Superfund Research Program

Developmental Neurotoxicants: Sensitization, Consequences, and Mechanisms

Project Leader: Theodore A. Slotkin (Duke University Medical Center)
Grant Number: P42ES010356
Funding Period: 2011-2017

Project-Specific Links

Publications

2017

• Slotkin TA, Skavicus S, Card JA, Di Giulio RT, Seidler FJ. 2017. In vitro models reveal differences in the developmental neurotoxicity of an environmental polycylic aromatic hydrocarbon mixture compared to benzo[a]pyrene: Neuronotypic PC12 Cells and embryonic neural stem cells. Toxicology 377:49-56. doi:10.1016/j.tox.2016.12.008 PMID:28049045 PMCID:PMC5250555
• Slotkin TA, Skavicus S, Seidler FJ. 2017. Diazinon and parathion diverge in their effects on development of noradrenergic systems. Brain Res Bull 130:268-273. doi:10.1016/j.brainresbull.2017.02.004 PMID:28235599

2016

• Slotkin TA, Skavicus S, Card JA, Levin ED, Seidler FJ. 2016. Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes. Toxicology 372:42-51. doi:10.1016/j.tox.2016.10.015 PMID:27816694 PMCID:PMC5137195

2015

• Slotkin TA, Seidler FJ. 2015. Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just different?. Brain Res Bull 110:54-67. doi:10.1016/j.brainresbull.2014.12.003 PMID:25510202 PMCID:PMC4297693
• Slotkin TA, Skavicus S, Levin ED, Seidler FJ. 2015. Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition. Brain Res Bull 111:84-96. doi:10.1016/j.brainresbull.2015.01.003 PMID:25592617 PMCID:PMC4324014
• Slotkin TA, Skavicus S, Seidler FJ. 2015. Prenatal drug exposures sensitize noradrenergic circuits to subsequent disruption by chlorpyrifos. Toxicology 338:8-16. doi:10.1016/j.tox.2015.09.005 PMID:26419632 PMCID:PMC4658258

2014

• Levin ED, Cauley M, Johnson JE, Cooper EM, Stapleton HM, Ferguson PL, Seidler FJ, Slotkin TA. 2014. Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor. Neurotoxicol Teratol 41:35-42. doi:10.1016/j.ntt.2013.10.004 PMID:24177596 PMCID:PMC3943881
• Slotkin TA, Card JA, Seidler FJ. 2014. Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways. Brain Res Bull 100:44-54. doi:10.1016/j.brainresbull.2013.10.014 PMID:24280657 PMCID:PMC3891922

2013

• Slotkin TA, Card JA, Infante A, Seidler FJ. 2013. BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells. Neurotoxicol Teratol 37:13-17. doi:10.1016/j.ntt.2013.02.001 PMID:23422510 PMCID:PMC3669237
• Slotkin TA, Card JA, Infante A, Seidler FJ. 2013. Prenatal dexamethasone augments the sex-selective developmental neurotoxicity of chlorpyrifos: Implications for vulnerability after pharmacotherapy for preterm labor. Neurotoxicol Teratol 37:1-12. doi:10.1016/j.ntt.2013.02.002 PMID:23416428 PMCID:PMC3669256
• Slotkin TA, Card JA, Seidler FJ. 2013. Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: Interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells. Environ Health Perspect 121:825-831. doi:10.1289/ehp.1306528 PMID:23603068 PMCID:PMC3702011
• Slotkin TA, Cooper EM, Stapleton HM, Seidler FJ. 2013. Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?. Environ Toxicol Pharmacol 36(2):284-287. doi:10.1016/j.etap.2013.04.003 PMID:23686008 PMCID:PMC3745805
• Slotkin TA, Seidler FJ. 2013. Terbutaline impairs the development of peripheral noradrenergic projections: Potential implications for autism spectrum disorders and pharmacotherapy of preterm labor. Neurotoxicol Teratol 36:91-96. doi:10.1016/j.ntt.2012.07.003 PMID:22813780 PMCID:PMC3492522

2012

• Slotkin TA, Card JA, Seidler FJ. 2012. Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells. Neurotoxicol Teratol 34:505-512. doi:10.1016/j.ntt.2012.07.002 PMID:22796634 PMCID:PMC3462281
• Slotkin TA, Seidler FJ. 2012. Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro. Neurotoxicol Teratol 34:232-241. doi:10.1016/j.ntt.2011.12.001 PMID:22222554 PMCID:PMC3303931

2011

• Seidler FJ, Slotkin TA. 2011. Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: Effects of organophosphates are distinct from those of glucocorticoids. Brain Res Bull 85:225-230. doi:10.1016/j.brainresbull.2011.03.021 PMID:21453761 PMCID:PMC3109170
• Slotkin TA, Seidler FJ, Spindel ER. 2011. Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: amelioration by Vitamin C. Neurotoxicol Teratol 33:431-434. doi:10.1016/j.ntt.2011.02.001 PMID:21320590 PMCID:PMC3109087

2010

• Adigun A, Ryde IT, Seidler FJ, Slotkin TA. 2010. Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells. Brain Res 1329:36-44. doi:10.1016/j.brainres.2010.03.025 PMID:20298678 PMCID:PMC2857560
• Slotkin TA, Lobner D, Seidler FJ. 2010. Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants. Brain Res Bull 83:76-83. doi:10.1016/j.brainresbull.2010.06.010 PMID:20600679 PMCID:PMC2922476
• Slotkin TA, Seidler FJ. 2010. Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an In vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PCI2 cells. Brain Res 1353:36-52. doi:10.1016/j.brainres.2010.07.073 PMID:20682304 PMCID:PMC2933311
• Slotkin TA, Seidler FJ. 2010. Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss. Neurotoxicol Teratol 32(2):124-131. doi:10.1016/j.ntt.2009.12.001 PMID:20004241 PMCID:PMC2838986