| Project Title: | TOXICOLOGICAL IMPORTANCE OF CYP3A4 CATALYSIS AND INHIBITION |
|---|---|
| PI: | Sevrioukova, Irina F |
| Institution: | University Of California-Irvine |
| Grant Number: | R01ES025767 |
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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| Interaction of CYP3A4 with the inhibitor cobicistat: Structural and mechanistic insights and compari ... | Sevrioukova, Irina F | R01ES025767 | Arch Biochem Biophys (2024 Aug) |
38909836
|
2024 |
| Mixed Ru(II)-Ir(III) Complexes as Photoactive Inhibitors of the Major Human Drug Metabolizing Enzyme ... | Ahrens, Justin J; Denison, Madeline; Garcia, Santana; Gupta, Sayak; Kocarek, Thomas A; Sevriouk ... | R01ES025767 | Inorg Chem (2024 Oct 07) |
39283981
|
2024 |
| Synthesis and anticancer properties of a hybrid molecule with the testosterone and estradiol head-gr ... | Paquin, Alexis; Nolin, Fayanne; Bouzriba, Chahrazed; Fortin, Sébastien; Sevrioukova, Irina F; B ... | R01ES025767 | Steroids (2024 Sep) |
38992454
|
2024 |
| Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4. | Denison, Madeline; Ahrens, Justin J; Dunbar, Marilyn N; Warmahaye, Habon; Majeed, Aliza; Turro, ... | R01ES025767 | Inorg Chem (2023 Feb 20) |
36758158
|
2023 |
| Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding. | Sevrioukova, Irina F | R01ES025767 | J Biol Chem (2023 Sep) |
37524132
|
2023 |
| Investigating a new C2-symmetric testosterone dimer and its dihydrotestosterone analog: Synthesis, a ... | Paquin, Alexis; Fortin, Laurie; Girouard, Julie; Reyes-Moreno, Carlos; Sevrioukova, Irina F; Bé ... | R01ES025767 | Eur J Med Chem (2023 Mar 15) |
36848848
|
2023 |
| Crystal Structure of CYP3A4 Complexed with Fluorol Identifies the Substrate Access Channel as a High ... | Sevrioukova, Irina F | R01ES025767 | Int J Mol Sci (2022 Oct 20) |
36293445
|
2022 |
| Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imp ... | Samuels, Eric R; Sevrioukova, Irina F | R01ES025767 | Int J Mol Sci (2022 Jun 30) |
35806297
|
2022 |
| Ir(III)-Based Agents for Monitoring the Cytochrome P450 3A4 Active Site Occupancy. | Denison, Madeline; Steinke, Sean J; Majeed, Aliza; Turro, Claudia; Kocarek, Thomas A; Sevriouko ... | R01ES025767 | Inorg Chem (2022 Sep 05) |
35994607
|
2022 |
| Innovative C2-symmetric testosterone and androstenedione dimers: Design, synthesis, biological evalu ... | Paquin, Alexis; Oufqir, Yassine; Sevrioukova, Irina F; Reyes-Moreno, Carlos; Bérubé, Gervais | R01ES025767 | Eur J Med Chem (2021 Aug 05) |
33933755
|
2021 |
| Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4. | Toupin, Nicholas; Steinke, Sean J; Nadella, Sandeep; Li, Ao; Rohrabaugh Jr, Thomas N; Samuels, ... | R01ES025767 | J Am Chem Soc (2021 06 23) |
34110801
|
2021 |
| Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads ... | Samuels, Eric R; Sevrioukova, Irina F | R01ES025767 | Int J Mol Sci (2021 Jan 16) |
33467005
|
2021 |
| Structural Basis for the Diminished Ligand Binding and Catalytic Ability of Human Fetal-Specific CYP ... | Sevrioukova, Irina F | R01ES025767 | Int J Mol Sci (2021 May 29) |
34072457
|
2021 |
| Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reducta ... | Ducharme, Julie; Sevrioukova, Irina F; Thibodeaux, Christopher J; Auclair, Karine | R01ES025767 | Biochemistry (2021 07 20) |
34196520
|
2021 |
| An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors o ... | Samuels, Eric R; Sevrioukova, Irina F | R01ES025767 | Bioorg Med Chem (2020 03 15) |
32044230
|
2020 |
| Unexpected Differences between Two Closely Related Bacterial P450 Camphor Monooxygenases. | Murarka, Vidhi C; Batabyal, Dipanwita; Amaya, Jose A; Sevrioukova, Irina F; Poulos, Thomas L | R01ES025767 | Biochemistry (2020 07 28) |
32551522
|
2020 |
| Conformational Response of N-Terminally Truncated Cytochrome P450 3A4 to Ligand Binding in Solution. | Chuo, Shih-Wei; Liou, Shu-Hao; Wang, Lee-Ping; Britt, R David; Poulos, Thomas L; Sevrioukova, ... | R01ES025767 | Biochemistry (2019 09 17) |
31456404
|
2019 |
| Interaction of Human Drug-Metabolizing CYP3A4 with Small Inhibitory Molecules. | Sevrioukova, Irina | R01ES025767 | Biochemistry (2019 02 19) |
30676743
|
2019 |
| Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deox ... | Chen, Yu-Jie; Zhang, Jian; Zhu, Ping-Ping; Tan, Xian-Wen; Lin, Qiu-Hong; Wang, Wen-Xia; Yin, ... | R01ES025767 | Drug Metab Dispos (2019 06) |
30918015
|
2019 |
| Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, ... | Sevrioukova, Irina F | R01ES025767 | Int J Mol Sci (2019 Aug 30) |
31480231
|
2019 |
| Structure-Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group St ... | Samuels, Eric R; Sevrioukova, Irina | R01ES025767 | Biochemistry (2019 Apr 16) |
30912932
|
2019 |
| Direct Synthesis of α-Thio Aromatic Acids from Aromatic Amino Acids. | Samuels, Eric R; Sevrioukova, Irina | R01ES025767 | Tetrahedron Lett (2018 Mar 21) |
30140110
|
2018 |
| Inhibition of Human CYP3A4 by Rationally Designed Ritonavir-Like Compounds: Impact and Interplay of ... | Samuels, Eric R; Sevrioukova, Irina | R01ES025767 | Mol Pharm (2018 Jan 02) |
29232137
|
2018 |
| Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling ... | Polic, Vanja; Sevrioukova, Irina F; Auclair, Karine | R01ES025767 | Arch Biochem Biophys (2018 Sep 01) |
29958895
|
2018 |
| Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. | Guo, Zhijun; Sevrioukova, Irina F; Denisov, Ilia G; Zhang, Xia; Chiu, Ting-Lan; Thomas, Dafydd ... | P30ES013508, R01ES025767 | Cell Chem Biol (2017 Oct 19) |
28919040
|
2017 |
| High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4. | Sevrioukova, Irina F | R01ES025767 | Biochemistry (2017 Jun 20) |
28590129
|
2017 |
| Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4. | Sevrioukova, Irina F; Poulos, Thomas L | R01ES025767 | Proc Natl Acad Sci U S A (2017 Jan 17) |
28031486
|
2017 |