| Project Title: | TRANSLESION SYNTHESIS DNA POLYMERASES AND GENOME INSTABILITY |
|---|---|
| PI: | Shcherbakova, Polina V |
| Institution: | University Of Nebraska Medical Center |
| Grant Number: | R01ES015869 |
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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ varia ... | Barbari, Stephanie R; Beach, Annette K; Markgren, Joel G; Parkash, Vimal; Moore, Elizabeth A; J ... | R01ES015869 | Nucleic Acids Res (2022 Aug 12) |
35822874
|
2022 |
| Compensation for the absence of the catalytically active half of DNA polymerase ε in yeast by positi ... | Stepchenkova, Elena I; Zhuk, Anna S; Cui, Jian; Tarakhovskaya, Elena R; Barbari, Stephanie R; S ... | R01ES015869 | Genetics (2021 06 24) |
33844024
|
2021 |
| DNA polymerase δ proofreads errors made by DNA polymerase ε. | Bulock, Chelsea R; Xing, Xuanxuan; Shcherbakova, Polina V | R01ES015869 | Proc Natl Acad Sci U S A (2020 03 17) |
32123096
|
2020 |
| Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorecta ... | Lee, Minyi; Eng, George; Barbari, Stephanie R; Deshpande, Vikram; Shcherbakova, Polina V; Gala, ... | R01ES015869 | Clin Transl Gastroenterol (2020 03) |
32352724
|
2020 |
| Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading stran ... | Bulock, Chelsea R; Xing, Xuanxuan; Shcherbakova, Polina V | R01ES015869 | Nucleic Acids Res (2020 09 18) |
32756902
|
2020 |
| A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme. | Xing, Xuanxuan; Kane, Daniel P; Bulock, Chelsea R; Moore, Elizabeth A; Sharma, Sushma; Chabes, ... | R01ES015869 | Nat Commun (2019 01 22) |
30670691
|
2019 |
| Structural consequence of the most frequently recurring cancer-associated substitution in DNA polyme ... | Parkash, Vimal; Kulkarni, Yashraj; Ter Beek, Josy; Shcherbakova, Polina V; Kamerlin, Shina Caro ... | R01ES015869 | Nat Commun (2019 01 22) |
30670696
|
2019 |
| Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae. | Barbari, Stephanie R; Kane, Daniel P; Moore, Elizabeth A; Shcherbakova, Polina V | R01ES015869 | G3 (Bethesda) (2018 Mar 02) |
29352080
|
2018 |
| Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polym ... | Mertz, T M; Baranovskiy, A G; Wang, J; Tahirov, T H; Shcherbakova, P V | R01ES015869 | Oncogene (2017 Aug) |
28368425
|
2017 |
| Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for ... | Barbari, Stephanie R; Shcherbakova, Polina V | R01ES015869 | DNA Repair (Amst) (2017 Aug) |
28687338
|
2017 |
| Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiol ... | Kochenova, Olga V; Bezalel-Buch, Rachel; Tran, Phong; Makarova, Alena V; Chabes, Andrei; Burger ... | R01ES015869 | Nucleic Acids Res (2017 02 17) |
28180291
|
2017 |
| Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing i ... | Mertz, Tony M; Sharma, Sushma; Chabes, Andrei; Shcherbakova, Polina V | R01ES015869 | Proc Natl Acad Sci U S A (2015 May 12) |
25827231
|
2015 |
| DNA polymerase ζ-dependent lesion bypass in Saccharomyces cerevisiae is accompanied by error-prone c ... | Kochenova, Olga V; Daee, Danielle L; Mertz, Tony M; Shcherbakova, Polina V | R01ES015869 | PLoS Genet (2015 Mar) |
25826305
|
2015 |
| A common cancer-associated DNA polymerase ε mutation causes an exceptionally strong mutator phenotyp ... | Kane, Daniel P; Shcherbakova, Polina V | R01ES015869 | Cancer Res (2014 Apr 1) |
24525744
|
2014 |
| DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures. | Northam, Matthew R; Moore, Elizabeth A; Mertz, Tony M; Binz, Sara K; Stith, Carrie M; Stepchenk ... | R01ES015869 | Nucleic Acids Res (2014 Jan) |
24049079
|
2014 |
| A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in m ... | Kadyrova, Lyudmila Y; Mertz, Tony M; Zhang, Yu; Northam, Matthew R; Sheng, Ziwei; Lobachev, Ki ... | R01ES015869 | PLoS Genet (2013 Oct) |
24204308
|
2013 |
| Role of DNA polymerases in repeat-mediated genome instability. | Shah, Kartik A; Shishkin, Alexander A; Voineagu, Irina; Pavlov, Youri I; Shcherbakova, Polina V ... | R01ES015869 | Cell Rep (2012 Nov 29) |
23142667
|
2012 |
| Participation of translesion synthesis DNA polymerases in the maintenance of chromosome integrity in ... | Kochenova, O V; Soshkina, J V; Stepchenkova, E I; Inge-Vechtomov, S G; Shcherbakova, P V | R01ES015869 | Biochemistry (Mosc) (2011 Jan) |
21568839
|
2011 |
| The non-canonical protein binding site at the monomer-monomer interface of yeast proliferating cell ... | Sharma, Neeru M; Kochenova, Olga V; Shcherbakova, Polina V | R01ES015869 | J Biol Chem (2011 Sep 23) |
21799021
|
2011 |
| A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in ... | Daee, Danielle L; Mertz, Tony M; Shcherbakova, Polina V | R01ES015869 | Proc Natl Acad Sci U S A (2010 Jan 5) |
19966286
|
2010 |
| DNA polymerases at the eukaryotic fork-20 years later. | Pavlov, Youri I; Shcherbakova, Polina V | R01ES015869 | Mutat Res (2010 Mar 01) |
19682465
|
2010 |
| Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiae. | Northam, Matthew R; Robinson, Heather A; Kochenova, Olga V; Shcherbakova, Polina V | R01ES015869 | Genetics (2010 Jan) |
19841096
|
2010 |