Superfund Research Program

Neurobehavioral Mechanisms of Cognitive and Affective Impairment from Fetal Exposure to Superfund Chemicals

Project Leader: Edward D. Levin
Grant Number: P42ES010356
Funding Period: 2005-2011

Project-Specific Links

Publications

2011

• Levin ED. 2011. Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development. Rev Neurosci 22:75-84. doi:10.1515/RNS.2011.009 PMID:21615262 PMCID:PMC4691346
• Levin ED, Petro A, Donerly S, Linney EA, Sledge D, Roach S. 2011. Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish. Neurotoxicol Teratol 33:668-673. doi:10.1016/j.ntt.2011.06.004 PMID:21741476 PMCID:PMC3225500
• Powers CM, Levin ED, Seidler FJ, Slotkin TA. 2011. Silver exposure in developing zebrafish produces persistent synaptic and behavioral changes. Neurotoxicol Teratol 33:329-332. doi:10.1016/j.ntt.2010.10.006 PMID:21035540 PMCID:PMC3071894
• Sledge D, Yen J, Morton T, Dishaw L, Petro A, Donerly S, Linney EA, Levin ED. 2011. Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity. Neurotoxicol Teratol 33:742-751. doi:10.1016/j.ntt.2011.06.005 PMID:21745564 PMCID:PMC3225562
• Yen J, Donerly S, Levin ED, Linney EA. 2011. Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. Neurotoxicol Teratol 33:735-741. doi:10.1016/j.ntt.2011.10.004 PMID:22036888 PMCID:PMC3225599

2009

• Cerutti DT, Levin ED, Eddins D, Petro A, Williams P. 2009. Nicotine effects on learning in zebrafish: the role of dopaminergic systems. Psychopharmacology (Berl) 202(1-3):103-109. doi:10.1007/s00213-008-1287-4 PMID:18716760
• Levin ED, Aschner M, Heberlein U, Ruden D, Welsh-Bohmer KA, Bartlett S, Berger K, Chen L, Corl AB, Eddins D, French R, Hayden KM, Helmcke K, Hirsch HV, Linney EA, Lnenicka G, Page GP, Possidente D, Possidente B, Kirshner A. 2009. Genetic aspects of behavioral neurotoxicology. Neurotoxicology 30(5):741-753. doi:10.1016/j.neuro.2009.07.014 PMID:19647018 PMCID:PMC4086839

2008

• Bencan Z, Levin ED. 2008. The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish. Physiol Behav 95(3):408-412. doi:10.1016/j.physbeh.2008.07.009 PMID:18671990 PMCID:PMC3174522
• Lassiter TL, Ryde IT, MacKillop EA, Brown KK, Levin ED, Seidler FJ, Slotkin TA. 2008. Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood. Environ Health Perspect 116(11):1456-1462. doi:10.1289/ehp.11673 PMID:19057696 PMCID:PMC2592263
• Slotkin TA, Bodwell BE, Levin ED, Seidler FJ. 2008. Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems. Environ Health Perspect 116(3):340-348. doi:10.1289/ehp.11005 PMID:18335101 PMCID:PMC2265026
• Slotkin TA, Bodwell BE, Ryde IT, Levin ED, Seidler FJ. 2008. Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood. Environ Health Perspect 116(10):1308-1314. doi:10.1289/ehp.11451 PMID:18941570 PMCID:PMC2569087
• Slotkin TA, Ryde IT, Levin ED, Seidler FJ. 2008. Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood. Brain Res Bull 75(5):640-647. doi:10.1016/j.brainresbull.2007.10.008 PMID:18355640 PMCID:PMC2322865
• Timofeeva OA, Roegge CS, Seidler FJ, Slotkin TA, Levin ED. 2008. Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon. Neurotoxicol Teratol 30(1):38-45. doi:10.1016/j.ntt.2007.10.002 PMID:18096363 PMCID:PMC2262840
• Timofeeva OA, Sanders D, Seemann K, Yang L, Hermanson D, Regenbogen S, Kallepalli A, Rastogi A, Braddy D, Wells C, Perraut C, Seidler FJ, Slotkin TA, Levin ED, Agoos S. 2008. Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion. Brain Res Bull 77(6):404-411. doi:10.1016/j.brainresbull.2008.08.019 PMID:18817854 PMCID:PMC2612039
• West AK, Hidalgo J, Eddins D, Levin ED, Aschner M. 2008. Metallothionein in the central nervous system: roles in protection, regeneration and cognition. Neurotoxicology 29(3):489-503. doi:10.1016/j.neuro.2007.12.006 PMID:18313142 PMCID:PMC2486367

2007

• Levin ED, Bencan Z, Cerutti DT. 2007. Anxiolytic effects of nicotine in zebrafish. Physiol Behav 90(1):54-8. PMID:17049956
• Slotkin TA, Seidler FJ. 2007. Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects. Reprod Toxicol 23(3):421-7. PMID:17267174

2006

• Cerutti DT, Levin ED. 2006. Cognitive impairments models using complementary species. In: Animal Models of Cognitive Impairment. CRC Press, NY. pp.315-342.
• Levin ED, Buccafusco JJ. 2006. Animal Models of Cognitive Impairment CRC Press, NY.
• Levin ED, Perraut C, Pollard N, Freedman JH. 2006. Metallothionein expression and neurocognitive function in mice. Physiol Behav 87(3):513-518. PMID:16430929
• Slotkin TA, Levin ED, Seidler FJ. 2006. Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environ Health Perspect 114(5):746-751. PMID:16675431
• Slotkin TA, Tate CA, Ryde IT, Levin ED, Seidler FJ. 2006. Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environ Health Perspect 114:1542-1545. PMID:17035140
• Timme-Laragy AR, Levin ED, Di Giulio RT. 2006. Developmental and behavioral effects of embryonic exposure to the polybrominated diphenylether mixture DE-71 in the killifish (Fundulus heteroclitus). Chemosphere 62(7):1097-1104. PMID:16045967

2005

• Aldridge JE, Levin ED, Seidler FJ, Slotkin TA. 2005. Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. Environ Health Perspect 113(5):527-531. PMID:15866758
• Aldridge JE, Meyer A, Seidler FJ, Slotkin TA. 2005. Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure. Environ Health Perspect 113(8):1027-1031. PMID:16079074 PMCID:PMC1280344
• Aldridge JE, Meyer A, Seidler FJ, Slotkin TA. 2005. Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. Toxicol Appl Pharmacol 203(2):132-144. PMID:15710174
• Slotkin TA, Brown KK, Seidler FJ. 2005. Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood. Environ Health Perspect 113(10):1291-1294. PMID:16203236 PMCID:PMC1281268
• Slotkin TA, Seidler FJ. 2005. The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. Brain Res Dev Brain Res 158(1-2):115-119. doi:10.1016/j.devbrainres.2005.06.008 PMID:16024092