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Who We Fund: Publication Detail

Project Title: TRANSLESION SYNTHESIS DNA POLYMERASES AND GENOME INSTABILITY
PI: Shcherbakova, Polina V
Institution: University Of Nebraska Medical Center
Grant Number: R01ES015869

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Viewing 23 publications
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Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors.   Ostroverkhova, Daria; Tyryshkin, Kathrin; Beach, Annette K; Moore, Elizabeth A; Masoudi-Sobhanza ... R01ES015869 Cell Rep (2024 Jan 23) 38219146 Exiting the NIEHS site 2024 
Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ varia ...   Barbari, Stephanie R; Beach, Annette K; Markgren, Joel G; Parkash, Vimal; Moore, Elizabeth A; J ... R01ES015869 Nucleic Acids Res (2022 Aug 12) 35822874 Exiting the NIEHS site 2022 
Compensation for the absence of the catalytically active half of DNA polymerase ε in yeast by positi ...   Stepchenkova, Elena I; Zhuk, Anna S; Cui, Jian; Tarakhovskaya, Elena R; Barbari, Stephanie R; S ... R01ES015869 Genetics (2021 06 24) 33844024 Exiting the NIEHS site 2021 
DNA polymerase δ proofreads errors made by DNA polymerase ε.   Bulock, Chelsea R; Xing, Xuanxuan; Shcherbakova, Polina V R01ES015869 Proc Natl Acad Sci U S A (2020 03 17) 32123096 Exiting the NIEHS site 2020 
Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorecta ...   Lee, Minyi; Eng, George; Barbari, Stephanie R; Deshpande, Vikram; Shcherbakova, Polina V; Gala, ... R01ES015869 Clin Transl Gastroenterol (2020 03) 32352724 Exiting the NIEHS site 2020 
Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading stran ...   Bulock, Chelsea R; Xing, Xuanxuan; Shcherbakova, Polina V R01ES015869 Nucleic Acids Res (2020 09 18) 32756902 Exiting the NIEHS site 2020 
A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme.   Xing, Xuanxuan; Kane, Daniel P; Bulock, Chelsea R; Moore, Elizabeth A; Sharma, Sushma; Chabes, ... R01ES015869 Nat Commun (2019 01 22) 30670691 Exiting the NIEHS site 2019 
Structural consequence of the most frequently recurring cancer-associated substitution in DNA polyme ...   Parkash, Vimal; Kulkarni, Yashraj; Ter Beek, Josy; Shcherbakova, Polina V; Kamerlin, Shina Caro ... R01ES015869 Nat Commun (2019 01 22) 30670696 Exiting the NIEHS site 2019 
Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae.   Barbari, Stephanie R; Kane, Daniel P; Moore, Elizabeth A; Shcherbakova, Polina V R01ES015869 G3 (Bethesda) (2018 Mar 02) 29352080 Exiting the NIEHS site 2018 
Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polym ...   Mertz, T M; Baranovskiy, A G; Wang, J; Tahirov, T H; Shcherbakova, P V R01ES015869 Oncogene (2017 Aug) 28368425 Exiting the NIEHS site 2017 
Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for ...   Barbari, Stephanie R; Shcherbakova, Polina V R01ES015869 DNA Repair (Amst) (2017 Aug) 28687338 Exiting the NIEHS site 2017 
Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiol ...   Kochenova, Olga V; Bezalel-Buch, Rachel; Tran, Phong; Makarova, Alena V; Chabes, Andrei; Burger ... R01ES015869 Nucleic Acids Res (2017 02 17) 28180291 Exiting the NIEHS site 2017 
Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing i ...   Mertz, Tony M; Sharma, Sushma; Chabes, Andrei; Shcherbakova, Polina V R01ES015869 Proc Natl Acad Sci U S A (2015 May 12) 25827231 Exiting the NIEHS site 2015 
DNA polymerase ζ-dependent lesion bypass in Saccharomyces cerevisiae is accompanied by error-prone c ...   Kochenova, Olga V; Daee, Danielle L; Mertz, Tony M; Shcherbakova, Polina V R01ES015869 PLoS Genet (2015 Mar) 25826305 Exiting the NIEHS site 2015 
A common cancer-associated DNA polymerase ε mutation causes an exceptionally strong mutator phenotyp ...   Kane, Daniel P; Shcherbakova, Polina V R01ES015869 Cancer Res (2014 Apr 1) 24525744 Exiting the NIEHS site 2014 
DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures.   Northam, Matthew R; Moore, Elizabeth A; Mertz, Tony M; Binz, Sara K; Stith, Carrie M; Stepchenk ... R01ES015869 Nucleic Acids Res (2014 Jan) 24049079 Exiting the NIEHS site 2014 
A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in m ...   Kadyrova, Lyudmila Y; Mertz, Tony M; Zhang, Yu; Northam, Matthew R; Sheng, Ziwei; Lobachev, Ki ... R01ES015869 PLoS Genet (2013 Oct) 24204308 Exiting the NIEHS site 2013 
Role of DNA polymerases in repeat-mediated genome instability.   Shah, Kartik A; Shishkin, Alexander A; Voineagu, Irina; Pavlov, Youri I; Shcherbakova, Polina V ... R01ES015869 Cell Rep (2012 Nov 29) 23142667 Exiting the NIEHS site 2012 
Participation of translesion synthesis DNA polymerases in the maintenance of chromosome integrity in ...   Kochenova, O V; Soshkina, J V; Stepchenkova, E I; Inge-Vechtomov, S G; Shcherbakova, P V R01ES015869 Biochemistry (Mosc) (2011 Jan) 21568839 Exiting the NIEHS site 2011 
The non-canonical protein binding site at the monomer-monomer interface of yeast proliferating cell ...   Sharma, Neeru M; Kochenova, Olga V; Shcherbakova, Polina V R01ES015869 J Biol Chem (2011 Sep 23) 21799021 Exiting the NIEHS site 2011 
A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in ...   Daee, Danielle L; Mertz, Tony M; Shcherbakova, Polina V R01ES015869 Proc Natl Acad Sci U S A (2010 Jan 5) 19966286 Exiting the NIEHS site 2010 
DNA polymerases at the eukaryotic fork-20 years later.   Pavlov, Youri I; Shcherbakova, Polina V R01ES015869 Mutat Res (2010 Mar 01) 19682465 Exiting the NIEHS site 2010 
Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiae.   Northam, Matthew R; Robinson, Heather A; Kochenova, Olga V; Shcherbakova, Polina V R01ES015869 Genetics (2010 Jan) 19841096 Exiting the NIEHS site 2010 
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