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Who We Fund: Application Of Technology To Disease - Predictive Toxicology / Assay Development

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Title Principal Investigator Institution Grant Number RFA PA Number Program Officer Pubs Primary Science Code Secondary Science Code
A NONANIMAL TEST METHOD TO DETERMINE THE OCULAR SAFETY OF CONSUMER PRODUCTS AND CHEMICALS: COMMERCIALIZATION lebrun, stewart Lebrun Labs, Llc SB1ES025501 PAR20-128 Ravichandran, Lingamanaidu 2 72 - Predictive Toxicology/Assay Development -
A SEARCH FOR SAFER PLASTICS: SYNTHESIS AND REPRODUCTIVE TOXICITY EVALUATION OF NOVEL BISPHENOLS kuzmanov, aleksandra Lawrence Technological University R15ES034520 PAR21-155 Ravichandran, Lingamanaidu 0 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
AN ASSAY SUITE FEATURING HIPSC-DERIVED NEURONS AND SUPPORT CELLS, TO TEST TOXICANTS AND INDUSTRIAL CHEMICALS FOR DEVELOPMENTAL NEUROTOXIC EFFECTS mcdonough, patrick m Vala Sciences, Inc. R44ES036385 ES23-008 Shaughnessy, Daniel 0 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
BARCODED HUMAN CELLS ENGINEERED WITH HETEROZYGOUS GENETIC DIVERSITY TO UNCOVER TOXICODYNAMIC VARIABILITY george, jay Amelia Technologies, Llc R44ES032522 ES20-008 Shaughnessy, Daniel 16 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
DEVELOPING AN IN VITRO TO IN VIVO PIPELINE OF MAMMARY GLAND EXPOSURE-RESPONSE RELATIONSHIPS TO PER- AND POLY-FLUOROALKYL SUBSTANCES (PFAS) oldenburg, amy l Univ Of North Carolina Chapel Hill R01ES032730 PA19-056 Ravichandran, Lingamanaidu 1 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
DEVELOPMENT OF A COMPREHENSIVE HEN'S EGG MODEL FOR GENOTOXICITY TESTING briggs, erica Litron Laboratories, Ltd. R44ES036902 PA23-230 Shaughnessy, Daniel 0 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
DEVELOPMENT OF A RAPID SCREENING TEST FOR THE DETECTION OF DIHYDROANATOXIN-A ford, lance p Attogene R43ES034301 PA21-259 Shaughnessy, Daniel 0 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
DEVELOPMENT OF CELL CULTURE INSERTS AND 3D IN VITRO TISSUE MODELS UTILIZING NOVEL ELECTROSPUN SCAFFOLDS hayden, patrick j Biosurfaces R44ES034681 PA22-176 Shaughnessy, Daniel 0 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
DIVISION OF CHEMICAL TOXICOLOGY SYMPOSIA AT THE 268TH NATIONAL ACS MEETING shuck, sarah c. Beckman Research Institute/City Of Hope R13ES036856 PA21-151 Shaughnessy, Daniel 0 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
GENE-EDITED LIVER ORGANOIDS FOR PREDICTIVE HEPATOTOXICITY joshi, pranav Bioprinting Laboratories, Inc. R43ES035653 PA22-176 Ravichandran, Lingamanaidu 4 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
HIGH THROUGHPUT SCREEN AND HIGH INFORMATION FOLLOW-UP TESTS FOR GENOTOXICANTS dertinger, stephen d Litron Laboratories, Ltd. R44ES033138 PA20-260 Shaughnessy, Daniel 2 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
HIGH-CONTENT IN VIVO DNT TEST BATTERIES USING CELL-SPECIFIC CHARACTERIZATION OF THE NEURODEVELOPMENT AND SYNAPTOGENESIS IN C. ELEGANS AS NAMS mondal, sudip Vivoverse, Llc R43ES036387 ES23-008 Ravichandran, Lingamanaidu 0 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
IN VITRO TOXICITY TESTING AT MASSIVE SCALE IN DIVERSE PRIMARY HUMAN CELLS borch jensen, martin Gordian Biotechnology, Inc. R44ES032515 ES20-008 Shaughnessy, Daniel 2 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
INVESTIGATING ENVIRONMENTAL CONTAMINANT INTERACTIONS ON THE GPCROME: AN UNEXPLORED LANDSCAPE OF ACTIVITY roman, david l. University Of Iowa R21ES036329 PA20-195 Ravichandran, Lingamanaidu 0 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
MODELING THE RESPONSIVENESS OF SENSITIVE POPULATIONS TO GENOTOXIC AGENTS USING DNA REPAIR INHIBITORS dertinger, stephen d Litron Laboratories, Ltd. R43ES035550 ES22-006 Shaughnessy, Daniel 0 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
MULTIFACTORIAL ENVIRONMENTAL INHIBITION OF SONIC HEDGEHOG SIGNALING: IMPACT OF CHEMICAL INTERACTIONS ON PATHWAY ACTIVITY AND CRANIOFACIAL DEVELOPMENT beames, tyler george University Of Wisconsin-Madison F31ES034632 PA21-051 Ravichandran, Lingamanaidu 0 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
OPTIMIZATION AND VALIDATION OF MINIMALLY-INVASIVE AND LOW-COST BLOOD COLLECTION DEVICE FOR LEAD TESTING ahuja, punkaj Skyway Biosciences R41ES036480 PA23-232 Shaughnessy, Daniel 0 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
PROTECTING CHILDREN'S HEALTH BY APPLYING NOVEL APPROACHES TO ASSESS URBAN AND RURAL DRINKING WATER garcia-jaramillo, manuel Oregon State University K01ES035397 PAR21-172 Ravichandran, Lingamanaidu 0 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
THE TOXIFIN PLATFORM: ADVANCING HIGH-THROUGHPUT SCREENING AND MECHANISTIC INSIGHTS FOR DEVELOPMENTAL NEUROTOXICANTS USING THE ZEBRAFISH MODEL preston, mary a. Nemametrix, Inc. R43ES036386 ES23-008 Ravichandran, Lingamanaidu 0 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
TRIAGE OF DEVELOPMENTAL AND REPRODUCTIVE TOXICANTS USING AN IN VITRO TO IN VIVO EXTRAPOLATION (IVIVE)-TOXICOKINETIC COMPUTATIONAL MODELING APPLICATION moreau, marjory Scitovation, Llc R43ES035657 PA22-176 Ravichandran, Lingamanaidu 1 72 - Predictive Toxicology/Assay Development 03 - Carcinogenesis/Cell Transformation
VALIDATION OF THE UPAS+: A FILTER-BASED AIR SAMPLER COUPLED WITH A SUITE OF REAL-TIME SENSORS miller-lionberg, daniel d Access Sensor Technologies, Llc R44ES024041 ES20-016 Shaughnessy, Daniel 4 72 - Predictive Toxicology/Assay Development -
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