McClusky LM, Betka M, Callard GV. 1998. Stage-specific actions of cadmium on apoptosis during spermatogenesis. In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA.
• Morrison HG, Weil EJ, Karchner SI, Sogin ML, Stegeman JJ. 1998. Molecular cloning of CYP1A from the estuarine fish Fundulus heteroclitus and phylogenetic analysis of CYP1A genes: Update with new sequences. Comp Biochem Physiol 121C:231-240. PMID:9972465
• Ozonoff DM. 1998. Assessing uncertainty in decision processes. In: Setting Priorities for Drinking Water Contaminants, National Research Council. National Academy Press,
• Ozonoff DM, Webster T. 1998. The Lattice Diagram and 2x2 Tables. In: Hazardous Waste: Impacts on Human and Ecological Health (Proceedings of the 2nd International Congress on Hazardous Waste). Princeton Scientific, Princeton, NJ. pp.441-458.
• Paulu C. 1998. Cancer Risk and Tetrachloroethylene-Contaminated Drinking Water in Massachusetts: Colorectal, Lung, and Other Cancers. In: Proceedings of the Joint Conference of the International Society for Environmental Epidemiology and International Society for Exposure Assessment.
• Paulu C, Ozonoff DM. 1998. Exploring associations between residential history and breast cancer risk in a case-control study. In: Proceedings of the Joint Conference of the International Society for Environmental Epidemiology and International Society for Exposure Assessment.
• Powell WH, Karchner SI, Hahn ME. 1998. Aryl Hydrocarbon Signaling Components in Fundulus heteroclitus: A Phylogenetic Perspective. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC) 19^th Annual Meeting. Charlotte, NC.
• Quadri SA, Qadri AN, Sherr DH. 1998. Inhibition of polyaromatic hydrocarbon-induced apoptosis in murine pre-B cells by a dietary flavonoid, galangin. Environ Health Perspect 42:189.
• Rie MT. 1998. Reproductive and hepatic parameters as bioindicators of xenobiotic exposure in fresh water turtles. In: Proceedings of Gordon Conference on Endocrine Disruptors.
• Rie MT, Lendas KA, Woodin BR, Stegeman JJ, Callard IP. 1998. Seasonal, sex-related and habitat differences in hepatic CYP1A and glutathione-s-transferase in field-trapped turtles (Chrysemys picta). In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA. pp.45.
• Rie MT, Lendas KA, Woodin BR, Stegeman JJ, Callard IP. 1998. Seasonal, sex-related and habitat differences in hepatic CYP1A and glutathione-s-transferase in field-trapped turtles (Chrysemys picta). Biol Reprod 58(1):351.
• Schlezinger JJ, Parker C, Zeldin DC, Stegeman JJ. 1998. Arachidonic acid metabolism in the marine fish Stenotomus chrysops (scup) and the effects of cytochrome P4501A inducers. Arch Biochem Biophys 353(2):265-275. PMID:9606961
• Schlezinger JJ, Struntz WD, Stegeman JJ. 1998. Cytochrome P4501A (CYP1A) and planar halogenated hydrocarbons (pHAH): Oxidative inactivation and reactive oxygen production. In: Proceedings of the 37^th Society of Toxicology Annual Meeting, March 1-5. Seattle, WA.
• Trombino AF, Matulka RA, Yang S, Hafer LF, Rogers AE, Sherr DH. 1998. Nuclear expression of the aryl hydrocarbon receptor (AhR) in 7,12-dimethylbenz[a]anthracene (DMBA)- induced rat mammary tumors and human breast cancer cell lines. Environ Health Perspect 42:316.
• Webster T, Poole C, Ozonoff DM. 1998. Moving the cutpoint: What does it tell us about dose-response?. In: Proceedings of the Joint Conference of the International Society for Environmental Epidemiology and International Society for Exposure Assessment.
• Yawetz A, Woodin BR, Stegeman JJ. 1998. Cytochromes P450 (CYP) in liver of the turtle, Chrysemes picta picta and the induction and partial purification of CYP1A-like proteins. Biochim Biophys Acta 1381(1):12-26. PMID:9659368
• Zhou Y. 1998. JAK-STAT interaction with PPARα. In: Proceedings of the 80th Annual Endocrine Society Meeting.
• Zhou Y, Waxman DJ. 1998. Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids. Environ Health Perspect 106Suppl.4:983-988. PMID:9703482
• Zhou Y, Waxman DJ. 1998. Cross-talk between JAK-STAT and PPARα signaling pathways: Growth hormone (GH) inhibition of PPARα activity mediated by STAT5b. In: Proceedings of the 12th International Symposium on Microsomes and Drug Oxidations. pp.123.

1997

• Bello SM, Stegeman JJ, Hahn ME. 1997. Lack of cytochrome P450-1A inducibility in Fundulus heteroclitus from New Bedford Harbor: A case of dioxin resistance?. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA.
• Betka M. 1997. Cadmium accumulation in cardiac and skeletal muscle of Squalus acanthias. Bull Mt Desert Isl Biol Lab Salisb Cove Maine 36:89.
• Callard GV. 1997. Unconventional models for toxicology research. In: Comprehensive Toxicology, Vol. 10, Reproductive and Endocrine Toxicology. Section I. Male Reproductive Toxicology. Elsevier, NY. pp.235-247.
• Chang TK. 1997. Catalytic assays for human cytochrome P450. Chapter 9 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.95-102.
• Chang TK. 1997. Enzymatic Analysis of cDNA-expressed human CYP1A1,CYP1A2 and CYP1B1 with 7-ethoxyresorufin as substrate. Chapter 10 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.103-110.
• Chang TK, Crespi CL, Waxman DJ. 1997. Spectrophotometric Analysis of Human CY P2El -Catalyzed pNitrophenol Hydroxylation. Chapter 17 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.147-152.
• Crespi CL, Chang TK, Waxman DJ. 1997. CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high performance liquid chromatography with fluorescence detection. Chapter 16 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.141-146.
• Guiney PD, Smolowitz RM, Peterson RE, Stegeman JJ. 1997. Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction of cytochrome P450 1A in vascular endothelium with toxicity in early life stages of lake trout. Toxicol Appl Pharmacol 143(2):256-273. PMID:9144443
• Hahn ME, Karchner SI, Perera SA, Shapiro MA. 1997. Evolution of the Ah receptor: evidence for two AhR genes in early vertebrates. Environ Health Perspect 36:242.
• Hahn ME, Karchner SI, Shapiro MA, Perera SA. 1997. Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family. Proc Natl Acad Sci U S A 94(25):13743-13748. PMID:9391097 PMCID:PMC28377
• Karchner SI, Hahn ME. 1997. Molecular Characterization of Two Aryl Hydrocarbon (Ah) Receptors in the Mummichog Fundulus heteroclitus. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA. pp.426.
• Mann KK, Kerkvliet NI, Lawrence BP, Sherr DH, Trombino AF. 1997. DMBA-induced pre-B cell apoptosis is both stromal and AhR-dependent, but not P-4501A mediated. Environ Health Perspect
• Marsh DE, Gensemer RW. 1997. Photosynthetic endpoints for the toxicity of organics and heavy metals using freshwater phytoplankton. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA.
• McClusky LM, Betka M, Callard GV. 1997. Preferential accumulation of cadmium and effects on apoptosis during premiotic stages of spermatogenesis. In: Proceedings of the XIVth Testis Workshop: Germ cell development, division, disruption and death. Serono Symposium. Baltimore, MD.
• McClusky LM, Callard GV. 1997. In situ end-labeling of fragmented DNA in apoptotic germ cells in the spiny dogfish (Squalus acanthias) testis. Bull Mt Desert Isl Biol Lab Salisb Cove Maine 36:106-107.
• Ozonoff DM. 1997. Environmental Epidemiology: A natural application for discrete mathematics. In: Proceedings of the DIMACS (Discrete Mathematics and Theoretical Computer Science ) Miniworkshop exploring large data sets using classification, consensus, and pattern recognition techniques. Piscataway, NJ.
• Ozonoff DM, Paulu C, Webster TF. 1997. New methods for analyzing disease clusters in relation to environmental features. In: Silent Spring Institute, Breast Cancer and Environmental Features of Cape Cod. Massachusetts Department of Public Health, Boston, MA.
• Ozonoff DM, Webster TF. 1997. The lattice diagram and 2 x 2 tables. Toxicol Ind Health 13(2-3):339-355. PMID:9200799
• Rie MT, Callard IP. 1997. Tissue heavy metal content in a freshwater species, the turtle, Chrsemys picta, on Cape Cod, Massachusetts: Habitat, tissue and sex related differences. Biol Reprod 56(1):97.
• Schlezinger JJ, White RD, Stegeman JJ. 1997. Inactivation of cytochrome P4501A1 by 3,3',4,4'-tetrachlorobiphenyl and the formation of reactive oxygen species. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA.
• Shneider AM, Sherr DH. 1997. Benzo(a)pyrene induces NF-XB in mouse hepatoma cells. Environ Health Perspect
• Trombino AF, Yang S, Hafer LF, Qadri AN, Rogers AE, Sherr DH. 1997. Modulation of aromatic hydrocarbon receptor expression in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors. Environ Health Perspect
• Waxman DJ, Chang TK. 1997. Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYPI, CYP2, and CYP3 Families. Chapter 21 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.175-180.
• White RD, Shea D, Stegeman JJ. 1997. Metabolism of the aromatic hydrocarbon receptor agonist 3,3',4,4'-tetrachlorobiphenyl by the marine fish scup (Stenotomus chrysops) in vivo and in vitro. Drug Metab Dispos 25(5):564-572. PMID:9152595
• Yamaguchi K, Matulka RA, Shneider AM, Toselli P, Trombino AF, Yang S, Hafer LJ, Mann KK, Tao X, Tilly JL, Near RI, Sherr DH. 1997. Induction of preB cell apoptosis by 7,12 dimethylbenz[a]anthracene in long term primary bone marrow cultures. Toxicol Appl Pharmacol 147(2):190-203. PMID:9439715
• Yamaguchi K, Near RI, Matulka RA, Shneider AM, Toselli P, Trombino AF, Sherr DH. 1997. Activation of the aryl hydrocarbon receptor/transcription factor and bone marrow stromal cell-dependent preB cell apoptosis. J Immunol 158(5):2165-2173. PMID:9036962
• Zhou Y, Waxman DJ. 1997. Cross-talk between PPAR and JAK-STAT signaling pathways regulating liver P450 expression. In: Proceedings of the 15th New England Membrane Enzyme Conference.

1996

• Betka M. 1996. Metallothionein induction during spermatogenesis. Bull Mt Desert Isl Biol Lab Salisb Cove Maine 35:93.
• Callard GV. 1996. Endocrinology of Leydig cells in nonmammalian vertebrates. In: The Leydig Cell. Cache River Press, Clearwater, FL. pp.307-332.
• Cui H, Ju S, Sherr DH. 1996. Functional expression of Fas (CD95) protein in autoimmune lpr mice. Cell Immunol 174:35-41. PMID:8929452
• Gillett JW, Ram RN. 1996. Mobilization of Sediment Contamination from the Lake Erie-Lake Ontario-St. Lawrence River basin: The Critical Role of the Food Webs. In: Proceedings of the International Symposium on the St. Lawrence Ecosystem. Cornwall, Ontario, Canada. pp.735.
• Hahn ME, Karchner SI, Perera SA. 1996. Molecular studies on the Ah receptor (AhR) in early vertebrates (bony and cartilaginous fish) and evidence for a second vertebrate AhR gene. In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.232.
• McClusky LM, Betka M, Miller D, Callard GV. 1996. Analysis of the apoptotic form of programmed cell death (PCD) during spermatogenesis in spiny dogfish (Squalus acanthias). Bull Mt Desert Isl Biol Lab Salisb Cove Maine 35:96-97.
• Peters JM, Zhou Y, Ram PA, Lee SS, Gonzalez FJ, Waxman DJ. 1996. Peroxisome proliferator-activated receptor a required for gene induction by dehydroepiandrosterone 3b-sulfate. Mol Pharmacol 50(1):67-74.
• Schlezinger JJ, White RD, Stegeman JJ. 1996. 3,3',4,4'-tetrachlorobiphenyl stimulates release of active oxygen from hepatic microsomes and the oxidative inactivation of cytochrome P4501A1. In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.192.
• Waxman DJ. 1996. Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator. Journal of Endocrinology 150:S129-S147. PMID:8943797
• Wu M, Arsura M, Bellas RE, Fitzgerald MJ, Lee H, Schauer SL, Sherr DH, Sonenshein GE. 1996. Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells. Mol Cell Biol 16(9):5015-5025. PMID:8756660
• Yamaguchi K, Near RI, Shneider AM, Cui H, Ju S, Sherr DH. 1996. Fluoranthene-induced apoptosis in murine T cell hybridomas is independent of the aromatic hydrocarbon receptor. Toxicol Appl Pharmacol 139(1):144-152. PMID:8685897
• Zhou Y, Peters JM, Ram PA, Lee SS, Gonzalez FJ, Waxman DJ. 1996. Peroxisome proliferator-activated receptor a (PPARa) mediates gene induction by dehydroepiandrosterone 3b-sulfate (DHEA-S). In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.209.

1995

• Roberts MA, Durst RA. 1995. Detection of polychlorinated biphenyls by liposome-based immunomigration assays. In: Proceedings of the Pacific Basin Conference on Hazardous Waste, Edmonton, Alberta, Canada, 7-12 May, 1995. Edmonton, Alberta, Canada.
• Roberts MA, Durst RA. 1995. Investigation of liposome-based immunomigration sensors for the detection of polychlorinated biphenyls. Anal Chem 67:482-491. PMID:7892998
• Siebert ST, Reeves SG, Roberts MA, Durst RA. 1995. Improved liposome immunomigration strip assay for alachlor determination. Anal Chim Acta 311(3):309-318.
• Waxman DJ. 1995. Metabolism of DHEA and related steroids: interaction with liver cytochromes P450 (CYPs). In: Proceedings of the International Symposium on DHEA (Dehydroepiandrosterone) Transformation. pp.29.

1994

• Neilson JW, Josephson KL, Pepper IL, Arnold RG, DiGiovanni GD, Sinclair NA. 1994. Frequency of horizontal gene transfer of a large catabolic plasmid (pJP4) in soil. Appl Environ Microbiol 60:4053-4058. PMID:7993092

1993

• Dawson BV, Johnson PD, Goldberg SJ, Ulreich JB. 1993. Cardiac teratogenesis of halogenated hydrocarbon-contaminated drinking water. J Am Coll Cardiol 21:1466-1472. PMID:8473657
• Lowe TP, Chen Q, Fernando Q, Keith RL, Gandolfi A. 1993. Elemental analysis of renal slices by proton-induced X-ray emission. Environ Health Perspect 101:302. PMID:8275986

1992

• Neilson JW, Josephson KL, Pillai SD, Pepper IL. 1992. Polymerase chain reaction and gene probe detection of the 2,4-dichlorophenoxyacetic acid degradation plasmid pJP4. Appl Environ Microbiol 58:1271-1275. PMID:1599246

1991

• Grosser RJ, Warshawsky D, Vestal JR. 1991. Indigenous and enhanced mineralization of pyrene, benzo(a)-pyrene and carbazole in soils. Appl Environ Microbiol 57:3462-3469. PMID:1785924