Project Title: | ROLE OF ALVEOLAR MACROPHAGES IN PARTICULATE MATTER-INDUCED CARDIOPULMONARY DISEASE |
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PI: | Mutlu, Gokhan M. |
Institution: | University Of Chicago |
Grant Number: | R01ES015024 |
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Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
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Loss of heme oxygenase 2 causes reduced expression of genes in cardiac muscle development and contra ... | Cetin-Atalay, Rengul; Meliton, Angelo Y; Ozcan, Cevher; Woods, Parker S; Sun, Kaitlyn A; Fang, ... | R01ES015024 | PLoS One (2023) |
37844118
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2023 |
HIF-1α induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survi ... | Woods, Parker S; Kimmig, Lucas M; Sun, Kaitlyn A; Meliton, Angelo Y; Shamaa, Obada R; Tian, Yu ... | R01ES015024 | Elife (2022 Jul 13) |
35822617
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2022 |
Our Compliments to the Authors: Decay Accelerating Factor and the Complement System in Pulmonary Fib ... | Hamanaka, Robert B; Mutlu, Gökhan M | R01ES015024 | Am J Respir Cell Mol Biol (2022 Oct) |
35901283
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2022 |
Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism. | Hamanaka, Robert B; Mutlu, Gökhan M | P30ES027792, R01ES015024 | FEBS J (2021 11) |
33393204
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2021 |
More to Explore: Further Definition of Risk Factors for COPD - Differential Gender Difference, Modes ... | Zhang, Yixuan; Wang, Lu; Mutlu, Gökhan M; Cai, Hua | R01ES015024 | Front Physiol (2021) |
34025456
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2021 |
Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cell ... | Wu, David; Harrison, Devin L; Szasz, Teodora; Yeh, Chih-Fan; Shentu, Tzu-Pin; Meliton, Angelo; ... | R01ES015024 | Nat Metab (2021 May) |
34031595
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2021 |
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging. | McQuattie-Pimentel, Alexandra C; Ren, Ziyou; Joshi, Nikita; Watanabe, Satoshi; Stoeger, Thomas; ... | P30ES027792, R01ES015024 | J Clin Invest (2021 02 15) |
33586677
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2021 |
The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production ... | Hamanaka, Robert B; Mutlu, Gökhan M | P30ES027792, R01ES015024 | Amino Acids (2021 Dec) |
33963932
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2021 |
Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory ... | Sun, Kaitlyn A; Li, Yan; Meliton, Angelo Y; Woods, Parker S; Kimmig, Lucas M; Cetin-Atalay, Re ... | P30ES027792, R01ES015024 | Elife (2020 04 07) |
32255424
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2020 |
The Airway Epithelial Response to Air Pollution: It's Not Just Inflammation. | Hamanaka, Robert B; Mutlu, Gökhan M | R01ES015024 | Am J Respir Cell Mol Biol (2020 08) |
32311285
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2020 |
Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation. | Woods, Parker S; Kimmig, Lucas M; Meliton, Angelo Y; Sun, Kaitlyn A; Tian, Yufeng; O'Leary, Er ... | R01ES015024 | Am J Respir Cell Mol Biol (2020 02) |
31469581
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2020 |
Air Pollution, Asthma, and Sleep Apnea: New Epidemiological Links? | Mutlu, Gökhan M; Peker, Yüksel | R01ES015024 | Ann Am Thorac Soc (2019 Mar) |
31339334
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2019 |
Alveolar Epithelial Cells Burn Fat to Survive Acute Lung Injury. | Hamanaka, Robert B; Mutlu, Gökhan M | R01ES015024 | Am J Respir Cell Mol Biol (2019 02) |
30278142
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2019 |
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts. | Hamanaka, Robert B; O'Leary, Erin M; Witt, Leah J; Tian, Yufeng; Gökalp, Gizem A; Meliton, Ang ... | R01ES015024 | Am J Respir Cell Mol Biol (2019 11) |
30973753
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2019 |
Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis. | Soberanes, Saul; Misharin, Alexander V; Jairaman, Amit; Morales-Nebreda, Luisa; McQuattie-Piment ... | P30ES027792, R01ES015024 | Cell Metab (2019 02 05) |
30318339
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2019 |
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmona ... | Reyfman, Paul A; Walter, James M; Joshi, Nikita; Anekalla, Kishore R; McQuattie-Pimentel, Alexa ... | R01ES015024 | Am J Respir Crit Care Med (2019 06 15) |
30554520
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2019 |
Inhalational exposure to particulate matter air pollution alters the composition of the gut microbio ... | Mutlu, Ece A; Comba, Işın Y; Cho, Takugo; Engen, Phillip A; Yazıcı, Cemal; Soberanes, Saul; Ha ... | R01ES015024 | Environ Pollut (2018 Sep) |
29783199
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2018 |
Letter by Mutlu and Budinger Regarding Article, "Particulate Matter Exposure and Stress Hormone Leve ... | Mutlu, Gökhan M; Budinger, G R Scott | R01ES015024 | Circulation (2018 03 13) |
29530899
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2018 |
Particulate Matter Air Pollution: Effects on the Cardiovascular System. | Hamanaka, Robert B; Mutlu, Gökhan M | P30ES027792, R01ES015024 | Front Endocrinol (Lausanne) (2018) |
30505291
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2018 |
Role of Cellular Metabolism in Pulmonary Diseases. | Wu, David; Woods, Parker S; Duong, Heng T; Mutlu, Gökhan M | R01ES015024 | Am J Respir Cell Mol Biol (2018 07) |
29634283
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2018 |
Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regu ... | Huang, Ru-Ting; Wu, David; Meliton, Angelo; Oh, Myung-Jin; Krause, Matthew; Lloyd, Joyce A; Ni ... | R01ES015024 | Am J Respir Crit Care Med (2017 03 01) |
27855271
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2017 |
HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular ... | Wu, David; Huang, Ru-Ting; Hamanaka, Robert B; Krause, Matt; Oh, Myung-Jin; Kuo, Cheng-Hsiang; ... | R01ES015024 | Elife (2017 05 30) |
28556776
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2017 |
Letter by Wu et al Regarding Article, "Mechanical Activation of Hypoxia-Inducible Factor 1α Drives E ... | Wu, David; Hamanaka, Robert B; Fang, Yun; Mutlu, Gökhan M | R01ES015024 | Arterioscler Thromb Vasc Biol (2017 12) |
29162600
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2017 |
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span ... | Misharin, Alexander V; Morales-Nebreda, Luisa; Reyfman, Paul A; Cuda, Carla M; Walter, James M; ... | R01ES015024 | J Exp Med (2017 Aug 07) |
28694385
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2017 |
PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epider ... | Hamanaka, Robert B; Mutlu, Gökhan M | R01ES015024 | J Invest Dermatol (2017 06) |
28108301
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2017 |
Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection. | Peteranderl, Christin; Morales-Nebreda, Luisa; Selvakumar, Balachandar; Lecuona, Emilia; Vadász, ... | R01ES015024 | J Clin Invest (2016 Apr 01) |
26999599
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2016 |
Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production. | Nigdelioglu, Recep; Hamanaka, Robert B; Meliton, Angelo Y; O'Leary, Erin; Witt, Leah J; Cho, T ... | R01ES015024 | J Biol Chem (2016 Dec 30) |
27836973
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2016 |
Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans. | Bharat, Ankit; Cunningham, Scott A; Scott Budinger, G R; Kreisel, Daniel; DeWet, Charl J; Gelma ... | R01ES015024 | Sci Transl Med (2015 Apr 22) |
25904745
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2015 |
Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis. | Morales-Nebreda, Luisa I; Rogel, Micah R; Eisenberg, Jessica L; Hamill, Kevin J; Soberanes, Sau ... | R01ES015024 | Am J Respir Cell Mol Biol (2015 Apr) |
25188360
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2015 |
Muscle dysfunction in patients with lung diseases: a growing epidemic. | Barreiro, Esther; Sznajder, Jacob I; Nader, Gustavo A; Budinger, G R Scott | R01ES015024 | Am J Respir Crit Care Med (2015 Mar 15) |
25767924
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2015 |
Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect. | Ghio, Andrew J; Soukup, Joleen M; Dailey, Lisa A; Tong, Haiyan; Kesic, Matthew J; Budinger, G ... | R01ES015024 | Chem Res Toxicol (2015 Nov 16) |
26462088
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2015 |
β₂-Agonist therapy may contribute to the air pollution and IL-6-associated risk of developing severe ... | Chiarella, Sergio E; Budinger, G R Scott; Mutlu, Gökhan M | R01ES015024 | J Allergy Clin Immunol (2015 Jan) |
25445822
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2015 |
Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of l ... | Radigan, Kathryn A; Morales-Nebreda, Luisa; Soberanes, Saul; Nicholson, Trevor; Nigdelioglu, Re ... | R01ES015024 | PLoS One (2014) |
25232724
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2014 |
Loss of TLR4 does not prevent influenza A-induced mortality. | Morales-Nebreda, Luisa; Mutlu, Gökhan M; Scott Budinger, G R; Radigan, Kathryn A | R01ES015024 | Am J Respir Crit Care Med (2014 May 15) |
24832747
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2014 |
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. | Wheaton, William W; Weinberg, Samuel E; Hamanaka, Robert B; Soberanes, Saul; Sullivan, Lucas B; ... | R01ES015024 | Elife (2014 May 13) |
24843020
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2014 |
Promotion of lung health: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. | Camargo Jr, Carlos A; Budinger, G R Scott; Escobar, Gabriel J; Hansel, Nadia N; Hanson, Corrine ... | R01ES015024 | Ann Am Thorac Soc (2014 Apr) |
24754821
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2014 |
Reply: β2-agonists and acute respiratory distress syndrome. | Budinger, G R Scott; Mutlu, Gökhan M | R01ES015024 | Am J Respir Crit Care Med (2014 Jun 1) |
24881949
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2014 |
β2-agonists and acute respiratory distress syndrome. | Budinger, G R Scott; Mutlu, Gökhan M | R01ES015024 | Am J Respir Crit Care Med (2014 Mar 15) |
24628310
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2014 |
β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis. | Chiarella, Sergio E; Soberanes, Saul; Urich, Daniela; Morales-Nebreda, Luisa; Nigdelioglu, Rece ... | R01ES015024 | J Clin Invest (2014 Jul) |
24865431
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2014 |
Balancing the risks and benefits of oxygen therapy in critically III adults. | Budinger, G R Scott; Mutlu, Gökhan M | R01ES015024 | Chest (2013 Apr) |
23546490
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2013 |
Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung. | Misharin, Alexander V; Morales-Nebreda, Luisa; Mutlu, Gökhan M; Budinger, G R Scott; Perlman, H ... | R01ES015024 | Am J Respir Cell Mol Biol (2013 Oct) |
23672262
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2013 |
Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ. | Do-Umehara, Hanh Chi; Chen, Cong; Urich, Daniela; Zhou, Liang; Qiu, Ju; Jang, Samuel; Zander, ... | R01ES015024 | Nat Immunol (2013 May) |
23525087
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2013 |
Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 r ... | Dada, Laura; Gonzalez, Angel R; Urich, Daniela; Soberanes, Saul; Manghi, Tomas S; Chiarella, S ... | R01ES015024 | PLoS One (2012) |
22272351
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2012 |
Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial RO ... | Soberanes, Saul; Gonzalez, Angel; Urich, Daniela; Chiarella, Sergio E; Radigan, Kathryn A; Osor ... | R01ES015024 | Sci Rep (2012) |
22355787
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2012 |
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling. | Mutlu, Gökhan M; Budinger, G R Scott; Wu, Minghua; Lam, Anna P; Zirk, Aaron; Rivera, Stephanie ... | R01ES015024 | Thorax (2012 Feb) |
21921091
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2012 |
The effect of rosuvastatin in a murine model of influenza A infection. | Radigan, Kathryn A; Urich, Daniela; Misharin, Alexander V; Chiarella, Sergio E; Soberanes, Saul ... | R01ES015024 | PLoS One (2012) |
22536437
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2012 |
Epithelial cell death is an important contributor to oxidant-mediated acute lung injury. | Budinger, G R Scott; Mutlu, Gökhan M; Urich, Daniela; Soberanes, Saul; Buccellato, Leonard J; H ... | R01ES015024 | Am J Respir Crit Care Med (2011 Apr 15) |
20959557
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2011 |
Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome prol ... | Jain, Manu; Budinger, G R Scott; Lo, Amy; Urich, Daniela; Rivera, Stephanie E; Ghosh, Asish K; ... | R01ES015024 | Am J Respir Crit Care Med (2011 Jun 01) |
21317313
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2011 |
Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury. | Urich, Daniela; Eisenberg, Jessica L; Hamill, Kevin J; Takawira, Desire; Chiarella, Sergio E; S ... | R01ES015024 | J Cell Sci (2011 Sep 01) |
21878500
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2011 |
Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in th ... | Duch, Matthew C; Budinger, G R Scott; Liang, Yu Teng; Soberanes, Saul; Urich, Daniela; Chiarell ... | R01ES015024 | Nano Lett (2011 Dec 14) |
22023654
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2011 |
Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast ... | Lam, Anna P; Flozak, Annette S; Russell, Susan; Wei, Jun; Jain, Manu; Mutlu, Gökhan M; Budinge ... | R01ES015024 | Am J Respir Cell Mol Biol (2011 Nov) |
21454805
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2011 |
Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice. | Mutlu, Ece A; Engen, Phillip A; Soberanes, Saul; Urich, Daniela; Forsyth, Christopher B; Nigdel ... | R01ES015024 | Part Fibre Toxicol (2011 Jun 09) |
21658250
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2011 |
Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagul ... | Budinger, G R Scott; McKell, Joanne L; Urich, Daniela; Foiles, Nancy; Weiss, Ivy; Chiarella, S ... | R01ES015024 | PLoS One (2011 Apr 11) |
21494547
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2011 |
The lung macrophage: a Jack of all trades. | Misharin, Alexander V; Scott Budinger, G R; Perlman, Harris | R01ES015024 | Am J Respir Crit Care Med (2011 Sep 01) |
21885631
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2011 |
Update in environmental and occupational medicine 2010. | Budinger, G R Scott; Mutlu, Gokhan M | R01ES015024 | Am J Respir Crit Care Med (2011 Jun 15) |
21693716
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2011 |
Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and m ... | Flozak, Annette S; Lam, Anna P; Russell, Susan; Jain, Manu; Peled, Ofra N; Sheppard, Kerry A; ... | R01ES015024 | J Biol Chem (2010 Jan 29) |
19933277
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2010 |
Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary tox ... | Mutlu, Gökhan M; Budinger, G R Scott; Green, Alexander A; Urich, Daniela; Soberanes, Saul; Chia ... | R01ES015024 | Nano Lett (2010 May 12) |
20377197
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2010 |
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. | Weinberg, Frank; Hamanaka, Robert; Wheaton, William W; Weinberg, Samuel; Joseph, Joy; Lopez, M ... | R01ES015024 | Proc Natl Acad Sci U S A (2010 May 11) |
20421486
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2010 |
Update in environmental and occupational medicine 2009. | Van Hee, Victor C; Kaufman, Joel D; Budinger, G R Scott; Mutlu, Gokhan M | P30ES007033, R01ES015024 | Am J Respir Crit Care Med (2010 Jun 1) |
20516491
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2010 |
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cel ... | Soberanes, Saul; Urich, Daniela; Baker, Christina M; Burgess, Zach; Chiarella, Sergio E; Bell, ... | R01ES015024 | J Biol Chem (2009 Jan 23) |
19033436
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2009 |
Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation. | Urich, Daniela; Soberanes, Saul; Burgess, Zach; Chiarella, Sergio E; Ghio, Andrew J; Ridge, Ka ... | R01ES015024 | FASEB J (2009 Jul) |
19237507
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2009 |
Alveolar epithelial beta2-adrenergic receptors. | Mutlu, Gokhan M; Factor, Phillip | R01ES015024 | Am J Respir Cell Mol Biol (2008 Feb) |
17709598
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2008 |
Stretch-induced activation of AMP kinase in the lung requires dystroglycan. | Budinger, G R Scott; Urich, Daniela; DeBiase, Phillip J; Chiarella, Sergio E; Burgess, Zachary ... | R01ES015024 | Am J Respir Cell Mol Biol (2008 Dec) |
18556591
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2008 |
Adenosine regulation of alveolar fluid clearance. | Factor, Phillip; Mutlu, Goskhan M; Chen, Lan; Mohameed, Jameel; Akhmedov, Alexander T; Meng, F ... | R01ES015024 | Proc Natl Acad Sci U S A (2007 Mar 6) |
17360481
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2007 |
Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. | Mutlu, Gökhan M; Green, David; Bellmeyer, Amy; Baker, Christina M; Burgess, Zach; Rajamannan, ... | R01ES015024 | J Clin Invest (2007 Oct) |
17885684
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2007 |
Leptin resistance protects mice from hyperoxia-induced acute lung injury. | Bellmeyer, Amy; Martino, Janice M; Chandel, Navdeep S; Scott Budinger, G R; Dean, David A; Mutl ... | R01ES015024 | Am J Respir Crit Care Med (2007 Mar 15) |
17185651
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2007 |
The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell dea ... | Wang, Helena L; Akinci, I Ozkan; Baker, Christina M; Urich, Daniela; Bellmeyer, Amy; Jain, Man ... | R01ES015024 | J Immunol (2007 Aug 01) |
17641050
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2007 |