Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.

Progress Reports: Texas A&M University: Halogenated Aromatics

Superfund Research Program

Halogenated Aromatics

Project Leader: Stephen H. Safe
Grant Number: P42ES004917
Funding Period: 1995 - 2000

Progress Reports

Year:   1999  1998  1997  1996  1995 

Researchers developed a battery of E2-responsive bioassays for studies on AhR-mediated antiestrogenic activity and this objective has been expanded to investigate estrogenic activities of xenoestrogens and their mixtures. Research on endocrine disruptors was conducted in collaboration with scientists from the Chemical Industry Institute of Toxicology (Dr. Kevin Gaido), Duke University School of Medicine (Dr. Donald McDonnell), and NIEHS (Dr. Ken Korach). Because of this extensive inter-institutional collaboration, researchers were able to employ diverse in vivo and in vitro bioassays and our results demonstrated that interactions of weakly estrogenic pesticides and hydroxy-PCBs were essentially additive. Results of proposed studies will reduce the uncertainty in the risk assessment process for these Superfund chemicals. E2-responsive bioassays developed by these researchers were also used for environmental exposure assessment utilizing groundwater and soil extracts from areas in South Texas. The bioassays detected estrogenic activity in some extracts and the presence of industrial phenolics was subsequently confirmed by GC-MS analysis. Thus, research on endocrine disruptors and their interactions has addressed important environmental and public health issues on risk/exposure assessment, stimulated new basic research on the mechanisms of action of xenoestrogens and resulted in new collaborative studies on environmental distribution of industrial-derived endocrine-active compounds.

to Top