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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: University of California-Davis: Biomarkers of Exposure to Pulmonary Toxicants

Superfund Research Program

Biomarkers of Exposure to Pulmonary Toxicants

Project Leader: Alan R. Buckpitt
Grant Number: P42ES004699
Funding Period: 1995-2010

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Publications

2008

  • Lee MG, Wheelock AM, Boland BC, Plopper CG. 2008. Long-term ozone exposure attenuates 1-nitronaphthalene-induced cytotoxicity in nasal mucosa. Am J Respir Cell Mol Biol 38:300-309. PMID:17901409
  • Morisseau C, Newman JW, Wheelock CE, Hill T, Morin D, Buckpitt AR, Hammock BD. 2008. Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. Chem Res Toxicol 21(4):951-957. doi:10.1021/tx700446u PMID:18363382

2005

  • Baldwin RM, Shultz MA, Buckpitt AR. 2005. Bioactivation of the pulmonary toxicants naphthalene and 1-nitronaphthalene by rat CYP2F4. J Pharmacol Exp Ther 312(2):857-865. PMID:15509722
  • Lee MG, Phimister AJ, Morin D, Buckpitt AR, Plopper CG. 2005. In situ naphthalene bioactivation and nasal airflow cause region-specific injury patterns in the nasal mucosa of rats exposed to naphthalene by inhalation. J Pharmacol Exp Ther 314(1):103-110. PMID:15833892

2004

  • Baldwin RM, Jewell WT, Fanucchi MV. 2004. Comparison of pulmonary/nasal CYP2F expression levels in rodents and rhesus macaque. J Pharmacol Exp Ther 309(1):127-136. PMID:14724224
  • Shultz MA, Zhang L, Gu Y, Baker GL, Fanucchi MV, Padua AM, Gurske WA, Morin D, Penn SG, Jovanovich SB, Plopper CG, Buckpitt AR. 2004. Gene expression analysis in response to lung toxicants: I Sequencing and microarray development. Am J Respir Cell Mol Biol 30(3):296-310. doi:10.1165/rcmb.2003-0214OC PMID:12947022
  • Wheelock AM, Zhang L, Tran M, Morin D, Penn SG, Buckpitt AR, Plopper CG. 2004. Isolation of rodent airway epithelial cell proteins facilitates in vivo proteomics studies of lung toxicity. Am J Physiol 286(2):L399-L410. doi:10.1152/ajplung.00072.2003 PMID:14594729

2003

  • West JA, Van Winkle LS, Morin D, Fleschner CA, Forman HJ, Plopper CG. 2003. Repeated inhalation exposures to the bioactivated cytotoxicant naphthalene (NA) produce airway-specific Clara cell tolerance in mice. Toxicol Sci 75:161-168. PMID:12805647
  • Williams KJ, Cruikshank MK, Plopper CG. 2003. Pulmonary heat shock protein expression after exposure to a metabolically activated Clara cell toxicant: relationship to protein adduct formation. Toxicol Appl Pharmacol 192(2):107-118. PMID:14550745

2002

  • Buckpitt AR, Boland BC, Isbell MA, Morin D, Shultz MA, Baldwin RM, Chan K, Karlsson A, Lin C, Taff A, West JA, Fanucchi MV, Van Winkle LS, Plopper CG. 2002. Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity. J Mol Biol 34(4):791-820. PMID:12487150
  • Lawson GW, Van Winkle LS, Toskala E, Senior RM, Parks WC, Plopper CG. 2002. Mouse strain modulates the role of the ciliated cell in acute tracheobronchial airway injury-distal airways. Am J Pathol 160(1):315-327. PMID:11786425
  • Pakehham G, Lango J, Buonarati M, Morin D, Buckpitt AR. 2002. Urinary naphthalene mercapturates as biomarkers of exposure and stereoselectivity of naphthalene epoxidation. Drug Metab Dispos 30(3):247-253. PMID:11854141
  • West JA, Williams KJ, Toskala E, Nishio SJ, Fleschner CA, Forman HJ, Buckpitt AR, Plopper CG. 2002. Induction of tolerance to naphthalene in Clara cells is dependent on a stable phenotypic adaptation favoring maintenance of the glutathione pool. Am J Pathol 160(3):1115-1127. PMID:11891208

2001

  • Bartosiewicz MJ, Jenkins D, Penn SG, Emery J, Buckpitt AR. 2001. Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants. J Pharmacol Exp Ther 297(3):895-905. PMID:11356909
  • Bartosiewicz MJ, Penn SG, Buckpitt AR. 2001. Applications of gene arrays in environmental toxicology: fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene. Environ Health Perspect 109(1):71-74. PMID:11171528
  • Plopper CG, Van Winkle LS, Fanucchi MV, Malburg SR, Nishio SJ, Chang A, Buckpitt AR. 2001. Early events in naphthalene-induced acute Clara cell toxicity - II. Comparison of glutathione depletion and histopathology by airway location. Am J Respir Cell Mol Biol 24(3):272-281. PMID:11245626
  • Shultz MA, Morin D, Chang A, Buckpitt AR. 2001. Metabolic capabilities of CYP2F2 with various pulmonary toxicants and its relative abundance in mouse lung subcompartments. J Pharmacol Exp Ther 296(2):510-519. PMID:11160638
  • West JA, Pakehham G, Morin D, Fleschner CA, Plopper CG, Buckpitt AR. 2001. Inhaled naphthalene causes dose dependent Clara cell toxicity in mice but not in rats. Toxicol Appl Pharmacol 173(2):114-119. PMID:11384213
  • Zheng J, Plopper CG, Lakritz J, Storms DH, Hammock BD. 2001. Leukotoxin-diol - a putative toxic mediator involved in acute respiratory distress syndrome. Am J Respir Cell Mol Biol 25(4):434-438. PMID:11694448

2000

  • Bartosiewicz MJ, Trounstine M, Barker D, Johnston R, Buckpitt AR. 2000. Development of a toxicological gene array and quantitative assessment of this technology. Arch Biochem Biophys 376(1):66-73. PMID:10729191
  • Fanucchi MV, Buckpitt AR, Murphy M, Storms DH, Hammock BD, Plopper CG. 2000. Development of phase II xenobiotic metabolizing enzymes in differentiating murine Clara cells. Toxicol Appl Pharmacol 168(3):253-267. PMID:11042098
  • Lakritz J, Winder BS, Noorouz-Zadeh J, Huang TL, Buckpitt AR, Hammock BD, Plopper CG. 2000. Hepatic and pulmonary enzyme activities in horses. American Journal of Veterinary Research 61(2):152-157. PMID:10685686
  • Watt KC, Buckpitt AR. 2000. Species differences in the regio- and stereo-selectivity of 1-nitronaphthalene metabolism. Drug Metab Dispos 28(4):376-378.
  • West JA, Buckpitt AR, Plopper CG. 2000. Elevated airway GSH resynthesis confers protection to Clara cells from naphthalene injury in mice made tolerant by repeated exposures. J Pharmacol Exp Ther 294(2):516-523. PMID:10900227
  • West JA, Chichester C, Buckpitt AR, Tyler NK, Brennan P, Helton C, Plopper CG. 2000. Heterogeneity of Clara cell glutathione - A possible basis for differences in cellular responses to pulmonary cytotoxicants. Am J Respir Cell Mol Biol 23(1):27-36. PMID:10873150

1999

  • Shultz MA, Choudary P, Buckpitt AR. 1999. Role of murine CYP2F2 in the metabolic activation of naphthalene and in the metabolism of other xenobiotics. J Pharmacol Exp Ther 290(1):281-288. PMID:10381788
  • Van Winkle LS, Johnson ZA, Nishio SJ, Brown C, Plopper CG. 1999. Early events in naphthalene-induced acute Clara cell toxicity - Comparison of membrane permeability and ultrastructure. Am J Respir Cell Mol Biol 21(1):44-53. PMID:10385592
  • Watt KC, Morin D, Kurth M, Mercer RS, Plopper CG, Buckpitt AR. 1999. Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: Identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy. Chem Res Toxicol 12(9):831-839. PMID:10490505

1997

  • Lakritz J, Plopper CG, Buckpitt AR. 1997. Validated high-performance liquid chromatography-electrochemical method for determination of glutathione and glutathione disulfide in small tissue samples. Anal Biochem 247(1):63-68. PMID:9126372
  • Paige R, Wong VJ, Plopper CG. 1997. Dose-related airway-selective epithelial toxicity of 1-nitronaphthalene in rats. Toxicol Appl Pharmacol 147(2):224-233. PMID:9439718

1996

  • Lakritz J, Chang A, Weir AJ, Nishio SJ, Hyde D, Philpot RM, Buckpitt AR, Plopper CG. 1996. Cellular and metabolic basis of clara cell tolerance to multiple doses of cytochrome P450-activated cytotoxicants. I: Bronchiolar epithelial reorganization and expression of cytochrome P450 monooxygenases in mice exposed to multiple doses of naphthalene. J Pharmacol Exp Ther 278(3):1408-1418. PMID:8819528
  • Van Winkle LS, Buckpitt AR, Plopper CG. 1996. Maintenance of differentiated murine clara cells in microdissected airway cultures. Am J Respir Cell Mol Biol 14(6):586-598. PMID:8652187
  • Van Winkle LS, Isaac JM, Plopper CG. 1996. Repair of naphthalene-injured microdissected airways in vitro. Am J Respir Cell Mol Biol 15(1):1-8. PMID:8679213

1995

  • Buckpitt AR, Chang A, Weir AJ, Van Winkle LS, Duan X, Philpot RM, Plopper CG. 1995. Relationship of cytochrome P450 activity to Clara cell cytotoxicity. IV. Metabolism of naphthalene and naphthalene oxide in microdissected airways from mice, rats, and hamsters. Mol Pharmacol 47(1):74-81. PMID:7838135
  • Cho M, Chichester C, Plopper CG, Buckpitt AR. 1995. Biochemical factors important in Clara cell selective toxicity in the lung. J Mol Biol 27(1-2):369-386. PMID:7641583
  • Van Winkle LS, Buckpitt AR, Nishio SJ, Isaac JM, Plopper CG. 1995. Cellular response in naphthalene-induced Clara cell injury and bronchiolar epithelial repair in mice. Am J Physiol 269(6):L800-L818. PMID:8572242
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