Project Title: | CHROMATIN CONTACTS ARE GERMLINE-TRANSMISSABLE VEHICLES UNDERLYING EPIGENETIC TRANSGENERATIONAL INHERITANCE |
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PI: | Blumberg, Bruce |
Institution: | University Of California-Irvine |
Grant Number: | R01ES023316 |
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Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
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2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid ... | Ren, Xiao-Min; Chang, Richard C; Huang, Yikai; Amorim Amato, Angélica; Carivenc, Coralie; Grima ... | R01ES023316, R01ES023316, R01ES031139, R01ES031139 | Endocrinology (2023 Feb 11) | 36750942 | 2023 |
Heritable changes in chromatin contacts linked to transgenerational obesity. | Blumberg, Bruce; Cheng-An Chang, Richard; Egusquiza, Riann; Amato, Angélica; Li, Zhuorui; Joloy ... | R01ES023316, R01ES023316, R01ES031139, R01ES031139, R21ES034468 | Res Sq (2023 Nov 28) | 38077066 | 2023 |
miR-223 Plays a Key Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgen ... | Chang, Richard C; Joloya, Erika M; Li, Zhuorui; Shoucri, Bassem M; Shioda, Toshi; Blumberg, Br ... | R01ES023316, R01ES023316, R01ES031139, R01ES031139 | Endocrinology (2023 Mar 13) | 36740725 | 2023 |
Cannabidiol promotes adipogenesis of human and mouse mesenchymal stem cells via PPARγ by inducing li ... | Chang, Richard C; Thangavelu, Chloe S; Joloya, Erika M; Kuo, Angela; Li, Zhuorui; Blumberg, Br ... | R01ES023316, R01ES023316, R01ES031139, R01ES031139 | Biochem Pharmacol (2022 Mar) | 35026188 | 2022 |
Corrigendum to "Obesity III: Obesogen assays: Limitations, strengths, and new directions" [Biochem. ... | Kassotis, Christopher D; Vom Saal, Frederick S; Babin, Patrick J; Lagadic-Gossmann, Dominique; L ... | R01ES023316, R01ES023316, R01ES031139, R01ES031139 | Biochem Pharmacol (2022 Aug) | 35716579 | 2022 |
Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features ... | Kobayashi, Mutsumi; Kobayashi, Misato; Odajima, Junko; Shioda, Keiko; Hwang, Young Sun; Sasaki, ... | R01ES023316, R01ES023316, R01ES031139, R01ES031139 | Stem Cell Reports (2022 Mar 08) | 35148847 | 2022 |
Obesity II: Establishing causal links between chemical exposures and obesity. | Heindel, Jerrold J; Howard, Sarah; Agay-Shay, Keren; Arrebola, Juan P; Audouze, Karine; Babin, ... | P01ES028942, P30ES005022, P30ES025128, P30ES027792, P30ES030283, P42ES023716, R01ES023316, R01ES023316, R01ES031139, R01ES031139, R35ES028373, R35ES028373, T32ES011564 | Biochem Pharmacol (2022 May) | 35395240 | 2022 |
Obesity III: Obesogen assays: Limitations, strengths, and new directions. | Kassotis, Christopher D; Vom Saal, Frederick S; Babin, Patrick J; Lagadic-Gossmann, Dominique; L ... | R01ES023316, R01ES023316, R01ES031139, R01ES031139 | Biochem Pharmacol (2022 May) | 35393121 | 2022 |
The Crowded Uterine Horn Mouse Model for Examining Postnatal Metabolic Consequences of Intrauterine ... | Taylor, Julia A; Coe, Benjamin L; Shioda, Toshi; Vom Saal, Frederick S | R01ES023316, R01ES023316 | Metabolites (2022 Jan 22) | 35208177 | 2022 |
Transgenerational Transcriptomic and DNA Methylome Profiling of Mouse Fetal Testicular Germline and ... | Shioda, Keiko; Odajima, Junko; Blumberg, Bruce; Shioda, Toshi | R01ES023316, R01ES023316, R01ES031139, R01ES031139 | Metabolites (2022 Jan 20) | 35208169 | 2022 |
Epigenetic Transgenerational Inheritance of the Effects of Obesogen Exposure. | Mohajer, Nicole; Joloya, Erika M; Seo, Jeongbin; Shioda, Toshi; Blumberg, Bruce | R01ES023316, R01ES023316, R01ES031139, R01ES031139 | Front Endocrinol (Lausanne) (2021) | 34975759 | 2021 |
Obesity and endocrine-disrupting chemicals. | Amato, Angelica Amorim; Wheeler, Hailey Brit; Blumberg, Bruce | R01ES023316, R01ES023316, R01ES031139, R01ES031139 | Endocr Connect (2021 Feb) | 33449914 | 2021 |
Obesogens: How They Are Identified and Molecular Mechanisms Underlying Their Action. | Mohajer, Nicole; Du, Chrislyn Y; Checkcinco, Christian; Blumberg, Bruce | R01ES023316, R01ES023316, R01ES031139, R01ES031139 | Front Endocrinol (Lausanne) (2021) | 34899613 | 2021 |
PFAS and Potential Adverse Effects on Bone and Adipose Tissue Through Interactions With PPARγ. | Kirk, Andrea B; Michelsen-Correa, Stephani; Rosen, Cliff; Martin, Clyde F; Blumberg, Bruce | R01ES023316, R01ES023316, R01ES031139, R01ES031139 | Endocrinology (2021 12 01) | 34480479 | 2021 |
Production and Analysis of Human Primordial Germ Cell-Like Cells. | Mitsunaga, Shino; Shioda, Keiko; Hanna, Jacob H; Isselbacher, Kurt J; Shioda, Toshi | R01ES023316, R01ES023316 | Methods Mol Biol (2021) | 32852762 | 2021 |
Transcriptomic and Epigenetic Preservation of Genetic Sex Identity in Estrogen-feminized Male Chicke ... | Shioda, Keiko; Odajima, Junko; Kobayashi, Misato; Kobayashi, Mutsumi; Cordazzo, Bianca; Isselba ... | R01ES023316, R01ES023316 | Endocrinology (2021 01 01) | 33170207 | 2021 |
Transgenerational metabolomic fingerprints in mice ancestrally exposed to the obesogen TBT. | Chamorro-García, Raquel; Poupin, Nathalie; Tremblay-Franco, Marie; Canlet, Cécile; Egusquiza, R ... | R01ES023316, R01ES023316 | Environ Int (2021 12) | 34455191 | 2021 |
Agrochemicals and obesity. | Ren, Xiao-Min; Kuo, Yun; Blumberg, Bruce | R01ES023316, R01ES023316 | Mol Cell Endocrinol (2020 09 15) | 32619583 | 2020 |
Environmental Obesogens and Their Impact on Susceptibility to Obesity: New Mechanisms and Chemicals. | Egusquiza, Riann Jenay; Blumberg, Bruce | R01ES023316, R01ES023316 | Endocrinology (2020 03 01) | 32067051 | 2020 |
Current Research Approaches and Challenges in the Obesogen Field. | Chamorro-Garcia, Raquel; Blumberg, Bruce | R01ES023316, R01ES023316 | Front Endocrinol (Lausanne) (2019) | 30967838 | 2019 |
DNA methylome of human neonatal umbilical cord: Enrichment of differentially methylated regions comp ... | Sakurai, Kenichi; Shioda, Keiko; Eguchi, Akifumi; Watanabe, Masahiro; Miyaso, Hidenori; Mori, ... | R01ES023316, R01ES023316 | PLoS One (2019) | 31063509 | 2019 |
Environmental Obesogens: Mechanisms and Controversies. | Heindel, Jerrold J; Blumberg, Bruce | R01ES023316, R01ES023316 | Annu Rev Pharmacol Toxicol (2019 01 06) | 30044726 | 2019 |
Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pl ... | Mitsunaga, Shino; Shioda, Keiko; Isselbacher, Kurt J; Hanna, Jacob H; Shioda, Toshi | R01ES023316, R01ES023316 | J Vis Exp (2019 01 11) | 30688291 | 2019 |
Transgenerational effects of obesogens. | Lee, Michelle Kira; Blumberg, Bruce | R01ES023316, R01ES023316 | Basic Clin Pharmacol Toxicol (2019 Aug) | 30801972 | 2019 |
Transgenerational Self-Reconstruction of Disrupted Chromatin Organization After Exposure To An Envir ... | Diaz-Castillo, Carlos; Chamorro-Garcia, Raquel; Shioda, Toshi; Blumberg, Bruce | P30ES007048, R01ES023316, R01ES023316 | Sci Rep (2019 09 10) | 31506492 | 2019 |
Effects of Perinatal Exposure to Dibutyltin Chloride on Fat and Glucose Metabolism in Mice, and Mole ... | Chamorro-García, Raquel; Shoucri, Bassem M; Willner, Sigal; Käch, Heidi; Janesick, Amanda; Blum ... | R01ES023316, R01ES023316 | Environ Health Perspect (2018 May) | 29787037 | 2018 |
Evolutionarily diverse mechanisms of germline specification among mammals: what about us? | Mitsunaga, Shino; Shioda, Toshi | R01ES023316, R01ES023316 | Stem Cell Investig (2018) | 29782583 | 2018 |
Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Pr ... | Taylor, Julia A; Shioda, Keiko; Mitsunaga, Shino; Yawata, Shiomi; Angle, Brittany M; Nagel, Su ... | R01ES023316, R01ES023316 | Endocrinology (2018 Feb 01) | 29220483 | 2018 |
Retinoid X Receptor Activation During Adipogenesis of Female Mesenchymal Stem Cells Programs a Dysfu ... | Shoucri, Bassem M; Hung, Victor T; Chamorro-García, Raquel; Shioda, Toshi; Blumberg, Bruce | R01ES023316, R01ES023316 | Endocrinology (2018 Aug 01) | 29860300 | 2018 |
Technical adequacy of bisulfite sequencing and pyrosequencing for detection of mitochondrial DNA met ... | Owa, Chie; Poulin, Matthew; Yan, Liying; Shioda, Toshi | R01ES023316, R01ES023316 | PLoS One (2018) | 29420656 | 2018 |
Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice. | Chamorro-Garcia, Raquel; Diaz-Castillo, Carlos; Shoucri, Bassem M; Käch, Heidi; Leavitt, Ron; S ... | R01ES023316, R01ES023316 | Nat Commun (2017 Dec 08) | 29222412 | 2017 |
Correction to: Parma consensus statement on metabolic disruptors. | Heindel, Jerrold J; Vom Saal, Frederick S; Blumberg, Bruce; Bovolin, Patrizia; Calamandrei, Gem ... | R01ES023316, R01ES023316 | Environ Health (2017 Dec 06) | 29212512 | 2017 |
Endocrine Disruptors and Health Effects in Africa: A Call for Action. | Bornman, Maria S; Aneck-Hahn, Natalie H; de Jager, Christiaan; Wagenaar, Gesina M; Bouwman, Hin ... | R01ES023316, R01ES023316 | Environ Health Perspect (2017 Aug 22) | 28935616 | 2017 |
Is it time to reassess current safety standards for glyphosate-based herbicides? | Vandenberg, Laura N; Blumberg, Bruce; Antoniou, Michael N; Benbrook, Charles M; Carroll, Lynn; ... | R01ES023316, R01ES023316 | J Epidemiol Community Health (2017 Jun) | 28320775 | 2017 |
Metabolism disrupting chemicals and metabolic disorders. | Heindel, Jerrold J; Blumberg, Bruce; Cave, Mathew; Machtinger, Ronit; Mantovani, Alberto; Mende ... | R01ES023316, R01ES023316 | Reprod Toxicol (2017 03) | 27760374 | 2017 |
Relevance of iPSC-derived human PGC-like cells at the surface of embryoid bodies to prechemotaxis mi ... | Mitsunaga, Shino; Odajima, Junko; Yawata, Shiomi; Shioda, Keiko; Owa, Chie; Isselbacher, Kurt ... | R01ES023316, R01ES023316 | Proc Natl Acad Sci U S A (2017 11 14) | 29087313 | 2017 |
Reply to "Comment on 'On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens' ... | Janesick, Amanda S; Dimastrogiovanni, Giorgio; Chamorro-Garcia, Raquel; Blumberg, Bruce | R01ES023316, R01ES023316 | Environ Health Perspect (2017 Jan 01) | 28055946 | 2017 |
Retinoid X Receptor Activation Alters the Chromatin Landscape To Commit Mesenchymal Stem Cells to th ... | Shoucri, Bassem M; Martinez, Eric S; Abreo, Timothy J; Hung, Victor T; Moosova, Zdena; Shioda, ... | R01ES023316, R01ES023316 | Endocrinology (2017 Oct 01) | 28977589 | 2017 |
The unexpected teratogenicity of RXR antagonist UVI3003 via activation of PPARγ in Xenopus tropicali ... | Zhu, Jingmin; Janesick, Amanda; Wu, Lijiao; Hu, Lingling; Tang, Weiyi; Blumberg, Bruce; Shi, ... | R01ES023316, R01ES023316 | Toxicol Appl Pharmacol (2017 Jan 01) | 27894914 | 2017 |
Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus st ... | Myers, John Peterson; Antoniou, Michael N; Blumberg, Bruce; Carroll, Lynn; Colborn, Theo; Evere ... | R01ES023316, R01ES023316 | Environ Health (2016 Feb 17) | 26883814 | 2016 |
Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model deriv ... | Miyoshi, Norikatsu; Stel, Jente M; Shioda, Keiko; Qu, Na; Odajima, Junko; Mitsunaga, Shino; Zh ... | R01ES023316, R01ES023316 | Proc Natl Acad Sci U S A (2016 Aug 23) | 27486249 | 2016 |
Obesogens: an emerging threat to public health. | Janesick, Amanda S; Blumberg, Bruce | R01ES023316, R01ES023316 | Am J Obstet Gynecol (2016 May) | 26829510 | 2016 |
On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens. | Janesick, Amanda Shaine; Dimastrogiovanni, Giorgio; Vanek, Lenka; Boulos, Christy; Chamorro-Garc ... | R01ES023316, R01ES023316 | Environ Health Perspect (2016 Aug) | 26757984 | 2016 |
Reply. | Janesick, Amanda S; Blumberg, Bruce | R01ES023316, R01ES023316 | Am J Obstet Gynecol (2016 Oct) | 27242202 | 2016 |
Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic. | Lind, Lars; Lind, P Monica; Lejonklou, Margareta H; Dunder, Linda; Bergman, Åke; Guerrero-Bosag ... | R01ES023316, R01ES023316 | Environ Health Perspect (2016 May 01) | 27135406 | 2016 |
Obesity, diabetes, and associated costs of exposure to endocrine-disrupting chemicals in the Europea ... | Legler, Juliette; Fletcher, Tony; Govarts, Eva; Porta, Miquel; Blumberg, Bruce; Heindel, Jerro ... | R01ES023316, R01ES023316 | J Clin Endocrinol Metab (2015 Apr) | 25742518 | 2015 |
Parma consensus statement on metabolic disruptors. | Heindel, Jerrold J; Vom Saal, Frederick S; Blumberg, Bruce; Bovolin, Patrizia; Calamandrei, Gem ... | R01ES023316, R01ES023316 | Environ Health (2015 Jun 20) | 26092037 | 2015 |
Transgenerational effects of obesogens and the obesity epidemic. | Chamorro-García, Raquel; Blumberg, Bruce | R01ES023316, R01ES023316 | Curr Opin Pharmacol (2014 Dec) | 25460228 | 2014 |
Transgenerational inheritance of prenatal obesogen exposure. | Janesick, Amanda S; Shioda, Toshihiro; Blumberg, Bruce | R01ES023316, R01ES023316 | Mol Cell Endocrinol (2014 Dec) | 25218215 | 2014 |