Health Effects - Animal Studies
Superfund Research Program
Research Briefs By Category: Health Effects - Animal Studies
- 221 - Novel Method Identifies Potential Key Pathway in Arsenic-Induced Birth Defects -- Fry
Release Date: 05/01/2013Blocking the glucocorticoid receptor (GR) pathway in a chick embryo model prevents structural birth defects induced by arsenic, according to a 2013 NIEHS-funded study at the University of North Carolina at Chapel Hill Superfund Research Program (UNC SRP). The laboratory study was performed after computationally predicting the association between the GR pathway and metal-induced birth defects with a novel approach to identify targeted biological pathways.
- 220 - Commonly Manufactured Nanomaterial Induces Neurovascular Toxicity -- Toborek
Release Date: 04/03/2013Nanoalumina, a widely manufactured nanomaterial, was shown to accumulate in brain cells, inducing nerve and blood vessel damage and protein degradation in the brain. Study results also suggest that exposure to nanoalumina disrupts the blood-brain barrier and may worsen the outcomes of neurological disorders such as stroke.
- 213 - Widely Used Antibacterial Agents May Lead to Significant Health Concerns -- Pessah, Hammock
Release Date: 09/05/2012Researchers at UC Davis show that triclosan, a chemical widely used in antibacterial products, impairs heart and skeletal muscle activity in animal models. Other studies link another antibacterial agent, triclocarban, to changes in regulatory pathways in mice and in human cells.
- 210 - A New Role for MicroRNAs in Neurobehavioral Development -- Tanguay, Tal
Release Date: 06/06/2012MicroRNAs may be tiny, but these short pieces of RNA regulate important human genes. The genes they regulate are also more sensitive to environmental chemical exposures. In a new study, researchers found environmental disruption of miRNAs can affect neurobehavioral development in zebrafish.
- 207 - Particulate matter pollution: A particular problem for the young? -- Kennedy
Release Date: 03/07/2012Newborns and infants may be uniquely susceptible to harm from tiny particles in air pollution (particulate matter), a study shows. Researchers exposed 7-day-old rats to a level of PM similar to that found in Fresno, Calif., which resulted in biological changes not found in adults rats, including markers of cellular toxicity.
- 206 - Arsenic Linked to Developmental Changes in the Heart -- Camenisch
Release Date: 02/01/2012Adults exposed to arsenic in their drinking water are at increased risk for high blood pressure and heart disease, among other health problems. New research using mice shows these cardiovascular effects can start early in life if mice are exposed to arsenic during development.
- 195 - Mechanism of Resistance to PCB Toxicity in Fish -- Hahn, Wirgin
Release Date: 03/02/2011A team unravels the mystery of how Atlantic tomcod living in waters contaminated with polychlorinated biphenyls (PCBs) not only survive in their polluted environment, but thrive.
- 188 - TCDD May Contribute to Immune System Instability -- Kaminski
Release Date: 08/04/2010 A new computational model shows how the environmental contaminant TCDD causes immune system mayhem by interfering with the activation of crucial B cells. - 185 - Childhood Exposures to Pesticides May Contribute to Obesity and Diabetes in Adults -- Slotkin
Release Date: 05/05/2010Organophosphates represent nearly 50 percent of worldwide insecticide use. Unfortunately, they may also contribute to another statistic: the increased incidence of obesity and diabetes.
- 184 - Linking Site Specific Contaminant Mixtures to Biological Responses -- Anderson
Release Date: 04/05/2010New tools could help Superfund site managers evaluate the nuances of chemical mixtures and identify the most pressing threats to ecosystem and human health.
- 175 - Do Mirror Differences Among Non-coplanar PCBs Influence Their Developmental Neurotoxicity? -- Lehmler, Pessah
Release Date: 07/01/2009 - 174 - Gene-Environment Interactions: PCB Exposures and Adverse Effects on Pregnancy -- Sharma
Release Date: 06/03/2009 - 170 - Biomarkers to Investigate the Toxicity and Carcinogenicity of PHAHs -- Swenberg
Release Date: 02/04/2009 - 162 - Toxicogenomics Studies Focus on Largemouth Bass -- Denslow
Release Date: 06/04/2008 - 161 - PCB77 Promotes Obesity-associated Atherosclerosis -- Cassis
Release Date: 05/07/2008 - 159 - Research Brief 159: In utero and Early Postnatal Exposure to Arsenic May Alter Pulmonary Function -- Lantz
Release Date: 03/05/2008 - 157 - SBRP Investigators Find Evidence Suggesting a New Type of Endocrine Disruptor -- Lasley, Chen
Release Date: 01/02/2008 - 154 - Understanding the Underlying Mechanism of Asbestos Carcinogenesis -- Hei
Release Date: 10/03/2007 - 141 - MMA(III) - a Role in Arsenic Carcinogenesis -- Gandolfi
Release Date: 09/06/2006 - 124 - DNA Damage Index: A New Tool for Assessing Toxic Effects of Contaminants -- Malins, Stegeman
Release Date: 04/06/2005 - 122 - Factors Affecting the Impact of Exposures to Metals -- Costa, Rossman
Release Date: 02/02/2005 - 116 - Investigating the Impact of Organic Mixtures on Cardiac Development of the Killifish -- Di Giulio
Release Date: 08/04/2004 - 106 - The Effects of Chlorinated Hydrocarbons on Wildlife -- Gross, Sepulveda
Release Date: 10/01/2003 - 102 - Multidisciplinary Research to Develop Models to Study the Impacts of Exposure to Chlorpyrifos -- Levin, Linney
Release Date: 06/04/2003 - 94 - Anthrax invades and evades the immune system to cause widespread infection -- Karin
Release Date: 10/02/2002 - 92 - Biomarkers of Chromogenic Solvent Exposure & Neurodegeneration -- Sabri
Release Date: 08/07/2002 - 81 - Developmental Neurotoxicity of Xenoestrogens in Zebrafish -- Callard
Release Date: 09/05/2001 - 80 - Mechanisms of Chlorpyrifos Developmental Neurotoxicity -- Slotkin
Release Date: 08/01/2001 - 78 - Role of Oxyradicals in Genotoxicity of Arsenic -- Hei
Release Date: 06/06/2001 - 72 - An Investigation of the Behavioral Toxicity of Lead -- Strupp
Release Date: 12/06/2000 - 63 - Stage-specific Actions of Cadmium During Spermatogenesis -- Callard
Release Date: 02/02/2000 - 58 - Mechanisms Underlying Arsenic-Induced Vascular Disease -- Barchowsky
Release Date: 11/11/1999 - 55 - Potent Inhibitors are Discovered for Soluble Epoxide Hydrolases, Enzymes That Have an Important Role in the Metabolism of Environmental Contaminants -- Hammock
Release Date: 09/22/1999 - 52 - The Effects of Nutrition on Polychlorinated Biphenyl-Mediated Endothelial Cell Activation - Implications in Atherosclerosis -- Hennig, Toborek, Robertson
Release Date: 08/11/1999 - 51 - Diversity of Inorganic Arsenic Metabolism -- Aposhian
Release Date: 07/28/1999 - 49 - Exploring the Mechanisms of Neurotoxicity Caused by Exposure to Polychlorinated Biphenyls -- Carpenter
Release Date: 06/30/1999 - 48 - Mechanisms of Vanadium Toxicity in the Respiratory System -- Godleski
Release Date: 06/16/1999 - 44 - Studies Examine the Mechanisms of Chromium Mutagenesis -- Dixon
Release Date: 04/21/1999 - 42 - Mechanisms and Consequences of Neutrophil Activation by Polychlorinated Biphenyls -- Ganey
Release Date: 03/24/1999 - 40 - The Effects of Organophosphate Compounds on the Developing Eye -- Hinton
Release Date: 02/24/1999 - 39 - Tracking Down the Mechanisms of Trichloroethylene-Induced Toxicity -- Waxman
Release Date: 02/10/1999 - 30 - Understanding the Molecular Basis for Metal-Induced Cancers -- Hamilton
Release Date: 09/30/1998 - 25 - Comparative Metabolism Studies of Dichloroacetate -- Stacpoole
Release Date: 07/22/1998 - 14 - Studies Examine Cardiac Teratogenicity of a Common Drinking Water Contaminant -- Johnson
Release Date: 02/18/1998 - 3 - Low Levels of Arsenite Found to Decrease Hepatic Cytochrome P450 Activity -- Sinclair
Release Date: 09/03/1997
