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Your Environment. Your Health.

Progress Reports: Michigan State University: Research Translation Core

Superfund Research Program

Research Translation Core

Project Leader: Brad L. Upham
Grant Number: P42ES004911
Funding Period: 2006-2020
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's eNewsletter page

Progress Reports

Year:   2019  2018  2017  2016  2015  2014  2013  2012  2011  2010  2009  2008  2007  2006 

Overall Goal: To facilitate the integration of scientific knowledge generated by all the individual research projects of this Program Project Grant, such that the communication of this knowledge can be transmitted to regional federal, State, academic and private industry that would have both responsibilities and interest in using this information. The manner by which this is proposed with be through an annual conference, a mid-project international symposium and a publicly accessible website which will contain an interactive set of molecular tools for the use in identifying the capacity of microbial consortia to degrade hazardous chemicals in the environment. All of Dr. Trosko's group members participated in all three of NIEHS's teleconferences to share goals of the Superfund Basic research Program consortium of Program Projects. They presented a PowerPoint slide presentation of their Core.

Objective 1: To date, the group has already organized two seminars offered to the members of the Program Project, broader academic, State/Federal regulatory agencies, and industry. [David Bell/ Martin Rose of University of Nottingham and Central Science Laboratory, York, England, respectively, "TCDD is a potent developmental toxicant; a robust examination of the developmental effects of TCDD on the reproductive system" and Laurie C. Haws, Ph.D., DABT of ChemRisk, Inc., "The Use of Toxic Equivalency Factors to Assess Potential Human Health Risks Posed By Dioxin-like Compounds: Keeping Up With the Science".

In addition, they have already identified and communicated with various "stakeholders" who have indicated their willingness to attend an annual 1 day workshop [date has been set for MAY, 2007, on campus], during which 1/2 day session will be for a very brief overview of aims and current progress to date by all projects & Cores and the other 1/2 day for participation, feedback, suggestions for identifying common areas of overlap between the research aims of projects and needs to be met by stakeholders. Depending on the results of this first workshop will determine the nature of the sequent workshops.

Although not formally integrated in the Core goals, several members of this program have strong international connections (Drs. Trosko, Kaminski & Tiedje) with (a) the Chulabhorn Research Institute, Bangkok, Thailand which has regular organized workshops on training Southeastern scientists various aspects of environmental toxicity/pollution issues; (b) Korean FDA, KIST, various universities in Korea- Seoul National University, Yongsei University, Inha University, etc. and (c) the National Institute of Health Sciences- Toxicology Division. With any progress made on their project, transmission of this information could facilitate international dissemination via the Research Translation Core's close connections with these major international institutions.

Objective 2: The Core group is going to plan an international meeting at the end of the third year on the tentative subject: "Computational Analyses: Modeling and the Contaminated Environment". While neither the detailed goals, intended topics, nor invited speakers, have yet to be determined, a Conference Scientific Committee will be determined this next year, with a Chairperson to help identify topics, speakers, venue, specific time and place for the conference. During this year, already several meetings have been attended by Core Director, Dr. Trosko, to gain information on various foreign governments' involvement in this area, on international experts in this area, as well as individuals with the Superfund consortium of Program Project grants sharing this common goal. This information will be passed on to the Chairperson of the International Conference.

Objective 3: With the hiring of a number of individuals in this Core, progress has been made on the web development of an interactive web site [Molecular Biology Tools Repository (MTBR)] for bioremediation workers, researchers and policy decision makers to be created for the enhancement of the quality and efficiency of risk assessment purposes. To date, the progress includes: (a) the production of video tutorials to make tools being enhanced under the Core more accessible to other environmental microbiologists and environmental engineers. These include tutorials for the Functional Gene Pipeline/Repository holding the Rieske-type ring-cleaving (di)oxygenase and corrinoid-type reductive (Rdh) dehalogenase databases ( used for primer development in the "Molecular Insight into Palyaromatic Toxicant Degradation by Microbial Communities" and the "Geoshemical Controls on the Adsorption, Bioavailability, and Longterm Environmental Fate of Dioxins, PCBs, and PAHs" projects and the high-throughput survey sequence processing pipeline (; login required) used for oxygenase gene library screening in the "Molecular Insight into Palyaromatic Toxicant Degradation by Microbial Communities" project and (b) the latter tool has been made publicly accessible by providing user accounts so that interested researchers can process their own data using this pipeline and associated tools.

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