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Who We Fund: Publication Detail

Project Title: DNA METHYLTRANSFERASE GENE EXPRESSION IN COLON CANCER
PI: Baylin, Stephen B.
Institution: Johns Hopkins University
Grant Number: R01ES011858

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Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locatio ...   You, Qinglong; Feng, Xiang; Cai, Yi; Baylin, Stephen B; Li, Huilin R01ES011858 Commun Biol (2024 Sep 28) 39341999 Exiting the NIEHS site 2024 
The Epigenetic Hallmarks of Cancer.   Esteller, Manel; Dawson, Mark A; Kadoch, Cigall; Rassool, Feyruz V; Jones, Peter A; Baylin, St ... R01ES011858 Cancer Discov (2024 Oct 04) 39363741 Exiting the NIEHS site 2024 
Tissue-location-specific transcription programs drive tumor dependencies in colon cancer.   Yang, Lijing; Tu, Lei; Bisht, Shilpa; Mao, Yiqing; Petkovich, Daniel; Thursby, Sara-Jayne; Lia ... R01ES011858 Nat Commun (2024 Feb 15) 38360902 Exiting the NIEHS site 2024 
Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable ...   Kanholm, Tomas; Rentia, Uzma; Hadley, Melissa; Karlow, Jennifer A; Cox, Olivia L; Diab, Noor; ... R01ES011858 Cancer Res (2023 Aug 01) 37249603 Exiting the NIEHS site 2023 
Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colo ...   Bhandari, Yuba R; Krishna, Vinod; Powers, Rachael; Parmar, Sehej; Thursby, Sara-Jayne; Gupta, ... R01ES011858 Proc Natl Acad Sci U S A (2023 Aug) 37487069 Exiting the NIEHS site 2023 
Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenes ...   DeStefano Shields, Christina E; White, James R; Chung, Liam; Wenzel, Alyssa; Hicks, Jessica L; ... R01ES011858 Cancer Discov (2021 07) 33632774 Exiting the NIEHS site 2021 
Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Indu ...   Tao, Yong; Kang, Byunghak; Petkovich, Daniel A; Bhandari, Yuba R; In, Julie; Stein-O'Brien, Ge ... R01ES011858 Cancer Cell (2019 Feb 11) 30753828 Exiting the NIEHS site 2019 
Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic ...   Kong, Xiangqian; Chen, Jie; Xie, Wenbing; Brown, Stephen M; Cai, Yi; Wu, Kaichun; Fan, Daimin ... R01ES011858 Cancer Cell (2019 04 15) 30956060 Exiting the NIEHS site 2019 
Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational C ...   Ye, Fei; Kong, Xiangqian; Zhang, Hao; Liu, Yan; Shao, Zhiyuan; Jin, Jia; Cai, Yi; Zhang, Ruk ... R01ES011858 ACS Chem Biol (2018 03 16) 29381856 Exiting the NIEHS site 2018 
Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative S ...   Zhang, Yang W; Wang, Zhihong; Xie, Wenbing; Cai, Yi; Xia, Limin; Easwaran, Hariharan; Luo, Ji ... R01ES011858 Mol Cell (2017 Jan 19) 28107650 Exiting the NIEHS site 2017 
CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor ...   Xia, Limin; Huang, Wenjie; Bellani, Marina; Seidman, Michael M; Wu, Kaichun; Fan, Daiming; Nie ... R01ES011858 Cancer Cell (2017 May 08) 28486105 Exiting the NIEHS site 2017 
Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cel ...   Vaz, Michelle; Hwang, Stephen Y; Kagiampakis, Ioannis; Phallen, Jillian; Patil, Ashwini; O'Haga ... R01ES011858 Cancer Cell (2017 Sep 11) 28898697 Exiting the NIEHS site 2017 
Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across ...   Cai, Yi; Tsai, Hsing-Chen; Yen, Ray-Whay Chiu; Zhang, Yang W; Kong, Xiangqian; Wang, Wei; Xia, ... R01ES011858 Genome Res (2017 04) 28232479 Exiting the NIEHS site 2017 
Epigenetic Therapeutics: A New Weapon in the War Against Cancer.   Ahuja, Nita; Sharma, Anup R; Baylin, Stephen B R01ES011858 Annu Rev Med (2016) 26768237 Exiting the NIEHS site 2016 
Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage.   Ding, Ning; Bonham, Emily M; Hannon, Brooke E; Amick, Thomas R; Baylin, Stephen B; O'Hagan, He ... R01ES011858 J Mol Cell Biol (2016 Jun) 26186941 Exiting the NIEHS site 2016 
A recombinant reporter system for monitoring reactivation of an endogenously DNA hypermethylated gen ...   Cui, Ying; Hausheer, Frederick; Beaty, Robert; Zahnow, Cynthia; Issa, Jean Pierre; Bunz, Frede ... R01ES011858 Cancer Res (2014 Jul 15) 24876104 Exiting the NIEHS site 2014 
Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance.   Easwaran, Hariharan; Tsai, Hsing-Chen; Baylin, Stephen B R01ES011858 Mol Cell (2014 Jun 05) 24905005 Exiting the NIEHS site 2014 
Harnessing the potential of epigenetic therapy to target solid tumors.   Ahuja, Nita; Easwaran, Hariharan; Baylin, Stephen B R01ES011858 J Clin Invest (2014 Jan) 24382390 Exiting the NIEHS site 2014 
The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor gene ...   Cai, Y; Geutjes, E-J; de Lint, K; Roepman, P; Bruurs, L; Yu, L-R; Wang, W; van Blijswijk, J; ... R01ES011858 Oncogene (2014 Apr 24) 23708667 Exiting the NIEHS site 2014 
Epigenetic abnormalities in cancer find a "home on the range".   Easwaran, Hariharan; Baylin, Stephen B R01ES011858 Cancer Cell (2013 Jan 14) 23328477 Exiting the NIEHS site 2013 
Novel methylation biomarker panel for the early detection of pancreatic cancer.   Yi, Joo Mi; Guzzetta, Angela A; Bailey, Vasudev J; Downing, Stephanie R; Van Neste, Leander; Ch ... R01ES011858 Clin Cancer Res (2013 Dec 01) 24088737 Exiting the NIEHS site 2013 
A DNA hypermethylation module for the stem/progenitor cell signature of cancer.   Easwaran, Hariharan; Johnstone, Sarah E; Van Neste, Leander; Ohm, Joyce; Mosbruger, Tim; Wang, ... R01ES011858 Genome Res (2012 May) 22391556 Exiting the NIEHS site 2012 
DNMT1 modulates gene expression without its catalytic activity partially through its interactions wi ...   Clements, Eriko G; Mohammad, Helai P; Leadem, Benjamin R; Easwaran, Hariharan; Cai, Yi; Van Nes ... R01ES011858 Nucleic Acids Res (2012 May) 22278882 Exiting the NIEHS site 2012 
The cancer epigenome: its origins, contributions to tumorigenesis, and translational implications.   Baylin, Stephen B R01ES011858 Proc Am Thorac Soc (2012 May) 22550245 Exiting the NIEHS site 2012 
Genomic and epigenomic integration identifies a prognostic signature in colon cancer.   Yi, Joo Mi; Dhir, Mashaal; Van Neste, Leander; Downing, Stephanie R; Jeschke, Jana; Glöckner, ... R01ES011858 Clin Cancer Res (2011 Mar 15) 21278247 Exiting the NIEHS site 2011 
Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice.   Mohammad, H P; Zhang, W; Prevas, H S; Leadem, B R; Zhang, M; Herman, J G; Hooker, C M; Watkin ... R01ES011858 Oncogene (2011 Jun 9) 21297660 Exiting the NIEHS site 2011 
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to ...   O'Hagan, Heather M; Wang, Wei; Sen, Subhojit; Destefano Shields, Christina; Lee, Stella S; Zhan ... R01ES011858, T32ES007141 Cancer Cell (2011 Nov 15) 22094255 Exiting the NIEHS site 2011 
Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spa ...   Easwaran, Hariharan P; Van Neste, Leander; Cope, Leslie; Sen, Subhojit; Mohammad, Helai P; Page ... R01ES011858 Cancer Res (2010 Oct 15) 20736368 Exiting the NIEHS site 2010 
Mapping networks of protein-mediated physical interactions between chromatin elements.   Tiwari, Vijay K; Baylin, Stephen B R01ES011858 Curr Protoc Mol Biol (2010 Jan) 20069537 Exiting the NIEHS site 2010 
Role of nuclear architecture in epigenetic alterations in cancer.   Easwaran, H P; Baylin, S B R01ES011858 Cold Spring Harb Symp Quant Biol (2010) 21447817 Exiting the NIEHS site 2010 
Stress and the epigenetic landscape: a link to the pathobiology of human diseases?   Johnstone, Sarah E; Baylin, Stephen B R01ES011858 Nat Rev Genet (2010 Nov) 20921961 Exiting the NIEHS site 2010 
A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations.   Tiwari, Vijay K; Cope, Leslie; McGarvey, Kelly M; Ohm, Joyce E; Baylin, Stephen B R01ES011858 Genome Res (2008 Jul) 18502945 Exiting the NIEHS site 2008 
A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.   Ting, Angela H; Suzuki, Hiromu; Cope, Leslie; Schuebel, Kornel E; Lee, Byron H; Toyota, Minoru ... R01ES011858 Cancer Res (2008 Apr 15) 18413723 Exiting the NIEHS site 2008 
Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors.   Yi, Joo Mi; Tsai, Hsing-Chen; Glöckner, Sabine C; Lin, Steven; Ohm, Joyce E; Easwaran, Hari; J ... R01ES011858 Cancer Res (2008 Oct 01) 18829568 Exiting the NIEHS site 2008 
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict fo ...   Chan, Timothy A; Glockner, Sabine; Yi, Joo Mi; Chen, Wei; Van Neste, Leander; Cope, Leslie; He ... R01ES011858 PLoS Med (2008 May 27) 18507500 Exiting the NIEHS site 2008 
Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells.   McGarvey, Kelly M; Van Neste, Leander; Cope, Leslie; Ohm, Joyce E; Herman, James G; Van Criekin ... R01ES011858 Cancer Res (2008 Jul 15) 18632628 Exiting the NIEHS site 2008 
Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal can ...   Zhang, Wei; Glöckner, Sabine C; Guo, Mingzhou; Machida, Emi Ota; Wang, David H; Easwaran, Hari ... R01ES011858 Cancer Res (2008 Apr 15) 18413743 Exiting the NIEHS site 2008 
PcG proteins, DNA methylation, and gene repression by chromatin looping.   Tiwari, Vijay K; McGarvey, Kelly M; Licchesi, Julien D F; Ohm, Joyce E; Herman, James G; Schübe ... R01ES011858 PLoS Biol (2008 Dec 02) 19053175 Exiting the NIEHS site 2008 
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer.   Schuebel, Kornel E; Chen, Wei; Cope, Leslie; Glöckner, Sabine C; Suzuki, Hiromu; Yi, Joo-Mi; C ... R01ES011858 PLoS Genet (2007 Sep) 17892325 Exiting the NIEHS site 2007 
DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZ ...   McGarvey, Kelly M; Greene, Eriko; Fahrner, Jill A; Jenuwein, Thomas; Baylin, Stephen B R01ES011858 Cancer Res (2007 Jun 1) 17545586 Exiting the NIEHS site 2007 
hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethyl ...   Zinn, Rebekah L; Pruitt, Kevin; Eguchi, Sayaka; Baylin, Stephen B; Herman, James G R01ES011858 Cancer Res (2007 Jan 1) 17210699 Exiting the NIEHS site 2007 
Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberra ...   Huang, Yi; Greene, Eriko; Murray Stewart, Tracy; Goodwin, Andrew C; Baylin, Stephen B; Woster, ... R01ES011858 Proc Natl Acad Sci U S A (2007 May 8) 17463086 Exiting the NIEHS site 2007 
The epigenomics of cancer.   Jones, Peter A; Baylin, Stephen B R01ES011858 Cell (2007 Feb 23) 17320506 Exiting the NIEHS site 2007 
De novo CpG island methylation in human cancer cells.   Jair, Kam-Wing; Bachman, Kurtis E; Suzuki, Hiromu; Ting, Angela H; Rhee, Ina; Yen, Ray-Whay Ch ... R01ES011858 Cancer Res (2006 Jan 15) 16423997 Exiting the NIEHS site 2006 
Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter ...   Ting, Angela H; Jair, Kam-wing; Schuebel, Kornel E; Baylin, Stephen B R01ES011858 Cancer Res (2006 Jan 15) 16424002 Exiting the NIEHS site 2006 
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromati ...   McGarvey, Kelly M; Fahrner, Jill A; Greene, Eriko; Martens, Joost; Jenuwein, Thomas; Baylin, S ... R01ES011858 Cancer Res (2006 Apr 1) 16585178 Exiting the NIEHS site 2006 
Aberrant gene silencing in tumor progression: implications for control of cancer.   Baylin, S B; Chen, W Y R01ES011858 Cold Spring Harb Symp Quant Biol (2005) 16869780 Exiting the NIEHS site 2005 
GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epi ...   Akiyama, Yoshimitsu; Watkins, Neil; Suzuki, Hiromu; Jair, Kam-Wing; van Engeland, Manon; Estell ... R01ES011858 Mol Cell Biol (2003 Dec) 14612389 Exiting the NIEHS site 2003 
Gene silencing in cancer in association with promoter hypermethylation.   Herman, James G; Baylin, Stephen B R01ES011858 N Engl J Med (2003 Nov 20) 14627790 Exiting the NIEHS site 2003 
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer.   Fahrner, Jill A; Eguchi, Sayaka; Herman, James G; Baylin, Stephen B R01ES011858 Cancer Res (2002 Dec 15) 12499261 Exiting the NIEHS site 2002 
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Last Reviewed: October 17, 2024