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Who We Fund: Publications associated with Application Of Technology To Disease - Predictive Toxicology / Assay Development

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Viewing 36 publications
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Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
A three-zone hypoxia chamber capable of regulating unique oxygen and carbon dioxide partial pressure ...   Sitte, Zachary R; Miranda, Abel A; DiProspero, Thomas J; Lockett, Matthew R R01ES032730 HardwareX (2024 Sep) 39114295 Exiting the NIEHS site 2024 
CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stres ...   Acharya, Ganesh; Mani, Chinnadurai; Sah, Naresh; Saamarthy, Karunakar; Young, Robert; Reedy, M ... P01ES028949, R44ES032522, U01ES029518, U01ES029518 Cell Death Discov (2024 Jun 11) 38862485 Exiting the NIEHS site 2024 
Continuous flow delivery system for the perfusion of scaffold-based 3D cultures.   Sitte, Zachary R; Karlsson, Elizabeth E; Li, Haolin; Zhou, Haibo; Lockett, Matthew R P30ES010126, R01ES032730, T32ES007018 Lab Chip (2024 Aug 20) 39099241 Exiting the NIEHS site 2024 
Cryopreservation of neuroectoderm on a pillar plate and in situ differentiation into human brain org ...   Zolfaghar, Mona; Acharya, Prabha; Joshi, Pranav; Choi, Na Young; Shrestha, Sunil; Lekkala, Vin ... R43ES035653 bioRxiv (2024 Jul 25) 39091876 Exiting the NIEHS site 2024 
Dynamic culture of cerebral organoids using a pillar/perfusion plate for the assessment of developme ...   Acharya, Prabha; Shrestha, Sunil; Joshi, Pranav; Choi, Na Young; Lekkala, Vinod Kumar Reddy; Ka ... R43ES035653 bioRxiv (2024 Mar 13) 38559002 Exiting the NIEHS site 2024 
Enhanced Maturity and Functionality of Vascularized Human Liver Organoids through 3D Bioprinting and ...   Lekkala, Vinod Kumar Reddy; Shrestha, Sunil; Qaryoute, Ayah Al; Dhinoja, Sanchi; Acharya, Prabh ... R43ES035653 bioRxiv (2024 Aug 22) 39229042 Exiting the NIEHS site 2024 
Fundamentals of low-cost aerosol sensor design and operation.   Ouimette, James; Arnott, W Patrick; Laven, Philip; Whitwell, Richard; Radhakrishnan, Nagarajan; ... R44ES024041 Aerosol Sci Technol (2024) 38993374 Exiting the NIEHS site 2024 
Impact of polβ/XRCC1 Interaction Variants on the Efficiency of Nick Sealing by DNA Ligase IIIα in th ...   Almohdar, Danah; Gulkis, Mitchell; Ortiz, Abigail; Tang, Qun; Sobol, Robert W; Çağlayan, Melik ... P01ES028949, R44ES032522, U01ES029518, U01ES029518 J Mol Biol (2024 Feb 15) 38135179 Exiting the NIEHS site 2024 
Inspiring basic and applied research in genome integrity mechanisms: Dedication to Samuel H. Wilson.   Yan, Shan; Gaddameedhi, Shobhan; Sobol, Robert W P01ES028949, P30ES025128, R01ES030113, R21ES032966, R44ES032522, U01ES029518, U01ES029518 Environ Mol Mutagen (2024 Apr) 38619433 Exiting the NIEHS site 2024 
Mouse models to explore the biological and organismic role of DNA polymerase beta.   Sobol, Robert W P01ES028949, R44ES032522, U01ES029518, U01ES029518 Environ Mol Mutagen (2024 Apr) 38619421 Exiting the NIEHS site 2024 
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhanc ...   Saville, Kate M; Al-Rahahleh, Rasha Q; Siddiqui, Aisha H; Andrews, Morgan E; Roos, Wynand P; Ko ... P01ES028949, R44ES032522, U01ES029518, U01ES029518 DNA Repair (Amst) (2024 Aug) 38897003 Exiting the NIEHS site 2024 
Poly-ADP-ribosylation dynamics, signaling, and analysis.   Al-Rahahleh, Rasha Q; Sobol, Robert W P01ES028949, R44ES032522, U01ES029518, U01ES029518 Environ Mol Mutagen (2024 Sep 02) 39221603 Exiting the NIEHS site 2024 
Regenerative human liver organoids (HLOs) in a pillar/perfusion plate for hepatotoxicity assays.   Shrestha, Sunil; Acharya, Prabha; Kang, Soo-Yeon; Vanga, Manav Goud; Lekkala, Vinod Kumar Reddy ... R43ES035653 bioRxiv (2024 Jul 25) 38586058 Exiting the NIEHS site 2024 
Reproducible generation of human liver organoids (HLOs) on a pillar plate platform via microarray 3D ...   Shrestha, Sunil; Lekkala, Vinod Kumar Reddy; Acharya, Prabha; Kang, Soo-Yeon; Vanga, Manav Goud ... R43ES035653 Lab Chip (2024 May 14) 38660778 Exiting the NIEHS site 2024 
Reproducible generation of human liver organoids (HLOs) on a pillar plate platform via microarray 3D ...   Shrestha, Sunil; Lekkala, Vinod Kumar Reddy; Acharya, Prabha; Kang, Soo-Yeon; Vanga, Manav Goud ... R43ES035653 bioRxiv (2024 Mar 13) 38559126 Exiting the NIEHS site 2024 
Supported gel slab scaffolds as a three-dimensional cell-based assay platform.   Sitte, Zachary R; Karlsson, Elizabeth E; Larson, Tyler S; Li, Haolin; Zhou, Haibo; Lockett, Ma ... P30ES010126, R01ES032730, T32ES007018 Analyst (2024 Sep 09) 39072359 Exiting the NIEHS site 2024 
Visualization strategies to aid interpretation of high-dimensional genotoxicity data.   Dertinger, Stephen D; Briggs, Erica; Hussien, Yusuf; Bryce, Steven M; Avlasevich, Svetlana L; C ... R44ES033138 Environ Mol Mutagen (2024 Jun) 38757760 Exiting the NIEHS site 2024 
A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonucle ...   Das, Debanu; Duncton, Matthew A J; Georgiadis, Taxiarchis M; Pellicena, Patricia; Clark, Jennif ... P01ES028949, R44ES032522, U01ES029518, U01ES029518 Int J Mol Sci (2023 Nov 23) 38068959 Exiting the NIEHS site 2023 
Animal-free assessment of developmental toxicity: Combining PBPK modeling with the ReproTracker assa ...   Moreau, Marjory; Jamalpoor, Amer; Hall, John Carter; Fisher, Jeffrey; Hartvelt, Sabine; Hendrik ... R43ES035657 Toxicology (2023 Dec) 38029956 Exiting the NIEHS site 2023 
Editorial: DNA repair and nucleic acid therapeutics in cancer.   Sobol, Robert W P01ES028949, R44ES032522, U01ES029518, U01ES029518 NAR Cancer (2023 Sep) 37645072 Exiting the NIEHS site 2023 
Expansion of the application domain of a macromolecular ocular irritation test (OptiSafe™).   Lebrun, Stewart; Chavez, Sara; Nguyen, Linda; Chan, Roxanne SB1ES025501 Toxicol In Vitro (2023 Feb) 36351539 Exiting the NIEHS site 2023 
Further optimisation of a macromolecular ocular irritation test (OptiSafeTM).   Lebrun, Stewart; Chavez, Sara; Nguyen, Linda; Chan, Roxanne SB1ES025501 Cutan Ocul Toxicol (2023 Mar) 36669195 Exiting the NIEHS site 2023 
Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA dama ...   Al-Rahahleh, Rasha Q; Saville, Kate M; Andrews, Joel F; Wu, Zhijin; Koczor, Christopher A; Sobo ... P01ES028949, R44ES032522, U01ES029518, U01ES029518 bioRxiv (2023 Dec 29) 38234836 Exiting the NIEHS site 2023 
Polβ/XRCC1 heterodimerization dictates DNA damage recognition and basal Polβ protein levels without ...   Koczor, Christopher A; Thompson, Marlo K; Sharma, Nidhi; Prakash, Aishwarya; Sobol, Robert W P01ES028949, R01ES030084, R44ES032522, U01ES029518, U01ES029518 DNA Repair (Amst) (2023 Mar) 36702010 Exiting the NIEHS site 2023 
Quantitative Analysis of Nuclear Poly(ADP-Ribose) Dynamics in Response to Laser-Induced DNA Damage.   Koczor, Christopher A; Saville, Kate M; Al-Rahahleh, Rasha Q; Andrews, Joel F; Li, Jianfeng; So ... P01ES028949, R44ES032522, U01ES029518, U01ES029518 Methods Mol Biol (2023) 36515828 Exiting the NIEHS site 2023 
WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/misma ...   Sobol, Robert W P01ES028949, R44ES032522, U01ES029518, U01ES029518 Proc Natl Acad Sci U S A (2023 Jan 10) 36598947 Exiting the NIEHS site 2023 
A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular res ...   Li, Jianfeng; Beiser, Alison; Dey, Nupur B; Takeda, Shunichi; Saha, Liton Kumar; Hirota, Kouji ... R44ES032522, U01ES029518, U01ES029518 NAR Genom Bioinform (2022 Sep) 36110898 Exiting the NIEHS site 2022 
Live Cell Detection of Poly(ADP-Ribose) for Use in Genetic and Genotoxic Compound Screens.   Koczor, Christopher A; Haider, Aaron J; Saville, Kate M; Li, Jianfeng; Andrews, Joel F; Beiser, ... P01ES028949, R44ES032522, U01ES029518, U01ES029518 Cancers (Basel) (2022 Jul 28) 35954352 Exiting the NIEHS site 2022 
A machine learning approach for prioritizing groundwater testing for per-and polyfluoroalkyl substan ...   George, Sarabeth; Dixit, Atray R44ES032515 J Environ Manage (2021 Jul 24) 34346391 Exiting the NIEHS site 2021 
Biomarkers of DNA damage response improve in vitro micronucleus assays by revealing genotoxic mode o ...   Avlasevich, Svetlana; Pellegrin, Tina; Godse, Manali; Bryce, Steven; Bemis, Jeffrey; Bajorski, ... R44ES033138 Mutagenesis (2021 11 29) 34718711 Exiting the NIEHS site 2021 
Exploiting DNA Endonucleases to Advance Mechanisms of DNA Repair.   Thompson, Marlo K; Sobol, Robert W; Prakash, Aishwarya P01ES028949, R01ES030084, R35ES031708, R44ES032522, U01ES029518, U01ES029518 Biology (Basel) (2021 Jun 14) 34198612 Exiting the NIEHS site 2021 
Exploring carbon particle type and plasma treatment to improve electrochemical properties of stencil ...   Kava, Alyssa A; Henry, Charles S R44ES024041 Talanta (2021 Jan 01) 33076109 Exiting the NIEHS site 2021 
Method for analysis of environmental lead contamination in soils.   Beardsley, Chloe A; Fuller, Kai Z; Reilly 3rd, Thomas H; Henry, Charles S R44ES024041 Analyst (2021 Dec 06) 34806095 Exiting the NIEHS site 2021 
Multi-Drug Featurization and Deep Learning Improve Patient-Specific Predictions of Adverse Events.   Anastopoulos, Ioannis N; Herczeg, Chloe K; Davis, Kasey N; Dixit, Atray C R44ES032515 Int J Environ Res Public Health (2021 03 05) 33807714 Exiting the NIEHS site 2021 
Primary saturation of α, β-unsaturated carbonyl containing fatty acids does not abolish electrophili ...   Snyder, Nathaniel W; O'Brien, James; Singh, Bhupinder; Buchan, Gregory; Arroyo, Alejandro D; Li ... P01ES028949, P30ES013508, R44ES032522, U01ES029518, U01ES029518 Chem Biol Interact (2021 Dec 01) 34634267 Exiting the NIEHS site 2021 
Disposable glassy carbon stencil printed electrodes for trace detection of cadmium and lead.   Kava, Alyssa A; Beardsley, Chloe; Hofstetter, Josephine; Henry, Charles S R44ES024041 Anal Chim Acta (2020 Mar 22) 32081189 Exiting the NIEHS site 2020 
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Last Reviewed: October 02, 2024