Project Title: | DNA METHYLTRANSFERASE GENE EXPRESSION IN COLON CANCER |
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PI: | Baylin, Stephen B. |
Institution: | Johns Hopkins University |
Grant Number: | R01ES011858 |
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Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
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Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locatio ... | You, Qinglong; Feng, Xiang; Cai, Yi; Baylin, Stephen B; Li, Huilin | R01ES011858 | Commun Biol (2024 Sep 28) | 39341999 | 2024 |
The Epigenetic Hallmarks of Cancer. | Esteller, Manel; Dawson, Mark A; Kadoch, Cigall; Rassool, Feyruz V; Jones, Peter A; Baylin, St ... | R01ES011858 | Cancer Discov (2024 Oct 04) | 39363741 | 2024 |
Tissue-location-specific transcription programs drive tumor dependencies in colon cancer. | Yang, Lijing; Tu, Lei; Bisht, Shilpa; Mao, Yiqing; Petkovich, Daniel; Thursby, Sara-Jayne; Lia ... | R01ES011858 | Nat Commun (2024 Feb 15) | 38360902 | 2024 |
Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable ... | Kanholm, Tomas; Rentia, Uzma; Hadley, Melissa; Karlow, Jennifer A; Cox, Olivia L; Diab, Noor; ... | R01ES011858 | Cancer Res (2023 Aug 01) | 37249603 | 2023 |
Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colo ... | Bhandari, Yuba R; Krishna, Vinod; Powers, Rachael; Parmar, Sehej; Thursby, Sara-Jayne; Gupta, ... | R01ES011858 | Proc Natl Acad Sci U S A (2023 Aug) | 37487069 | 2023 |
Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenes ... | DeStefano Shields, Christina E; White, James R; Chung, Liam; Wenzel, Alyssa; Hicks, Jessica L; ... | R01ES011858 | Cancer Discov (2021 07) | 33632774 | 2021 |
Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Indu ... | Tao, Yong; Kang, Byunghak; Petkovich, Daniel A; Bhandari, Yuba R; In, Julie; Stein-O'Brien, Ge ... | R01ES011858 | Cancer Cell (2019 Feb 11) | 30753828 | 2019 |
Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic ... | Kong, Xiangqian; Chen, Jie; Xie, Wenbing; Brown, Stephen M; Cai, Yi; Wu, Kaichun; Fan, Daimin ... | R01ES011858 | Cancer Cell (2019 04 15) | 30956060 | 2019 |
Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational C ... | Ye, Fei; Kong, Xiangqian; Zhang, Hao; Liu, Yan; Shao, Zhiyuan; Jin, Jia; Cai, Yi; Zhang, Ruk ... | R01ES011858 | ACS Chem Biol (2018 03 16) | 29381856 | 2018 |
Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative S ... | Zhang, Yang W; Wang, Zhihong; Xie, Wenbing; Cai, Yi; Xia, Limin; Easwaran, Hariharan; Luo, Ji ... | R01ES011858 | Mol Cell (2017 Jan 19) | 28107650 | 2017 |
CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor ... | Xia, Limin; Huang, Wenjie; Bellani, Marina; Seidman, Michael M; Wu, Kaichun; Fan, Daiming; Nie ... | R01ES011858 | Cancer Cell (2017 May 08) | 28486105 | 2017 |
Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cel ... | Vaz, Michelle; Hwang, Stephen Y; Kagiampakis, Ioannis; Phallen, Jillian; Patil, Ashwini; O'Haga ... | R01ES011858 | Cancer Cell (2017 Sep 11) | 28898697 | 2017 |
Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across ... | Cai, Yi; Tsai, Hsing-Chen; Yen, Ray-Whay Chiu; Zhang, Yang W; Kong, Xiangqian; Wang, Wei; Xia, ... | R01ES011858 | Genome Res (2017 04) | 28232479 | 2017 |
Epigenetic Therapeutics: A New Weapon in the War Against Cancer. | Ahuja, Nita; Sharma, Anup R; Baylin, Stephen B | R01ES011858 | Annu Rev Med (2016) | 26768237 | 2016 |
Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage. | Ding, Ning; Bonham, Emily M; Hannon, Brooke E; Amick, Thomas R; Baylin, Stephen B; O'Hagan, He ... | R01ES011858 | J Mol Cell Biol (2016 Jun) | 26186941 | 2016 |
A recombinant reporter system for monitoring reactivation of an endogenously DNA hypermethylated gen ... | Cui, Ying; Hausheer, Frederick; Beaty, Robert; Zahnow, Cynthia; Issa, Jean Pierre; Bunz, Frede ... | R01ES011858 | Cancer Res (2014 Jul 15) | 24876104 | 2014 |
Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. | Easwaran, Hariharan; Tsai, Hsing-Chen; Baylin, Stephen B | R01ES011858 | Mol Cell (2014 Jun 05) | 24905005 | 2014 |
Harnessing the potential of epigenetic therapy to target solid tumors. | Ahuja, Nita; Easwaran, Hariharan; Baylin, Stephen B | R01ES011858 | J Clin Invest (2014 Jan) | 24382390 | 2014 |
The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor gene ... | Cai, Y; Geutjes, E-J; de Lint, K; Roepman, P; Bruurs, L; Yu, L-R; Wang, W; van Blijswijk, J; ... | R01ES011858 | Oncogene (2014 Apr 24) | 23708667 | 2014 |
Epigenetic abnormalities in cancer find a "home on the range". | Easwaran, Hariharan; Baylin, Stephen B | R01ES011858 | Cancer Cell (2013 Jan 14) | 23328477 | 2013 |
Novel methylation biomarker panel for the early detection of pancreatic cancer. | Yi, Joo Mi; Guzzetta, Angela A; Bailey, Vasudev J; Downing, Stephanie R; Van Neste, Leander; Ch ... | R01ES011858 | Clin Cancer Res (2013 Dec 01) | 24088737 | 2013 |
A DNA hypermethylation module for the stem/progenitor cell signature of cancer. | Easwaran, Hariharan; Johnstone, Sarah E; Van Neste, Leander; Ohm, Joyce; Mosbruger, Tim; Wang, ... | R01ES011858 | Genome Res (2012 May) | 22391556 | 2012 |
DNMT1 modulates gene expression without its catalytic activity partially through its interactions wi ... | Clements, Eriko G; Mohammad, Helai P; Leadem, Benjamin R; Easwaran, Hariharan; Cai, Yi; Van Nes ... | R01ES011858 | Nucleic Acids Res (2012 May) | 22278882 | 2012 |
The cancer epigenome: its origins, contributions to tumorigenesis, and translational implications. | Baylin, Stephen B | R01ES011858 | Proc Am Thorac Soc (2012 May) | 22550245 | 2012 |
Genomic and epigenomic integration identifies a prognostic signature in colon cancer. | Yi, Joo Mi; Dhir, Mashaal; Van Neste, Leander; Downing, Stephanie R; Jeschke, Jana; Glöckner, ... | R01ES011858 | Clin Cancer Res (2011 Mar 15) | 21278247 | 2011 |
Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice. | Mohammad, H P; Zhang, W; Prevas, H S; Leadem, B R; Zhang, M; Herman, J G; Hooker, C M; Watkin ... | R01ES011858 | Oncogene (2011 Jun 9) | 21297660 | 2011 |
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to ... | O'Hagan, Heather M; Wang, Wei; Sen, Subhojit; Destefano Shields, Christina; Lee, Stella S; Zhan ... | R01ES011858, T32ES007141 | Cancer Cell (2011 Nov 15) | 22094255 | 2011 |
Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spa ... | Easwaran, Hariharan P; Van Neste, Leander; Cope, Leslie; Sen, Subhojit; Mohammad, Helai P; Page ... | R01ES011858 | Cancer Res (2010 Oct 15) | 20736368 | 2010 |
Mapping networks of protein-mediated physical interactions between chromatin elements. | Tiwari, Vijay K; Baylin, Stephen B | R01ES011858 | Curr Protoc Mol Biol (2010 Jan) | 20069537 | 2010 |
Role of nuclear architecture in epigenetic alterations in cancer. | Easwaran, H P; Baylin, S B | R01ES011858 | Cold Spring Harb Symp Quant Biol (2010) | 21447817 | 2010 |
Stress and the epigenetic landscape: a link to the pathobiology of human diseases? | Johnstone, Sarah E; Baylin, Stephen B | R01ES011858 | Nat Rev Genet (2010 Nov) | 20921961 | 2010 |
A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations. | Tiwari, Vijay K; Cope, Leslie; McGarvey, Kelly M; Ohm, Joyce E; Baylin, Stephen B | R01ES011858 | Genome Res (2008 Jul) | 18502945 | 2008 |
A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells. | Ting, Angela H; Suzuki, Hiromu; Cope, Leslie; Schuebel, Kornel E; Lee, Byron H; Toyota, Minoru ... | R01ES011858 | Cancer Res (2008 Apr 15) | 18413723 | 2008 |
Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. | Yi, Joo Mi; Tsai, Hsing-Chen; Glöckner, Sabine C; Lin, Steven; Ohm, Joyce E; Easwaran, Hari; J ... | R01ES011858 | Cancer Res (2008 Oct 01) | 18829568 | 2008 |
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict fo ... | Chan, Timothy A; Glockner, Sabine; Yi, Joo Mi; Chen, Wei; Van Neste, Leander; Cope, Leslie; He ... | R01ES011858 | PLoS Med (2008 May 27) | 18507500 | 2008 |
Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells. | McGarvey, Kelly M; Van Neste, Leander; Cope, Leslie; Ohm, Joyce E; Herman, James G; Van Criekin ... | R01ES011858 | Cancer Res (2008 Jul 15) | 18632628 | 2008 |
Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal can ... | Zhang, Wei; Glöckner, Sabine C; Guo, Mingzhou; Machida, Emi Ota; Wang, David H; Easwaran, Hari ... | R01ES011858 | Cancer Res (2008 Apr 15) | 18413743 | 2008 |
PcG proteins, DNA methylation, and gene repression by chromatin looping. | Tiwari, Vijay K; McGarvey, Kelly M; Licchesi, Julien D F; Ohm, Joyce E; Herman, James G; Schübe ... | R01ES011858 | PLoS Biol (2008 Dec 02) | 19053175 | 2008 |
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. | Schuebel, Kornel E; Chen, Wei; Cope, Leslie; Glöckner, Sabine C; Suzuki, Hiromu; Yi, Joo-Mi; C ... | R01ES011858 | PLoS Genet (2007 Sep) | 17892325 | 2007 |
DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZ ... | McGarvey, Kelly M; Greene, Eriko; Fahrner, Jill A; Jenuwein, Thomas; Baylin, Stephen B | R01ES011858 | Cancer Res (2007 Jun 1) | 17545586 | 2007 |
hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethyl ... | Zinn, Rebekah L; Pruitt, Kevin; Eguchi, Sayaka; Baylin, Stephen B; Herman, James G | R01ES011858 | Cancer Res (2007 Jan 1) | 17210699 | 2007 |
Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberra ... | Huang, Yi; Greene, Eriko; Murray Stewart, Tracy; Goodwin, Andrew C; Baylin, Stephen B; Woster, ... | R01ES011858 | Proc Natl Acad Sci U S A (2007 May 8) | 17463086 | 2007 |
The epigenomics of cancer. | Jones, Peter A; Baylin, Stephen B | R01ES011858 | Cell (2007 Feb 23) | 17320506 | 2007 |
De novo CpG island methylation in human cancer cells. | Jair, Kam-Wing; Bachman, Kurtis E; Suzuki, Hiromu; Ting, Angela H; Rhee, Ina; Yen, Ray-Whay Ch ... | R01ES011858 | Cancer Res (2006 Jan 15) | 16423997 | 2006 |
Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter ... | Ting, Angela H; Jair, Kam-wing; Schuebel, Kornel E; Baylin, Stephen B | R01ES011858 | Cancer Res (2006 Jan 15) | 16424002 | 2006 |
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromati ... | McGarvey, Kelly M; Fahrner, Jill A; Greene, Eriko; Martens, Joost; Jenuwein, Thomas; Baylin, S ... | R01ES011858 | Cancer Res (2006 Apr 1) | 16585178 | 2006 |
Aberrant gene silencing in tumor progression: implications for control of cancer. | Baylin, S B; Chen, W Y | R01ES011858 | Cold Spring Harb Symp Quant Biol (2005) | 16869780 | 2005 |
GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epi ... | Akiyama, Yoshimitsu; Watkins, Neil; Suzuki, Hiromu; Jair, Kam-Wing; van Engeland, Manon; Estell ... | R01ES011858 | Mol Cell Biol (2003 Dec) | 14612389 | 2003 |
Gene silencing in cancer in association with promoter hypermethylation. | Herman, James G; Baylin, Stephen B | R01ES011858 | N Engl J Med (2003 Nov 20) | 14627790 | 2003 |
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. | Fahrner, Jill A; Eguchi, Sayaka; Herman, James G; Baylin, Stephen B | R01ES011858 | Cancer Res (2002 Dec 15) | 12499261 | 2002 |