| Project Title: | MECHANISMS OF DNA DOUBLE-STRAND BREAK END RESECTION AND REPAIR PATHWAY CHOICE |
|---|---|
| PI: | Sung, Patrick |
| Institution: | University Of Texas Hlth Science Center |
| Grant Number: | R01ES007061 |
These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.
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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response. | Jiang, Haoyang; Zhang, Tianpeng; Kaur, Hardeep; Shi, Tao; Krishnan, Aravind; Kwon, Youngho; Su ... | R01ES007061 | Mol Cell (2024 May 02) |
38593805
|
2024 |
| Break-induced replication orchestrates resection-dependent template switching. | Zhang, Tianpeng; Rawal, Yashpal; Jiang, Haoyang; Kwon, Youngho; Sung, Patrick; Greenberg, Roge ... | R01ES007061 | Nature (2023 Jul) |
37316655
|
2023 |
| Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester trans ... | Afsar, Mohammad; Liu, GuanQun; Jia, Lijia; Ruben, Eliza A; Nayak, Digant; Sayyad, Zuberwasim; ... | R01ES007061 | Nat Commun (2023 Aug 08) |
37553340
|
2023 |
| DICER ribonuclease removes harmful R-loops. | Camino, Lola P; Dutta, Arijit; Barroso, Sonia; Pérez-Calero, Carmen; Katz, Jeffrey N; García-Ru ... | R01ES007061 | Mol Cell (2023 Oct 19) |
37827159
|
2023 |
| DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork ... | Kwon, Youngho; Rösner, Heike; Zhao, Weixing; Selemenakis, Platon; He, Zhuoling; Kawale, Ajinky ... | R01ES007061 | Nat Commun (2023 Jan 26) |
36702902
|
2023 |
| Single-molecule visualization of Pif1 helicase translocation on single-stranded DNA. | Mustafi, Mainak; Kwon, Youngho; Sung, Patrick; Greene, Eric C | R01ES007061 | J Biol Chem (2023 Jun) |
37178921
|
2023 |
| Structural insights into BCDX2 complex function in homologous recombination. | Rawal, Yashpal; Jia, Lijia; Meir, Aviv; Zhou, Shuo; Kaur, Hardeep; Ruben, Eliza A; Kwon, Youn ... | P30ES013508, R01ES007061, R01ES030335, R01ES031796 | Nature (2023 Jul) |
37344589
|
2023 |
| Biochemical Analysis of RNA-DNA Hybrid and R-Loop Unwinding Via Motor Proteins. | Dutta, Arijit; Kwon, Youngho; Sung, Patrick | R01ES007061 | Methods Mol Biol (2022) |
35704200
|
2022 |
| Bloom helicase mediates formation of large single-stranded DNA loops during DNA end processing. | Xue, Chaoyou; Salunkhe, Sameer J; Tomimatsu, Nozomi; Kawale, Ajinkya S; Kwon, Youngho; Burma, ... | R01ES007061 | Nat Commun (2022 Apr 26) |
35473934
|
2022 |
| Homologous recombination-deficient mutation cluster in tumor suppressor RAD51C identified by compreh ... | Prakash, Rohit; Rawal, Yashpal; Sullivan, Meghan R; Grundy, McKenzie K; Bret, Hélène; Mihalevic ... | R01ES007061, R01ES031796 | Proc Natl Acad Sci U S A (2022 Sep 20) |
36099300
|
2022 |
| RAD51AP1 and RAD54L Can Underpin Two Distinct RAD51-Dependent Routes of DNA Damage Repair via Homolo ... | Selemenakis, Platon; Sharma, Neelam; Uhrig, Mollie E; Katz, Jeffrey; Kwon, Youngho; Sung, Patr ... | R01ES007061 | Front Cell Dev Biol (2022) |
35652094
|
2022 |
| RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA. | Kaminski, Nicole; Wondisford, Anne R; Kwon, Youngho; Lynskey, Michelle Lee; Bhargava, Ragini; B ... | R01ES007061 | Mol Cell (2022 Nov 03) |
36265488
|
2022 |
| Rad54 and Rdh54 prevent Srs2-mediated disruption of Rad51 presynaptic filaments. | Meir, Aviv; Crickard, J Brooks; Kwon, Youngho; Sung, Patrick; Greene, Eric C | R01ES007061 | Proc Natl Acad Sci U S A (2022 Jan 25) |
35042797
|
2022 |
| Long-term survival of an ovarian cancer patient harboring a RAD51C missense mutation. | Sullivan, Meghan R; Prakash, Rohit; Rawal, Yashpal; Wang, Weibin; Sung, Patrick; Radke, Marc R ... | R01ES007061, R01ES030335, R01ES031796 | Cold Spring Harb Mol Case Stud (2021 Apr) |
33832919
|
2021 |
| The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination. | Roy, Upasana; Kwon, Youngho; Marie, Lea; Symington, Lorraine; Sung, Patrick; Lisby, Michael; G ... | R01ES007061 | Mol Cell (2021 03 04) |
33421364
|
2021 |
| Rad54 and Rdh54 occupy spatially and functionally distinct sites within the Rad51-ssDNA presynaptic ... | Crickard, J Brooks; Kwon, Youngho; Sung, Patrick; Greene, Eric C | R01ES007061 | EMBO J (2020 Oct 15) |
32790929
|
2020 |
| Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination. | Crickard, J Brooks; Moevus, Corentin J; Kwon, Youngho; Sung, Patrick; Greene, Eric C | R01ES007061 | Cell (2020 06 11) |
32502392
|
2020 |
| Specificity of end resection pathways for double-strand break regions containing ribonucleotides and ... | Daley, James M; Tomimatsu, Nozomi; Hooks, Grace; Wang, Weibin; Miller, Adam S; Xue, Xiaoyu; Ng ... | R01ES007061 | Nat Commun (2020 06 18) |
32555206
|
2020 |
| The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication. | Tarsounas, Madalena; Sung, Patrick | R01ES007061 | Nat Rev Mol Cell Biol (2020 05) |
32094664
|
2020 |
| The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homolo ... | Liang, Fengshan; Miller, Adam S; Tang, Caroline; Maranon, David; Williamson, Elizabeth A; Hroma ... | R01ES007061 | J Biol Chem (2020 06 12) |
32350107
|
2020 |
| Ddc2ATRIP promotes Mec1ATR activation at RPA-ssDNA tracts. | Biswas, Himadri; Goto, Greicy; Wang, Weibin; Sung, Patrick; Sugimoto, Katsunori | R01ES007061 | PLoS Genet (2019 08) |
31369547
|
2019 |
| Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombination. | Steinfeld, Justin B; Beláň, Ondrej; Kwon, Youngho; Terakawa, Tsuyoshi; Al-Zain, Amr; Smith, Mi ... | R01ES007061 | Genes Dev (2019 Sep 01) |
31371435
|
2019 |
| DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage re ... | Liang, Fengshan; Miller, Adam S; Longerich, Simonne; Tang, Caroline; Maranon, David; Williamson ... | R01ES007061 | Nat Commun (2019 06 28) |
31253762
|
2019 |
| Dynamic interactions of the homologous pairing 2 (Hop2)-meiotic nuclear divisions 1 (Mnd1) protein c ... | Crickard, J Brooks; Kwon, Youngho; Sung, Patrick; Greene, Eric C | R01ES007061 | J Biol Chem (2019 Jan 11) |
30420424
|
2019 |
| Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes. | Klein, Hannah L; Ang, Kenny K H; Arkin, Michelle R; Beckwitt, Emily C; Chang, Yi-Hsuan; Fan, J ... | R01ES007061 | Microb Cell (2019 Jan 07) |
30652106
|
2019 |
| MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers. | Srinivasan, Gayathri; Williamson, Elizabeth A; Kong, Kimi; Jaiswal, Aruna S; Huang, Guangcun; K ... | R01ES007061 | Proc Natl Acad Sci U S A (2019 08 27) |
31395736
|
2019 |
| Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast. | Yan, Zhenxin; Xue, Chaoyou; Kumar, Sandeep; Crickard, J Brooks; Yu, Yang; Wang, Weibin; Pham, ... | R01ES007061 | Mol Cell (2019 12 05) |
31542296
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2019 |
| Regulatory control of Sgs1 and Dna2 during eukaryotic DNA end resection. | Xue, Chaoyou; Wang, Weibin; Crickard, J Brooks; Moevus, Corentin J; Kwon, Youngho; Sung, Patri ... | R01ES007061 | Proc Natl Acad Sci U S A (2019 03 26) |
30850524
|
2019 |
| Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA ... | Xue, Chaoyou; Daley, James M; Xue, Xiaoyu; Steinfeld, Justin; Kwon, Youngho; Sung, Patrick; Gr ... | R01ES007061 | Nucleic Acids Res (2019 Dec 02) |
31544923
|
2019 |
| The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination. | Zhao, Weixing; Wiese, Claudia; Kwon, Youngho; Hromas, Robert; Sung, Patrick | R01ES007061 | Annu Rev Biochem (2019 06 20) |
30917004
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2019 |
| The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway. | Rosenbaum, Joel C; Bonilla, Braulio; Hengel, Sarah R; Mertz, Tony M; Herken, Benjamin W; Kazemi ... | R01ES007061 | Nat Commun (2019 08 05) |
31383866
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2019 |
| The RecQ helicase Sgs1 drives ATP-dependent disruption of Rad51 filaments. | Crickard, J Brooks; Xue, Chaoyou; Wang, Weibin; Kwon, Youngho; Sung, Patrick; Greene, Eric C | R01ES007061 | Nucleic Acids Res (2019 May 21) |
30916344
|
2019 |
| A DNA nick at Ku-blocked double-strand break ends serves as an entry site for exonuclease 1 (Exo1) o ... | Wang, Weibin; Daley, James M; Kwon, Youngho; Xue, Xiaoyu; Krasner, Danielle S; Miller, Adam S; ... | R01ES007061 | J Biol Chem (2018 11 02) |
30224356
|
2018 |
| Importance of homo-dimerization of Fanconi-associated nuclease 1 in DNA flap cleavage. | Rao, Timsi; Longerich, Simonne; Zhao, Weixing; Aihara, Hideki; Sung, Patrick; Xiong, Yong | R01ES007061 | DNA Repair (Amst) (2018 04) |
29518739
|
2018 |
| Introduction to the Thematic Minireview Series: DNA double-strand break repair and pathway choice. | Sung, Patrick | R01ES007061 | J Biol Chem (2018 07 06) |
29853635
|
2018 |
| Meiosis-specific recombinase Dmc1 is a potent inhibitor of the Srs2 antirecombinase. | Crickard, J Brooks; Kaniecki, Kyle; Kwon, Youngho; Sung, Patrick; Greene, Eric C | R01ES007061 | Proc Natl Acad Sci U S A (2018 Oct 23) |
30301803
|
2018 |
| Regulation of Hed1 and Rad54 binding during maturation of the meiosis-specific presynaptic complex. | Crickard, J Brooks; Kaniecki, Kyle; Kwon, YoungHo; Sung, Patrick; Lisby, Michael; Greene, Eric ... | R01ES007061 | EMBO J (2018 Apr 03) |
29444896
|
2018 |
| Spontaneous self-segregation of Rad51 and Dmc1 DNA recombinases within mixed recombinase filaments. | Crickard, J Brooks; Kaniecki, Kyle; Kwon, YoungHo; Sung, Patrick; Greene, Eric C | R01ES007061 | J Biol Chem (2018 03 16) |
29382724
|
2018 |
| A novel role of the Dna2 translocase function in DNA break resection. | Miller, Adam S; Daley, James M; Pham, Nhung Tuyet; Niu, Hengyao; Xue, Xiaoyu; Ira, Grzegorz; S ... | R01ES007061 | Genes Dev (2017 Mar 01) |
28336516
|
2017 |
| BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing. | Zhao, Weixing; Steinfeld, Justin B; Liang, Fengshan; Chen, Xiaoyong; Maranon, David G; Jian Ma, ... | R01ES007061 | Nature (2017 Oct 19) |
28976962
|
2017 |
| Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange. | Xu, Jingfei; Zhao, Lingyun; Xu, Yuanyuan; Zhao, Weixing; Sung, Patrick; Wang, Hong-Wei | R01ES007061 | Nat Struct Mol Biol (2017 Jan) |
27941862
|
2017 |
| Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2 ... | Kaniecki, Kyle; De Tullio, Luisina; Gibb, Bryan; Kwon, Youngho; Sung, Patrick; Greene, Eric C | R01ES007061 | Cell Rep (2017 Dec 12) |
29241544
|
2017 |
| Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP. | Daley, James M; Jimenez-Sainz, Judit; Wang, Weibin; Miller, Adam S; Xue, Xiaoyu; Nguyen, Kevin ... | R01ES007061 | Cell Rep (2017 Oct 10) |
29020620
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2017 |
| Human RAD52 interactions with replication protein A and the RAD51 presynaptic complex. | Ma, Chu Jian; Kwon, Youngho; Sung, Patrick; Greene, Eric C | R01ES007061 | J Biol Chem (2017 07 14) |
28551686
|
2017 |
| Nucleosome-like, Single-stranded DNA (ssDNA)-Histone Octamer Complexes and the Implication for DNA D ... | Adkins, Nicholas L; Swygert, Sarah G; Kaur, Parminder; Niu, Hengyao; Grigoryev, Sergei A; Sung, ... | P30ES025128, R01ES007061 | J Biol Chem (2017 Mar 31) |
28202543
|
2017 |
| Plasticity of the Mre11-Rad50-Xrs2-Sae2 nuclease ensemble in the processing of DNA-bound obstacles. | Wang, Weibin; Daley, James M; Kwon, Youngho; Krasner, Danielle S; Sung, Patrick | R01ES007061 | Genes Dev (2017 Dec 01) |
29321177
|
2017 |
| Role of the Pif1-PCNA Complex in Pol δ-Dependent Strand Displacement DNA Synthesis and Break-Induced ... | Buzovetsky, Olga; Kwon, Youngho; Pham, Nhung Tuyet; Kim, Claire; Ira, Grzegorz; Sung, Patrick; ... | R01ES007061 | Cell Rep (2017 Nov 14) |
29141206
|
2017 |
| Sequence imperfections and base triplet recognition by the Rad51/RecA family of recombinases. | Lee, Ja Yil; Steinfeld, Justin B; Qi, Zhi; Kwon, YoungHo; Sung, Patrick; Greene, Eric C | R01ES007061 | J Biol Chem (2017 06 30) |
28476890
|
2017 |
| Yeast Srs2 Helicase Promotes Redistribution of Single-Stranded DNA-Bound RPA and Rad52 in Homologous ... | De Tullio, Luisina; Kaniecki, Kyle; Kwon, Youngho; Crickard, J Brooks; Sung, Patrick; Greene, ... | R01ES007061 | Cell Rep (2017 Oct 17) |
29045827
|
2017 |
| Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by ... | Xue, Xiaoyu; Papusha, Alma; Choi, Koyi; Bonner, Jacob N; Kumar, Sandeep; Niu, Hengyao; Kaur, ... | R01ES007061 | Genes Dev (2016 03 15) |
26966246
|
2016 |
| Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end ... | Chen, Xuefeng; Niu, Hengyao; Yu, Yang; Wang, Jingjing; Zhu, Shuangyi; Zhou, Jianjie; Papusha, ... | R01ES007061 | Nucleic Acids Res (2016 Apr 07) |
26801641
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2016 |
| Mek1 Down Regulates Rad51 Activity during Yeast Meiosis by Phosphorylation of Hed1. | Callender, Tracy L; Laureau, Raphaelle; Wan, Lihong; Chen, Xiangyu; Sandhu, Rima; Laljee, Saif ... | R01ES007061 | PLoS Genet (2016 Aug) |
27483004
|
2016 |
| Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex. | Liang, Fengshan; Longerich, Simonne; Miller, Adam S; Tang, Caroline; Buzovetsky, Olga; Xiong, ... | R01ES007061 | Cell Rep (2016 Jun 07) |
27239033
|
2016 |
| Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks. | Cassani, Corinne; Gobbini, Elisa; Wang, Weibin; Niu, Hengyao; Clerici, Michela; Sung, Patrick; ... | R01ES007061 | PLoS Biol (2016 Feb) |
26901759
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2016 |
| DNA sequence alignment by microhomology sampling during homologous recombination. | Qi, Zhi; Redding, Sy; Lee, Ja Yil; Gibb, Bryan; Kwon, YoungHo; Niu, Hengyao; Gaines, William ... | R01ES007061 | Cell (2015 Feb 26) |
25684365
|
2015 |
| Functions and regulation of the multitasking FANCM family of DNA motor proteins. | Xue, Xiaoyu; Sung, Patrick; Zhao, Xiaolan | R01ES007061 | Genes Dev (2015 Sep 01) |
26341555
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2015 |
| Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry. | Zhao, Weixing; Vaithiyalingam, Sivaraja; San Filippo, Joseph; Maranon, David G; Jimenez-Sainz, ... | R01ES007061 | Mol Cell (2015 Jul 16) |
26145171
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2015 |
| Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Ra ... | Gaines, William A; Godin, Stephen K; Kabbinavar, Faiz F; Rao, Timsi; VanDemark, Andrew P; Sung, ... | R01ES007061 | Nat Commun (2015 Jul 28) |
26215801
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2015 |
| Selective modulation of the functions of a conserved DNA motor by a histone fold complex. | Xue, Xiaoyu; Choi, Koyi; Bonner, Jacob N; Szakal, Barnabas; Chen, Yu-Hung; Papusha, Alma; Saro ... | R01ES007061 | Genes Dev (2015 05 15) |
25956905
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2015 |
| Significance of ligand interactions involving Hop2-Mnd1 and the RAD51 and DMC1 recombinases in homol ... | Zhao, Weixing; Sung, Patrick | R01ES007061 | Nucleic Acids Res (2015 Apr 30) |
25820426
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2015 |
| Synthetic viability genomic screening defines Sae2 function in DNA repair. | Puddu, Fabio; Oelschlaegel, Tobias; Guerini, Ilaria; Geisler, Nicola J; Niu, Hengyao; Herzog, ... | R01ES007061 | EMBO J (2015 Jun 03) |
25899817
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2015 |
| Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms. | Potenski, Catherine J; Niu, Hengyao; Sung, Patrick; Klein, Hannah L | R01ES007061 | Nature (2014 Jul 10) |
24896181
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2014 |
| Concentration-dependent exchange of replication protein A on single-stranded DNA revealed by single- ... | Gibb, Bryan; Ye, Ling F; Gergoudis, Stephanie C; Kwon, YoungHo; Niu, Hengyao; Sung, Patrick; G ... | R01ES007061 | PLoS One (2014) |
24498402
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2014 |
| Down-regulation of Rad51 activity during meiosis in yeast prevents competition with Dmc1 for repair ... | Liu, Yan; Gaines, William A; Callender, Tracy; Busygina, Valeria; Oke, Ashwini; Sung, Patrick; ... | R01ES007061 | PLoS Genet (2014 Jan) |
24465215
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2014 |
| Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing. | Zhao, Weixing; Saro, Dorina; Hammel, Michal; Kwon, Youngho; Xu, Yuanyuan; Rambo, Robert P; Wil ... | R01ES007061 | Nucleic Acids Res (2014 Jan) |
24150939
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2014 |
| Protein dynamics during presynaptic-complex assembly on individual single-stranded DNA molecules. | Gibb, Bryan; Ye, Ling F; Kwon, YoungHo; Niu, Hengyao; Sung, Patrick; Greene, Eric C | R01ES007061 | Nat Struct Mol Biol (2014 Oct) |
25195049
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2014 |
| Restriction of replication fork regression activities by a conserved SMC complex. | Xue, Xiaoyu; Choi, Koyi; Bonner, Jacob N; Chiba, Tamara; Kwon, Youngho; Xu, Yuanyuan; Sanchez, ... | R01ES007061 | Mol Cell (2014 11 06) |
25439736
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2014 |
| Functional attributes of the Saccharomyces cerevisiae meiotic recombinase Dmc1. | Busygina, Valeria; Gaines, William A; Xu, Yuanyuan; Kwon, Youngho; Williams, Gareth J; Lin, Sh ... | R01ES007061 | DNA Repair (Amst) (2013 Sep) |
23769192
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2013 |
| Nucleosome dynamics regulates DNA processing. | Adkins, Nicholas L; Niu, Hengyao; Sung, Patrick; Peterson, Craig L | R01ES007061 | Nat Struct Mol Biol (2013 Jul) |
23728291
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2013 |
| Pif1 helicase and Polýý promote recombination-coupled DNA synthesis via bubble migration. | Wilson, Marenda A; Kwon, YoungHo; Xu, Yuanyuan; Chung, Woo-Hyun; Chi, Peter; Niu, Hengyao; May ... | R01ES007061 | Nature (2013 Oct 17) |
24025768
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2013 |
| RIF1 in DNA break repair pathway choice. | Daley, James M; Sung, Patrick | R01ES007061 | Mol Cell (2013 Mar 07) |
23473603
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2013 |
| Role of replication protein A in double holliday junction dissolution mediated by the BLM-Topo IIIα- ... | Xue, Xiaoyu; Raynard, Steven; Busygina, Valeria; Singh, Akhilesh K; Sung, Patrick | R01ES007061 | J Biol Chem (2013 May 17) |
23543748
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2013 |
| Roles of DNA helicases in the mediation and regulation of homologous recombination. | Daley, James M; Niu, Hengyao; Sung, Patrick | R01ES007061 | Adv Exp Med Biol (2013) |
23161012
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2013 |
| Mechanistic insights into RAD51-associated protein 1 (RAD51AP1) action in homologous DNA repair. | Dunlop, Myun Hwa; Dray, Eloïse; Zhao, Weixing; San Filippo, Joseph; Tsai, Miaw-Sheue; Leung, S ... | R01ES007061 | J Biol Chem (2012 Apr 06) |
22375013
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2012 |
| Novel attributes of Hed1 affect dynamics and activity of the Rad51 presynaptic filament during meiot ... | Busygina, Valeria; Saro, Dorina; Williams, Gareth; Leung, Wing-Kit; Say, Amanda F; Sehorn, Mic ... | R01ES007061 | J Biol Chem (2012 Jan 06) |
22115747
|
2012 |
| Activation of protein kinase Tel1 through recognition of protein-bound DNA ends. | Fukunaga, Kenzo; Kwon, Youngho; Sung, Patrick; Sugimoto, Katsunori | R01ES007061 | Mol Cell Biol (2011 May) |
21402778
|
2011 |
| Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like fac ... | Chi, Peter; Kwon, YoungHo; Visnapuu, Mari-Liis; Lam, Isabel; Santa Maria, Sergio R; Zheng, Xiu ... | R01ES007061 | Nucleic Acids Res (2011 Aug) |
21558173
|
2011 |
| Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylatio ... | Chen, Xuefeng; Niu, Hengyao; Chung, Woo-Hyun; Zhu, Zhu; Papusha, Alma; Shim, Eun Yong; Lee, S ... | R01ES007061 | Nat Struct Mol Biol (2011 Sep) |
21841787
|
2011 |
| Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51 ... | Dray, Eloïse; Dunlop, Myun Hwa; Kauppi, Liisa; San Filippo, Joseph; Wiese, Claudia; Tsai, Miaw ... | R01ES007061 | Proc Natl Acad Sci U S A (2011 Mar 01) |
21307306
|
2011 |
| Processing of DNA structures via DNA unwinding and branch migration by the S. cerevisiae Mph1 protei ... | Zheng, Xiao-Feng; Prakash, Rohit; Saro, Dorina; Longerich, Simonne; Niu, Hengyao; Sung, Patric ... | R01ES007061 | DNA Repair (Amst) (2011 Oct 10) |
21880555
|
2011 |
| RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserve ... | Dunlop, Myun Hwa; Dray, Eloïse; Zhao, Weixing; Tsai, Miaw-Sheue; Wiese, Claudia; Schild, David ... | R01ES007061 | J Biol Chem (2011 Oct 28) |
21903585
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2011 |
| The Rad50 coiled-coil domain is indispensable for Mre11 complex functions. | Hohl, Marcel; Kwon, Youngho; Galván, Sandra Muñoz; Xue, Xiaoyu; Tous, Cristina; Aguilera, Andr ... | R01ES007061 | Nat Struct Mol Biol (2011 Sep 04) |
21892167
|
2011 |
| Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex. | Wang, Feng; Yang, Yuting; Singh, Thiyam Ramsing; Busygina, Valeria; Guo, Rong; Wan, Ke; Wang, ... | R01ES007061 | Structure (2010 Sep 08) |
20826342
|
2010 |
| Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. | Dray, Eloïse; Etchin, Julia; Wiese, Claudia; Saro, Dorina; Williams, Gareth J; Hammel, Michal; ... | R01ES007061 | Nat Struct Mol Biol (2010 Oct) |
20871616
|
2010 |
| Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae. | Niu, Hengyao; Chung, Woo-Hyun; Zhu, Zhu; Kwon, Youngho; Zhao, Weixing; Chi, Peter; Prakash, R ... | R01ES007061 | Nature (2010 Sep 2) |
20811460
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2010 |
| MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via ... | Singh, Thiyam Ramsing; Saro, Dorina; Ali, Abdullah Mahmood; Zheng, Xiao-Feng; Du, Chang-hu; Kil ... | R01ES007061 | Mol Cell (2010 Mar 26) |
20347429
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2010 |
| Promotion and regulation of homologous recombination by DNA helicases. | Colavito, Sierra; Prakash, Rohit; Sung, Patrick | R01ES007061 | Methods (2010 Jul) |
20156560
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2010 |
| Rad52 SUMOylation affects the efficiency of the DNA repair. | Altmannova, Veronika; Eckert-Boulet, Nadine; Arneric, Milica; Kolesar, Peter; Chaloupkova, Radk ... | R01ES007061 | Nucleic Acids Res (2010 Aug) |
20371517
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2010 |
| Assay for human Rad51-mediated DNA displacement loop formation. | Raynard, Steven; Sung, Patrick | R01ES007061 | Cold Spring Harb Protoc (2009 Jan) |
20147015
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2009 |
| Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermedia ... | Matulova, Petra; Marini, Victoria; Burgess, Rebecca C; Sisakova, Alexandra; Kwon, Youngho; Roth ... | R01ES007061 | J Biol Chem (2009 Mar 20) |
19129197
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2009 |
| Functional interactions of meiotic recombination factors Rdh54 and Dmc1. | Chi, Peter; Kwon, Youngho; Moses, Dana N; Seong, Changhyun; Sehorn, Michael G; Singh, Akhilesh ... | R01ES007061 | DNA Repair (Amst) (2009 Feb 1) |
19028606
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2009 |
| Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption. | Colavito, Sierra; Macris-Kiss, Margaret; Seong, Changhyun; Gleeson, Olive; Greene, Eric C; Klei ... | R01ES007061 | Nucleic Acids Res (2009 Nov) |
19745052
|
2009 |
| Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivo. | Burgess, Rebecca C; Lisby, Michael; Altmannova, Veronika; Krejci, Lumir; Sung, Patrick; Rothste ... | R01ES007061 | J Cell Biol (2009 Jun 15) |
19506039
|
2009 |
| Regulation of Rad51 recombinase presynaptic filament assembly via interactions with the Rad52 mediat ... | Seong, Changhyun; Colavito, Sierra; Kwon, Youngho; Sung, Patrick; Krejci, Lumir | R01ES007061 | J Biol Chem (2009 Sep 04) |
19605344
|
2009 |
| Role of the Rad52 amino-terminal DNA binding activity in DNA strand capture in homologous recombinat ... | Shi, Idina; Hallwyl, Swee C L; Seong, Changhyun; Mortensen, Uffe; Rothstein, Rodney; Sung, Pat ... | R01ES007061 | J Biol Chem (2009 Nov 27) |
19812039
|
2009 |
| Structural transitions within human Rad51 nucleoprotein filaments. | Robertson, Ragan B; Moses, Dana N; Kwon, YoungHo; Chan, Pamela; Chi, Peter; Klein, Hannah; Sun ... | R01ES007061 | Proc Natl Acad Sci U S A (2009 Aug 4) |
19622740
|
2009 |
| Visualizing the disassembly of S. cerevisiae Rad51 nucleoprotein filaments. | Robertson, Ragan B; Moses, Dana N; Kwon, YoungHo; Chan, Pamela; Zhao, Weixing; Chi, Peter; Kle ... | R01ES007061 | J Mol Biol (2009 May 15) |
19327367
|
2009 |
| Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic re ... | Prakash, Rohit; Satory, Dominik; Dray, Eloïse; Papusha, Almas; Scheller, Jürgen; Kramer, Wilfr ... | R01ES007061 | Genes Dev (2009 Jan 01) |
19136626
|
2009 |
| ATP-dependent chromatin remodeling by the Saccharomyces cerevisiae homologous recombination factor R ... | Kwon, YoungHo; Seong, Changhyun; Chi, Peter; Greene, Eric C; Klein, Hannah; Sung, Patrick | R01ES007061 | J Biol Chem (2008 Apr 18) |
18292093
|
2008 |
| Interaction with RPA is necessary for Rad52 repair center formation and for its mediator activity. | Plate, Iben; Hallwyl, Swee C L; Shi, Idina; Krejci, Lumir; Müller, Christian; Albertsen, Line; ... | R01ES007061 | J Biol Chem (2008 Oct 24) |
18703507
|
2008 |
| Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52. | Seong, Changhyun; Sehorn, Michael G; Plate, Iben; Shi, Idina; Song, Binwei; Chi, Peter; Morten ... | R01ES007061 | J Biol Chem (2008 May 02) |
18310075
|
2008 |
| Rad52 multimerization is important for its nuclear localization in Saccharomyces cerevisiae. | Plate, Iben; Albertsen, Line; Lisby, Michael; Hallwyl, Swee C L; Feng, Qi; Seong, Changhyun; R ... | R01ES007061 | DNA Repair (Amst) (2008 Jan 1) |
17888746
|
2008 |
| Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase. | Chi, Peter; San Filippo, Joseph; Sehorn, Michael G; Petukhova, Galina V; Sung, Patrick | R01ES007061 | Genes Dev (2007 Jul 15) |
17639080
|
2007 |
| Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous ... | Zhang, Yu; Hefferin, Melissa L; Chen, Ling; Shim, Eun Yong; Tseng, Hui-Min; Kwon, Youngho; Sun ... | R01ES007061 | Nat Struct Mol Biol (2007 Jul) |
17589524
|
2007 |
| Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide. | San Filippo, Joseph; Chi, Peter; Sehorn, Michael G; Etchin, Julia; Krejci, Lumir; Sung, Patric ... | R01ES007061 | J Biol Chem (2006 Apr 28) |
16513631
|
2006 |
| Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function. | Chi, Peter; Van Komen, Stephen; Sehorn, Michael G; Sigurdsson, Stefan; Sung, Patrick | R01ES007061 | DNA Repair (Amst) (2006 Mar 7) |
16388992
|
2006 |
| Yeast recombination factor Rdh54 functionally interacts with the Rad51 recombinase and catalyzes Rad ... | Chi, Peter; Kwon, Youngho; Seong, Changhyun; Epshtein, Anastasiya; Lam, Isabel; Sung, Patrick; ... | R01ES007061 | J Biol Chem (2006 Sep 08) |
16831867
|
2006 |
| Effect of amino acid substitutions in the rad50 ATP binding domain on DNA double strand break repair ... | Chen, Ling; Trujillo, Kelly M; Van Komen, Stephen; Roh, Dong Hyun; Krejci, Lumir; Lewis, L Kev ... | R01ES007061 | J Biol Chem (2005 Jan 28) |
15546877
|
2005 |
| Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidanc ... | Prakash, Rohit; Krejci, Lumir; Van Komen, Stephen; Anke Schürer, Kirsten; Kramer, Wilfried; Sun ... | R01ES007061 | J Biol Chem (2005 Mar 04) |
15634678
|
2005 |
| Differential arrangements of conserved building blocks among homologs of the Rad50/Mre11 DNA repair ... | de Jager, Martijn; Trujillo, Kelly M; Sung, Patrick; Hopfner, Karl-Peter; Carney, James P; Tain ... | R01ES007061 | J Mol Biol (2004 Jun 11) |
15165861
|
2004 |
| Meiotic recombination: an affair of two recombinases. | Sehorn, Michael G; Sung, Patrick | R01ES007061 | Cell Cycle (2004 Nov) |
15547324
|
2004 |
| Multiple interactions with the Rad51 recombinase govern the homologous recombination function of Rad ... | Raschle, Markus; Van Komen, Stephen; Chi, Peter; Ellenberger, Tom; Sung, Patrick | R01ES007061 | J Biol Chem (2004 Dec 10) |
15465810
|
2004 |
| Physical and functional interaction between the XPF/ERCC1 endonuclease and hRad52. | Motycka, Teresa A; Bessho, Tadayoshi; Post, Sean M; Sung, Patrick; Tomkinson, Alan E | R01ES007061 | J Biol Chem (2004 Apr 02) |
14734547
|
2004 |
| Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein. | Krejci, Lumir; Macris, Margaret; Li, Ying; Van Komen, Stephen; Villemain, Jana; Ellenberger, T ... | R01ES007061 | J Biol Chem (2004 May 28) |
15047689
|
2004 |
| Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand break ... | Lewis, L Kevin; Storici, Francesca; Van Komen, Stephen; Calero, Shanna; Sung, Patrick; Resnick, ... | R01ES007061 | Genetics (2004 Apr) |
15126391
|
2004 |
| ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2. | Van Komen, Stephen; Reddy, Mothe Sreedhar; Krejci, Lumir; Klein, Hannah; Sung, Patrick | R01ES007061 | J Biol Chem (2003 Nov 07) |
12966095
|
2003 |
| Rad51 recombinase and recombination mediators. | Sung, Patrick; Krejci, Lumir; Van Komen, Stephen; Sehorn, Michael G | R01ES007061 | J Biol Chem (2003 Oct 31) |
12912992
|
2003 |
| Yeast xrs2 binds DNA and helps target rad50 and mre11 to DNA ends. | Trujillo, Kelly M; Roh, Dong Hyun; Chen, Ling; Van Komen, Stephen; Tomkinson, Alan; Sung, Patr ... | R01ES007061 | J Biol Chem (2003 Dec 05) |
14522986
|
2003 |
| Functional cross-talk among Rad51, Rad54, and replication protein A in heteroduplex DNA joint format ... | Van Komen, Stephen; Petukhova, Galina; Sigurdsson, Stefan; Sung, Patrick | R01ES007061 | J Biol Chem (2002 Nov 15) |
12226081
|
2002 |
| Interaction with Rad51 is indispensable for recombination mediator function of Rad52. | Krejci, Lumir; Song, Binwei; Bussen, Wendy; Rothstein, Rodney; Mortensen, Uffe H; Sung, Patric ... | R01ES007061 | J Biol Chem (2002 Oct 18) |
12171935
|
2002 |
| Basis for avid homologous DNA strand exchange by human Rad51 and RPA. | Sigurdsson, S; Trujillo, K; Song, B; Stratton, S; Sung, P | R01ES007061 | J Biol Chem (2001 Mar 23) |
11124265
|
2001 |
| DNA pairing and strand exchange by the Escherichia coli RecA and yeast Rad51 proteins without ATP hy ... | Rice, K P; Eggler, A L; Sung, P; Cox, M M | R01ES007061 | J Biol Chem (2001 Oct 19) |
11504729
|
2001 |
| DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex. | Trujillo, K M; Sung, P | R01ES007061 | J Biol Chem (2001 Sep 21) |
11454871
|
2001 |
| Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange. | Sigurdsson, S; Van Komen, S; Bussen, W; Schild, D; Albala, J S; Sung, P | R01ES007061 | Genes Dev (2001 Dec 15) |
11751636
|
2001 |
| Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes. | Chen, L; Trujillo, K; Ramos, W; Sung, P; Tomkinson, A E | R01ES007061 | Mol Cell (2001 Nov) |
11741545
|
2001 |
| Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microsco ... | Anderson, D E; Trujillo, K M; Sung, P; Erickson, H P | R01ES007061 | J Biol Chem (2001 Oct 05) |
11470800
|
2001 |
| Functional interactions among yeast Rad51 recombinase, Rad52 mediator, and replication protein A in ... | Song, B; Sung, P | R01ES007061 | J Biol Chem (2000 May 26) |
10748203
|
2000 |
| Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase. | Chen, L; Trujillo, K; Sung, P; Tomkinson, A E | R01ES007061 | J Biol Chem (2000 Aug 25) |
10854421
|
2000 |
| Promotion of Rad51-dependent D-loop formation by yeast recombination factor Rdh54/Tid1. | Petukhova, G; Sung, P; Klein, H | R01ES007061 | Genes Dev (2000 Sep 01) |
10970884
|
2000 |
| Recombination factors of Saccharomyces cerevisiae. | Sung, P; Trujillo, K M; Van Komen, S | R01ES007061 | Mutat Res (2000 Jun 30) |
10915877
|
2000 |
| Superhelicity-driven homologous DNA pairing by yeast recombination factors Rad51 and Rad54. | Van Komen, S; Petukhova, G; Sigurdsson, S; Stratton, S; Sung, P | R01ES007061 | Mol Cell (2000 Sep) |
11030336
|
2000 |
| Single strand DNA binding and annealing activities in the yeast recombination factor Rad59. | Petukhova, G; Stratton, S A; Sung, P | R01ES007061 | J Biol Chem (1999 Nov 26) |
10567339
|
1999 |
| Yeast Rad54 promotes Rad51-dependent homologous DNA pairing via ATP hydrolysis-driven change in DNA ... | Petukhova, G; Van Komen, S; Vergano, S; Klein, H; Sung, P | R01ES007061 | J Biol Chem (1999 Oct 08) |
10506208
|
1999 |
| Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95 ... | Trujillo, K M; Yuan, S S; Lee, E Y; Sung, P | R01ES007061 | J Biol Chem (1998 Aug 21) |
9705271
|
1998 |
| Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinas ... | Sung, P | R01ES007061 | J Biol Chem (1997 Nov 07) |
9353267
|
1997 |
| Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promo ... | Sung, P | R01ES007061 | Genes Dev (1997 May 01) |
9159392
|
1997 |
| Dual requirement for the yeast MMS19 gene in DNA repair and RNA polymerase II transcription. | Lauder, S; Bankmann, M; Guzder, S N; Sung, P; Prakash, L; Prakash, S | R01ES007061 | Mol Cell Biol (1996 Dec) |
8943333
|
1996 |
| Yeast Rad51 recombinase mediates polar DNA strand exchange in the absence of ATP hydrolysis. | Sung, P; Stratton, S A | R01ES007061 | J Biol Chem (1996 Nov 08) |
8910403
|
1996 |
| DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that ... | Sung, P; Robberson, D L | R01ES007061 | Cell (1995 Aug 11) |
7634335
|
1995 |