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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Brad L. Upham

Superfund Research Program

Brad L. Upham

Michigan State University
Department of Pediatrics and Human Development
1129 Farm Lane, Room 243
Food Safety Toxicology Building
East Lansing, Michigan 48824-1302
Phone: 517-884-2051
Email: brad.upham@ht.msu.edu

Projects

Hazardous Waste Sites

Tittabawassee River, Saginaw River and Bay

  • Michigan State University: Molecular Insight into Dioxin Degradation by Microbes and Microbial Communities

Publications

2019

2017

  • Stedtfeld RD, Stedtfeld TM, Waseem H, Fitschen-Brown M, Guo X, Chai B, Williams MR, Shook T, Logan A, Graham A, Chae J, Sul WJ, VanHouten J, Cole JR, Zylstra GJ, Tiedje JM, Upham BL, Hashsham SA. 2017. Isothermal assay targeting class 1 integrase gene for environmental surveillance of antibiotic resistance markers. J Environ Manage 198:213-220. doi:10.1016/j.jenvman.2017.04.079 PMID:28460328
  • Williams MR, Stedtfeld RD, Waseem H, Stedtfeld TM, Upham BL, Khalife WT, Etchebarne B, Hughes M, Tiedje JM, Hashsham SA. 2017. Implications of direct amplification for measuring antimicrobial resistance using point-of-care devices. Analytical Methods 9:1229-1241. doi:10.1039/C6AY03405E PMID:29657581 PMCID:PMC5898395

2016

2010

  • Trosko JE, Upham BL. 2010. A paradigm shift is required for the risk assessment of potential human health after exposure to low level chemical exposures - a response to the toxicity testing in the 21st century report. Int J Toxicol 29(4):344-357. doi:10.1177/1091581810371384 PMID:20634539

2007

  • Tai M, Upham BL, Olson LK, Tsao M, Reed DN, Trosko JE. 2007. Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells. Int J Cancer 120(9):1855-62. PMID:17266035
  • Upham BL, Guzvic M, Scott J, Carbone JM, Blaha L, Coe C, Li L, Rummel AM, Trosko JE. 2007. Inhibition of gap junctional intercellular communication and activation of mitogen-activated protein kinase by tumor-promoting organic peroxides and protection by resveratrol. Nutr Cancer 57(1):38-47. PMID:17516861

2005

  • Loch-Caruso R, Upham BL, Harris C, Trosko JE. 2005. Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions. Toxicol Sci 85(1):694-702. PMID:15716478
  • Trosko JE, Upham BL. 2005. The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment. Mutagenesis 20(2):81-92. PMID:15784692

2004

  • Nakamura Y, Trosko JE, Chang C, Upham BL. 2004. Psyllium extracts decreased neoplastic phenotypes induced by the Ha-Ras oncogene transfected into a rat liver oval cell line. Cancer Lett 203(1):13-24. PMID:14670613
  • Trosko JE, Chang C, Upham BL, Tai M. 2004. Ignored hallmarks of carcinogenesis: stem cells and cell-cell communication. Ann N Y Acad Sci 1028:192-201. doi:10.1196/annals.1322.023 PMID:15650245

2003

  • Hilscherova K, Blankenship AL, Kannan K, Nie M, Williams LL, Coady KK, Upham BL, Trosko JE, Bursian SJ, Giesy JP. 2003. Oxidative stress in laboratory-incubated double-crested cormorant eggs collected from the Great Lakes. Arch Environ Contam Toxicol 45(4):533-546. PMID:14708670
  • Hilscherova K, Blankenship AL, Nie M, Coady KK, Upham BL, Trosko JE, Giesy JP. 2003. Oxidative stress in liver and brain of the hatchling chicken (Gallus domesticus) following in ovo injection with TCDD. Comp Biochem Physiol C Toxicol Pharmacol 136(1):29-45. PMID:14522597
  • Machala M, Blaha L, Kapplova P, Pencikova K, Neca J, Andrysik Z, Upham BL, Vondracek J. 2003. Acute Exposure to Polycyclic Aromatic Hydrocarbons Affects Multiple Cell Signaling Components in Rat Liver Epthelial Cell Line. In: Proceedings of the Annual Meeting of EuroTox, September 28. Florence, Italy.
  • Machala M, Blaha L, Kapplova P, Pencikova K, Neca J, Andrysik Z, Upham BL, Vondracek J. 2003. Inhibition of GJIC by Polycyclic Aromatic Hydrocarbons and Polychlorinated Biphenyls: Relative Inhibitory Potencies and Screening for Potential Mode(s) of Action. In: Proceedings of the International Gap Junction Congress, August 23. Cambridge, England.
  • Machala M, Blaha L, Vondracek J, Trosko JE, Scott J, Upham BL. 2003. Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: Inhibitory potencies and screening for potential mode(s) of action. Toxicol Sci 76(1):102-111. PMID:12915713
  • Trosko JE, Chang C, Tai M, Upham BL. 2003. The role of stem cells and cell-cell communication in cancer chemoprevention stategies. In: Proceedings of the ICMAA-VII (8th International Conference on mechanisms of anti-mutagenesis and anticarcinogenesis) Oct. 4-8. Pisa, Italy.
  • Upham BL. 2003. Integrated Signaling Effects of Epigenetic Toxicants. In: Proceedings of the Epigenetic Toxicant Symposium at the 2003 Congress on in vitro Biology, May 31. Portland, OR.
  • Upham BL, Koski TR, Rummel AM, Wilson MR, Horvath A, Trosko JE. 2003. Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis. Cancer Lett 191(1):27-34. PMID:12609706
  • Upham BL, Rummel AM, Carbone JM, Trosko JE, Ouyang Y, Crawford RB, Kaminski NE. 2003. Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line. Int J Cancer 104(1):12-18. doi:10.1002/ijc.10899 PMID:12532414
  • Upham BL, Suzuki J, Chen G, Wang Y, McCabe LR, Chang C, Krutovskikh VA, Yamasaki H, Trosko JE. 2003. Reduced gap junctional intercellular communication and altered biological effects in mouse osteoblast and rat liver oval cell lines transfected with dominant-negative connexin 43. Mol Carcinog 37(4):192-201. PMID:12891628

2002

  • Blaha L, Kapplova P, Vondracek J, Upham BL, Machala M. 2002. Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons. Toxicol Sci 65:43-51. PMID:11752684
  • Horvath A, Upham BL, Ganev V, Trosko JE. 2002. Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line. Toxicon 40:273-282. PMID:11711124
  • Hu W, Jones PD, Upham BL, Trosko JE, Lau C, Giesy JP. 2002. Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo. Toxicol Sci 68(2):429-436. PMID:12151638
  • Trosko JE, Chang C, Upham BL. 2002. Modulation of gap junctional communication by 'epigenetic toxicants': A shared mechanism in teratogenesis, carcinogenesis, atherogenesis, immunomodulation, reproductive- and neuro-toxicities. In: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives. CRC Press Company, Boca Raton, FL. pp.445-454.
  • Upham BL, Davis JM, Trosko JE, Schwartz KA. 2002. Polycyclic aromatic hydrocarbons with bay-like structures inhibited gap junctional intercellular communication in neonatal rat cardiomyocytes and caused asynchronous beating. Toxicol Sci 00:1410.

2001

  • Blaha L, Machala M, Vondracek J, Neca J, Upham BL. 2001. In vitro assessment of non-genotoxic effects of polycyclic aromatic hydrocarbons. Toxicology 164:154-155.
  • Masten S, Tian M, Upham BL, Trosko JE. 2001. Effect of selected pesticides and their ozonation by-products on gap junctional intercellular communication using rat liver epithelial cell lines. Chemosphere 44(3):457-465. PMID:11459151
  • Trosko JE, Kwan K, Upham BL, Halgren R, Zacharewski TR, Chang C. 2001. Stem cell biology in toxicology. Toxicol Sci 60:150.
  • Upham BL, Rummel AM, Carbone JM, Trosko JE, Ouyang Y, Kaminski NE. 2001. Cannabinoids inhibited gap junctional intercellular communication and activated extracellular receptor kinase in a rat liver epithelial cell line. Toxicol Sci 60:750.
  • Upham BL, Trosko JE, Hirose I, Hasegawa R, Kanno J, Inoue T, Sai K. 2001. Structure-activity relationships of perfluorinated fatty acids on gap junctional intercellular communication and MAPK using in vivo and in vitro model systems. Toxicol Sci 60:746.
  • Upham BL, Wagner JG. 2001. Toxicological Highlight: Toxicant-induced oxidative stress in cancer. Toxicol Sci 64:1-3.

2000

  • Trosko JE, Chang C, Wilson MR, Upham BL, Hayashi T, Wade M. 2000. Gap junctions and the regulation of cellular functions of stem cells during development and differentiation. Methods 20(2):245-264. PMID:10671317

1999

  • Ghoshal S, Weber WJ, Rummel AM, Trosko JE, Upham BL. 1999. Epigenetic toxicity of a mixture of polycyclic aromatic hydrocarbons on gap junctional intercellular communication before and after biodegradation. Environ Sci Technol 33:1044-1050.
  • Rummel AM, Trosko JE, Wilson MR, Upham BL. 1999. Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity. Toxicol Sci 49:232-240. PMID:10416268

1998

  • Trosko JE, Chang C, Upham BL, Wilson MR. 1998. Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication. Toxicol Lett 102-103:71-78. PMID:10022235
  • Upham BL, DeoCampo ND, Wurl B, Trosko JE. 1998. Inhibition of gap junctional intercellular communication by perfluorinated fatty acids dependent on the chain length of the fluorinated tail. Int J Cancer 78:491-495. PMID:9797139
  • Upham BL, Weis LM, Trosko JE. 1998. Modulated gap junctional intercellular communication as a biomarker of PAH epigenetic toxicity: structure-function relationship. Environ Health Perspect 106:975-984. PMID:9703481
  • Weis LM, Rummel AM, Masten S, Trosko JE, Upham BL. 1998. Bay or bay-like regions of polycyclic aromatic hydrocarbons were potent inhibitors of gap junction intercellular communication. Environ Health Perspect 106(1):17-22.

1997

  • Upham BL, Boddy B, Xing X, Trosko JE, Masten S. 1997. Non-genotoxic effects of selected pesticides and their disinfection by-products on gap junctional intercellular communication. Ozone: Science & Engineering 19(4):351-369.
  • Upham BL, Kang K, Cho H, Trosko JE. 1997. Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells. Carcinogenesis 18(1):37-42. PMID:9054587

1996

  • Upham BL, Boddy B, Xing X, Trosko JE, Masten S. 1996. Non-genotoxic effects of selected pesticides and their disinfection by-products on gap junctional intercellular communication. In: Proceedings of the IOA (International Ozone Association) Pan American Conference: Applications and Optimization of Ozone for Potable Water Treatment, Sept. 8-11. Ottawa, Ontario, Canada.
  • Upham BL, Weis LM, Rummel AM, Masten S, Trosko JE. 1996. The effects of anthracene and methylated anthracenes on gap junctional intercellular communication in rat liver epithelial cells. Fundam Appl Toxicol 34(2):260-264. PMID:8954755

1995

  • Upham BL, Yao JJ, Trosko JE, Masten S. 1995. Determination of the efficacy of ozone treatment systems using a gap junction intercellular communication bioassay. Environ Sci Technol 29:2923-2928. PMID:22148197
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