| Project Title: | THE ROLE OF MONO-ADP-RIBOSYLATION BY PARP14 IN RADIORESISTANCE |
|---|---|
| PI: | Moldovan, George Lucian |
| Institution: | Pennsylvania State Univ Hershey Med Ctr |
| Grant Number: | R01ES026184 |
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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| Role of Translesion DNA Synthesis in the Metabolism of Replication-associated Nascent Strand Gaps. | Khatib, Jude B; Nicolae, Claudia M; Moldovan, George-Lucian | R01ES026184 | J Mol Biol (2024 Jan 01) |
37714300
|
2024 |
| USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during ... | Nusawardhana, Alexandra; Pale, Lindsey M; Nicolae, Claudia M; Moldovan, George-Lucian | R01ES026184 | Nucleic Acids Res (2024 Mar 21) |
38180818
|
2024 |
| Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nuclea ... | Hale, Anastasia; Dhoonmoon, Ashna; Straka, Joshua; Nicolae, Claudia M; Moldovan, George-Lucian | R01ES026184 | Nat Commun (2023 Oct 07) |
37805499
|
2023 |
| Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identif ... | Khatib, Jude B; Schleicher, Emily M; Jackson, Lindsey M; Dhoonmoon, Ashna; Moldovan, George-Luc ... | R01ES026184 | Oncotarget (2022) |
36187556
|
2022 |
| CRISPR screens guide the way for PARP and ATR inhibitor biomarker discovery. | Schleicher, Emily M; Moldovan, George-Lucian | R01ES026184 | FEBS J (2022 Dec) |
34601817
|
2022 |
| Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through ... | Thakar, Tanay; Dhoonmoon, Ashna; Straka, Joshua; Schleicher, Emily M; Nicolae, Claudia M; Moldo ... | R01ES026184 | Nat Commun (2022 Sep 09) |
36085347
|
2022 |
| Mechanisms of PARP1 inhibitor resistance and their implications for cancer treatment. | Jackson, Lindsey M; Moldovan, George-Lucian | R01ES026184 | NAR Cancer (2022 Dec) |
36568963
|
2022 |
| The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1. | Hirschler-Laszkiewicz, Iwona; Festa, Fernanda; Huang, Suming; Moldovan, George-Lucian; Nicolae, ... | R01ES026184 | Sci Rep (2022 Apr 15) |
35428820
|
2022 |
| The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and ... | Dhoonmoon, Ashna; Nicolae, Claudia M; Moldovan, George-Lucian | R01ES026184 | Nat Commun (2022 Aug 27) |
36030235
|
2022 |
| The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells. | Schleicher, Emily M; Dhoonmoon, Ashna; Jackson, Lindsey M; Khatib, Jude B; Nicolae, Claudia M; ... | R01ES026184 | Oncogenesis (2022 Jun 18) |
35717336
|
2022 |
| Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability i ... | Jackson, Lindsey M; Dhoonmoon, Ashna; Hale, Anastasia; Dennis, Kady A; Schleicher, Emily M; Nic ... | R01ES026184 | Nucleic Acids Res (2021 Dec 16) |
34871431
|
2021 |
| PARP14 regulates cyclin D1 expression to promote cell-cycle progression. | O'Connor, Michael J; Thakar, Tanay; Nicolae, Claudia M; Moldovan, George-Lucian | R01ES026184 | Oncogene (2021 Jul) |
34158578
|
2021 |
| The emerging determinants of replication fork stability. | Thakar, Tanay; Moldovan, George-Lucian | R01ES026184 | Nucleic Acids Res (2021 Jul 21) |
33978751
|
2021 |
| WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells. | Datta, Arindam; Biswas, Kajal; Sommers, Joshua A; Thompson, Haley; Awate, Sanket; Nicolae, Cla ... | R01ES026184 | Nat Commun (2021 11 12) |
34772932
|
2021 |
| Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the ... | Schleicher, Emily M; Dhoonmoon, Ashna; Jackson, Lindsey M; Clements, Kristen E; Stump, Coryn L; ... | R01ES026184 | PLoS Genet (2020 11) |
33137164
|
2020 |
| FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cro ... | Awate, Sanket; Sommers, Joshua A; Datta, Arindam; Nayak, Sumeet; Bellani, Marina A; Yang, Oliv ... | R01ES026184 | Nucleic Acids Res (2020 09 18) |
32797166
|
2020 |
| Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP1 ... | Dhoonmoon, Ashna; Schleicher, Emily M; Clements, Kristen E; Nicolae, Claudia M; Moldovan, Georg ... | R01ES026184 | Nucleic Acids Res (2020 07 27) |
32542389
|
2020 |
| Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary ... | Clements, Kristen E; Schleicher, Emily M; Thakar, Tanay; Hale, Anastasia; Dhoonmoon, Ashna; Tol ... | R01ES026184 | Nat Commun (2020 Nov 30) |
33257658
|
2020 |
| Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki f ... | Thakar, Tanay; Leung, Wendy; Nicolae, Claudia M; Clements, Kristen E; Shen, Binghui; Bielinsky, ... | R01ES026184 | Nat Commun (2020 05 01) |
32358495
|
2020 |
| Error-prone replication of a 5-formylcytosine-mediated DNA-peptide cross-link in human cells. | Naldiga, Spandana; Ji, Shaofei; Thomforde, Jenna; Nicolae, Claudia M; Lee, Marietta; Zhang, Zh ... | R01ES023350, R01ES026184 | J Biol Chem (2019 07 05) |
31138652
|
2019 |
| Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient c ... | Clements, Kristen E; Thakar, Tanay; Nicolae, Claudia M; Liang, Xinwen; Wang, Hong-Gang; Moldova ... | R01ES026184 | Nucleic Acids Res (2018 Sep 28) |
30032296
|
2018 |
| PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress. | Schleicher, Emily M; Galvan, Adri M; Imamura-Kawasawa, Yuka; Moldovan, George-Lucian; Nicolae, ... | R01ES026184 | Nucleic Acids Res (2018 09 28) |
30032250
|
2018 |
| Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork. | Choe, Katherine N; Moldovan, George-Lucian | R01ES026184 | Mol Cell (2017 Feb 02) |
28157503
|
2017 |
| HUWE1 interacts with PCNA to alleviate replication stress. | Choe, Katherine N; Nicolae, Claudia M; Constantin, Daniel; Imamura Kawasawa, Yuka; Delgado-Diaz, ... | R01ES026184 | EMBO Rep (2016 06) |
27146073
|
2016 |
| PARP10 deficiency manifests by severe developmental delay and DNA repair defect. | Shahrour, Maher Awni; Nicolae, Claudia M; Edvardson, Simon; Ashhab, Motee; Galvan, Adri M; Cons ... | R01ES026184 | Neurogenetics (2016 Oct) |
27624574
|
2016 |