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Your Environment. Your Health.

Progress Reports: Boston University: Mechanisms and Impacts of PCB Resistant Fish

Superfund Research Program

Mechanisms and Impacts of PCB Resistant Fish

Project Leader: Mark E. Hahn (Woods Hole Oceanographic Institution)
Co-Investigators: Sibel I. Karchner (Woods Hole Oceanographic Institution), Neelakanteswar Aluru (Woods Hole Oceanographic Institution)
Grant Number: P42ES007381
Funding Period: 1995-2020
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Progress Reports

Year:   2019  2018  2017  2016  2015  2014  2013  2012  2010  2009  2008  2007  2006  2005  2004  2003  2002  2001  2000  1999  1998  1997  1996  1995 

During the past year, adult Fundulus were collected from New Bedford Harbor (NBH, a Superfund site contaminated with PCBs) and from a clean creek on Cape Cod, Massachusetts. The content of the biomarker enzyme cytochrome P450-1A (CYP1A) was measured. Mean CYP1A levels were low and not significantly different between fish from the two sites, despite the difference in contaminant levels. However, the fish from NBH have developed resistance to dioxin-like chemicals, as evidenced by the inability to induce CYP1A by TCDF, in contrast to strong induction in fish from the clean environment. In vitro fertilization was performed using sperm and eggs from the captured fish within each site. The resulting embryos are being raised for future experiments requiring fish with site-specific genetic background but lacking the chemical burden present in fish raised in the wild.

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