Publications
Publications |
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14-Day Toxicity Studies of Tetravalent and Pentavalent Vanadium Compounds in Harlan Sprague Dawley Rats and B6C3F1/N Mice via Drinking Water Exposure
Roberts GK, Stout MD, Sayers B, Fallacara DM, Hejtmancik MR, Waidyanatha S, Hooth MJ.
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3-Month Toxicity Studies of Tetravalent and Pentavalent Vanadium Compounds in Hsd:Sprague Dawley SD Rats and B6C3F1/N Mice via Drinking Water Exposure |
Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER)
National Toxicology Program. 2018. Data Release: Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER). Last Updated: December 3, 2018.
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A 13-week subchronic toxicity study of hexyl acetate in SD rats
Toyoda T1, Cho YM1, Matsushita K1, Tachibana S2, Senuma M2, Akagi JI1, Ogawa K1.
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A Black Cohosh Extract Causes Hematologic and Biochemical Changes Consistent with a Functional Cobalamin Deficiency in Female B6C3F1/N Mice
Michelle C. Cora, William Gwinn, Ralph Wilson, Debra King, Suramya Waidyanatha, Grace E. Kissling, Sukhdev S. Brar, Dorian Olivera, Chad Blystone, and Greg Travlos.
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A Hybrid Gene Selection Approach to Create the S1500+ Targeted Gene Sets for Use in High-Throughput Transcriptomics
Deepak Mav, Ruchir R. Shah, Brian E. Howard, Scott S. Auerbach, Pierre R. Bushel, Jennifer B. Collins, David L. Gerhold, Richard S. Judson, Agnes L. Karmaus, Elizabeth A. Maull, Donna L. Mendrick, B. Alex Merrick, Nisha S. Sipes, Daniel Svoboda, Richard S. Paules.
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A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro
Melanie Adler, Susanne Ramm, Marc Hafner, Jeremy L. Muhlich, Esther Maria Gottwald, Elijah Weber, Alenka Jaklic, Amrendra Kumar Ajay, Daniel Svoboda, Scott Auerbach, Edward J. Kelly, Jonathan Himmelfarb and Vishal S. Vaidya
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A comparison of three nucleoside analogs with anti-retroviral activity on immune and hematopoietic functions in mice: in vitro toxicity to precursor cells and microstromal environment
Luster MI, Germolec DR, White KL Jr, Fuchs BA, Fort MM, Tomaszewski JE, Thompson M, Blair PC, McCay JA, Munson AE, et al.
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A high-throughput toxicity screen of 42 per- and polyfluoroalkyl substances (PFAS) and functional assessment of migration and gene expression in human placental trophoblast cells
Bevin E. Blake, Brittany P. Rickard, and Suzanne E. Fenton |
Accelerating Adverse Outcome Pathway Development Using Publicly Available Data Sources
Noffisat O. Oki, Mark D. Nelms, Shannon M. Bell, Holly M. Mortensen, Stephen W. Edwards.
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Advancing Alternative Analysis: Integration of Decision Science
Malloy TF, Zaunbrecher VM, Batteate CM, Blake A, Carroll WF, Jr., Corbett CJ, Hansen SF, Lempert RJ, Linkov I, McFadden R, Moran KD, Olivetti E, Ostrom NK, Romero M, Schoenung JM, Seager TP, Sinsheimer P, Thayer KA.
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Advancing Alternatives Analysis: The Role of Predictive Toxicology in Selecting Safer Chemical Products and Processes
Timothy Malloy, Virginia Zaunbrecher, Elizabeth Beryt, Richard Judson, Raymond Tice, Patrick Allard, Ann Blake, Ila Cote, Hilary Godwin, Lauren Heine, Patrick Kerzic, Jakub Kostal, Gary Marchant, Jennifer McPartland, Kelly Moran, Andre Nel, Oladele Ogunseitan, Mark Rossi, Kristina Thayer, Joel Tickner, Margaret Whittaker, Ken Zarker.
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Airway Injury in an in vitro Human Epithelium-Fibroblast Model of Diacetyl Vapor Exposure: Diacetyl-Induced Basal/Suprabasal Spongiosis
William M. Gwinn, Gordon P. Flake, Ronald W. Bousquet, Genie J. Taylor, and Daniel L. Morgan.
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Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing
Jon Hamm, Kristie Sullivan, Amy J. Clippinger, Judy Strickland, Shannon Bell, Barun Bhhatarai, Bas Blaauboer, Warren Casey, David Dorman, Anna Forsby, Natàlia Garcia-Reyero, Sean Gehen, Rabea Graepel, Jon Hotchkiss, Anna Lowit, Joanna Matheson, Elissa Reaves, Louis Scarano, Catherine Sprankle, Jay Tunkel, Dan Wilson, Menghang Xia, Hao Zhu, David Allen.
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An Evaluation of Neurotoxicity Following Fluoride Exposure from Gestational Through Adult Ages in Long-Evans Hooded Rats
Christopher A. McPherson, Guozhu Zhang, Richard Gilliam, Sukhdev S. Brar, Ralph Wilson, Amy Brix, Catherine Picut, and G. Jean Harry
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An Integrated Chemical Environment to Support 21st-Century Toxicology
Bell SM, Phillips J, Sedykh A, Tandon A, Sprankle C, Morefield SQ, Shapiro A, Allen D, Shah R, Maull EA, Casey WM, Kleinstreuer NC.
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An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library
Sipes NS, Wambaugh JF, Pearce R, Auerbach SS, Wetmore BA, Hsieh JH, Shapiro AJ, Svoboda D, DeVito MJ, Ferguson SS.
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An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents
Minerva Mercado-Feliciano, Michelle C. Cora, Kristine L. Witt,
Courtney A. Granville, Milton R. Hejtmancik, Laurene Fomby, Katherine A. Knostman, Michael J. Ryan, Retha Newbold, Cynthia Smith, Paul M. Foster, Molly K. Vallant, Matthew D. Stout
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An investigation of systemic exposure to bisphenol AF during critical periods of development in the rat
Suramya Waidyanatha, Bradley J. Collins, Helen Cunny, Kristin Aillon, Felicia Riordan, Katie Turner, and Vicki Sutherland
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Application of Adverse Outcome Pathways to U.S. EPA's Endocrine Disruptor Screening Program
Browne P, Noyes PD, Casey WM, Dix DJ
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Application of Sholl Analysis to Quantify Changes in Growth and Development in Rat Mammary Gland Whole Mounts
Stanko JP, Easterling MR, Fenton SE
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Assessment of immunotoxicity in female Fischer 344/N and Sprague Dawley rats and female B(6)C(3)F(1) mice exposed to hexavalent chromium via the drinking water
Shipkowski KA, Sheth CM, Smith MJ, Hooth MJ, White KL Jr, Germolec DR.
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Assessment of the DNA Damaging Potential of Environmental Chemicals Using a Quantitative High-throughput Screening Approach to Measure p53 Activation
Witt KL, Hsieh JH, Smith-Roe SL, Xia M, Huang R, Zhao J, Auerbach SS, Hur J, Tice RR.
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Benchmark Concentrations for Untargeted Metabolomics vs. Transcriptomics for Liver Injury Compounds in In Vitro Liver Models
David M Crizer, Sreenivasa C Ramaiahgari, Stephen S Ferguson, Julie R Rice, Paul E Dunlap, Nisha S Sipes, Scott S Auerbach, B Alex Merrick, Michael J DeVito
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Benchmark Dose Analysis for Neoplastic and Non-neoplastic Lesions
Benchmark Dose (BMD) analysis for all public neoplastic and non-neoplastic lesion incidence data with best fit models.
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Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort
Julia E. Rager, Scott S. Auerbach, Grace A. Chappell, Elizabeth Martin, Chad M. Thompson, and Rebecca C. Fry
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Beyond the RfD: Broad Application of a Probabilistic Approach to Improve Chemical Dose-Response Assessments for Noncancer Effects
Weihsueh A. Chiu, Daniel A. Axelrad, Chimeddulam Dalaijamts, Chris Dockins, Kan Shao, Andrew J. Shapiro, and Greg Paoli
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Binding of Bisphenol A, Bisphenol AF, and Bisphenol S on the Androgen Receptor: Coregulator Recruitment and Stimulation of Potential Interaction Sites
Lalith Perera, Yin Li, Laurel A. Coons, Rene Houtman, Rinie van Beuningen, Bonnie Goodwin, Scott S. Auerbach, and Christina T. Teng.
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Bisphenol A Exposure, Ovarian Follicle Numbers, and Female Sex Steroid Hormone Levels: Results From a CLARITY-BPA Study
Shreya Patel, Emily Brehm, Liying Gao, Saniya Rattan, Ayelet Ziv-Gal, and Jodi A. Flaws.
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Black Cohosh Extracts and Powders Induce Micronuclei, A Biomarker of Genetic Damage, in Human Cells
Stephanie L. Smith‐Roe, Carol D. Swartz, Kim G. Shepard, Steven M. Bryce, Stephen D. Dertinger, Suramya Waidyanatha, Grace E. Kissling, Scott S. Auerbach, Kristine L. Witt, and E. Zeiger.
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Botanical Safety Consortium – Chemical Analysis |
CATMoS: Collaborative Acute Toxicity Modeling Suite Collaborators contributions
Individual contributions from the different members of the consortium
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CEBS Documentation
DOI:
https://doi.org/10.22427/NTP-DATA-002-00094-0002-0000-7
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CEBS Release Notes |
CEBS update: curated toxicology database with enhanced tools for data integration
Cari Martini, Ying Frances Liu, Hui Gong, Nicole Sayers, German Segura, Jennifer Fostel
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CEBS: A Comprehensive Annotated Database of Toxicological Data
Lea IA, Gong H, Paleja A, Rashid A, Fostel J.
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CEBSR Data Warehouse API Documentation and Examples
DOI: https://doi.org/10.22427/NTP-DATA-002-00091-0001-0000-3 |
CLARITY-BPA: Effects of Chronic Bisphenol A Exposure on the Immune System: Part 1 – Quantification of the Relative Number and Proportion of Leukocyte Populations in the Spleen and Thymus
Jinpeng Li, Anthony Bach, Robert B. Crawford, Ashwini S. Phadnis-Moghe, Weimin Chen, Shawna D’Ingillo, Natalia Kovalova, Jose E. Suarez-Martinez, Jiajun Zhou, Barbara L. F. Kaplan, and Norbert E. Kaminski.
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CLARITY-BPA: Effects of Chronic Bisphenol A Exposure on the Immune System: Part 2 – Characterization of Lymphoproliferative and Immune Effector Responses by Splenic Leukocytes
Jinpeng Li, Anthony Bach, Robert B. Crawford, Ashwini S. Phadnis-Moghe, Weimin Chen, Shawna D’Ingillo, Natalia Kovalova, Jose E. Suarez-Martinez, Jiajun Zhou, Barbara L. F. Kaplan, and Norbert E. Kaminski.
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Carbon tetrachloride is immunosuppressive and decreases host resistance to Listeria monocytogenes and Streptococcus pneumoniae in female B6C3F1 mice
Guo TL, McCay JA, Brown RD, Musgrove DL, Germolec DR, Butterworth L, Munson AE, White KL Jr.
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Carcinogenic Activity of Pentabrominated Diphenyl Ether Mixture (DE-71) in Rats and Mice
J.K. Dunnick, A.R. Pandiri, B.A. Merrick, G.E. Kissling, H. Cunny, E. Mutlu, S. Waidyanatha, R. Sills, H.L. Hong, TV. Ton, T. Maynor, L. Recio, S.L. Phillips, M.J. Devito, and A. Brix.
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Channel Interactions and Robust Inference for Ratiometric β-Lactamase Assay Data: A Tox21 Library Analysis
Fjodor Melnikov, Jui-Hua Hsieh, Nisha S. Sipes, and Paul T. Anastas
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Characterization of Estrogenic and Androgenic Activities for Bisphenol A-like Chemicals (BPs): In Vitro Estrogen and Androgen Receptors Transcriptional Activation, Gene Regulation, and Binding Profiles
Katherine E. Pelch, Yin Li, Lalith Perera, Kristina A. Thayer, Kenneth S. Korach
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Characterization of Polybrominated Diphenyl Ether Toxicity in Wistar Han Rats and Use of Liver Microarray Data for Predicting Disease Susceptibilities
Dunnick JK, Brix A, Cunny H, Vallant M, Shockley KR.
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Characterization of Zinc Carbonate Basic as a Source of Zinc in a Rodent Study Investigating the Effects of Dietary Deficiency or Excess
Keith E. Levine, Bradley J. Collins, Matthew D. Stout, Michael Wyde, Scott E. Afton, Amal S. Essader, Todd J. Ennis, Kelly E. Amato, Andrea C. McWilliams, Brenda L. Fletcher, Reshan A. Fernando, James M. Harrington, Natasha Catlin, Veronica G. Robinson & Suramya Waidyanatha.
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Chemical Reactivity and Respiratory Toxicity of the α-Diketone Flavoring Agents 2,3-Butanedione, 2,3-Pentanedione, and 2,3-Hexanedione
Morgan DL, Jokinen MP, Johnson CL, Price HC, Gwinn WM, Bousquet RW, Flake GP.
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Combination of Multiple Neural Crest Migration Assays to Identify Environmental Toxicants from a Proof-of-Concept Chemical Library
Nyffeler J, Dolde X, Krebs A, Pinto-Gil K, Pastor M, Behl M, Waldmann T, Leist M.
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Combined Analysis of Oligonucleotide Microarray Data from Transgenic and Knockout Mice Identifies Direct SREBP Target Genes
Jay D. Horton, Nila A. Shah, Janet A. Warrington, Norma N. Anderson, Sahng Wook Park, Michael S. Brown and Joseph L. Goldstein
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Comparative Inhalation Toxicity of Ethyltoluene Isomers in Rats and Mice
Georgia K. Roberts, Cynthia J. Willson, Dorian S. Olivera, David E. Malarkey, Daniel L. Morgan.
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Comparative Pulmonary Toxicity of Inhaled Metalworking Fluids in Rats and Mice
Ryan KR, Cesta MF, Herbert R, Brix A, Cora M, Witt K, Kissling G, Morgan DL.
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Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to Caenorhabditis elegans
Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA.
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Comparative Toxicokinetics of Bisphenol S in Rats and Mice following Gavage Administration
Suramya Waidyanatha, Sherry R. Black, Melanie Silinski, Vicki Sutherland, Brenda L. Fletcher, Reshan A. Fernando, and Timothy R. Fennell
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Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat
Keith R Shockley, Michelle C Cora, David E Malarkey, Daven Jackson-Humbles, Molly Vallant, Brad J Collins, Esra Mutlu, Veronica G Robinson, Surayma Waidyanatha, Amy Zmarowski, Nicholas Machesky, Jamie Richey, Sam Harbo, Emily Cheng, Kristin Patton, Barney Sparrow, June K Dunnick
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Comparison of sulfolane effects in Sprague Dawley rats, B6C3F1/N mice, and Hartley guinea pigs after 28 days of exposure via oral gavage
K A Shipkowski 1, M C Cora 1, M F Cesta 1, V G Robinson 1, S Waidyanatha 1, K L Witt 1, M K Vallant 1, D M Fallacara 2, M R Hejtmancik 2, S A Masten 1, S D Cooper 3, R A Fernando 3, C R Blystone 1
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Completion of the DrugMatrix Toxicogenomics Database using ToxCompl
Authors:
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Contact sensitizing potential of annatto extract and its two primary color components, cis-bixin and norbixin, in female BALB/c mice
Auttachoat W, Germolec DR, Smith MJ, White KL Jr, Guo TL.
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Contact sensitizing potential of pyrogallol and 5-amino-o-cresol in female BALB/c mice
Guo TL, Germolec DR, Zhang LX, Auttachoat W, Smith MJ, White KL Jr.
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Cumulative Effects of Antiandrogenic Chemical Mixtures and Their Relevance to Human Health Risk Assessment
Kembra L. Howdeshell, Andrew K. Hotchkiss, L. Earl Gray Jr.
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Cylindrospermopsin Toxicity in Mice following a 90-d Oral Exposure
N. Chernoff, D.J. Hill, I. Chorus, D.L. Diggs, H. Huang, D. King, J.R. Lang, T.-T. Le, J.E. Schmid, G.S. Travlos, E.M. Whitley, R.E. Wilson & C.R. Wood.
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DART – Rabbit Historical Control Data (2015-2018) |
DNA Product Formation in Female Sprague-Dawley Rats Following Polyhalogenated Aromatic Hydrocarbon (PHAH) Exposure
Gao L, Mutlu E, Collins LB, Walker NJ, Hartwell HJ, Olson JR, Sun W, Gold A, Ball LM, Swenberg JA
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DTT Data Dictionary - Past Versions |
DTT Data Dictionary 2022-Present
DTT supports FAIR data principles https://www.go-fair.org/fair-principles/. One component of FAIR is to ensure that data are interoperable with applications and workflows, and in particular, that “(Meta)data use vocabularies that follow FAIR principles”. In support of this aim, DTT is developing the DTT Data Dictionary (DDD), a list of terms, metadata and endpoints used in DTT studies. The DDD is growing as data are consolidated and will be updated or extended approximately monthly. Older versions and change logs will be available. The DDD contains links to external ontologies or other external IDs where available. We welcome your comments and suggestions. Please contact dttresearchdatacoordinator@mail.nih.gov DOI: https://doi.org/10.22427/NTP-DATA-002-00092-0002-0000-5 |
DTT Pathology Dictionary 2019-2021
The Division of Translational Toxicology (DTT) has been collecting and reporting histopathology and clinical pathology data since 1976. Over the years, pathology terminologies have evolved. This dictionary includes legacy terms and their current equivalent, and mappings to external ontologies. This dictionary is currently in progress and under review (Version: November 2021) |
Development and Validation of a Computational Model for Androgen Receptor Activity
Kleinstreuer NC, Ceger P, Watt ED, Martin M, Houck K, Browne P, Thomas RS, Casey WM, Dix DJ, Allen D, Sakamuru S, Xia M, Huang R, Judson R.
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Development of Novel Cell Lines for High-Throughput Screening to Detect Estrogen-Related Receptor Alpha Modulators
Christina T. Teng, Jui-Hua Hsieh, Jinghua Zhao, Ruili Huang, Menghang Xia, Negin Martin, Xiaohua Gao, Darlene Dixon, Scott S. Auerbach, Kristine L. Witt, B. Alex Merrick.
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Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits
Boyd WA, Smith MV, Co CA, Pirone JR, Rice JR, Shockley KR, Freedman JH.
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Developmental Exposure to Low Concentrations of Organophosphate Flame Retardants Causes Life-Long Behavioral Alterations in Zebrafish
Lilah Glazer, Andrew B Hawkey, Corinne N Wells, Meghan Drastal, Kathryn-Ann Odamah, Mamta Behl, and Edward D Levin.
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Developmental Exposure to Low Concentrations of Two Brominated Flame Retardants, BDE-47 and BDE-99, Causes Life-Long Behavioral Alterations in Zebrafish
Lilah Glazer, Corinne N. Wells, Meghan Drastal, Kathryn-Ann Odamah, Richard E. Galat, Mamta Behl, Edward D. Levin.
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Dietary methoxychlor exposure modulates splenic natural killer cell activity, antibody-forming cell response and phenotypic marker expression in F0 and F1 generations of Sprague Dawley rats
White KL Jr, Germolec DR, Booker CD, Hernendez DM, McCay JA, Delclos KB, Newbold RR, Weis C, Guo TL.
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Differences in the Rate of in Situ Mammary Gland Development and Other Developmental Endpoints in Three Strains of Female Rat Commonly Used in Mammary Carcinogenesis Studies: Implications for Timing of Carcinogen Exposure
Stanko JP, Kissling GE, Chappell VA, Fenton SE.
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Differential DNA Methylation Profile of Key Genes in Malignant Prostate Epithelial Cells Transformed by Inorganic Arsenic or Cadmium
Katherine E. Pelch, Erik J. Tokar, B. Alex Merrick, Michael P. Waalkes.
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Differential stimulation of IgE production, STAT activation and cytokine and CD86 expression by 2,4-dinitrochlorobenzene and trimellitic anhydride
Guo TL, Zhang XL, Leffel EK, Peachee VL, Karrow NA, Germolec DR, White KL Jr.
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Disposition and Metabolism of 2',2'''-Dithiobisbenzanilide in Rodents following Intravenous and Gavage Administration and Dermal Application
C. Edwin Garner, Christopher J. Wegerski, Joseph Lucak, Melanie Doyle-Eisele, Jacob D. McDonald, J. Michael Sanders, Benjamin C. Moeller and Suramya Waidyanatha
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Disposition and Metabolism of 2,2’-Dimorpholinodiethyl Ether in Harlan Sprague Dawley Rats and B6C3F1/N Mice after Oral, Intravenous Administration, and Dermal Application
Jacob D. McDonald, J. Michael Sanders, C. Edwin Garner, Melanie Doyle-Eisele, Benjamin C. Moeller and Suramya Waidyanatha
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Disposition and Metabolism of the Bisphenol Analogue, Bisphenol S, in Harlan Sprague Dawley Rats and B6C3F1/N Mice and In Vitro in Hepatocytes from Rats, Mice, and Humans
Suramya Waidyanatha, Sherry R. Black, Rodney W. Snyder, Yun Lan Yueh, Vicki Sutherland, Purvi R. Patel, Scott L. Watson, and Timothy R. Fennell.
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Disposition and metabolism of Ethylene glycol 2-ethylhexyl ether in Sprague Dawley rats, B6C3F1/N mice, and in vitro in rat hepatocytes
Atlee T. D. Watson, Benjamin C. Moeller, Melanie Doyle-Eisele, C. Edwin Garner, Chad R. Blystone, Jacob D. McDonald, and Suramya Waidyanatha
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Disposition and metabolism of N-butylbenzenesulfonamide in Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans
Radiolabel Description: |
Disposition and metabolism of antibacterial agent, Triclocarban; a species and route comparison
Suramya Waidyanatha, Sherry R. Black, Purvi R. Patel, Jason Stanko, Scott L. Watson, Rodney W. Snyder, and Timothy R. Fennell
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Disposition and metabolism of sulfolane in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans
Waidyanatha S, Black S, Blystone C, Patel P,Watson S, Snyder R, Fennell T
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Disposition of Tris(4-chlorophenyl)methanol and Tris(4-chlorophenyl)methane in Male and Female Harlan Sprague Dawley Rats and B6C3F1/N Mice Following Oral and Intravenous Administration
Natasha Catlin, Suramya Waidyanatha, Sherry R. Black, James Mathews, Rodney W Snyder, Purvi Patel, Scott Watson, and Timothy R Fennell.
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Disposition of β-N-methylamino-L-alanine (L-BMAA), a Neurotoxin, in Rodents Following a Single or Repeated Oral Exposure
Suramya Waidyanatha, Kristen Ryan, J. Michael Sanders, Jacob D. McDonald, Christopher J. Wegerski, Melanie Doyle-Eisle, C. Edwin Garner
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Dose-Response Assessment of the Dermal Toxicity of Virginia Cedarwood Oil in F344/N Rats and B6C3F1/N Mice
Catlin NR, Herbert R, Janardhan K, Hejtmancik MR, Fomby LM, Vallant M, Kissling GE, DeVito MJ.
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Dose–Response Analysis of RNA-Seq Profiles in Archival Formalin-Fixed Paraffin-Embedded Samples
Susan D. Hester, Virunya Bhat, Brian N. Chorley, Gleta Carswell, Wendell Jones, Leah C. Wehmas, Charles E. Wood
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DrugMatrix
This page will be updated with more data as it becomes available.
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ERα36, a Variant of Estrogen Receptor α, is Predominantly Localized in Mitochondria of Human Uterine Smooth Muscle and Leiomyoma Cells
Yan Y, Yu L, Castro L, Dixon D.
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Effect of Cell Phone Radiofrequency Radiation on Body Temperature in Rodents: Pilot Studies of the National Toxicology Program's Reverberation Chamber Exposure System
Michael E. Wyde, Thomas L. Horn, Myles H. Capstick, John M. Ladbury, Galen Koepke, Perry F. Wilson, Grace E. Kissling, Matthew D. Stout, Niels Kuster, Ronald L. Melnick, James Gauger, John R. Bucher, and David L. McCormick.
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Effect of Graded Nrf2 Activation on Phase-I and -II Drug Metabolizing Enzymes and Transporters in Mouse Liver
Kai Connie Wu, Julia Yue Cui, Curtis D. Klaassen
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Effects of Bisphenol A on Incidence and Severity of Cardiac Lesions in the NCTR-Sprague-Dawley rat: A CLARITY-BPA Study
Robin Gear, Jessica A. Kendziorski, and Scott M. Belcher.
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Effects of Continuous Bisphenol A Exposure from Early Gestation on 90 Day Old Rat Testes Function and Sperm Molecular Profiles: A CLARITY-BPA Consortium Study
Edward Dere, Linnea M. Anderson, Susan M. Huse, Daniel J. Spade, Elizabeth McDonnell-Clark, Samantha J. Madnick, Susan J. Hall, Luísa Camacho, Sherry M. Lewis, Michelle M. Vanlandingham, and Kim Boekelheide.
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Effects of Developmental Exposure to Bisphenol A on Spatial Navigational Learning and Memory in Rats: A CLARITY-BPA Study
Sarah A. Johnson, Angela B. Javurek, Michele S. Painter, Mark R. Ellersieck, Thomas H. Welsh, Jr., Luísa Camacho, Sherry M. Lewis, Michelle M. Vanlandingham, Sherry A. Ferguson, and Cheryl S. Rosenfeld.
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Effects of Perfluorinated Chemicals on Thyroid Function, Markers of Ovarian Reserve, and Natural Fertility
Natalie M. Crawford, Suzanne E. Fenton, Mark Strynar, Erin P. Hines, David A. Pritchard, and Anne Z. Steiner.
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Effects of Perinatal Bisphenol A Exposure on the Volume of Sexually-dimorphic Nuclei of Juvenile Rats: A CLARITY-BPA Consortium Study
Sheryl E. Arambula, Joelle Fuchs, Jinyan Cao, and Heather B. Patisaul.
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Effects of perinatal hydroxyurea treatment and investigation of maternal transfer and age-dependency of toxicokinetics in Sprague Dawley rats
Madelyn Huang, Katie Turner, Molly Vallant, Yi Lu, Catherine Price, Timothy Fennell, Melanie A. Silinski, Suramya Waidyanatha, Kristen Ryan, Sherry R. Black, Reshan Fernando, Barry McIntyre
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Embryo-Fetal Development Studies with The Dietary Supplement Vinpocetine in The Rat and Rabbit
Natasha Catlin, Suramya Waidyanatha, Eve Mylchreest, Lutfiya Miller-Pinsler, Helen Cunny, Paul Foster, Vicki Sutherland, Barry McIntyre
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Embryonic Vascular Disruption Adverse Outcomes: Linking High Throughput Signaling Signatures with Functional Consequences
Ellis-Hutchings RG, Settivari RS, McCoy AT, Kleinstreuer N, Franzosa J, Knudsen TB, Carney EW.
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Evaluation of 4-methylcyclohexanemethanol (MCHM) in a Combined Irritancy and Local Lymph Node Assay (LLNA) in Mice
Johnson VJ, Auerbach SS, Luster MI, Waidyanatha S, Masten SA, Wolfe MS, Burleson FG, Burleson GR, Germolec DR.
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Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes
William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito
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Evaluation of Immunotoxicity of Sodium Metavanadate Following Drinking Water Exposure in Female B6C3F1/N Mice in a 28-day Study
Rachel Frawley, Victor J. Johnson, Gary R. Burleson, Keith R Shockley, Mark F. Cesta, Greg Travlos, Michelle Cora, Georgia Roberts, Dori Germolec
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Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)
Bevin E. Blake, Harlie A. Cope, Samantha M. Hall, Robert D. Keys, Beth W. Mahler, James McCord, Brittany Scott, Heather M. Stapleton, Mark J. Strynar, Susan A. Elmore, Suzanne E. Fenton
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Evaluation of Prenatal Exposure to Bisphenol Analogues on Development and Long-Term Health of the Mammary Gland in Female Mice
Tucker DK, Hayes Bouknight S, Brar SS, Kissling G, Fenton S
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Evaluation of Skin Sensitization Induced by Four Ionic Liquids
Rachel Frawley, Dori Germolec, Victor Johnson, Travis Gulledge, Wimolnut Manheng, Kimber White Jr, Keith R Shockley, Shawn F Harris, Michelle Hooth, Kristen Ryan
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Evaluation of the Respiratory Tract Toxicity of ortho-Phthalaldehyde, a Proposed Alternative for the Chemical Disinfectant Glutaraldehyde
Natasha R. Catlin, Cynthia J. Willson, Matthew Stout, Grace E. Kissling, Suramya Waidyanatha, Gregory L. Baker, Barry K. Hayden, Michael Wyde.
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Evaluation of the herbicide glyphosate, (aminomethyl)phosphonic acid, and glyphosate-based formulations for genotoxic activity using in vitro assays
Stephanie L. Smith-Roe, Carol D. Swartz, Asma Rashid, Nicholas C. Christy, Jamie E. Sly, Xiaoqing Chang, Nisha S. Sipes, Keith R. Shockley, Shawn F. Harris, Sandra J. McBride, Gary J. Larson, Bradley J. Collins, Esra Mutlu, Kristine L. Witt
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Evaluation of the immunomodulatory effects of the disinfection by-product, sodium chlorite, in female B6C3F1 mice: a drinking water study
Karrow NA, Guo TL, McCay JA, Johnson GW, Brown RD, Musgrove DL, Germolec DR, Luebke RW, White KL Jr.
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Evaluation of the immunomodulatory effects of the macrolide antibiotic, clarithromycin, in female B6C3F1 mice: a 28-day oral gavage study
Karrow NA, McCay JA, Brown RD, Musgrove DL, Germolec DR, White KL Jr.
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Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract
Derek T. Bernacki, Steven M. Bryce, Jeffrey C. Bemis, Stephen D. Dertinger, Kristine L. Witt, Stephanie L. Smith-Roe
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Experimental studies of the hematologic and immune system toxicity of nucleoside derivatives used against HIV infection
Luster MI, Rosenthal GJ, Cao W, Thompson MB, Munson AE, Prejean JD, Shopp G, Fuchs BA, Germolec DR, Tomaszewski JE.
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Exploring Drug Space with ChemMaps.com
Alexandre Borrel, Nicole Kleinstreuer, and Denis Fourches.
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Exposure to Select PFAS and PFAS Mixtures Alters Response to Platinum-Based Chemotherapy in Endometrial Cancer Cell Lines
Brittany P. Rickard, Marta Overchuk, Justin Tulino, Xianming Tan, Frances S. Ligler, Victoria L. Bae-Jump, Suzanne E. Fenton, and Imran Rizvi
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Expression Studies, Supporting Data
Expression Studies Dataset:
DOI:
https://doi.org/10.22427/NTP-DATA-022-00004-0003-000-1
|
Gene Expression Alterations in Immune System Pathways in the Thymus Following Exposure to Immunosuppressive Chemicals
Rachel Frawley, Kimber White, Jr., Ronnetta Brown, Deborah Musgrove, Nigel Walker, Dori Germolec |
Gene Ontology Mapping as an Unbiased Method for Identifying Molecular Pathways and Processes Affected by Toxicant Exposure: Application to Acute Effects Caused by the Rodent Non-Genotoxic Carcinogen Diethylhexylphthalate
Richard A. Currie, Vincent Bombail, Jason D. Oliver, David J. Moore, Fei Ling Lim, Victoria Gwilliam, Ian Kimber, Kevin Chipman, Jonathan G. Moggs, George Orphanides
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Genetic versus Chemoprotective Activation of Nrf2 Signaling: Overlapping yet Distinct Gene Expression Profiles between Keap1 Knockout and Triterpenoid-treated Mice
Melinda S. Yates, Quynh T. Tran, Patrick M. Dolan, William O. Osburn, Soona Shin, Colin C. McCulloch, Jay B. Silkworth, Keiko Taguchi, Masayuki Yamamoto, Charlotte R. Williams, Karen T. Liby, Michael B. Sporn, Thomas R. Sutter, Thomas W. Kensler
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Genistein modulates immune responses and increases host resistance to B16F10 tumor in adult female B6C3F1 mice
Guo TL, McCay JA, Zhang LX, Brown RD, You L, Karrow NA, Germolec DR, White KL Jr.
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Genistein modulates splenic natural killer cell activity, antibody-forming cell response, and phenotypic marker expression in F(0) and F(1) generations of Sprague-Dawley rats
Guo TL, White KL Jr, Brown RD, Delclos KB, Newbold RR, Weis C, Germolec DR, McCay JA.
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Genistein protects female nonobese diabetic mice from developing type 1 diabetes when fed a soy- and alfalfa-free diet
Guo TL, Germolec DR, Zheng JF, Kooistra L, Auttachoat W, Smith MJ, White KL,
Elmore SA.
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Genome-Wide Binding and Transcriptome Analysis of Human Farnesoid X Receptor in Primary Human Hepatocytes
Le Zhan, Hui-Xin Liu, Yaping Fang, Bo Kong, Yuqi He, Xiao-bo Zhong, Jianwen Fang, Yu-Jui Yvonne Wan, Grace L. Guo
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Genomic Models of Short-Term Exposure Accurately Predict Long-Term Chemical Carcinogenicity and Identify Putative Mechanisms of Action
Daniel Gusenleitner, Scott S. Auerbach, Tisha Melia, Harold F. Gómez, David H. Sherr, Stefano Monti
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Gestational Exposure to Perfluorooctanoic Acid (PFOA): Alterations in Motor Related Behaviors
David R. Goulding, Sally S. White, Sandra J. McBride, Suzanne E. Fenton, and G. Jean Harry.
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Glycidol modulation of the immune responses in female B6C3F1 mice
Guo TL, McCay JA, Brown RD, Musgrove DL, Butterworth L, Munson AE, Germolec DR, White KL Jr.
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Health Consequences of Electric Lighting Practices in The Modern World: A Report on The National Toxicology Program's Workshop on Shift Work At Night, Artificial Light At Night, and Circadian Disruption
Lunn RM, Blask DE, Coogan AN, Figueiro MG, Gorman MR, Hall JE, Hansen J, Nelson RJ, Panda S, Smolensky MH, Stevens RG, Turek FW, Vermeulen R, Carreón T, Caruso CC, Lawson CC, Thayer KA, Twery MJ, Ewens AD, Garner SC, Schwingl PJ, Boyd WA.
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Histology Atlas of the Developing Prenatal and Postnatal Mouse Central Nervous System, with Emphasis on Prenatal Days E7.5 to E18.5
Vivian S. Chen, James P. Morrison, Myra F. Southwell, Julie F. Foley, Brad Bolon, and Susan A. Elmore.
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House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies
Michael B. Fessler, Megan U. Carnes, Päivi M. Salo, Jesse Wilkerson, Richard D. Cohn, Debra King, Jane A. Hoppin, Dale P. Sandler, Greg Travlos, Stephanie J. London, Peter S. Thorne, and Darryl C. Zeldin.
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Identification of Estrogen-Related Receptor Alpha Agonists in the Tox21 Compound Library
Caitlin Lynch, Jinghua Zhao, Ruili Huang, Noriko Kanaya, Lauren Bernal, Jui-Hua Hsieh, Scott S Auerbach, Kristine L Witt, B Alex Merrick, Shiuan Chen, Christina T Teng, and Menghang Xia.
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Identification of Novel NRF2-regulated Genes by ChIP-Seq: Influence on Retinoid X Receptor alpha
Brian N. Chorley, Michelle R. Campbell, Xuting Wang, Mehmet Karaca, Deepa Sambandan, Fatu Bangura, Peng Xue, Jingbo Pi, Steven R. Kleeberger, Douglas A. Bell
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Identification of Vascular Disruptor Compounds by Analysis in Zebrafish Embryos and Mouse Embryonic Endothelial Cells
McCollum CW, Conde-Vancells J, Hans C, Vazquez-Chantada M, Kleinstreuer N, Tal T, Knudsen T, Shah SS, Merchant FA, Finnell RH, Gustafsson JÅ, Cabrera R, Bondesson M.
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Identification of p53 Activators in a Human Microarray Compendium
Corton JC, KL Witt and CL Yauk
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Identifying Environmental Chemicals as Agonists of the Androgen Receptor by using a Quantitative High-Throughput Screening Platform
Lynch C, Sakamuru S, Huang R, Stavreva DA, Varticovski L, Hager GL, Judson RS, Houck KA, Kleinstreuer NC, Casey W, Paules RS, Simeonov A, Xia M.
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Immunohistochemical Analysis of Rat Renal Tumours Caused by Ochratoxin A
Diana Herman and Peter Mantle.
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Immunohistochemistry in Investigative and Toxicologic Pathology
Kyathanahalli S. Janardhan, Heather Jensen, Natasha P. Clayton, and Ronald A. Herbert
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Immunomodulation in female B₆C₃F₁ mice following treatment with the HIV protease inhibitor saquinavir for 28 days by gavage
Guo TL, Germolec DR, Roesh DM, White KL Jr.
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Immunomodulatory activity of orphan drug Elmiron® in female B6C3F1/N mice
Thakur SA, Nyska A, White KL Jr, Smith MJ, Auttachoat W, Germolec DR.
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Immunotoxic Effects of Sodium Tungstate Dihydrate on Female B6C3F1/N Mice When Administered in Drinking Water
Frawley RP, Smith MJ, White KL Jr, Elmore SA, Herbert R, Moore R, Staska LM, Behl M, Hooth MJ, Kissling GE, Germolec DR.
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Immunotoxic and Hepatotoxic Effects of Perfluoro-n-decanoic Acid (PFDA) on Female Harlan Sprague–Dawley Rats and B6C3F1/N Mice when Administered by Oral Gavage for 28 Days
Rachel P. Frawley, Matthew Smith, Mark F. Cesta, Schantel Hayes-Bouknight, Chad Blystone, Grace E. Kissling, Shawn Harris & Dori Germolec.
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Immunotoxicity Studies of Sulfolane Following Developmental Exposure in Hsd:Sprague Dawley SD Rats and Adult Exposure in B6C3F1/N Mice.
K A Shipkowski 1, M C Cora 1, M F Cesta 1, V G Robinson 1, S Waidyanatha 1, K L Witt 1, M K Vallant 1, D M Fallacara 2, M R Hejtmancik 2, S A Masten 1, S D Cooper 3, R A Fernando 3, C R Blystone 1
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Immunotoxicity of 180 day exposure to polydimethylsiloxane (silicone) fluid, gel and elastomer and polyurethane disks in female B6C3F1 mice
Bradley SG, White KL Jr, McCay JA, Brown RD, Musgrove DL, Wilson S, Stern M, Luster MI, Munson AE.
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Immunotoxicity of N-Butylbenzenesulfonamide (NBBS): Impacts on Immune Function in Adult Mice and Developmentally Exposed Rats
Victor J. Johnson1, Cynthia V. Rider2, Michael I. Luster1, Amy Brix3, Gary R. Burleson1, Michelle Cora2, Susan A. Elmore2, Rachel P. Frawley2, Franklin R. Lopez4, Esra Mutlu2, Keith R. Shockley2,5, Jessica Pierfelice6, Brian Burback6, Caroll A. Co7, Dori R. Germolec2 |
Immunotoxicity of dibromoacetic acid administered via drinking water to female B₆C₃F₁ mice
Smith MJ, Germolec DR, Luebke RW, Sheth CM, Auttachoat W, Guo TL, White KL Jr.
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Immunotoxicity of sodium bromate in female B6C3F1 mice: a 28-day drinking water study
Guo TL, McCay JA, Karrow NA, Brown RD, Musgrove DL, Luebke RW, Germolec DR, White KL Jr.
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Immunotoxicity studies of trans-resveratrol in male B6C3F1/N mice
Madelyn C. Huang, Kimber L. White Jr., Susan A. Elmore, Tai L. Guo, Dori Germolec
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Immunotoxicological profile of chloramine in female B6C3F1 mice when administered in the drinking water for 28 days
Guo TL, Germolec DR, Collins BJ, Luebke RW, Auttachoat W, Smith MJ, White KL.
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Immunotoxicological profile of chloroform in female B6C3F1 mice when administered in drinking water
Auttachoat W, Germolec DR, Collins BJ, Luebke RW, White KL Jr, Guo TL.
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Immunotoxicology: a Brief History, Current Status and Strategies for Future Immunotoxicity Assessment
Dori Germolec, Robert Luebke, Andrew Rooney, Kelly Shipkowski, Rob Vandebriel, Henk van Loveren.
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Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on the Neonatal Rat Hypothalamic and Hippocampal Transcriptome: A CLARITY-BPA Consortium Study
Sheryl E. Arambula, Scott M. Belcher, Antonio Planchart, Stephen D. Turner, and Heather B. Patisaul.
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Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study
Meghan E. Rebuli, Luísa Camacho, Maria E. Adonay, David M. Reif, David L. Aylor, and Heather B. Patisaul.
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In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning
Zang Q, Mansouri K, Williams AJ, Judson RS, Allen DG, Casey WM, Kleinstreuer NC.
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In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making
Shannon M. Bell, Xiaoqing Chang, John F. Wambaugh, David G. Allen, Mike Bartels, Kim L.R. Brouwer, Warren M. Casey, Neepa Choksi, Stephen S. Ferguson, Grazyna Fraczkiewicz, Annie M. Jarabek, Alice Ke, Annie Lumen, Scott G. Lynn, Alicia Paini, Paul S. Price, Caroline Ring, Ted W. Simon, Nisha S. Sipes, Catherine S. Sprankle, Judy Strickland, John Troutman, Barbara A. Wetmore, Nicole C. Kleinstreuer.
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In utero Exposure to DDT and Incidence of Diarrhea Among Boys from Tropical Mexico
Lea A. Cupul-Uicab, Efraín A. Terrazas-Medina, Mauricio Hernández-Ávila, Matthew P. Longnecker.
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In vitro Cardiotoxicity Assessment of Environmental Chemicals Using an Organotypic Human Induced Pluripotent Stem Cell-Derived Model
Oksana Sirenko, Fabian A. Grimm, Kristen R. Ryan, Yasuhiro Iwata, Weihsueh A. Chiu, Frederick Parham, Jessica A. Wignall, Blake Anson, Evan F. Cromwell, Mamta Behl, Ivan Rusyn, and Raymond R. Tice.
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Incidences of Mast Cell Tumor and Histiocytic Sarcoma in Rats in NTP Studies
DOI: https://doi.org/10.22427/NTP-DATA-002-00070-0001-0000-0 |
Influence of Study Design on Developmental and Reproductive Toxicology Study Outcomes
Paul M. D. Foster
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Insecticide Use and Breast Cancer Risk among Farmers’ Wives in the Agricultural Health Study
Lawrence S. Engel, Emily Werder, Jaya Satagopan, Aaron Blair, Jane A. Hoppin, Stella Koutros, Catherine C. Lerro, Dale P. Sandler, Michael C. Alavanja, and Laura E. Beane Freeman
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Integrating Drug's Mode of Action into Quantitative Structure-Activity Relationships for Improved Prediction of Drug-Induced Liver Injury
Leihong Wu, Zhichao Liu, Scott Auerbach, Ruili Huang, Minjun Chen, Kristin McEuen, Joshua Xu, Hong Fang, and Weida Tong.
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Internal dose of vanadium in rats following repeated exposure to vanadyl sulfate and sodium orthovanadate via drinking water
James M. Harrington, Laura G. Haines, Keith E. Levine, Chamindu Liyanapatirana, Amal S. Essader, Reshan A. Fernando, Veronica G. Robinson, Georgia K. Roberts, Matthew D. Stout, Michelle J. Hooth and Suramya Waidyanatha
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Investigating the Generalizability of the MultiFlow® DNA Damage Assay and Several Companion Machine Learning Models with a Set of 103 Diverse Test Chemicals
Steven M Bryce, Derek T Bernacki, Stephanie L Smith-Roe, Kristine L Witt, Jeffrey C Bemis, and Stephen D Dertinger.
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Is It Adverse, Nonadverse, Adaptive, or Artifact?
Pandiri AR, Kerlin RL, Mann PC, Everds NE, Sharma AK, Myers LP, Steinbach TJ.
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Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation
Harlie A. Cope, Bevin E. Blake, Charlotte Love, James McCord, Susan A. Elmore, Janice B. Harvey, Vesna A. Chappell, Suzanne E. Fenton
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Low Dose Assessment of the Carcinogenicity of Furan in Male F344/N Nctr Rats in a 2-Year Gavage Study
Von Tungeln LS, Walker NJ, Olson GR, Mendoza MC, Felton RP, Thorn BT, Marques MM, Pogribny IP, Doerge DR, Beland FA. |
Lung Anatomy + Particle Deposition (lapd) Mouse Archive for Modeling and Computational Toxicology
Authors: |
Lung Deposition and Clearance of Microparticle and Nanoparticle C60 Fullerene Aggregates in B6C3F1 Mice and Wistar Han Rats Following Nose-Only Inhalation for 13 Weeks
Sayers BC, Walker NJ, Roycroft JH, Germolec DR, Baker GL, Clark ML, Hayden BK, DeFord H, Dill JA, Gupta A, Stout MD.
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Mammary Gland Evaluation in Juvenile Toxicity Studies: Temporal Developmental Patterns in the Male and Female Harlan Sprague-Dawley Rat
Filgo AJ, Foley JF, Puvanesarajah S, Borde AR, Midkiff BR, Reed CE, Chappell VA, Alexander LB, Borde PR, Troester MA, Hayes Bouknight SA, Fenton SE.
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Metabolic Disruption Early in Life is Associated With Latent Carcinogenic Activity of Dichloroacetic Acid in Mice
Leah C. Wehmas, Anthony B. DeAngelo, Susan D. Hester, Brian N. Chorley, Gleta Carswell, Greg R. Olson, Michael H. George, Julia H. Carter, Sandra R. Eldridge, Anna Fisher, Beena Vallanat, Charles E. Wood
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Metabolism and Disposition of 2-ethylhexyl-p-methoxycinnamate following Oral Gavage and Dermal Exposure in Harlan Sprague Dawley Rats and B6C3F1/N Mice and in Hepatocytes in vitro
Timothy R. Fennell, James M. Mathews, Rodney W. Snyder, Yan Hong, Scott L. Watson, Sherry R. Black, Barry S. McIntyre, and Suramya Waidyanatha.
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Modulation of immune response following dietary genistein exposure in F0 and F1 generations of C57BL/6 mice: evidence of thymic regulation
Guo TL, Chi RP, Zhang XL, Musgrove DL, Weis C, Germolec DR, White KL Jr.
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Molecular Effects of 1-Naphthyl-Methylcarbamate and Solar Radiation Exposures on Human Melanocytes
Bianca Ferrucio, Manoela Tiago, Richard D. Fannin, Liwen Liu, Kevin Gerrish, Silvya Stuchi Maria-Engler, Richard S. Paules, and Silvia Berlanga de Moraes Barros.
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Mouse Population-Based Evaluation of Urinary Protein and miRna Biomarker Performance Associated with Cisplatin Renal Injury
Alison H Harrill, Haixia Lin, Julia Tobacyk, John C Seely
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Multigenerational reproductive assessment of 4-methylimidazole administered in the diet to Hsd:Sprague Dawley SD rats
Mamta Behl, Cynthia J Willson, Helen Cunny, Paul M D Foster, Barry McIntyre, Cynthia Shackelford, Keith R Shockley, Sandra McBride, Katie Turner, Suramya Waidyanatha, Chad R Blystone
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Multivariate Models for Prediction of Human Skin Sensitization Hazard
Judy Strickland, Qingda Zang, Michael Paris, David M. Lehmann, David Allen, Neepa Choksi, Joanna Matheson, Abigail Jacobs, Warren Casey, Nicole Kleinstreuer.
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NIEHS/FDA CLARITY-BPA research program update
Heindel JJ, Newbold RR, Bucher JR, Camacho L, Delclos KB, Lewis SM, Vanlandingham M, Churchwell MI, Twaddle NC, McLellen M, Chidambaram M, Bryant M, Woodling K, Gamboa da Costa G, Ferguson SA, Flaws J, Howard PC, Walker NJ, Zoeller RT, Fostel J, Favaro C, Schug TT.
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NTP Provantis Glossaries
NOTE:The NTP Fetal Observation Classification Glossary, NTP Clinical Observation Symptom Glossary and NTP Measurements and Endpoints Glossary are now searchable excel files |
NTP short-term reproductive and developmental toxicity studies on triphenyl phosphate (TPHP) and isopropylated phenyl phosphate (IPP)
Shannah Witchey, Brad Collins, Georgia Roberts, Keith Shockley, Molly Vallant, Eve Mylchreest, Barney Sparrow, Robert Moyer, Tomas Guilarte, Helen Cunny, Jeffrey Krause, Mamta Behl
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Neurite Outgrowth in Human Induced Pluripotent Stem Cell-Derived Neurons as A High-Throughput Screen for Developmental Neurotoxicity or Neurotoxicity
Ryan KR, Sirenko O, Parham F, Hsieh JH, Cromwell EF, Tice RR, Behl M.
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New Rodent Population Models May Inform Human Health Risk Assessment and Identification of Genetic Susceptibility to Environmental Exposures
Alison H. Harrill and Kimberly A. McAllister
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Non-Animal Methods to Predict Skin Sensitization (I): The Cosmetics Europe Database
Sebastian Hoffmann, Nicole Kleinstreuer, Nathalie Alépée, David Allen, Anne Marie Api, Takao Ashikaga, Elodie Clouet, Magalie Cluzel, Bertrand Desprez, Nichola Gellatly, Carsten Goebel, Petra S. Kern, Martina Klaric, Jochen Kühnl, Jon F. Lalko, Silvia Martinozzi-Teissier, Karsten Mewes, Masaaki Miyazawa, Rahul Parakhia, Erwin van Vliet, Qingda Zang, Dirk Petersohn
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Non-Animal Methods to Predict Skin Sensitization (II): An Assessment of Defined Approaches
Nicole C. Kleinstreuer, Sebastian Hoffmann, Nathalie Alépée, David Allen, Takao Ashikaga, Warren Casey, Elodie Clouet, Magalie Cluzel, Bertrand Desprez, Nichola Gellatly, Carsten Göbel, Petra S. Kern, Martina Klaric, Jochen Kühnl, Silvia Martinozzi-Teissier, Karsten Mewes, Masaaki Miyazawa, Judy Strickland, Erwin van Vliet, Qingda Zang, Dirk Petersohn.
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Non-targeted Chemical Analysis of Consumer Botanical Products Labelled as Blue Cohosh (Caulophyllum thalictroides), Goldenseal (Hydrastis canadensis), or Yohimbe Bark (Pausinystalia johimbe) by NMR and MS
Giovanni O. Quiroz-Delfi123, Cynthia V. Rider3, Stephen Ferguson
3, Scott A. Gabel1, Alan K. Jarmusch2, Geoffrey A. Mueller1
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Nonylphenol alters the activity of splenic NK cells and the numbers of leukocyte subpopulations in Sprague-Dawley rats: a two-generation feeding study
Karrow NA, Guo TL, Delclos KB, Newbold RR, Weis C, Germolec DR, White KL Jr, McCay JA.
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ORIO (Online Resource for Integrative Omics): A Web-Based Platform for Rapid Integration of Next Generation Sequencing Data
Lavender CA, Shapiro AJ, Burkholder AB, Bennett BD, Adelman K, Fargo DC.
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Optimized Method for Robust Transcriptome Profiling of Minute Tissues Using Laser Capture Microdissection and Low-Input RNA-Seq
Shannon Farris, Yu Wang, James M. Ward, Serena M. Dudek.
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Oral Deoxynivalenol Toxicity in Sprague Dawley Rat dams and their offspring
Madelyn C. Huang, Johnathan R. Furr, Veronica G. Robinson, Laura Betz, Keith Shockley, Helen Cunny ,Kristine Witt, Suramya Waidyanatha, Dori Germolec
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Oral exposure to atrazine modulates cell-mediated immune function and decreases host resistance to the B16F10 tumor model in female B6C3F1 mice
Karrow NA, McCay JA, Brown RD, Musgrove DL, Guo TL, Germolec DR, White KL Jr.
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Pathology of Diacetyl and 2,3-Pentanedione Airway Lesions in A Rat Model of Obliterative Bronchiolitis
Gordon P. Flake, and Daniel L.Morgan.
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Performance of the BG1Luc ER TA Method in a qHTS Format
Ceger P, Allen D, Huang RL, Xia MH, Casey W.
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Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats
Suramya Waidyanatha, Esra Mutlu, Seth Gibbs, Jessica Pierfelice, Jeremy P. Smith, Brian Burback, and Chad T. Blystone
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Photodynamic Priming Overcomes Per- and Polyfluoroalkyl Substance (PFAS)-Induced Platinum Resistance in Ovarian Cancer
Brittany P Rickard, Xianming Tan, Suzanne E Fenton, Imran Rizvi |
Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed
BJ Collins, D Slade, K Aillon, M Stout, L Betz, S Waidyanatha, K Ryan
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Pred-Skin: A Fast and Reliable Web Application to Assess Skin Sensitization Effect of Chemicals
Rodolpho C. Braga, Vinicius M. Alves, Eugene N. Muratov, Judy Strickland∥, Nicole Kleinstreuer, Alexander Trospsha, and Carolina Horta Andrade.
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Prediction of Skin Sensitization Potency Using Machine Learning Approaches
Zang Q, Paris M, Lehmann DM, Bell S, Kleinstreuer N, Allen D, Matheson J, Jacobs A, Casey W, Strickland J.
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Prenatal Arsenic Exposure and the Epigenome: Altered microRNAs Associated With Innate and Adaptive Immune Signaling in Newborn Cord Blood
Julia E. Rager,
Kathryn A. Bailey,
Lisa Smeester,
Sloane K. Miller,
Joel S. Parker,
Jessica E. Laine,
Zuzana Drobná,
Jenna Currier,
Christelle Douillet,
Andrew F. Olshan,
Marisela Rubio-Andrade,
Miroslav Stýblo,
Gonzalo García-Vargas,
Rebecca C. Fry
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Prenatal Bisphenol A (BPA) Exposure Alters the Transcriptome of the Neonate Rat Amygdala in a Sex-specific Manner: a CLARITY-BPA Consortium Study
Sheryl E. Arambula, Dereje Jima, and Heather B. Patisaul.
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Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl
Foster MW, Gwinn WM, Kelly FL, Brass DM, Valente AM, Moseley MA, Thompson JW, Morgan DL, Palmer SM.
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QSAR Models of Human Data can Enrich or Replace LLNA Testing for Human Skin Sensitization
Vinicius M. Alves, Stephen J. Capuzzi, Eugene N. Muratov, Rodolpho C. Braga, Thomas E. Thornton, Denis Fourches, Judy Strickland, Nicole Kleinstreuer, Carolina H. Andrade and Alexander Tropsha.
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Quantifying Branching Density in Rat Mammary Gland Whole-mounts Using the Sholl Analysis Method
Stanko JP, Fenton SE.
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RNA-Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats
Merrick BA, Phadke DP, Auerbach SS, Mav D, Stiegelmeyer SM, Shah RR, Tice RR.
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Real-time Cell Toxicity Profiling of Tox21 10K Compounds Reveals Cytotoxicity Dependent Toxicity Pathway Linkage
Hsieh JH, Huang R, Lin JA, Sedykh A, Zhao J, Tice RR, Paules RS, Xia M, Auerbach SS.
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Reduced Disc Shedding and Phagocytosis of Photoreceptor Outer Segment Contributes to Kava Kava Extract-induced Retinal Degeneration in F344/N Rats
Haruhiro Yamashita, Mark J. Hoenerhoff, Keith R. Shockley, Shyamal D. Peddada, Kevin E. Gerrish, Deloris Sutton, Connie A. Cummings, Yu Wang, Julie F. Foley, Mamta Behl, Suramya Waidyanatha, Robert C. Sills, and Arun R. Pandiri.
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Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice
Frawley R, DeVito M, Walker NJ, Birnbaum L, White K Jr, Smith M, Maynor T, Recio L, Germolec D
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Repeat 5-day in vivo genomic dose response studies
Fred Parham, Michele R Balik-Meisner, William M Gwinn, Matthew D Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, Bruce Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R Shah, Deepak Mav, Dhiral P Phadke, Georgia Roberts, Michael J DeVito, Scott S Auerbach
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Reproductive and Developmental Toxicity Assessment of Butyl Paraben in Hsd: Sprague Dawley SD rats following Feed Exposure
https://doi.org/10.22427/NTP-DATA-NTP-DATA-RACB-BP
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Reproductive and Developmental Toxicity Assessment of Diisobutyl Phthalate in Sprague Dawley rats following Feed Exposure
https://doi.org/10.22427/NTP-DATA-002-02047-0004-0000-9
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Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats
Shannah K. Witchey, Vicki Sutherland, Brad Collins, Georgia Roberts, Keith R. Shockley, Molly Vallant, Jeff Krause, Helen Cunny, Suramya Waidyanatha, Eve Mylchreest, Barney Sparrow, Robert Moyer and Mamta Behl
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Respiratory toxicity and immunotoxicity evaluations of microparticle and nanoparticle C60 fullerene aggregates in mice and rats following nose-only inhalation for 13 weeks
Sayers BC, Germolec DR, Walker NJ, Shipkowski KA, Stout MD, Cesta MF, Roycroft JH, White KL, Baker GL, Dill JA, Smith MJ
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Respiratory, Dermal, and Eye Irritation Symptoms Associated with Corexit™ EC9527A/EC9500A following the Deepwater Horizon Oil Spill: Findings from the GuLF STUDY
Craig J. McGowan, Richard K. Kwok, Lawrence S. Engel, Mark R. Stenzel, Patricia A. Stewart, and Dale P. Sandler
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Screening a Mouse Liver Gene Expression Compendium Identifies Modulators of the Aryl hydrocarbon Receptor (AhR)
Keiyu Oshida, Naresh Vasani, Russell S. Thomas, Dawn Applegate, Frank J. Gonzalez, Lauren M. Aleksunes, Curtis D. Klaassen and J. Christopher Corton
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Screening for Angiogenic Inhibitors in Zebrafish to Evaluate A Predictive Model for Developmental Vascular Toxicity
Tamara Tal, Claire Kilty, Andrew Smith, Carlie LaLone, Brendán Kennedy, AlanTennant, Catherine W. McCollum, Maria Bondesson, Thomas Knudsen, Stephanie Padilla, and Nicole Kleinstreuer.
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Select Per- and Polyfluoroalkyl Substances (PFAS) Induce Resistance to Carboplatin in Ovarian Cancer Cell Lines
Brittany P. Rickard, Xianming Tan, Suzanne E. Fenton, and Imran Rizvi |
Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture
Szabo DT, Pathmasiri W, Sumner S, Birnbaum LS.
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Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon
Tao Yang, Niousha Ahmari, Jordan T. Schmidt, Ty Redler, Rebeca Arocha, Kevin Pacholec, Kacy L. Magee, Wendi Malphurs, Jennifer L. Owen, Gregory A. Krane, Eric Li, Gary P. Wang, Thomas W. Vickroy, Mohan K. Raizada, Christopher J. Martyniuk, and Jasenka Zubcevic.
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Short-term Toxicity Studies of Thallium (I) Sulfate Administered in Drinking Water to Sprague Dawley Rats and B6C3F1/N Mice
Kelly A. Shipkowski, Troy D. Hubbard, Kristen Ryan, Suramya Waidyanatha, Helen Cunny, Keith R. Shockley, Joshua L. Allen, Heather Toy, Keith Levine, James Harrington, Laura Betz, Barney Sparrow, Georgia K. Roberts
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Simultaneous Quantitation of 2-Hydroxy-4-Methoxybenzophenone, a Sunscreen Ingredient, and its Metabolites in Harlan Sprague Dawley Rat Plasma Following Perinatal Dietary Exposure
Mutlu E, Pierfelice J, McIntyre BS, Cunny HC, Kissling GE, Burback B, Waidyanatha S.
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Sodium metasilicate hypersensitivity in BALB/c mice
Karrow NA, Guo TL, Leffel EK, Zhang LX, McCay JA, Germolec DR, White KL Jr.
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Splenic cell targets in gallium arsenide-induced suppression of the primary antibody response
Sikorski EE, Burns LA, Stern ML, Luster MI, Munson AE
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Standardisation of Defined Approaches for Skin Sensitisation Testing to Support Regulatory Use and International Adoption: Position of the International Cooperation on Alternative Test Methods
Casati S, Aschberger K, Barroso J, Casey W, Delgado I, Kim TS, Kleinstreuer N, Kojima H, Lee JK, Lowit A, Park HK, Régimbald-Krnel MJ, Strickland J, Whelan M, Yang Y, Zuang V.
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Statistical Guidance for Reviewers of Toxicologic Pathology
Keith R. Shockley and Grace E. Kissling
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Stimulation of the immune response in B6C3F1 mice by genistein is affected by exposure duration, gender, and litter order
Guo TL, Chi RP, Germolec DR, White KL Jr.
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Subchronic 10 day immunotoxicity of polydimethylsiloxane (silicone) fluid, gel and elastomer and polyurethane disks in female B6C3F1 mice
Bradley SG, Munson AE, McCay JA, Brown RD, Musgrove DL, Wilson S, Stern M, Luster MI, White KL Jr.
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Supplemental Material for NTP Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives.
Pelch KE, Wignall JA, Goldstone AE, Ross PK, Blain RB, Shapiro AJ, Holmgren SD, Hsieh J-H, Svoboda D, Auerbach SS, Parham FM, Masten SA, Thayer KA.
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Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Interlaboratory Study Dose Range Finding (DRF) data |
Systematic Review of Community Health Impacts of Mountaintop Removal Mining
Boyles AL, Blain RB, Rochester JR, Avanasi R, Goldhaber SB, McComb S, Holmgren SD, Masten SA, Thayer KA.
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Systemic Exposure of Vinpocetine in Pregnant Sprague Dawley Rats Following Repeated Oral Exposure: An Investigation of Fetal Transfer
Suramya Waidyanatha, Heather Toy, Natalie South, Seth Gibbs, Esra Mutlu, Brian Burback, Barry S.McIntyre, and Natasha Catlin.
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Systemic exposure and urinary excretion of vanadium following perinatal subchronic exposure to vanadyl sulfate and sodium metavanadate via drinking water
Suramya Waidyanatha, Frank X. Weber, James M. Harrington, Dawn M. Fallacara, Keith Levine, Veronica G. Robinson, Barney R. Sparrow, Matthew D. Stout, Reshan Fernando, Michelle J. Hooth, Guanhua Xie, Chamindu Liyanapatirana, Georgia K. Roberts
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Systems Biology for Organotypic Cell Cultures
Grego S, Dougherty ER, Alexander FJ, Auerbach SS, Berridge BR, Bittner ML, Casey W, Cooley PC, Dash A, Ferguson SS, Fennell TR, Hawkins BT, Hickey AJ, Kleensang A, Liebman MNJ, Martin F, Maull EA, Paragas J, Qiao GG, Ramaiahgari S, Sumner SJ, Yoon M.
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TDMSE Glossaries |
Tetrabromobisphenol A Activates the Hepatic Interferon Pathway in Rats
Dunnick JK, Morgan DL, Elmore SA, Gerrish K, Pandiri A, Ton TV, Shockley KR, Merrick BA.
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Tetrabromobisphenol-A Promotes Early Adipogenesis and Lipogenesis in 3T3-L1 Cells
Chappell VA, Janesick A, Blumberg B, Fenton S
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Thalidomide enhances both primary and secondary host resistances to Listeria monocytogenes infection by a neutrophil-related mechanism in female B6C3F1 mice
Guo TL, Chi RP, Karrow NA, Zhang LX, Pruett SB, Germolec DR, White KL Jr.
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Thalidomide modulation of the immune response in female B6C3F1 mice: a host resistance study
Karrow NA, Guo TL, Zhang LX, McCay JA, Musgrove DL, Peachee VL, Germolec DR, White KL Jr.
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Thalidomide stimulates splenic IgM antibody response and cytotoxic T lymphocyte activity and alters leukocyte subpopulation numbers in female B6C3F1 mice
Karrow NA, McCay JA, Brown RD, Musgrove DL, Pettit DA, Munson AE, Germolec DR, White KL Jr.
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The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study
Grau-Perez M, Kuo CC, Spratlen M, Thayer KA, Mendez MA, Hamman RF, Dabelea D, Adgate JL, Knowler WC, Bell RA, Miller FW, Liese AD, Zhang C, Douillet C, Drobná Z, Mayer-Davis EJ, Styblo M, Navas-Acien A.
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The B lymphocyte is the immune cell target for 2',3'-dideoxyadenosine
Sikorski EE, Fuchs BA, Stern ML, Luster MI, Munson AE.
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The Concordance between RNA-seq and Microarray Data Depends on Chemical Treatment And Transcript Abundance
Charles Wang, Binsheng Gong, Pierre R Bushel, Jean Thierry-Mieg, Danielle Thierry-Mieg, Joshua Xu, Hong Fang, Huixiao Hong, Jie Shen, Zhenqiang Su, Joe Meehan, Xiaojin Li, Lu Yang, Haiqing Li, Paweł P Łabaj, David P Kreil, Dalila Megherbi, Stan Gaj, Florian Caiment, Joost van Delft, Jos Kleinjans, Andreas Scherer, Viswanath Devanarayan, Jian Wang, Yong Yang, Hui-Rong Qian, Lee J Lancashire, Marina Bessarabova, Yuri Nikolsky, Cesare Furlanello, Marco Chierici, Davide Albanese, Giuseppe Jurman, Samantha Riccadonna, Michele Filosi, Roberto Visintainer, Ke K Zhang, Jianying Li, Jui-Hua Hsieh, Daniel L Svoboda, James C Fuscoe, Youping Deng, Leming Shi, Richard S Paules, Scott S Auerbach, and Weida Tong.
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The Diacetyl-Exposed Human Airway Epithelial Secretome: New Insights into Flavoring-Induced Airways Disease
Brass DM, Gwinn WM, Valente AM, Kelly FL, Brinkley CD, Nagler AE, Moseley MA, Morgan DL, Palmer SM, Foster MW.
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The Genomic Analysis of the Impact of Steroid Receptor Coactivators Ablation on Hepatic Metabolism
Jae-Wook Jeong, Inseok Kwak, Kevin Y. Lee, Lisa D. White, Xiao-Ping Wang, F. C. Brunicardi, Bert W. O’Malley, Francesco J. DeMayo
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The Mammary Gland is a Sensitive Pubertal Target in CD-1 and C57Bl/6 Mice Following Perinatal Perfluorooctanoic Acid (PFOA) Exposure
Tucker DK, Macon MB, Strynar MJ, Dagnino S, Andersen E, Fenton SE.
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The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals using High Throughput Transcriptomics and Benchmark Concentration Modeling
Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS
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The TGx-28.65 Biomarker Online Application for Analysis of Transcriptomics Data to Identify DNA Damage-inducing Chemicals in Human Cell Cultures
Jackson MA, Yang L, Lea IA, Rashid A, Kuo B, Williams A, Yauk CL, Fostel J.
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The common indoor air pollutant α-pinene is metabolized to a genotoxic metabolite α-pinene oxide
Suramya Waidyanatha, Sherry R. Black, Kristine L. Witt, Timothy R. Fennell, Carol Swartz, Leslie Recio, Scott L. Watson, Purvi R. Patel, Reshan A. Fernando, and Cynthia V. Rider
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Three-Dimensional (3D) HepaRG Spheroid Model with Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening
Sreenivasa C. Ramaiahgari, Suramya Waidyanatha, Darlene Dixon, Michael J. DeVito, Richard S. Paules, Stephen S. Ferguson.
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Tox21 Enricher: Web-based Chemical/Biological Functional Annotation Analysis Tool Based on Tox21 Toxicity Screening Platform
Junguk Hur, Larson Danes, Jui‐Hua Hsieh, Brett McGregor, Dakota Krout, Scott Auerbach.
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Toxicogenomics Profiling of Bone Marrow from Rats Treated with Topotecan in Combination with Oxaliplatin: a Mechanistic Strategy to Inform Combination Toxicity
Myrtle Davis, Jianying Li, Elaine Knight, Sandy R. Eldridge, Kellye K. Daniels and Pierre R. Bushel
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Toxicogenomics of the Flame Retardant tris(2-butoxyethyl)Phosphate in HepG2 Cells using RNA-seq
Boris V. Krivoshiev, Gerrit T.S. Beemster, Katrien Sprangers, Bart Cuypers, Kris Laukens, Ronny Blust and Steven J. Husson.
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Toxicokinetic Evaluation (K01090C) of Resveratrol (501-36-0) in Harlan Sprague Dawley Rats and B6C3F1/N Mice Exposed via Intravenous Injection or Gavage
Esra Mutlu, Seth T. Gibbs, Natalie South, Jessica Pierfelice, Brian Burback, Dori Germolec, Suramya Waidyanatha
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Toxicokinetic Evaluation (K08002D) of Bisphenol AF (1478-61-1) in Harlan Sprague Dawley Rats and B6C3F1/N Mice Exposed via Dosed Feed
DOI: https://doi.org/10.22427/NTP-DATA-002-03263-0011-0000-8 |
Toxicokinetic Evaluation (K94150C) of Bisphenol S (80-09-1) in Harlan Sprague Dawley Rats and B6C3F1/N Mice Exposed via Dosed Feed
DOI: https://doi.org/10.22427/NTP-DATA-002-03311-0008-0000-8 |
Toxicokinetic evaluation of the common indoor air pollutant, α-pinene, and its potential reactive metabolite, α-pinene oxide, following inhalation exposure in rodents
Suramya Waidyanatha, Michael Hackett, Sherry R. Black, Timothy R. Fennell, Mathew D. Stout, Melanie R. Silinski, Scott L. Watson, Joseph Licause, Veronica G. Robinson, Barney Sparrow, Reshan A. Fernando, Stephen Cooper and Cynthia V. Rider
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Toxicokinetics and bioavailability of sulfolane, a ground water contaminant, following oral and intravenous administration in rodents: A dose, species, and sex comparison
Suramya Waidyanatha, Sherry R. Black, Timothy R. Fennell, Scott L. Watson, Purvi R.Patel, Stephen D. Cooper, James Blake, Veronica Godfrey Robinson, Reshan A.Fernando, Chad R. Blystone DOI: https://doi.org/10.1016/j.taap.2019.114690 |
Toxicokinetics of 8:2 Fluorotelomer Alcohol (8:2-FTOH) in Male and Female Hsd:Sprague Dawley SD Rats after Intravenous and Gavage Administration
Huang M.C, Robinson V.G., Waidyanatha S., Dzierlenga A.L, DeVito M.J, Eifrid M.A, Gibbs S.T, Blystone CR
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Toxicokinetics of Perfluorobutane Sulfonate (PFBS), Perfluorohexane-1-Sulphonic Acid (PFHxS), and Perfluorooctane Sulfonic Acid (PFOS) in Male and Female Hsd:Sprague Dawley SD Rats after Intravenous and Gavage Administration
Huang M.C., Dzierlenga A., Robinson V.G, Waidyanatha S, DeVito M.J, Eifrid M.A, Granville C.A., Gibbs S.T, Blystone C.R
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Toxicokinetics of Perfluorohexanoic acid (PFHxA), Perfluorooctanoic acid (PFOA), and Perfluorodecanoic Acid (PFDA) in Male and Female Hsd:Sprague Dawley SD Rats following Intravenous or Gavage Administration
Dzierlenga A.L, Robinson V.G, Waidyanatha S, DeVito M.J, Eifrid M.A, Gibbs S.T, Granville C.A, *Blystone C.R
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Toxicokinetics of the plasticizer, N-butylbenzenesulfonamide, in plasma and brain following oral exposure in rodents: Route, species, and sex comparison
Suramya Waidyanatha, Seth Gibbs, Natalie South, Jeremy P. Smith, Esra Mutlu, Brian Burback, Yu Cao, Cynthia V. Rider
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Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 mice
Bevin E. Blake, Colette N. Miller, Helen Nguyen, Vesna A. Chappell, Trina P. Phan, Dhiral P. Phadke, Michele R. Balik-Meisner, Deepak Mav, Ruchir R. Shah, Suzanne E. Fenton |
Transcriptomic Profiling of Rat Liver Samples in A Comprehensive Study Design by RNA-Seq
Binsheng Gong, Charles Wang, Zhenqiang Su, Huixiao Hong, Jean Thierry-Mieg, Danielle Thierry-Mieg, Leming Shi, Scott S. Auerbach, Weida Tong, and Joshua Xu
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Urinary miRNA biomarkers of drug-induced kidney injury and their site specificity within the nephron
Brian Chorley, Heidrun Ellinger-Ziegelbauer, Michael Tackett, Frank J. Simutis, Alison H. Harrill, James McDuffie, Elnaz Atabakhsh, Rounak Nassirpour, Laurence O. Whiteley, Jean-François Léonard, Ernie Harpur, Connie L. Chen, Jean-Charles Gautier
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Using Tox21 High Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements
DOI:
https://doi.org/10.22427/NTP-DATA-023-00001-0001-000-7
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Uterine Paramesonephric Cysts in Sprague-Dawley Rats from National Toxicology Program Studies
Daven N. Jackson-Humbles, John Curtis Seely, Ronald A. Herbert, David E. Malarkey, Barry S. McIntyre, Paul M. Foster, and Darlene Dixon
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Vinclozolin modulates splenic natural killer cell activity, antibody-forming cell response and phenotypic marker expression in sprague dawley rats: a two-generation feeding study
White KL Jr, Germolec DR, Musgrove DL, Delclos KB, Newbold RR, Weis C, Guo TL.
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Whole-body inhalation exposure to 1-bromopropane suppresses the IgM response to sheep red blood cells in female B6C3F1 mice and Fisher 344/N rats
Anderson SE, Munson AE, Butterworth LF, Germolec D, Morgan DL, Roycroft JA, Dill J, Meade BJ.
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Whole-body inhalation exposure to 2-ethyltoluene for two weeks produced nasal lesions in rats and mice
Madelyn C. Huang, Cynthia J. Willson, Sridhar Jaligama, Gregory L. Baker, Alan W. Singer, Yu Cao, Jessica Pierfelice, Esra Mutlu, Brian Burback, Guanhua Xie, David E. Malarkey, Barney Sparrow, Kristen Ryan, Matthew Stout, and Georgia K. Roberts |
Zileuton Liver Toxicity Study in DO Mice
Dahea You, Lascelles E. Lyn-Cook Jr., Daniel M. Gatti, Natalie Bell,, Philip R. Mayeux, Laura P. James, William B. Mattes, Alison H. Harrill.
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httk: R Package for High-Throughput Toxicokinetics
Robert G. Pearce, R. Woodrow Setzer, Cory L. Strope, Nisha S. Sipes, John F. Wambaugh.
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