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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Program Publications: Duke University: Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation

Superfund Research Program

Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation

Center Director: Heather M. Stapleton
Grant Number: P42ES010356
Funding Period: 2000-2027
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

  • Stapleton HM, Olshan A. Cancer Research Advisory Panel Recommendations. In: Cancer Research Advisory Panel.

2024

  • Clark AS, Huayta J, Morton KS, Meyer JN, San-Miguel A. 2024. Morphological hallmarks of dopaminergic neurodegeneration are associated with altered neuron function in Caenorhabditis elegans. Neurotoxicology 100:100-106. doi:10.1016/j.neuro.2023.12.005 PMID:38070655
  • Hawkey AB, Shekey N, Dean C, Asrat H, Koburov R, Holloway Z, Kullman SW, Levin ED. 2024. Developmental exposure to pesticides that disrupt retinoic acid signaling causes persistent retinoid and behavioral dysfunction in zebrafish. Toxicol Sci doi:10.1093/toxsci/kfae001 PMID:38237923
  • King DE, Lalwani P, Mercado G, Dolan E, Frierson J, Meyer JN, Murphy SK. 2024. The use of race terms in epigenetics research: considerations moving forward. Front Genet 15:doi:10.3389/fgene.2024.1348855 PMID:38356697 PMCID:10864599
  • Marchese M, Zhu T, Hawkey AB, Wang K, Yuan E, Wen J, Be S, Levin ED, Feng L. 2024. Prenatal and perinatal exposure to Per- and polyfluoroalkyl substances (PFAS)-contaminated drinking water impacts offspring neurobehavior and development. Sci Total Environ 917:170459. doi:10.1016/j.scitotenv.2024.170459 PMID:38290673
  • Stickler A, Hawkey AB, Gondal A, Natarajan S, Mead M, Levin ED. 2024. Embryonic exposures to cadmium and PAHs cause long-term and interacting neurobehavioral effects in zebrafish. Neurotoxicol Teratol 102:107339. doi:10.1016/j.ntt.2024.107339 PMID:38452988 PMCID:10990771
  • Wadle A, Neal-Walthall N, Ndu U, Hsu-Kim H. 2024. Distribution and homogenization of multiple mercury species input to freshwater wetland mesocosms. Environ Sci Technol doi:10.1021/acs.est.3c07169 PMID:38181227

2023

  • Berky AJ, Weinhouse C, Vissoci J, Rivera NA, Ortiz EJ, Navio S, Miranda JJ, Mallipudi A, Fixen E, Hsu-Kim H, Pan WK. 2023. In utero exposure to metals and birth outcomes in an artisanal and small-scale gold mining birth cohort in Madre de Dios, Peru. Environ Health Perspect 131(9):97008. doi:10.1289/EHP10557 PMID:37747404 PMCID:PMC10519195
  • Bihari E, Grewal G, Richter DD. 2023. Legacies of pre-1960s municipal waste incineration in the Pb of city soils. Environ Sci Technol Lett doi:10.1021/acs.estlett.3c00488
  • Clark AS, Kalmanson Z, Morton KS, Hartman JH, Meyer JN, San-Miguel A. 2023. An unbiased, automated platform for scoring dopaminergic neurodegeneration in C. elegans. PLoS One doi:10.1371/journal.pone.0281797 PMID:37418455 PMCID:PMC10328331
  • Hall SM, Zhang S, Tait GH, Hoffman K, Collier D, Hoppin JA, Stapleton HM. 2023. PFAS levels in paired drinking water and serum samples collected from an exposed community in Central North Carolina. Sci Total Environ 895:165091. doi:10.1016/j.scitotenv.2023.165091 PMID:37355130
  • Hawkey AB, Mead M, Natarajan S, Gondal A, Jarrett O, Levin ED. 2023. Embryonic exposure to PFAS causes long-term, compound-specific behavioral alterations in zebrafish. Neurotoxicol Teratol 97:107165. doi:10.1016/j.ntt.2023.107165 PMID:36801483 PMCID:PMC10198882
  • Hawkey AB, Unal D, Holloway Z, Levin ED. 2023. Developmental exposure of zebrafish to neonicotinoid pesticides: long-term effects on neurobehavioral function. Neurotoxicology 96:240-253. doi:10.1016/j.neuro.2023.05.003 PMID:37149154 PMCID:PMC10204077
  • Jasperse L, Di Giulio RT, Jayasundara N. 2023. Bioenergetic effects of polycyclic aromatic hydrocarbon resistance manifest later in life in offspring of fundulus heteroclitus from the Elizabeth River. Environ Sci Technol 57(42):15806-15815. doi:10.1021/acs.est.3c03610 PMID:37818763
  • Kozal JS, Jayasundara N, Massarsky A, Lindberg C, Oliveri A, Cooper EM, Levin ED, Meyer JN, Di Giulio RT. 2023. Mitochondrial dysfunction and oxidative stress contribute to cross-generational toxicity of benzo(a)pyrene in Danio rerio. Aquat Toxicol 263:106658. doi:10.1016/j.aquatox.2023.106658 PMID:37722151 PMCID:PMC10591944
  • Lalwani P, King DE, Morton KS, Rivera NA, Huayta J, Hsu-Kim H, Meyer JN. 2023. Increased cytotoxicity of Pb2+ with co-exposures to a mitochondrial uncoupler and mitochondrial calcium uniporter inhibitor. Environ Sci Process Impacts doi:10.1039/d3em00188a PMID:37503664
  • Morton KS, Hartman JH, Heffernan N, Ryde IT, Kenny-Ganzert IW, Meng L, Sherwood DR, Meyer JN. 2023. Chronic high-sugar diet in adulthood protects Caenorhabditis elegans from 6-OHDA-induced dopaminergic neurodegeneration. BMC Biol 21(1):252. doi:10.1186/s12915-023-01733-9 PMID:37950228 PMCID:PMC10636816
  • Samon S, Herkert N, Ghassabian A, Liu H, Hammel SC, Trasande L, Stapleton HM, Hoffman K. 2023. Measuring semi-volatile organic compound exposures during pregnancy using silicone wristbands. Chemosphere 339:139778. doi:10.1016/j.chemosphere.2023.139778 PMID:37567263
  • Sparling A, King DE, Meyer JN. 2023. rol-6 and dpy-10 C. elegans mutants have normal mitochondrial function after normalizing to delayed development. J Hazard Mater Lett doi:10.17912/MICROPUB.BIOLOGY.000798

2022

  • Addis SD, Formel SK, Kim YJ, Varner PM, Raudabaugh DB, Lefevre E, Bernik BM, Elango V, Van Bael SA, Pardue JH, Gunsch C. 2022. Alterations of endophytic microbial community function in Spartina alterniflora as a result of crude oil exposure. Biodegradation 33:87-98. doi:10.1007/s10532-021-09968-5 PMID:35039995
  • Berky AJ, Robie E, Chipa SN, Ortiz EJ, Palmer EJ, Rivera NA, Avalos AM, Hsu-Kim H, Pan WK. 2022. Risk of lead exposure from wild game consumption from cross-sectional studies in Madre de Dios, Peru. Lancet Regional Health- Americas 12:100266. doi:10.1016/j.lana.2022.100266
  • Bozinovic G, Feng Z, Shea D, Oleksiak MF. 2022. Cardiac physiology and metabolic gene expression during late organogenesis among F. heteroclitus embryo families from crosses between pollution-sensitive and -resistant parents. BMC Ecol Evol 22(3):doi:10.1186/s12862-022-01959-1 PMID:34996355 PMCID:PMC8739662
  • Habre R, Dorman DC, Abbat J, Bahnfleth WP, Carter E, Farmer D, Gawne-Mittelstaedt G, Grassian VH, Morrison G, Peccia JL, Poppendieck D, Prather KA, Shiraiwa M, Stapleton HM, Willilams H, Harries ME. 2022. Why indoor chemistry matters: A national academies consensus report. Environ Sci Technol doi:10.1021/acs.est.2c04163 PMID:35833728
  • Hawkey AB, Evans J, Holloway Z, Pippen E, Jarrett O, Kenou B, Slotkin TA, Seidler FJ, Levin ED. 2022. Developmental exposure to the flame retardant, triphenyl phosphate, causes long-lasting neurobehavioral and neurochemical dysfunction. Birth Defects Res doi:10.1002/bdr2.2125 PMID:36369782 PMCID:PMC10197196
  • Hawkey AB, Pippen E, Kenou B, Holloway Z, Slotkin TA, Seidler FJ, Levin ED. 2022. Persistent neurobehavioral and neurochemical anomalies in middle-aged rats after maternal diazinon exposure. Toxicology 472:153189. doi:10.1016/j.tox.2022.153189 PMID:35452779
  • Joglekar R, Grenier C, Hoyo C, Hoffman K, Murphy SK. 2022. Maternal tobacco smoke exposure is associated with increased DNA methylation at human metastable epialleles in infant cord blood. Environ Epigenet 8(1):doi:10.1093/eep/dvac005 PMID:35355955 PMCID:PMC8962709
  • King DE, Sparling A, Lloyd D, Satusky MJ, Martinez M, Grenier C, Bergemann CM, Maguire R, Hoyo C, Meyer JN, Murphy SK. 2022. Sex-specific DNA methylation and associations with in utero tobacco smoke exposure at nuclear-encoded mitochondrial genes. Epigenetics doi:10.1080/15592294.2022.2043591 PMID:35238269
  • Leuthner T, Benzing L, Kohrn BF, Bergemann CM, Hipp MJ, Hershberger KA, Mello DF, Sokolskyi T, Stevenson K, Merutka IR, Seay SA, Gregory SG, Kennedy SR, Meyer JN. 2022. Resistance of mitochondrial DNA to cadmium and Aflatoxin B1 damage-induced germline mutation accumulation in C. elegans. Nucleic Acids Res 50(15):8696-8642. doi:10.1093/nar/gkac666 PMID:35947695 PMCID:PMC9410910
  • Maglioni S, Schiavi A, Melcher M, Brinkmann V, Luo Z, Laromaine A, Raimundo N, Meyer JN, Distelmaier F, Ventura N. 2022. Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans. Nat Commun doi:10.1038/s41467-022-29972-4 PMID:35551180 PMCID:PMC9098500
  • Markovich Z, Hartman JH, Ryde IT, Hershberger KA, Joyce A, Ferguson PL, Meyer JN. 2022. Mild pentachlorophenol-mediated uncoupling of mitochondria depletes ATP but does not cause an oxidized redox state or dopaminergic neurodegeneration in Caenorhabditis elegans. Curr Res Toxicol 3:doi:10.1016/j.crtox.2022.100084 PMID:35957653 PMCID:PMC9361317
  • Mello DF, Bergemann CM, Fisher K, Chitrakar R, Bijwadia SR, Wang Y, Caldwell A, Baugh LR, Meyer JN. 2022. Rotenone modulates Caenorhabditis elegans immunometabolism and pathogen susceptibility. Front Immunol 13:840272. doi:10.3389/fimmu.2022.840272 PMID:35273616 PMCID:PMC8902048
  • Mello DF, Maurer LL, Ryde IT, Songr D, Marinakos SM, Jiang C, Wiesner MR, Hsu-Kim H, Meyer JN. 2022. In vivo effects of silver nanoparticles on development, behavior, and mitochondrial function are altered by genetic defects in mitochondrial dynamics. Environ Sci Technol 56:1113-1124. doi:10.1021/acs.est.1c05915 PMID:35038872 PMCID:PMC8802983
  • Neal-Walthall N, Ndu U, Rivera NA, Elias DA, Hsu-Kim H. 2022. Utility of diffusive gradient in thin-film passive samplers for predicting mercury methylation potential and bioaccumulation in freshwater wetlands. Environ Sci Technol 56:doi:10.1021/acs.est.1c06796 PMID:35044747
  • Trevisan R, Ranasinghe P, Jayasundara N, Di Giulio RT. 2022. Nanoplastics in aquatic environments: Impacts on aquatic species and interactions with environmental factors and pollutants. Toxics 10(6):doi:10.3390/toxics10060326 PMID:35736934 PMCID:PMC9230143
  • Varner PM, Gunsch C. 2022. Complete genome sequence of NAH7-harboring pseudomonas putida strain G7. Microbiol Resour Ann doi:10.1128/mra.00394-22 PMID:36129275 PMCID:PMC9584282
  • Volkoff SJ, Rodriguez DL, Singleton DR, McCumber AW, Aitken MD, Stewart JR, Gunsch C. 2022. Identifying bioaugmentation candidates for bioremediation of polycyclic aromatic hydrocarbons in contaminated estuarine sediment of the Elizabeth River, VA, USA. Appl Microbiol Biotechnol 106:1715-1727. doi:10.1007/s00253-021-11754-5 PMID:35089401

2021

  • Bijwadia SR, Morton KS, Meyer JN. 2021. Quantifying levels of dopaminergic neuron morphological alteration and degeneration in Caenorhabditis elegans. J Vis Exp 177:doi:10.3791/62894 PMID:34866619
  • Boyda J, Hawkey AB, Holloway Z, Trevisan R, Di Giulio RT, Levin ED. 2021. The organophosphate insecticide diazinon and aging: Neurobehavioral and mitochondrial effects in zebrafish exposed as embryos or during aging. Neurotoxicol Teratol 87:doi:10.1016/j.ntt.2021.107011 PMID:34224825 PMCID:PMC8440393
  • Bozinovic G, Shea D, Feng Z, Hinton DE, Sit TL, Oleksiak MF. 2021. PAH-pollution effects on sensitive and resistant embryos: Integrating structure and function with gene expression. PLoS One 16(4):e0249432. doi:10.1371/journal.pone.0249432 PMID:33822796 PMCID:PMC8023486
  • Chernick M, Lieberman N, Brown DR, Di Giulio RT, Hinton DE, Burke T. 2021. Heart development in two populations of Atlantic killifish (Fundulus heteroclitus) following exposure to a polycyclic aromatic hydrocarbon mixture. Ecotoxicol Environ Saf 208:111580. doi:10.1016/j.ecoenv.2020.111580 PMID:33396103
  • Hartman JH, Widmayer SJ, Bergemann CM, King DE, Morton KS, Romersi RF, Jameson LE, Leung MC, Andersen EC, Taubert S, Meyer JN. 2021. Xenobiotic metabolism and transport in Caenorhabditis elegans. J Toxicol Environ Health B Crit Rev 24(2):51-94. doi:10.1080/10937404.2021.1884921 PMID:33616007 PMCID:PMC7958427
  • Hawkey AB, Holloway Z, Levin ED. 2021. A behavioral test battery to assess larval and adult zebrafish after developmental neurotoxic exposure. Experimental Neurotoxicology Methods 172:353-380. doi:10.1007/978-1-0716-1637-6_16
  • Hershberger KA, Rooney JP, Turner EA, Donoghue LJ, Bodhicharla R, Maurer LL, Ryde IT, Kim JJ, Joglekar R, Hibshman JD, Smith LL, Bhatt DP, Ilkayeva OR, Hirschey MD, Meyer JN. 2021. Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans. Redox Biol 43:102000. doi:10.1016/j.redox.2021.102000 PMID:33993056 PMCID:PMC8134077
  • Holloway Z, Hawkey AB, Asrat H, Boinapally N, Levin ED. 2021. The use of tocofersolan as a rescue agent in larval zebrafish exposed to benzo[a]pyrene in early development. Neurotoxicology 86:78-84. doi:10.1016/j.neuro.2021.07.003 PMID:34273383
  • Kim YJ, Womble JT, Gunsch C, Ingram JL. 2021. The gut/lung microbiome axis in obesity, asthma, and bariatric surgery: A literature review. Obesity (Silver Spring) 29(4):636-644. doi:10.1002/oby.23107 PMID:33759390 PMCID:PMC7995617
  • King DE, Sparling A, Joglekar R, Meyer JN, Murphy SK. 2021. Direct comparisons of bisulfite pyrosequencing versus targeted bisulfite sequencing. micropub bio doi:10.17912/micropub.biology.000444 PMID:34423283 PMCID:PMC8377520
  • Koenigsmark F, Weinhouse C, Berky AJ, Morales A, Ortiz EJ, Pierce EM, Pan WK, Hsu-Kim H. 2021. Efficacy of hair total mercury content as a biomarker of methylmercury exposure to communities in the area of artisanal and small-scale gold mining in Madre de Dios, Peru. Int J Environ Res Public Health 18(24):doi:10.3390/ijerph182413350 PMID:34948962 PMCID:PMC8707462
  • Leuthner T, Hartman JH, Ryde IT, Meyer JN. 2021. PCR-based determination of mitochondrial DNA copy number in multiple species. Methods Mol Biol 2310:91-111. doi:10.1007/978-1-0716-1433-4_8 PMID:34096001
  • Leuthner T, Meyer JN. 2021. Mitochondrial DNA mutagenesis: Feature of and biomarker for environmental exposures and aging. Curr Environ Health Rep 8(4):doi:10.1007/s40572-021-00329-1 PMID:34761353 (ahead of print)
  • Levin ED. 2021. Invited Perspective: Does developmental adaptation pose risks with changing toxicant exposures?. Environ Health Perspect 129(8):81302. doi:10.1289/ehp9560 PMID:34383604 PMCID:PMC8360002
  • Pan WK, Weinhouse C, Ortiz EJ, Berky AJ, Fixsen E, Mallipudi A, Feingold BJ, Navio S, Rivera NA, Hsu-Kim H, Miranda JJ. 2021. CoNaMad-Cohorte de Nacimiento de Madre de Dios / Madre de Dios Birth Cohort to Study Effects of in-utero Trace Metals Exposure in the Southern Peruvian Amazon. Ann Glob Health 87:doi:10.5334/aogh.3152 PMID:34327116 PMCID:PMC8300581
  • Patisaul HB, Behl M, Birnbaum LS, Blum A, Diamond ML, Fernandez SR, Hogberg HT, Kwiatkowski C, Page JD, Soehl A, Stapleton HM. 2021. Beyond cholinesterase inhibition: Developmental neurotoxicity of organophosphate ester flame retardants and plasticizers. Environ Health Perspect 129(10):105001. doi:10.1289/EHP9285 PMID:34612677 PMCID:PMC8493874
  • Redfern L, Jayasundara N, Singleton D, Di Giulio RT, Carlson J, Sumner SJ, Gunsch C. 2021. The role of gut microbial community and metabolomic shifts in adaptive resistance of Atlantic killifish (Fundulus heteroclitus) to polycyclic aromatic hydrocarbons. Sci Total Environ 776:145955. doi:10.1016/j.scitotenv.2021.145955 PMID:33647645 PMCID:PMC8294123
  • Silva RA, Di Giulio RT, Rice CD. 2021. The in vitro proinflammatory properties of water accommodated sediment extracts from a creosote-contaminated US Environmental Protection Agency Superfund Site. Environ Toxicol Chem 40(6):1576-1585. doi:10.1002/etc.5001 PMID:33512033
  • Slotkin TA, Levin ED, Seidler FJ. 2021. Paternal cannabis exposure prior to mating, but not 9-tetrahydrocannabinol, elicits deficits in dopaminergic synaptic activity in the offspring. Toxicol Sci 184(2):doi:10.1093/toxsci/kfab117 PMID:34590702
  • Ulrich JC, Ferguson PL. 2021. Development of a sensitive direct injection LC-MS/MS method for the detection of glyphosate and aminomethylphosphonic acid (AMPA) in hard waters. Anal Bioanal Chem 413(14):3763-3774. doi:10.1007/s00216-021-03324-5 PMID:33846826 PMCID:PMC8154743
  • Varner PM, Gunsch C. 2021. Properties affecting transfer and expression of degradative plasmids for the purpose of bioremediation. Biodegradation 32(4):doi:10.1007/s10532-021-09950-1 PMID:34046775 (ahead of print)
  • Wang L, Mello DF, Zucker RM, Rivera NA, Rogers NM, Geitner NK, Boyes W, Wiesner MR, Hsu-Kim H, Meyer JN. 2021. Lack of detectable direct effects of silver and silver nanoparticles on mitochondria in mouse hepatocytes. Environ Sci Technol 11166-11175. doi:10.1021/acs.est.1c02295 PMID:34346225 (ahead of print)

2020

  • Baldwin WS, Bain LJ, Di Giulio RT, Kullman SW, Rice CD, Ringwood AH, van den Hurk P. 2020. 20th Pollutant Responses in Marine Organisms (PRIMO 20): Global issues and fundamental mechanisms caused by pollutant stress in marine and freshwater organisms. Aquat Toxicol 227:doi:10.1016/j.aquatox.2020.105620 PMID:32932042
  • Brenner RG, Oliveri A, Sinnott-Armstrong W, Levin ED. 2020. Effects of sub-chronic methylphenidate on risk-taking and sociability in zebrafish (Danio rerio). Naunyn Schmiedebergs Arch Pharmacol doi:10.1007/s00210-020-01835-z PMID:32025747 PMCID:PMC7716188
  • Cooper EM, Rushing R, Hoffman K, Phillips AL, Hammel SC, Zylka MJ, Stapleton HM. 2020. Strobilurin fungicides in house dust: Is wallboard a source?. J Expo Sci Environ Epidemiol 30:247-252. doi:10.1038/s41370-019-0180-z PMID:31636368 PMCID:PMC7044059
  • Czaplicki LM, Redfern L, Cooper EM, Ferguson PL, Vilgalys R, Gunsch C. 2020. Investigating the mycobiome of the Holcomb Creosote Superfund Site. Chemosphere 252:9. doi:10.1016/j.chemosphere.2020.126208 PMID:32229362 PMCID:PMC7242165
  • Gonzalez-Hunt CP, Luz AL, Ryde IT, Turner EA, Ilkayeva OR, Bhatt DP, Hirschey MD, Meyer JN. 2020. Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone. Toxicology 447(10):152630. doi:10.1016/j.tox.2020.152630 PMID:33188857 PMCID:PMC7750303
  • Harris JB, Hartman JH, Luz AL, Wilson JY, Dinyari A, Meyer JN. 2020. Zebrafish CYP1A expression in transgenic Caenorhabditis elegans protects from exposures to benzo[a]pyrene and a complex polycyclic aromatic hydrocarbon mixture. Toxicology 440(11):doi:10.1016/j.tox.2020.152473 PMID:32360973 PMCID:PMC7313633
  • Hawkey AB, Glazer L, Dean C, Wells C, Odamah K, Slotkin TA, Seidler FJ, Levin ED. 2020. Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish. Neurotoxicol Teratol 78:doi:10.1016/j.ntt.2019.106853 PMID:31911208 PMCID:PMC7061078
  • Hawkey AB, Pippen E, White H, Kim J, Greengrove E, Kenou B, Holloway Z, Levin ED. 2020. Gestational and perinatal exposure to diazinon causes long-lasting neurobehavioral consequences in the Rat. Toxicology 429:doi:10.1016/j.tox.2019.152327 PMID:31704166 PMCID:PMC6925319
  • Hollander JA, Cory-Slechta DA, Jacka FN, Szabo ST, Guilarte TR, Bilbo SD, Mattingly CJ, Moy SS, Haroon E, Hornig M, Levin ED, Pletnikov MV, Zehr JL, McAllister KA, Dzierlenga AL, Garton AE, Lawler C, Ladd-Acosta C. 2020. Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease. Neuropsychopharmacology 45:doi:10.1038/s41386-020-0648-5 PMID:32109936 PMCID:PMC7234981
  • Holloway Z, Koburov R, Hawkey AB, Levin ED. 2020. Measuring attention in rats with a visual signal detection task: Signal intensity vs. signal duration. Pharmacol Biochem Behav 199:doi:10.1016/j.pbb.2020.173069 PMID:33144207 PMCID:PMC7726090
  • Kassotis CD, Herkert N, Hammel SC, Hoffman K, Xia Q, Kullman SW, Sosa JA, Stapleton HM. 2020. Thyroid receptor antagonism of chemicals extracted from personal silicone wristbands within a papillary thyroid cancer pilot study. Environ Sci Technol 54:15296-15312. doi:10.1021/acs.est.0c05972 PMID:33185092 PMCID:PMC7819617
  • Oliveri A, Glazer L, Mahapatra D, Kullman SW, Levin ED. 2020. Developmental exposure of zebrafish to vitamin D receptor acting drugs and environmental toxicants disrupts behavioral function. Neurotoxicol Teratol 81:10. doi:10.1016/j.ntt.2020.106902 PMID:32473203 PMCID:PMC7483728
  • Oliveri A, Knuth M, Glazer L, Bailey JM, Kullman SW, Levin ED. 2020. Zebrafish show long-term behavioral impairments resulting from developmental vitamin D deficiency. Physiol Behav 224:113016. doi:10.1016/j.physbeh.2020.113016 PMID:32561170 PMCID:PMC7737556 (ahead of print)
  • Phillips AL, Herkert N, Ulrich JC, Hartman JH, Ruis MT, Cooper EM, Ferguson PL, Stapleton HM. 2020. In vitro metabolism of isopropylated and tert-butylated triarylphosphate esters using human liver subcellular fractions. Chem Res Toxicol 33:1428-1441. doi:10.1021/acs.chemrestox.0c00002 PMID:32129605 PMCID:PMC7508416
  • Trevisan R, Uzochukwu D, Di Giulio RT. 2020. PAH sorption to nanoplastics and the Trojan Horse Effect as drivers of mitochondrial toxicity and PAH localization in zebrafish. front environ sci 8:doi:10.3389/fenvs.2020.00078
  • Weinhouse C, Gallis JA, Ortiz EJ, Berky AJ, Morales A, Diringer SE, Harrington JM, Bullins P, Rogers LA, Hare-Grogg J, Hsu-Kim H, Pan WK. 2020. A population-based mercury exposure assessment near an artisanal and small-scale gold mining site in the Peruvian Amazon. J Expo Sci Environ Epidemiol 11:doi:10.1038/s41370-020-0234-2 PMID:32467625
  • Zhang J, Hartman JH, Chen C, Yang S, Li Q, Tian Z, Huang P, Wang L, Meyer JN, Huang TJ. 2020. Fluorescence-based Sorting of Caenorhabditis Elegans via Acoustofluidics. Chem Sci 20:1729-1739. doi:10.1039/d0lc00051e PMID:32292982 PMCID:PMC723976

2019

  • Bachman H, Fu H, Huang P, Tian Z, Embry-Seckler J, Rufo J, Xie Z, Hartman JH, Zhao S, Yang S, Meyer JN, Huang TJ. 2019. Open source acoustofluidics. Lab Chip 19(14):2404-2414. doi:10.1039/c9lc00340a PMID:31240285 PMCID:PMC6934416
  • Berky AJ, Ryde IT, Feingold BJ, Ortiz EJ, Wyatt LH, Weinhouse C, Hsu-Kim H, Meyer JN, Pan WK. 2019. Predictors of mitochondrial DNA copy number and damage in a mercury-exposed rural Peruvian population near artisanal and small-scale gold mining: An exploratory study. Environ Mol Mutagen 60(2):197-210. doi:10.1002/em.22244 PMID:30289587 PMCID:PMC6452630
  • Budarz JF, Cooper EM, Gardner CM, Hodzic E, Ferguson PL, Gunsch C, Wiesner MR. 2019. Chlorpyrifos degradation via photoreactive TiO2 nanoparticles: Assessing the impact of a multi-component degradation scenario. J Hazard Mater 372:61-68. doi:10.1016/j.jhazmat.2017.12.028 PMID:29254886 PMCID:PMC5995634 (in press)
  • Di Giulio RT, Newman MC. 2019. Ecotoxicology. Chapter 30 in: Casarett & Doull's Toxicology: The Basic Science of Poisons, 9th Edition. McGraw Hill Education,
  • Dreier DA, Mello DF, Meyer JN, Martyniuk CJ. 2019. Linking mitochondrial dysfunction to organismal and population health in context of environmental pollutants: progress and considerations for mitochondrial adverse outcome pathways. Environ Toxicol Chem 38:1625-1634. doi:10.1002/etc.4453 PMID:31034624 PMCID:PMC6961808
  • Hartman JH, Gonzalez-Hunt CP, Hall SM, Ryde IT, Caldwell KA, Caldwell GA, Meyer JN. 2019. Genetic defects in mitochondrial dynamics in Caenorhabditis elegans impact ultraviolet C radiation- and 6-hydroxydopamine-induced neurodegeneration. Int J Mol Sci 20(13):E3202. doi:10.3390/ijms20133202 PMID:31261893 PMCID:PMC6651461
  • Haschek-Hock WM, Berenbaum M, Hinton DE, Cora MC, Chernoff N, Travios G, Liu C, Lu K, Law M. 2019. Pathology in ecological research with implications for one health: session summary. Toxicol Pathol 47:1072-1075. doi:10.1177/0192623319880530 PMID:31645202 PMCID:PMC6910945
  • Hawkey AB, Junaid S, Yao L, Spiera Z, White H, Cauley M, Levin ED. 2019. Gestational exposure to nicotine and/or benzo[a]pyrene causes long-lasting neurobehavioral consequences. Birth Defects Res 111(17):1248-1258. doi:10.1002/bdr2.1568 PMID:31368242 PMCID:PMC6983916
  • Hershberger KA, Leuthner T, Waters TA, Meyer JN. 2019. Caenorhabditis elegans strain sensitivity to sodium arsenite exposure is varied based on age and outcome measured. micropub bio doi:10.17912/micropub.biology.000186 PMID:32550437 PMCID:PMC7252313
  • House JS, Hall J, Park S, Planchart A, Money ES, Maguire R, Huang Z, Mattingly CJ, Skaar D, Tzeng J, Darrah T, Vengosh A, Murphy SK, Jirtle R, Hoyo C. 2019. Cadmium exposure and MEG3 methylation differences between Whites and African Americans in the NEST Cohort. Environ Epigenet 5(3):dvz014. doi:10.1093/eep/dvz014 PMID:31528362 PMCID:PMC6736358
  • Kassotis CD, Kollitz EM, Hoffman K, Sosa JA, Stapleton HM. 2019. Thyroid receptor antagonism as a contributory mechanism for adipogenesis induced by environmental mixtures in 3T3-L1 cells. Sci Total Environ 666:431-444. doi:10.1016/j.scitotenv.2019.02.273 PMID:30802659 PMCID:PMC6456385
  • Lefevre E, Redfern L, Cooper EM, Stapleton HM, Gunsch C. 2019. Acetate promotes microbial reductive debromination of tetrabromobisphenol A during the startup phase of anaerobic wastewater sludge bioreactors. Sci Total Environ 656:959-968. doi:10.1016/j.scitotenv.2018.11.403 PMID:30625682 PMCID:PMC6481660
  • Leung MC, Meyer JN. 2019. Mitochondria as a target of organophosphate and carbamate pesticides: Revisiting common mechanisms of action with new approach methodologies. Reprod Toxicol 89:83-92. doi:10.1016/j.reprotox.2019.07.007 PMID:31315019 PMCID:PMC6766410
  • Lindberg C, Di Giulio RT. 2019. Polycyclic aromatic hydrocarbon and hypoxia exposures result in mitochondrial dysfunction in zebrafish. Aquat Toxicol 216:doi:10.1016/j.aquatox.2019.105298 PMID:31586484 PMCID:PMC6917040
  • Maglioni S, Mello DF, Schiavi A, Meyer JN, Ventura N. 2019. Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span. Aging-US 11:6535-6554. doi:10.18632/aging.102208 PMID:31454791 PMCID:PMC6738431
  • Oliveri A, Levin ED. 2019. Dopamine D1 and D2 receptor antagonism during development alters later behavior in zebrafish. Behav Brain Res 356:250-256. doi:10.1016/j.bbr.2018.08.028 PMID:30172631 PMCID:PMC6192051
  • Redfern L, Gardner CM, Hodzic E, Ferguson PL, Hsu-Kim H, Gunsch C. 2019. A new framework for approaching precision bioremediation of PAH contaminated soils. J Hazard Mater 378:doi:10.1016/j.jhazmat.2019.120859 PMID:31327574 PMCID:PMC6833951
  • Sikdar S, Joehanes R, Joubert BR, Xu C, Vives-Usano M, Rezwan F, Felix J, Ward JM, Guan W, Richmond RC, Brody JA, Kupers LK, Baiz N, Haberg SE, Smith JA, Reese SE, Aslibekyan S, Hoyo C, Dhingra R, Markunas CA, Xu T, Reynolds LM, Just AC, Mandaviya PR, Ghantous A, Bennett BD, Wang T, BIOS-Consortium, Bakulski KM, Melen E, Zhao S, Juin J, Herceg Z, van Meurs JB, Taylor JA, Baccarelli A, Murphy SK, Liu Y, Minthe-Kaas MC, Deary IJ, Nystad W, Waldenberger M, Annesi-Maesano I, Conneely K, Jaddoe VW, Arnett D, Snieder H, Kardia SL, Relton CL, Ong KK, Ewart S, Moreno-Macias H, Romieu I, Sotoodehnia N, Fornage M, Motsinger-Reif A, Koppelman GH, Bustamante M, Levy D, London SJ. 2019. Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics 11(13):1487-1500. doi:10.2217/epi-2019-0066 PMID:31536415 PMCID:PMC6836223
  • Slotkin TA, Skavicus S, Ko A, Levin ED, Seidler FJ. 2019. Perinatal diazinon exposure compromises the development of acetylcholine and serotonin systems. Toxicology 424:10. doi:10.1016/j.tox.2019.152240 PMID:31251962 PMCID:PMC6689134
  • Slotkin TA, Skavicus S, Ko A, Levin ED, Seidler FJ. 2019. The developmental neurotoxicity of tobacco smoke can be mimicked by a combination of nicotine and benzo[a]pyrene: effects on cholinergic and serotonergic systems. Toxicol Sci 168:280. doi:10.1093/toxsci/kfy304 PMID:30247698 PMCID:PMC6681680
  • Smith LL, Ryde IT, Hartman JH, Romersi RF, Markovich Z, Meyer JN. 2019. Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans. Neurotoxicology 74:209-220. doi:10.1016/j.neuro.2019.07.002 PMID:31323240 PMCID:PMC6751008
  • Trevisan R, Voy C, Chen S, Di Giulio RT. 2019. Nanoplastics decrease the toxicity of a complex PAH mixture but impair mitochondrial energy production in developing zebrafish. Environ Sci Technol 53:8405-8415. doi:10.1021/acs.est.9b02003 PMID:31259535 PMCID:PMC6660138
  • Tuttle AH, Salazar G, Cooper EM, Stapleton HM, Zylka MJ. 2019. Choice of vehicle affects pyraclostrobin toxicity in mice. Chemosphere 218:501-506. doi:10.1016/j.chemosphere.2018.11.126 PMID:30497033 PMCID:PMC6338344
  • Volkoff SJ, Osterberg JS, Jayasundara N, Cooper EM, Hsu-Kim H, Rogers LA, Gehrke GE, Jayaraman S, Di Giulio RT. 2019. Embryonic fundulus heteroclitus responses to sediment extracts from differentially contaminated sites in the Elizabeth River, VA. Ecotoxicology 28:9:1126-1135. doi:10.1007/s10646-019-02116-z PMID:31620948 PMCID:PMC7768734
  • Watson AT, Nordberg RC, Loboa EG, Kullman SW. 2019. Evidence for aryl hydrocarbon receptor-mediated inhibition of osteoblast differentiation in human mesenchymal stem cells. Toxicol Sci 167(1):145-156. doi:10.1093/toxsci/kfy225 PMID:30203000 PMCID:PMC6317429
  • Zhang J, Yang S, Chen C, Hartman JH, Huang P, Wang L, Tian Z, Zhang P, Faulkenberry D, Meyer JN, Huang TJ. 2019. Surface acoustic waves enable rotational manipulation of Caenorhabditis elegans. Lab Chip 19(6):984-992. doi:10.1039/c8lc01012a PMID:30768117 PMCID:PMC6659422

2018

  • Cothren SD, Meyer JN, Hartman JH. 2018. Blinded visual scoring of images using the freely-available software Blinder. Bio Protoc 8(23):e3103. doi:10.21769/BioProtoc.3103 PMID:30761327 PMCID:PMC6370323
  • Czaplicki LM, Dharia M, Cooper EM, Ferguson PL, Vilgalys R, Gunsch C. 2018. Evaluating the mycostimulation potential of select carbon amendments for the degradation of a model PAH by an ascomycete strain enriched from a Superfund site. Biodegradation 29(5):463-471. doi:10.1007/s10532-018-9843-z PMID:30003496 PMCID:PMC6330244
  • Gearhart-Serna LM, Jayasundara N, Tacam M, Di Giulio RT, Devi GR. 2018. Assessing cancer risk associated with aquatic polycyclic aromatic hydrocarbon pollution reveals dietary routes of exposure and vulnerable populations. J Environ Public Health 2018:5610462. doi:10.1155/2018/5610462 PMID:30327676 PMCID:PMC6169233
  • Glazer L, Hawkey AB, Wells C, Drastal M, Odamah K, Behl M, Levin ED. 2018. Developmental exposure to low concentrations of organophosphate flame retardants causes life-long behavioral alterations in zebrafish. Toxicol Sci 165(2):487-498. doi:10.1093/toxsci/kfy173 PMID:29982741 PMCID:PMC6154272
  • Glazer L, Wells C, Drastal M, Odamah K, Galat RE, Behl M, Levin ED. 2018. Developmental exposure to low concentrations of two brominated flame retardants, BDE-47 and BDE-99, causes life-long behavioral alterations in zebrafish. Neurotoxicology 66:221-232. doi:10.1016/j.neuro.2017.09.007 PMID:28935585 PMCID:PMC5858967
  • Hammel SC, Phillips AL, Hoffman K, Stapleton HM. 2018. Evaluating the use of silicone wristbands to measure personal exposure to brominated flame retardants. Environ Sci Technol 52:11875-11885. doi:10.1021/acs.est.8b03755 PMID:30216050 PMCID:PMC6445795
  • Hartman JH, Smith LL, Gordon KL, Laranjeiro R, Drsicoll M, Sherwood DR, Meyer JN. 2018. Swimming exercise and transient food deprivation in Caenorhabditis elegans promote mitochondrial maintenance and protect against chemical-induced mitotoxicity. Sci Rep 8:8359. doi:10.1038/s41598-018-26552-9 PMID:29844465 PMCID:PMC597439
  • Hibshman JD, Leuthner T, Shoben C, Mello DF, Sherwood DR, Meyer JN, Baugh LR. 2018. Non-selective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans. Am J Physiol Cell Physiol 315:C781-C792. doi:10.1152/ajpcell.00109.2018 PMID:30133321 PMCID:PMC6336938
  • Kassotis CD, Kollitz EM, Ferguson PL, Stapleton HM. 2018. Nonionic ethoxylated surfactants induce adipogenesis in 3T3-L1 cells. Toxicol Sci 162(1):124-136. doi:10.1093/toxsci/kfx234 PMID:29106673 PMCID:PMC625695
  • Kollitz EM, De Carbonnel L, Stapleton HM, Ferguson PL. 2018. The affinity of brominated phenolic compounds for human and zebrafish thyroid receptor beta: Influence of chemical structure. Toxicol Sci doi:10.1093/toxsci/kfy028 PMID:29409039
  • Kollitz EM, Kassotis CD, Hoffman K, Ferguson PL, Sosa JA, Stapleton HM. 2018. Chemical mixtures isolated from house dust disrupt thyroid receptor beta signaling. Environ Sci Technol 52:11857-11864. doi:10.1021/acs.est.8b03283 PMID:30212187
  • Lefevre E, Bossa N, Gardner CM, Gehrke GE, Cooper EM, Stapleton HM, Hsu-Kim H, Gunsch C. 2018. Biochar and activated carbon act as promising amendments for promoting the microbial debromination of tetrabromobisphenol A. Water Res 128:102-110. doi:10.1016/j.watres.2017.09.047 PMID:29091801 PMCID:PMC5796758
  • Levin ED, Abreu-Villaca Y. 2018. Developmental neurotoxicity of nicotine and tobacco. Chapter 39 in: Handbook of Developmental Neurotoxicology, 2nd Edition. Elsevier Inc., pp.439-452.
  • Luz AL, Kassotis CD, Stapleton HM, Meyer JN. 2018. The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARgamma activation, in 3T3-L1 cells. Toxicology 393:150-159. doi:10.1016/j.tox.2017.11.010 PMID:29127035 PMCID:PMC5726929
  • Massarsky A, Abdel A, Glazer L, Levin ED, Di Giulio RT. 2018. Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio). Neurotoxicology 65:111-124. doi:10.1016/j.neuro.2018.02.007 PMID:29432853
  • Maurer LL, Luz AL, Meyer JN. 2018. Detection of Mitochondrial Toxicity of Environmental Pollutants Using Caenorhabditis elegans. Chapter 43 in: Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. John Wiley & Sons, Inc., pp.655-689.
  • Meyer JN, Hartman JH, Mello DF. 2018. Mitochondrial toxicity. Toxicol Sci 162(1):15-23. doi:10.1093/toxsci/kfy008 PMID:29340618 PMCID:PMC5837373 (in press)
  • Oliveri A, Ortiz E, Levin ED. 2018. Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae. Neurotoxicol Teratol 67:25-30. doi:10.1016/j.ntt.2018.03.002 PMID:29559250 PMCID:PMC5970957
  • Osterberg JS, Cammen KM, Schultz TF, Clark BW, Di Giulio RT. 2018. Genome-wide scan reveals signatures of selection related to pollution adaptation in non-model estuarine Atlantic killifish (Fundulus heteroclitus). Aquat Toxicol 200:73-82. doi:10.1016/j.aquatox.2018.04.017 PMID:29727773 PMCID:PMC6957077
  • Pitt JA, Kozal JS, Jayasundara N, Massarsky A, Trevisan R, Geiter N, Wiesner MR, Levin ED, Di Giulio RT. 2018. Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio). Aquat Toxicol 194:185-194. doi:10.1016/j.aquatox.2017.11.017 PMID:29197232
  • Pitt JA, Trevisan R, Massarsky A, Kozal JS, Levin ED, Di Giulio RT. 2018. Maternal transfer of nanoplastics to offspring in zebrafish (Danio rerio): A case study with nanopolystyrene. Sci Total Environ 643:324-334. doi:10.1016/j.scitotenv.2018.06.186 PMID:29940444
  • Sanders LH, Rouanet JP, Howlett EH, Leuthner T, Rooney JP, Greenamyre JT, Meyer JN. 2018. Newly revised quantitative PCR-based assay for mitochondrial and nuclear DNA damage. Curr Protoc Toxicol 76(1):e50. doi:10.1002/cptx.50 PMID:30040241 PMCID:PMC6060631
  • Slotkin TA, Skavicus S, Seidler FJ. 2018. Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled In Vitro: Terbutaline and dexamethasone, separately and together. Toxicology 30033-30037. doi:10.1016/j.tox.2018.03.001 PMID:29524569 PMCID:PMC5903951
  • Wang F, Fang M, Hinton DE, Chernick M, Jia S, Zhang Y, Xie L, Dong W, Dong W. 2018. Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47. Chemosphere 198:342-350. doi:10.1016/j.chemosphere.2018.01.081 PMID:29421749
  • Weinhouse C, Truong L, Meyer JN, Allard P. 2018. Caenorhabditis elegans as an emerging model system in environmental epigenetics. Environ Mol Mutagen 59:560-575. doi:10.1002/em.22203 PMID:30091255 PMCID:PMC6113102

2017

  • Abreu-Villaca Y, Levin ED. 2017. Developmental neurotoxicity of succeeding generations of insecticides. Environ Int 99:55-77. doi:10.1016/j.envint.2016.11.019 PMID:27908457 PMCID:PMC5285268
  • Barzen-Hanson KA, Roberts SC, Choyke S, Oetjen K, McAlees A, Riddell N, McCrindle R, Ferguson PL, Higgins CP, Field JA. 2017. Discovery of 40 classes of per- and polyfluoroalkyl substances in historical aqueous film-forming foams (AFFFs) and AFFF-impacted groundwater. Environ Sci Technol 51(4):2047-2057. doi:10.1021/acs.est.6b05843 PMID:28098989
  • Bossa N, Carpenter AW, Kumar N, de Lannoy C, Wiesner MR. 2017. Cellulose nanocrystal zero-valent iron nanocomposites for groundwater remediation. Environ Sci Nano 4:1294-1303. doi:10.1039/c6en00572a PMID:29725541 PMCID:PMC5929147
  • Brown DR, Thompson J, Chernick M, Hinton DE, Di Giulio RT. 2017. Later life swimming performance and persistent heart damage following subteratogenic PAH mixture exposure in the Atlantic killifish (Fundulus heteroclitus). Environ Toxicol Chem 36:3246-3253. doi:10.1002/etc.3877 PMID:28585726
  • Ferguson PL, Stapleton HM. 2017. Comment on: Mutagenic azo dyes, rather than flame retardants, are the predominant brominated compounds in house dust. Environ Sci Technol 51(6):3588-3590. doi:10.1021/acs.est.7b00372 PMID:28282131
  • Hammel SC, Hoffman K, Lorenzo AM, Chen A, Phillips AL, Butt CM, Sosa JA, Webster TF, Stapleton HM. 2017. Associations between flame retardant applications in furniture foam, house dust levels, and residents' serum levels. Environ Int 107:181-189. doi:10.1016/j.envint.2017.07.015 PMID:28750223 PMCID:PMC5572835
  • Hartman JH, Kozal JS, Di Giulio RT, Meyer JN. 2017. Zebrafish have an ethanol-inducible hepatic 4-nitrophenol hydroxylase that is not CYP2E1-like. Environ Toxicol Pharmacol 54:142-145. doi:10.1016/j.etap.2017.07.004 PMID:28728133 PMCID:PMC5563387
  • Henson R, Tenorio Fenton S, Tikalsky E. 2017. Understanding pathways to contaminant exposure In North Carolina’s community gardens. .
  • Hollender J, Schymanski EL, Singer HP, Ferguson PL. 2017. Nontarget screening with high resolution mass spectrometry in the environment: ready to go?. Environ Sci Technol 51(20):11505-11512. doi:10.1021/acs.est.7b02184 PMID:28877430
  • Jayasundara N, Fernando PW, Osterberg JS, Cammen KM, Schultz TF, Di Giulio RT. 2017. Cost of tolerance: Physiological consequences of evolved resistance to inhabit a polluted environmental in Teleost fish Fundulus heteroclitus. Environ Sci Technol 51:8763-8772. doi:10.1021/acs.est.7b01913 PMID:28682633
  • Levin ED. 2017. Neurodevelopmental Toxicity of Tobacco Smoke and Nicotine. Neurotoxicol Teratol 61:153. doi:10.1016/j.ntt.2017.04.004
  • Lindberg C, Jayasundara N, Kozal JS, Leuthner T, Di Giulio RT. 2017. Resistance to polycyclic aromatic hydrocarbon toxicity and associated bioenergetic consequences in a population of Fundulus heteroclitus. Ecotoxicology 26(3):435-448. doi:10.1007/s10646-017-1775-6 PMID:28213827
  • Luz AL, Godebo TR, Smith LL, Leuthner T, Maurer LL, Meyer JN. 2017. Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability. Toxicology 387:81-94. doi:10.1016/j.tox.2017.05.018 PMID:28602540
  • Macaulay LJ, Chernick M, Chen A, Hinton DE, Bailey JM, Kullman SW, Levin ED, Stapleton HM. 2017. Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development. Environ Toxicol Chem 36(1):36-48. doi:10.1002/etc.3535 PMID:27329031
  • Massarsky A, Abdel A, Glazer L, Levin ED, Di Giulio RT. 2017. Exposure to 1,2-propanediol impacts early development of zebrafish (Danio rerio) and induces hyperactivity. Zebrafish 14(3):216-222. doi:10.1089/zeb.2016.1400 PMID:28266909
  • Massarsky A, Kozal JS, Di Giulio RT. 2017. Glutathione and zebrafish: old assays to address a current issue. Chemosphere 168:707-715. doi:10.1016/j.chemosphere.2016.11.004 PMID:27836271 PMCID:PMC5182135
  • Meyer JN, Chan SS. 2017. Sources, mechanisms, and consequences of chemical-induced mitochondrial toxicity. Toxicology 391:2-4. doi:10.1016/j.tox.2017.06.002 PMID:28627407 PMCID:PMC5681391
  • Meyer JN, Leuthner T, Luz AL. 2017. Mitochondrial fusion, fission, and mitochondrial toxicity. Toxicology 391:42-53. doi:10.1016/j.tox.2017.07.019 PMID:28789970 PMCID:PMC5681418
  • Micic V, Schmid D, Bossa N, Gondikas A, Velimirovic M, von der Kammer F, Wiesner MR, Hofmann T. 2017. Impact of sodium humate coating on collector surfaces on deposition of polymer-coated nanoiron particles. Environ Sci Technol 51:9202-9209. doi:10.1021/acs.est.7b01224 PMID:28682625
  • Mu J, Chernick M, Dong W, Di Giulio RT, Hinton DE. 2017. Early life co-exposures to a real-world PAH mixture and hypoxia result in later life and next generation consequences in medaka (Oryzias latipes). Aquat Toxicol 190:162-173. doi:10.1016/j.aquatox.2017.06.026 PMID:28728047 PMCID:PMC5584607
  • Raftery TD, Jayasundara N, Di Giulio RT. 2017. A bioenergetics assay for studying the effects of environmental stressors on mitochondrial function in vivo in zebrafish larvae. Comp Biochem Physiol C Toxicol Pharmacol 192:23-32. doi:10.1016/j.cbpc.2016.12.001 PMID:27939721 PMCID:PMC5218841
  • Siebenaler R, Cameron R, Butt CM, Hoffman K, Higgins CP, Stapleton HM. 2017. Serum perfluoroalkyl acids (PFAAs) and associations with behavioral attributes. Chemosphere 184:687-693. doi:10.1016/j.chemosphere.2017.06.023 PMID:28633063 PMCID:PMC5535816
  • Slotkin TA, Skavicus S, Card JA, Di Giulio RT, Seidler FJ. 2017. In vitro models reveal differences in the developmental neurotoxicity of an environmental polycylic aromatic hydrocarbon mixture compared to benzo[a]pyrene: Neuronotypic PC12 Cells and embryonic neural stem cells. Toxicology 377:49-56. doi:10.1016/j.tox.2016.12.008 PMID:28049045 PMCID:PMC5250555
  • Slotkin TA, Skavicus S, Seidler FJ. 2017. Diazinon and parathion diverge in their effects on development of noradrenergic systems. Brain Res Bull 130:268-273. doi:10.1016/j.brainresbull.2017.02.004 PMID:28235599
  • Slotkin TA, Skavicus S, Stapleton HM, Seidler FJ. 2017. Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells. Toxicology 390:32-42. doi:10.1016/j.tox.2017.08.009 PMID:28851516 PMCID:PMC5633518

2016

  • Abreu-Villaca Y, Levin ED. 2016. Developmental neurobehavioral neurotoxicity of insecticides. In: Handbook of Development Neurotoxicology. Academic Press, San Diego, CA. pp.453-466.
  • Bailey JM, Oliveri A, Karbhari N, Brooks RA, De La Rocha AJ, Janardhan S, Levin ED. 2016. Persistent behavioral effects following early life exposure to retinoic acid or valproic acid in zebrafish. Neurotoxicology 52:23-33. doi:10.1016/j.neuro.2015.10.001 PMID:26439099 PMCID:PMC4753107
  • Brown DR, Bailey JM, Oliveri A, Levin ED, Di Giulio RT. 2016. Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish. Neurotoxicol Teratol 53:55-63. doi:10.1016/j.ntt.2015.10.007 PMID:26548404 PMCID:PMC4803068
  • Brown DR, Clark BW, Garner LV, Di Giulio RT. 2016. Embryonic cardiotoxicity of weak aryl hydrocarbon receptor agonists and CYP1A inhibitor fluoranthene in the Atlantic killifish (Fundulus heteroclitus). Comp Biochem Physiol C Toxicol Pharmacol 188:45-51. doi:10.1016/j.cbpc.2016.05.005 PMID:27211013
  • Carignan C, Fang M, Stapleton HM, Heiger-Bernays WJ, McClean MD, Webster TF. 2016. Urinary biomarkers of flame retardant exposure among collegiate US gymnasts. Environ Int 94:362-368. doi:10.1016/j.envint.2016.06.030 PMID:27395335 PMCID:PMC4980234
  • Cooper EM, Kroeger G, Davis K, Clark C, Ferguson PL, Stapleton HM. 2016. Results from screening polyurethane foam based consumer products for flame retardant chemicals: assessing impacts on the change in the furniture flammability standards. Environ Sci Technol 50(19):10653-10660. doi:10.1021/acs.est.6b01602 PMID:27552529 PMCID:PMC5052662
  • Czaplicki LM, Gunsch C. 2016. Reflection on molecular approaches influencing state-of-the-art bioremediation design: culturing to microbial community fingerprinting to omics. J Environ Eng (New York) 142(10):PMID:28348455 PMCID:PMC5364726
  • Czaplicki LN, Cooper EM, Ferguson PL, Stapleton HM, Vilgalys R, Gunsch C. 2016. A new perspective on sustainable soil remediation-case study suggests novel fungal genera could facilitate in situ biodegradation of hazardous contaminants. Remediation (N Y) 26(2):59-72. doi:10.1002/rem.21458 PMID:27917031 PMCID:PMC5130160
  • Gonzalez-Hunt CP, Rooney JP, Ryde IT, Anbalagan C, Joglekar R, Meyer JN. 2016. PCR-based analysis of mitochondrial DNA copy number, mitochondrial DNA damage, and nuclear DNA damage. Curr Protoc Toxicol 67:20.11.1-20.11.25. doi:10.1002/0471140856.tx2011s67 PMID:26828332 PMCID:PMC4928199
  • Lefevre E, Bossa N, Wiesner MR, Gunsch C. 2016. A review of the environmental implications of in situ remediation by nanoscale zero valent iron (nZVI): behavior, transport and impacts on microbial communities. Sci Total Environ 565:889-901. doi:10.1016/j.scitotenv.2016.02.003 PMID:26897610 PMCID:PMC5217753
  • Lefevre E, Cooper EM, Stapleton HM, Gunsch C. 2016. Characterization and adaptation of anaerobic sludge microbial communities exposed to tetrabromobisphenol A. PLoS One 11(7):e0157622. doi:10.1371/journal.pone.0157622 PMID:27463972 PMCID:PMC4963083
  • Luz AL, Godebo TR, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, Meyer JN. 2016. From the cover: arsenite uncouples mitochondrial respiration and induces a Warburg-like effect in Caenorhabditis elegans. Toxicol Sci 152(2):349-362. doi:10.1093/toxsci/kfw093 PMID:27208080 PMCID:PMC4960910
  • Luz AL, Lagido C, Hirschey MD, Meyer JN. 2016. In vivo determination of mitochondrial function using luciferase-expressing Caenorhabditis elegans: contribution of oxidative phosphorylation, glycolysis, and fatty acid oxidation to toxicant-induced dysfunction. Curr Protoc Toxicol 69:25.8.1-25.8.22. doi:10.1002/cptx.10 PMID:27479364 PMCID:PMC5002950
  • Petro A, Sexton HG, Miranda C, Rastogi A, Freedman JH, Levin ED. 2016. Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice. BMC Pharmacol Toxicol 17(1):55. doi:10.1186/s40360-016-0096-3 PMID:27802831 PMCID:PMC5090947
  • Riley AK, Chernick M, Brown DR, Hinton DE, Di Giulio RT. 2016. Hepatic responses of juvenile Fundulus heteroclitus from pollution-adapted and nonadapted populations exposed to Elizabeth River sediment extract. Toxicol Pathol 44(5):738-748. doi:10.1177/0192623316636717 PMID:26992886 PMCID:PMC4912431
  • Santa-Gonzalez GA, Gomez-Molina A, Arcos-Burgos M, Meyer JN, Camargo M. 2016. Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest. Redox Biol 9:124-133. doi:10.1016/j.redox.2016.07.004 PMID:27479053 PMCID:PMC4971155
  • Shan D, Deng S, Zhao T, Wang B, Wang Y, Huang J, Yu G, Winglee J, Wiesner MR. 2016. Preparation of ultrafine magnetic biochar and activated carbon for pharmaceutical adsorption and subsequent degradation by ball milling. J Hazard Mater 305:156-163. doi:10.1016/j.jhazmat.2015.11.047 PMID:26685062
  • Shan D, Deng S, Zhao T, Yu G, Winglee J, Wiesner MR. 2016. Preparation of regenerable granular carbon nanotubes by a simple heating-filtration method for efficient removal of typical pharmaceuticals. Chem Eng J 294:353-361. doi:10.1016/j.cej.2016.02.118
  • Slotkin TA, Skavicus S, Card JA, Levin ED, Seidler FJ. 2016. Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes. Toxicology 372:42-51. doi:10.1016/j.tox.2016.10.015 PMID:27816694 PMCID:PMC5137195
  • Van Houten B, Hunter SE, Meyer JN. 2016. Mitochondrial DNA damage induced autophagy, cell death, and disease. Front Biosci (Landmark Ed) 21:42-54. PMID:26709760 PMCID:PMC4750375

2015

2014

  • Colton MD, Kwok KW, Brandon JA, Warren IH, Ryde IT, Cooper EM, Hinton DE, Rittschof D, Meyer JN. 2014. Developmental toxicity and DNA damage from exposure to parking lot runoff retention pond samples in the Japanese medaka (Oryzias latipes). Mar Environ Res 99:117-124. doi:10.1016/j.marenvres.2014.04.007 PMID:24816191 PMCID:PMC4309550
  • Dong W, Macaulay LJ, Kwok KW, Hinton DE, Ferguson PL, Stapleton HM. 2014. The PBDE metabolite 6-OH-BDE 47 affects melanin pigmentation and THRβ MRNA expression in the eye of zebrafish embryos. Endocr Disruptors (Austin) 2(1):doi:10.4161/23273739.2014.969072 PMID:25767823 PMCID:PMC4354867
  • Fang M, Getzinger GJ, Cooper EM, Clark BW, Garner LV, Di Giulio RT, Ferguson PL, Stapleton HM. 2014. Effect-directed analysis of Elizabeth River porewater: developmental toxicity in zebrafish (Danio rerio). Environ Toxicol Chem 33(12):2767-2774. doi:10.1002/etc.2738 PMID:25196082 PMCID:PMC4393830
  • Levin ED, Cauley M, Johnson JE, Cooper EM, Stapleton HM, Ferguson PL, Seidler FJ, Slotkin TA. 2014. Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor. Neurotoxicol Teratol 41:35-42. doi:10.1016/j.ntt.2013.10.004 PMID:24177596 PMCID:PMC3943881
  • Pillai HK, Fang M, Beglov D, Kozakov D, Vajda S, Stapleton HM, Webster TF, Schlezinger JJ. 2014. Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. Environ Health Perspect 122(11):1225-1232. doi:10.1289/ehp.1408111 PMID:25062436 PMCID:PMC4216168
  • Shaughnessy DT, McAllister KA, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli A, Begley T, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. 2014. Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect 122(12):1271-1278. doi:10.1289/ehp.1408418 PMID:25127496 PMCID:PMC4256704
  • Slotkin TA, Card JA, Seidler FJ. 2014. Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways. Brain Res Bull 100:44-54. doi:10.1016/j.brainresbull.2013.10.014 PMID:24280657 PMCID:PMC3891922

2013

  • Bailey JM, Oliveri A, Levin ED. 2013. Zebrafish model systems for developmental neurobehavioral toxicology. Birth Defects Res C Embryo Today 99:14-23. doi:10.1002/bdrc.21027 PMID:23723169 PMCID:PMC4000730
  • Bess AS, Ryde IT, Hinton DE, Meyer JN. 2013. UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. J Biochem Mol Toxicol 27(1):28-41. doi:10.1002/jbt.21440 PMID:23132756 PMCID:PMC3640456
  • Bozinovic G, Sit TL, Di Giulio RT, Wills LF, Oleksiak MF. 2013. Genomic and physiological responses to strong selective pressure during late organogenesis: Few gene expression changes found despite striking morphological differences. BMC Genomics 14:779. doi:10.1186/1471-2164-14-779 PMID:24215130 PMCID:PMC3835409
  • Clark BW, Bone AJ, Di Giulio RT. 2013. Resistance to teratogenesis by F1 and F2 embryos of PAH-adapted Fundulus heteroclitus is strongly inherited despite reduced recalcitrance of the AHR pathway. Environ Sci Pollut Res Int doi:10.1007/s11356-013-2446-7 PMID:24374617 PMCID:PMC4074458
  • Clark BW, Cooper EM, Stapleton HM, Di Giulio RT. 2013. Compound- and mixture-specific differences in resistance to polycyclic aromatic hydrocarbons and PCB-126 among Fundulus heteroclitus subpopulations throughout the Elizabeth River Estuary (Virginia, USA). Environ Sci Technol 47(18):10556-10566. doi:10.1021/es401604b PMID:24003986 PMCID:PMC4079253
  • Dong W, Macaulay LJ, Kwok KW, Hinton DE, Stapleton HM. 2013. Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages. Aquat Toxicol 132-133:190-199. doi:10.1016/j.aquatox.2013.02.008 PMID:23531416 PMCID:PMC3642849
  • Garner LV, Brown DR, Di Giulio RT. 2013. Knockdown of AHR1A but not AHR1B exacerbates PAH and PCB-126 toxicity in zebrafish (Danio rerio) embryos. Aquat Toxicol 142-143:336-346. doi:10.1016/j.aquatox.2013.09.007 PMID:24084256 PMCID:PMC3837554
  • Levin ED, Landrigan PJ, Etzel R. 2013. Developmental Toxicology and Children's Environmental Health. In: The Oxford Textbook of Environmental Pediatrics: Environmental Influences on Health, Development and Disease. Oxford, New York, NY. pp.83-88.
  • Meyer JN, Leung MC, Rooney JP, Sendoel A, Hengartner MO, Kisby GE, Bess AS. 2013. Mitochondria as a target of environmental toxicants. Toxicol Sci 134:1-17. doi:10.1093/toxsci/kft102 PMID:23629515 PMCID:PMC3693132
  • Slotkin TA, Card JA, Infante A, Seidler FJ. 2013. BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells. Neurotoxicol Teratol 37:13-17. doi:10.1016/j.ntt.2013.02.001 PMID:23422510 PMCID:PMC3669237
  • Slotkin TA, Card JA, Infante A, Seidler FJ. 2013. Prenatal dexamethasone augments the sex-selective developmental neurotoxicity of chlorpyrifos: Implications for vulnerability after pharmacotherapy for preterm labor. Neurotoxicol Teratol 37:1-12. doi:10.1016/j.ntt.2013.02.002 PMID:23416428 PMCID:PMC3669256
  • Slotkin TA, Card JA, Seidler FJ. 2013. Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: Interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells. Environ Health Perspect 121:825-831. doi:10.1289/ehp.1306528 PMID:23603068 PMCID:PMC3702011
  • Slotkin TA, Cooper EM, Stapleton HM, Seidler FJ. 2013. Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?. Environ Toxicol Pharmacol 36(2):284-287. doi:10.1016/j.etap.2013.04.003 PMID:23686008 PMCID:PMC3745805
  • Slotkin TA, Seidler FJ. 2013. Terbutaline impairs the development of peripheral noradrenergic projections: Potential implications for autism spectrum disorders and pharmacotherapy of preterm labor. Neurotoxicol Teratol 36:91-96. doi:10.1016/j.ntt.2012.07.003 PMID:22813780 PMCID:PMC3492522
  • Van Wettere AJ, Hinton DE, Kullman SW, Law JM. 2013. Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injury. Toxicol Pathol 41(5):744-760. doi:10.1177/0192623312464308 PMID:23197195 PMCID:PMC4096295
  • Zhao B, Bohonowych JE, Timme-Laragy AR, Jung D, Affatato AA, Rice RH, Di Giulio RT, Denison MS. 2013. Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. PLoS One 8(2):e56860. doi:10.1371/journal.pone.0056860 PMID:23441220 PMCID:PMC3575475

2012

2011

2010

2009

2008

  • Bencan Z, Levin ED. 2008. The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish. Physiol Behav 95(3):408-412. doi:10.1016/j.physbeh.2008.07.009 PMID:18671990 PMCID:PMC3174522
  • Billiard SM, Meyer JN, Wassenberg DM, Hodson PV, Di Giulio RT. 2008. Nonadditive effects of PAHs on early vertebrate development: mechanisms and implications for risk assessment. Toxicol Sci 105(1):5-23. doi:10.1093/toxsci/kfm303 PMID:18156145 PMCID:PMC2734299
  • Carney MW, Erwin K, Hardman R, Yuen B, Volz DC, Hinton DE, Kullman SW. 2008. Differential developmental toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos. Mar Pollut Bull 57(6-12):255-266. doi:10.1016/j.marpolbul.2008.02.036 PMID:18433798 PMCID:PMC4299470
  • Lassiter TL, Ryde IT, MacKillop EA, Brown KK, Levin ED, Seidler FJ, Slotkin TA. 2008. Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood. Environ Health Perspect 116(11):1456-1462. doi:10.1289/ehp.11673 PMID:19057696 PMCID:PMC2592263
  • Matson CW, Clark BW, Jenny MJ, Fleming CR, Hahn ME, Di Giulio RT. 2008. Development of the morpholino gene knockdown technique in Fundulus heteroclitus: a tool for studying molecular mechanisms in an established environmental model. Aquat Toxicol 87(4):289-295. doi:10.1016/j.aquatox.2008.02.010 PMID:18378331 PMCID:PMC2413436
  • Mattie MD, McElwee MK, Freedman JH. 2008. Mechanism of copper-activated transcription: activation of AP-1, and the JNK/SAPK and p38 signal transduction pathways. J Mol Biol 383(5):1008-1018. doi:10.1016/j.jmb.2008.08.080 PMID:18793645 PMCID:PMC2662727
  • Miranda ML, Overstreet MA, Kim D. 2008. A framework for widespread replication of a highly spatially resolved childhood lead exposure risk model. Environ Health Perspect 116(12):1735-1739. doi:10.1289/ehp.11540 PMID:19079729 PMCID:PMC2599772
  • Roegge CS, Timofeeva OA, Seidler FJ, Slotkin TA, Levin ED. 2008. Developmental diazinon neurotoxicity in rats: later effects on emotional response. Brain Res Bull 75:168-172. PMID:18158111
  • Slotkin TA, Bodwell BE, Levin ED, Seidler FJ. 2008. Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems. Environ Health Perspect 116(3):340-348. doi:10.1289/ehp.11005 PMID:18335101 PMCID:PMC2265026
  • Slotkin TA, Bodwell BE, Ryde IT, Levin ED, Seidler FJ. 2008. Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood. Environ Health Perspect 116(10):1308-1314. doi:10.1289/ehp.11451 PMID:18941570 PMCID:PMC2569087
  • Slotkin TA, Ryde IT, Levin ED, Seidler FJ. 2008. Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood. Brain Res Bull 75(5):640-647. doi:10.1016/j.brainresbull.2007.10.008 PMID:18355640 PMCID:PMC2322865
  • Slotkin TA, Seidler FJ. 2008. Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel. Toxicol Appl Pharmacol 233(2):211-219. doi:10.1016/j.taap.2008.08.020 PMID:18835401 PMCID:PMC2645545
  • Slotkin TA, Seidler FJ, Fumagalli F. 2008. Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro. Brain Res Bull 76(4):424-438. doi:10.1016/j.brainresbull.2008.01.001 PMID:18502319 PMCID:PMC2430428
  • Slotkin TA, Seidler FJ, Ryde IT, Yanai J. 2008. Developmental neurotoxicity of chlorpyrifos in an avian model: effects on acetylcholine and serotonin pathways. Neurotoxicol Teratol PMID:18436430
  • Timme-Laragy AR, Noyes PD, Buhler DR, Di Giulio RT. 2008. CYP1B1 knockdown does not alter synergistic developmental toxicity of polycyclic aromatic hydrocarbons in zebrafish (Danio rerio). Mar Environ Res 66(1):85-87. doi:10.1016/j.marenvres.2008.02.030 PMID:18378296 PMCID:PMC2516962
  • Timofeeva OA, Roegge CS, Seidler FJ, Slotkin TA, Levin ED. 2008. Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon. Neurotoxicol Teratol 30(1):38-45. doi:10.1016/j.ntt.2007.10.002 PMID:18096363 PMCID:PMC2262840
  • Timofeeva OA, Sanders D, Seemann K, Yang L, Hermanson D, Regenbogen S, Kallepalli A, Rastogi A, Braddy D, Wells C, Perraut C, Seidler FJ, Slotkin TA, Levin ED, Agoos S. 2008. Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion. Brain Res Bull 77(6):404-411. doi:10.1016/j.brainresbull.2008.08.019 PMID:18817854 PMCID:PMC2612039
  • West AK, Hidalgo J, Eddins D, Levin ED, Aschner M. 2008. Metallothionein in the central nervous system: roles in protection, regeneration and cognition. Neurotoxicology 29(3):489-503. doi:10.1016/j.neuro.2007.12.006 PMID:18313142 PMCID:PMC2486367

2007

  • Buznikov GA, Nikitina LA, Rakic LM, Milosevic I, Bezuglov VV, Lauder JM, Slotkin TA. 2007. The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine. Brain Res Bull 74(4):221-231. PMID:17720543
  • Di Giulio RT, Hinton DE, eds. 2007. The Toxicology of Fishes. Taylor & Francis, Boca Raton, FL.
  • Hinton DE, Segner H, Au D, Kullman SW, Hardman R. 2007. Liver toxicity. In: The Toxicology of Fishes. Taylor & Francis, Boca Raton, FL.
  • Jameson RR, Seidler FJ, Slotkin TA. 2007. Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon. Environ Health Perspect 115(1):65-70. PMID:17366821 PMCID:PMC1797835
  • Lassiter CS, Linney EA. 2007. Embryonic expression and steroid regulation of brain aromatase cyp19a1b in zebrafish (Danio rerio). Zebrafish 4(1):49-57. doi:10.1089/zeb.2006.9995 PMID:18041942
  • Levin ED, Bencan Z, Cerutti DT. 2007. Anxiolytic effects of nicotine in zebrafish. Physiol Behav 90(1):54-8. PMID:17049956
  • Ostrander GK, Di Giulio RT, Hinton DE, Miller MR, Rotchell JR. 2007. Chemical Carcinogensis. In: The Toxicology of Fishes. Taylor & Francis, Boca Raton, FL.
  • Shemer H, Linden KG. 2007. Aqueous photodegradation and toxicity of the polycyclic aromatic hydrocarbons fluorene, dibenzofuran, and dibenzothiophene. Water Res 41(4):853-861. doi:10.1016/j.watres.2006.11.022 PMID:17217979 PMCID:PMC1876713
  • Slotkin TA, MacKillop EA, Ryde IT, Seidler FJ. 2007. Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. Environ Health Perspect 115:1306-1313. PMID:17805420
  • Slotkin TA, MacKillop EA, Ryde IT, Tate CA, Seidler FJ. 2007. Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel. Environ Health Perspect 115(1):93-101. PMID:17366826 PMCID:PMC1797840
  • Slotkin TA, Seidler FJ. 2007. Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems. Brain Res 72:232-274. PMID:17452286
  • Slotkin TA, Seidler FJ. 2007. Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats. Brain Res Bull 73(4-6):301-9. PMID:17562396
  • Slotkin TA, Seidler FJ. 2007. Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects. Reprod Toxicol 23(3):421-7. PMID:17267174
  • Slotkin TA, Seidler FJ, Fumagalli F. 2007. Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. Environ Health Perspect 115(6):909-16. PMID:17589599
  • Timme-Laragy AR, Cockman C, Matson CW, Di Giulio RT. 2007. Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish. Aquat Toxicol 85(4):241-50. PMID:17964672
  • Turski ML, Thiele D. 2007. Drosophila ctrl A functions as a copper transporter essential for development. J Biol Chem 282:24017-24026. PMID:17573340

2006

  • Arzuaga X, Wassenberg DM, Di Giulio RT, Elskus AA. 2006. The chlorinated AHR ligand 3,32,4,42,5-pentachlorobiphenyl (PCB126) promotes reactive oxygen species (ROS) production during embryonic development in the killifish (Fundulus heteroclitus). Aquat Toxicol 76(1):13-23.
  • Billiard SM, Timme-Laragy AR, Wassenberg DM, Cockman C, Di Giulio RT. 2006. The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. Toxicol Sci 92:526-536. PMID:16687390
  • Cerutti DT, Levin ED. 2006. Cognitive impairments models using complementary species. In: Animal Models of Cognitive Impairment. CRC Press, NY. pp.315-342.
  • Cook J, Denslow ND, Iguchi T, Linney EA, Miracle A, Shaw JR, Viant MR, Zacharewski TR. 2006. "Omics" approaches in the context of environment toxicology. (In: Emerging Molecular and Computational Approaches for Cross-Species Extrapolations). Chapter 1in: Society of Environmental Toxicology and Chemistry (SETAC) Annual Meeting 2006. Washington, DC. pp.1-29.
  • Embry MR, Billiard SM, Di Giulio RT. 2006. Lack of p53 induction in fish cells by model chemotherapeutics. Oncogene 25(14):2004-2010. doi:10.1038/sj.onc.1209238 PMID:16434976
  • Jameson RR, Seidler FJ, Qiao D, Slotkin TA. 2006. Adverse neurodevelopmental effects of dexamethasone modeled in PC12 Cells: identifying the critical stages and concentration thresholds for the targeting of cell acquisition, differentiation and viability. Neuropsychopharmacology 31(8):1647-1658. PMID:16319912
  • Jameson RR, Seidler FJ, Qiao D, Slotkin TA. 2006. Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells. Environ Health Perspect 114:667-672. PMID:16675418
  • Levin ED, Buccafusco JJ. 2006. Animal Models of Cognitive Impairment CRC Press, NY.
  • Levin ED, Perraut C, Pollard N, Freedman JH. 2006. Metallothionein expression and neurocognitive function in mice. Physiol Behav 87(3):513-518. PMID:16430929
  • Shemer H, Linden KG. 2006. Degradation and by-product formation of diazinon in water during UV and UV/H2O2 treatment. J Hazard Mater 136:553-559. PMID:16436313
  • Shemer H, Linden KG. 2006. Photolysis, oxidation and subsequent toxicity of a mixture of polycyclic aromatic hydrocarbons in natural waters. Journal of Photochemistry and Photobiology A: Chemistry 187(2-3):186-195. PMID:23772136
  • Slotkin TA, Levin ED, Seidler FJ. 2006. Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environ Health Perspect 114(5):746-751. PMID:16675431
  • Slotkin TA, Seidler FJ. 2006. Anomalous regulation of B-adrenoceptor signaling in brain regions of the newborn rat. Brain Res 1077(1):54-58.
  • Slotkin TA, Tate CA, Ryde IT, Levin ED, Seidler FJ. 2006. Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environ Health Perspect 114:1542-1545. PMID:17035140
  • Timme-Laragy AR, Levin ED, Di Giulio RT. 2006. Developmental and behavioral effects of embryonic exposure to the polybrominated diphenylether mixture DE-71 in the killifish (Fundulus heteroclitus). Chemosphere 62(7):1097-1104. PMID:16045967

2005

  • Aldridge JE, Levin ED, Seidler FJ, Slotkin TA. 2005. Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. Environ Health Perspect 113(5):527-531. PMID:15866758
  • Aldridge JE, Meyer A, Seidler FJ, Slotkin TA. 2005. Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure. Environ Health Perspect 113(8):1027-1031. PMID:16079074 PMCID:PMC1280344
  • Aldridge JE, Meyer A, Seidler FJ, Slotkin TA. 2005. Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. Toxicol Appl Pharmacol 203(2):132-144. PMID:15710174
  • Garcia SJ, Seidler FJ, Slotkin TA. 2005. Developmental neurotoxicity of chlorpyrifos: targeting glial cells. Environ Toxicol Pharmacol 19(3):455-461. doi:10.1016/j.etap.2004.12.007 PMID:21783512
  • Meyer A, Seidler FJ, Aldridge JE, Slotkin TA. 2005. Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos. Toxicol Appl Pharmacol 203(2):154-166. PMID:15710176
  • Meyer JN, Volz DC, Freedman JH, Di Giulio RT. 2005. Differential display of hepatic mRNA from killifish (Fundulus heteroclitus) inhabiting a Superfund estuary. Aquat Toxicol 73(4):327-341. PMID:15916819
  • Nacci DE, Coiro L, Wassenberg DM, Di Giulio RT. 2005. A non-destructive technique to measure cytochrome P4501A enzyme activity in living embryos of the estuarine fish Fundulus heteroclitus. Chapter Vol. 2 in: Techniques in Aquatic Toxicology. CRC Press, Inc., Boca Raton, FL. pp.209-226.
  • Qiao D, Seidler FJ, Slotkin TA. 2005. Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. Toxicol Appl Pharmacol 206(1):17-26. PMID:15963341
  • Roy TS, Sharma V, Seidler FJ, Slotkin TA. 2005. Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. Brain Res Dev Brain Res 155(1):71-80. doi:10.1016/j.devbrainres.2004.12.004 PMID:15763277
  • Shemer H, Sharpless CM, Linden KG. 2005. Photodegradation of 3,5,6-trichloro-2-pyridinol in aqueous solution. Water Air Soil Pollut 168(1-4):145-155.
  • Slotkin TA. 2005. Developmental Neurotoxicity of Organophosphates: A Case Study of Chlorpyrifos. Chapter 21 in: Toxicity of Organophosphate and Carbamate Compounds. (Gupta RC, ed). Elsevier Academic Press, San Diego, CA. pp.293-314.
  • Slotkin TA, Brown KK, Seidler FJ. 2005. Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood. Environ Health Perspect 113(10):1291-1294. PMID:16203236 PMCID:PMC1281268
  • Slotkin TA, Oliver CA, Seidler FJ. 2005. Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination. Brain Res Dev Brain Res 157(2):172-180. PMID:15963356
  • Slotkin TA, Seidler FJ. 2005. The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. Brain Res Dev Brain Res 158(1-2):115-119. doi:10.1016/j.devbrainres.2005.06.008 PMID:16024092
  • Slotkin TA, Tate CA, Cousins MM, Seidler FJ. 2005. Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination. Brain Res Dev Brain Res 160(2):219-230. PMID:16256208
  • Song MO, Freedman JH. 2005. Activation of mitogen activated protein kinases by PCB126 (3,3',4,4',5-pentachlorobiphenyl) in HepG2 cells. Toxicol Sci 84(2):308-318. doi:10.1093/toxsci/kfi084 PMID:15647597
  • Song MO, Freedman JH. 2005. Expression of copper-responsive genes in HepG2 cells. Mol Cell Biochem 279(1-2):141-147. doi:10.1007/s11010-005-8286-0 PMID:16283523
  • Timme-Laragy AR, Meyer JN, Waterland RA, Di Giulio RT. 2005. Analysis of CpG methylation in the killifish CYP1A promoter. Comp Biochem Physiol C Toxicol Pharmacol 141(4):406-411. PMID:16257583
  • Wassenberg DM, Nerlinger AL, Battle LP, Di Giulio RT. 2005. Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro CYP1A activity and polycyclic aromatic hydrocarbon-derived embryonic deformities. Environ Toxicol Chem 24(10):2526-2532. PMID:16268154

2004

  • Aldridge JE, Seidler FJ, Slotkin TA. 2004. Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environ Health Perspect 112(2):148-155. PMID:14754568
  • Bacanskas LR, Whitaker J, Di Giulio RT. 2004. Oxidative stress in two populations of killifish (Fundulus heteroclitus) with differing contaminant exposure histories. Mar Environ Res 58(2-5):597-601. doi:10.1016/j.marenvres.2004.03.048 PMID:15178085
  • Craft ES, Embry MR, Di Giulio RT, Freedman JH. 2004. Evidence for the role of p53 in metal-induced activation of metallothionein gene expression. In: Metal Ions in Biology and Medicine: Proceedings of the Eighth International Symposium on Metal Ions in Biology and Medicine. John Libbey Eurotext Publishers, Montrouge, France.
  • Dolinoy DC, Miranda ML. 2004. GIS modeling of air toxics releases from TRI-reporting and non-TRI-reporting facilities: impacts for environmental justice. Environ Health Perspect 112(17):1717-1724. PMID:15579419
  • Embry MR, Whitaker J, Freedman JH, Di Giulio RT. 2004. Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants. Comp Biochem Physiol C Toxicol Pharmacol 137(4):335-342. PMID:15228951
  • Icenogle LM, Christopher NC, Blackwelder WP, Caldwell DP, Qiao D, Seidler FJ, Slotkin TA, Levin ED. 2004. Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicol Teratol 26(1):95-101. PMID:15001218
  • Izrael M, Van der Zee EA, Slotkin TA, Yanai J. 2004. Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model. J Neurosci Res 78(4):499-507. doi:10.1002/jnr.20287 PMID:15470723
  • Levin ED, Swain HA, Donerly S, Linney EA. 2004. Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior. Neurotoxicol Teratol 26(6):719-723. PMID:15451035
  • Linney EA, Udvadia AJ. 2004. Construction and detection of fluorescent germline transgenic zebrafish. Chapter Vol. 254 in: Methods in Molecular Biology, 2004. Humana Press, Inc, Louisville, KY. pp.271-288.
  • Linney EA, Upchurch L, Donerly S. 2004. Zebrafish as a neurotoxicological model. Neurotoxicol Teratol 26(6):709-718. PMID:15451034
  • Mattie MD, Freedman JH. 2004. Copper-inducible transcription: regulation by metal- and oxidative stress-responsive pathways. Am J Physiol Cell Physiol 286(2):C293-C301. doi:10.1152/ajpcell.00293.2003 PMID:14576086
  • Meyer A, Seidler FJ, Aldridge JE, Tate CA, Cousins MM, Slotkin TA. 2004. Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure. Environ Health Perspect 112(3):295-301. PMID:14998743
  • Meyer A, Seidler FJ, Slotkin TA. 2004. Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling. Environ Health Perspect 112(2):170-178. PMID:14754571
  • Qiao D, Seidler FJ, Abreu-Villaca Y, Tate CA, Cousins MM, Slotkin TA. 2004. Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. Brain Res Dev Brain Res 148(1):43-52. PMID:14757517
  • Rhodes MC, Seidler FJ, Qiao D, Tate CA, Cousins MM, Slotkin TA. 2004. Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats. Toxicol Appl Pharmacol 195(2):203-217. doi:10.1016/j.taap.2003.11.008 PMID:14998686
  • Roy TS, Seidler FJ, Slotkin TA. 2004. Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia. Brain Res Dev Brain Res 148(2):197-206. doi:10.1016/j.devbrainres.2003.12.004 PMID:14766197
  • Slotkin TA. 2004. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicol Appl Pharmacol 198(2):132-151. PMID:15236950
  • Slotkin TA. 2004. Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspective. Neurotoxicology 25(4):631-640. PMID:15183016
  • Slotkin TA, Southard MC, Adam SJ, Cousins MM, Seidler FJ. 2004. Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos. Brain Res Bull 64(3):227-235. doi:10.1016/j.brainresbull.2004.07.005 PMID:15464859
  • Wassenberg DM, Di Giulio RT. 2004. Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus. Environ Health Perspect 112(17):1658-1664. PMID:15579409
  • Wassenberg DM, Di Giulio RT. 2004. Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors. Mar Environ Res 58(2-5):163-168. PMID:15178029

2003

  • Aldridge JE, Seidler FJ, Meyer A, Thillai I, Slotkin TA. 2003. Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. Environ Health Perspect 111(14):1736-1743. PMID:14594624
  • Buznikov GA, Slotkin TA, Lauder JM. 2003. Sea urchin embryos and larvae as biosensors for neurotoxins. In: Current Protocals in Toxicology. John Wiley & Sons, NY. pp.1.6.1-1.6.24.
  • Cooper EM, Vasudevan D. 2003. Comparison of hydroxynaphthoic acid isomer sorption onto goethite: Batch, ATR-FTIR and Computational chemistry approaches. In: Proceedings of the 226th ACS (American Chemical Society) National Meeting - Fall 2003. New York, NY.
  • Dam K, Seidler FJ, Slotkin TA. 2003. Transcriptional biomarkers distinguish between vunerable periods for developmental neurotoxicity of chlorpyrifos: implications for toxicogenomics. Brain Res Bull 59(4):261-265. PMID:12464398
  • Garcia SJ, Seidler FJ, Slotkin TA. 2003. Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: effects on neurospecific proteins indicate changing vulnerabilities. Environ Health Perspect 111(3):297-303. PMID:12611658 PMCID:PMC1241386
  • Levin ED, Chrysanthis E, Yacsin K, Linney EA. 2003. Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. Neurotoxicol Teratol 25(1):51-57. PMID:12633736
  • Linney EA, Udvadia AJ. 2003. Construction and detection of fluorescent germ-line transgenic zebrafish. In: Methods Mol Med. (). Humana Press,
  • Meyer A, Seidler FJ, Cousins MM, Slotkin TA. 2003. Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target?. Environ Health Perspect 111(16):1871-1876. PMID:14644659 PMCID:PMC1241759
  • Meyer JN, Di Giulio RT. 2003. Heritable adaptation and fitness costs in killifish (Fundulus heteroclitus) inhabiting a polluted estuary. Ecol Appl 13(2):490-503.
  • Meyer JN, Smith JD, Winston GW, Di Giulio RT. 2003. Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses. Aquat Toxicol 65(4):377-395. doi:10.1016/j.aquatox.2003.06.001 PMID:14568353
  • Meyer JN, Wassenberg DM, Karchner SI, Hahn ME, Di Giulio RT. 2003. Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environ Toxicol Chem 22(10):2337-2343. PMID:14551997
  • Nikitina LA, Buznikov GA, Lauder JM, Seidler FJ, Slotkin TA. 2003. The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity. Environ Health Perspect 111(14):536-544. PMID:14594623
  • Qiao D, Seidler FJ, Violin JD, Slotkin TA. 2003. Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. Brain Res Dev Brain Res 147(1-2):183-190. PMID:14741763
  • Seidler FJ, Tate CA, Cousins MM, Slotkin TA. 2003. Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. Environ Health Perspect 111(4):536-544. PMID:12676612 PMCID:PMC1241441
  • Udvadia AJ, Linney EA. 2003. Windows into development: historic, current, and future perspectives on transgenic zebrafish. Dev Biol 256(1):1-17. PMID:12654288

2002

  • Adams TK, Saydam N, Steiner F, Schaffner W, Freedman JH. 2002. Activation of gene expression by metal-responsive signal transduction pathways. Environ Health Perspect 110(5):813-817. PMID:12426137
  • Garcia SJ, Seidler FJ, Slotkin TA. 2002. Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein. Brain Res Dev Brain Res 133(2):151-161. PMID:11882345
  • Kimura Y, Corcoran EE, Eto K, Gengyo-Ando K, Muramatsu M, Kobayashi R, Freedman JH, Mitani S, Hagiwara M, Means AR, Tokumitsu H. 2002. A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO J 3:962-966. PMID:12231504
  • Lassiter CS, Linney EA, Kelley B. 2002. Genomic structure and embryonic expression of estrogen receptor beta a (ERBa) in zebrafish (Danio rerio). Gene 292(1-2):141-151. doi:10.1016/S0378-1119(02)01050-8 PMID:12459262
  • Levin ED, Addy N, Baruah A, Elias A, Christopher NC, Seidler FJ, Slotkin TA. 2002. Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicol Teratol 24(6):733-741. PMID:12460655
  • Liao VH, Dong J, Freedman JH. 2002. Molecular characterization of a novel, cadmium-inducible gene from the nematode Caenorhabditis elegans. A new gene that contributes to the resistance to cadmium toxicity. J Biol Chem 277(44):42049-42059. doi:10.1074/jbc.M206740200 PMID:12189149
  • Liao VH, Freedman JH. 2002. Differential display analysis of gene expression in invertebrates. Cellular and Molecular Life Sciences 59:1256-1263. PMID:12363029
  • Mattie MD, Freedman JH. 2002. Copper Inducible Gene Expression Regulated by Metals and Oxidative Stress Responsive Pathways. In: Metal Ions in Biology and Medicine: Proceedings of the Seventh International Symposium on Metal Ions in Biology and Medicine. John Libbey Eurotext Publishers, Reims, France. pp.108-112.
  • Mattie MD, Freedman JH. 2002. Copper inducible gene expression regulated by metals and oxidative stress responsive pathways. Trace Elem Med 3:46.
  • Maurer LL, Luz AL, Meyer JN. 2002. Detection of mitochondrial toxicity of environmental pollutants using Caenorhabditis elegans. In: Wiley Encyclopedia of Molecular Medicine. Medicine John Wiley & Sons Inc., New York, NY.
  • Meyer JN, Di Giulio RT. 2002. Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA. Mar Environ Res 54(3-5):621-626. PMID:12408627
  • Meyer JN, Nacci DE, Di Giulio RT. 2002. Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments. Toxicol Sci 68(1):69-81. PMID:12075112
  • Miranda ML, Dolinoy DC, Overstreet MA. 2002. Mapping for prevention: GIS models for directing childhood lead poisoning prevention programs. Environ Health Perspect 110(9):947-953. PMID:12204831
  • Saydam N, Adams TK, Steiner F, Schaffner W, Freedman JH. 2002. Regulation of metallothionein transcription by the metal responsive transcription factor MTF-1. Identification of signal transduction cascades that control metal-inducible transcription. J Biol Chem 277:20438-20445. PMID:11923282
  • Schlenk D, Di Giulio RT. 2002. Biochemical responses as indicators of aquatic ecosystem health. In: Biological Indicators of Aquatic Ecosystem Stress. American Fisheries Society, Bethesda, MD. pp.13-422.
  • Seidler FJ, Padilla S, Slotkin TA, Qiao D. 2002. Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period?. Environ Health Perspect 110(11):1097-1103. PMID:12417480 PMCID:PMC1241065
  • Slotkin TA, Tate CA, Cousins MM, Seidler FJ. 2002. Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure. Brain Res Dev Brain Res 133(2):163-173. PMID:11882346
  • Wassenberg DM, Swails EE, Di Giulio RT. 2002. Effects of combined exposures to benzo[a]pyrene and 3,3',4,4',5-pentachlorobiphenyl on Fundulus heteroclitus. Mar Environ Res 54(3-5):279-283.
  • Yanai J, Vatury O, Slotkin TA. 2002. Cell signaling as a target and underlying mechanism for neurobehavioral teratogenesis. Ann N Y Acad Sci 965:473-478. PMID:12105122

2001

  • Arthur D, Levin ED. 2001. Spatial and non-spatial visual discrimination learning in zebrafish (Danio rerio). Anim Cogn 4:125-131.
  • Buznikov GA, Bezuglov VV, Nikitina LA, Slotkin TA, Lauder JM. 2001. Cholinergic regulation of sea urchin embryonic and larval development. Ross Fiziol Zh Im I M Sechenova 87(11):1548-1556. PMID:11822358
  • Buznikov GA, Nikitina LA, Bezuglov VV, Lauder JM, Padilla S, Slotkin TA. 2001. An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae. Environ Health Perspect 109(7):651-661. PMID:11485862
  • Garcia SJ, Seidler FJ, Crumpton TL, Slotkin TA. 2001. Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells. Brain Res 891(1-2):54-68. PMID:11164809
  • Levin ED, Addy N, Nakajima A, Christopher NC, Seidler FJ, Slotkin TA. 2001. Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Brain Res Dev Brain Res 130(1):83-89. PMID:11557096
  • Mattie MD, Freedman JH. 2001. Protective effects of aspirin and Vitamin E (a-tocopherol) against copper- and cadmium-induced toxicity. Biochem Biophys Res Commun 285(4):921-925. PMID:11467839
  • Navarro HA, Basta PV, Seidler FJ, Slotkin TA. 2001. Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect?. Brain Res Dev Brain Res 130(2):249-252. PMID:11675126
  • Raines KW, Seidler FJ, Slotkin TA. 2001. Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. Brain Res Dev Brain Res 130(1):65-72. PMID:11557094
  • Seidler FJ, Slotkin TA, Qiao D. 2001. Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells. Environ Health Perspect 109(9):909-913. PMID:11673119 PMCID:PMC1240440
  • Slotkin TA, Cousins MM, Tate CA, Seidler FJ. 2001. Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Brain Res 902(2):229-243. PMID:11384617
  • Sutton D, Kabala Z, Francisco AB, Vasudevan D. 2001. Limitations and potential of commercially available rhodamine WT as a groundwater tracer. Water Resour Res 37(6):1641-1656.
  • Toomey BH, Bello SM, Hahn ME, Cantrell S, Wright P, Tillitt DE, Di Giulio RT. 2001. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquat Toxicol 53(2):127-138. PMID:11311389
  • Vasudevan D, Fimmen RL, Francisco AB. 2001. Tracer grade rhodamine WT: structure of constituent isomers and their sorption behavior. Environ Sci Technol 35(20):4089-4096. PMID:11686371
  • Willett KL, Lienesch L, Reichert W, Di Giulio RT. 2001. In vivo and in vitro inhibition of CYP1A-dependent activity in Fundulus heteroclitus by the polynuclear aromatic hydrocarbon (PAH) fluoranthene. Toxicol Appl Pharmacol 177(3):264-271. PMID:11749126

2000

  • Auman JT, Seidler FJ, Slotkin TA. 2000. Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity. Brain Res Dev Brain Res 121(1):19-27. PMID:10837889
  • Cioci LK, Qui L, Freedman JH. 2000. Transgenic strains of the nematode caenorhabditis elegans as biomonitors metal contamination. Environ Toxicol Chem 19(8):2122-2129.
  • Crumpton TL, Seidler FJ, Slotkin TA. 2000. Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation. Brain Res 857(1-2):87-98. PMID:10700556
  • Crumpton TL, Seidler FJ, Slotkin TA. 2000. Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?. Brain Res Dev Brain Res 121(2):189-195. PMID:10876031
  • Dam K, Seidler FJ, Slotkin TA. 2000. Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity. Brain Res Dev Brain Res 121(2):179-187. PMID:10876030
  • Tcherepanova I, Bhattacharyya L, Rubin CS, Freedman JH. 2000. Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1. J Biol Chem 275(34):26359-26369. doi:10.1074/jbc.M000956200 PMID:10854422
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