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Who We Fund: Publication Detail

Project Title: TOXICOLOGICAL IMPORTANCE OF CYP3A4 CATALYSIS AND INHIBITION
PI: Sevrioukova, Irina F
Institution: University Of California-Irvine
Grant Number: R01ES025767

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Viewing 24 publications
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Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4.   Denison, Madeline; Ahrens, Justin J; Dunbar, Marilyn N; Warmahaye, Habon; Majeed, Aliza; Turro, ... P30ES020957, R01ES025767 Inorg Chem (2023 Feb 20) 36758158 Exiting the NIEHS site 2023 
Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding.   Sevrioukova, Irina F R01ES025767 J Biol Chem (2023 Sep) 37524132 Exiting the NIEHS site 2023 
Investigating a new C2-symmetric testosterone dimer and its dihydrotestosterone analog: Synthesis, a ...   Paquin, Alexis; Fortin, Laurie; Girouard, Julie; Reyes-Moreno, Carlos; Sevrioukova, Irina F; Bé ... R01ES025767 Eur J Med Chem (2023 Mar 15) 36848848 Exiting the NIEHS site 2023 
Crystal Structure of CYP3A4 Complexed with Fluorol Identifies the Substrate Access Channel as a High ...   Sevrioukova, Irina F R01ES025767 Int J Mol Sci (2022 Oct 20) 36293445 Exiting the NIEHS site 2022 
Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imp ...   Samuels, Eric R; Sevrioukova, Irina F R01ES025767 Int J Mol Sci (2022 Jun 30) 35806297 Exiting the NIEHS site 2022 
Ir(III)-Based Agents for Monitoring the Cytochrome P450 3A4 Active Site Occupancy.   Denison, Madeline; Steinke, Sean J; Majeed, Aliza; Turro, Claudia; Kocarek, Thomas A; Sevriouko ... R01ES025767 Inorg Chem (2022 Sep 05) 35994607 Exiting the NIEHS site 2022 
Innovative C2-symmetric testosterone and androstenedione dimers: Design, synthesis, biological evalu ...   Paquin, Alexis; Oufqir, Yassine; Sevrioukova, Irina F; Reyes-Moreno, Carlos; Bérubé, Gervais R01ES025767 Eur J Med Chem (2021 Aug 05) 33933755 Exiting the NIEHS site 2021 
Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4.   Toupin, Nicholas; Steinke, Sean J; Nadella, Sandeep; Li, Ao; Rohrabaugh Jr, Thomas N; Samuels, ... R01ES025767 J Am Chem Soc (2021 06 23) 34110801 Exiting the NIEHS site 2021 
Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads ...   Samuels, Eric R; Sevrioukova, Irina F R01ES025767 Int J Mol Sci (2021 Jan 16) 33467005 Exiting the NIEHS site 2021 
Structural Basis for the Diminished Ligand Binding and Catalytic Ability of Human Fetal-Specific CYP ...   Sevrioukova, Irina F R01ES025767 Int J Mol Sci (2021 May 29) 34072457 Exiting the NIEHS site 2021 
Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reducta ...   Ducharme, Julie; Sevrioukova, Irina F; Thibodeaux, Christopher J; Auclair, Karine R01ES025767 Biochemistry (2021 07 20) 34196520 Exiting the NIEHS site 2021 
An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors o ...   Samuels, Eric R; Sevrioukova, Irina F R01ES025767 Bioorg Med Chem (2020 03 15) 32044230 Exiting the NIEHS site 2020 
Unexpected Differences between Two Closely Related Bacterial P450 Camphor Monooxygenases.   Murarka, Vidhi C; Batabyal, Dipanwita; Amaya, Jose A; Sevrioukova, Irina F; Poulos, Thomas L R01ES025767 Biochemistry (2020 07 28) 32551522 Exiting the NIEHS site 2020 
Conformational Response of N-Terminally Truncated Cytochrome P450 3A4 to Ligand Binding in Solution.   Chuo, Shih-Wei; Liou, Shu-Hao; Wang, Lee-Ping; Britt, R David; Poulos, Thomas L; Sevrioukova, ... R01ES025767 Biochemistry (2019 09 17) 31456404 Exiting the NIEHS site 2019 
Interaction of Human Drug-Metabolizing CYP3A4 with Small Inhibitory Molecules.   Sevrioukova, Irina R01ES025767 Biochemistry (2019 02 19) 30676743 Exiting the NIEHS site 2019 
Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deox ...   Chen, Yu-Jie; Zhang, Jian; Zhu, Ping-Ping; Tan, Xian-Wen; Lin, Qiu-Hong; Wang, Wen-Xia; Yin, ... R01ES025767 Drug Metab Dispos (2019 06) 30918015 Exiting the NIEHS site 2019 
Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, ...   Sevrioukova, Irina F R01ES025767 Int J Mol Sci (2019 Aug 30) 31480231 Exiting the NIEHS site 2019 
Structure-Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group St ...   Samuels, Eric R; Sevrioukova, Irina R01ES025767 Biochemistry (2019 Apr 16) 30912932 Exiting the NIEHS site 2019 
Direct Synthesis of α-Thio Aromatic Acids from Aromatic Amino Acids.   Samuels, Eric R; Sevrioukova, Irina R01ES025767 Tetrahedron Lett (2018 Mar 21) 30140110 Exiting the NIEHS site 2018 
Inhibition of Human CYP3A4 by Rationally Designed Ritonavir-Like Compounds: Impact and Interplay of ...   Samuels, Eric R; Sevrioukova, Irina R01ES025767 Mol Pharm (2018 Jan 02) 29232137 Exiting the NIEHS site 2018 
Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling ...   Polic, Vanja; Sevrioukova, Irina F; Auclair, Karine R01ES025767 Arch Biochem Biophys (2018 Sep 01) 29958895 Exiting the NIEHS site 2018 
Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.   Guo, Zhijun; Sevrioukova, Irina F; Denisov, Ilia G; Zhang, Xia; Chiu, Ting-Lan; Thomas, Dafydd ... P30ES013508, R01ES025767 Cell Chem Biol (2017 Oct 19) 28919040 Exiting the NIEHS site 2017 
High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4.   Sevrioukova, Irina F R01ES025767 Biochemistry (2017 Jun 20) 28590129 Exiting the NIEHS site 2017 
Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4.   Sevrioukova, Irina F; Poulos, Thomas L R01ES025767 Proc Natl Acad Sci U S A (2017 Jan 17) 28031486 Exiting the NIEHS site 2017 
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